Atracade 25mg/ml Injection (Atracurium): Comprehensive Medicine Profile
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
What is atb 25mg/ml injection used for?
Atracade 25mg/ml Injection contains atracurium, a non-depolarizing muscle relaxant used during surgery to relax muscles and help with intubation. It is given intravenously only by an anesthesiologist in a hospital setting. It causes temporary paralysis, so patients need breathing support until the effect wears off. It is not for self-administration.
- Generic Name: Atracurium besilate
- Manufacturer: Cachet Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 atb 25mg/ml injection के बारे में (Hindi Summary)
उपयोग: एट्राकेड 25mg/ml इंजेक्शन में एट्राक्यूरियम नामक दवा होती है, जिसका उपयोग सामान्य एनेस्थीसिया के दौरान मांसपेशियों को शिथिल करने के लिए किया जाता है। यह सर्जरी के दौरान मांसपेशियों को आराम देने, ट्रेकिया में ट्यूब डालने (इंट्यूबेशन) और मशीन से सांस देने में मदद करता है। यह दवा केवल अस्पताल में प्रशिक्षित एनेस्थेसियोलॉजिस्ट द्वारा नस के माध्यम से दी जाती है। मरीज को इस दौरान लगातार निगरानी की आवश्यकता होती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मांसपेशियों का लंबे समय तक शिथिल रहना, रक्तचाप में कमी, हृदय गति में वृद्धि और चेहरे पर लालिमा शामिल हैं। गंभीर दुष्प्रभावों में एनाफिलेक्सिस (गंभीर एलर्जी), गंभीर ब्रोंकोस्पाज्म, गंभीर हाइपोटेंशन और लंबे समय तक पक्षाघात हो सकता है। इन स्थितियों में तुरंत चिकित्सा सहायता लें।
सुरक्षा सलाह: यह दवा केवल अस्पताल में प्रशिक्षित डॉक्टर द्वारा ही दी जानी चाहिए। मरीज को कभी भी खुद से यह इंजेक्शन नहीं लगाना चाहिए। उपचार के दौरान हृदय गति, रक्तचाप, ऑक्सीजन स्तर और मांसपेशियों की कार्यप्रणाली की लगातार निगरानी की जानी चाहिए। एलर्जी के लक्षण दिखने पर तुरंत डॉक्टर को सूचित करें।
💊 atb 25mg/ml injection Uses & Benefits
[{"condition":"Skeletal muscle relaxation during general anesthesia","description":"Atracurium is used as an adjunct to general anesthesia to provide muscle relaxation for surgical procedures, including abdominal, orthopedic, and other surgeries requiring a relaxed surgical field."},{"condition":"Facilitation of endotracheal intubation","description":"It relaxes the muscles of the larynx and pharynx, aiding in the passage of an endotracheal tube during induction of anesthesia."},{"condition":"Mechanical ventilation in intensive care","description":"In carefully selected critically ill patients, atracurium may be used to facilitate mechanical ventilation when other measures are insufficient, though this use requires close monitoring and is generally reserved for specific situations."},{"condition":"Control of muscle spasms in selected procedures","description":"It may be used to provide muscle relaxation during certain diagnostic or therapeutic procedures where controlled paralysis is required."}]
Off-label uses: []
Primary treatment for: Skeletal muscle relaxation during general anesthesia
Also treats: Facilitation of endotracheal intubation, Mechanical ventilation in intensive care
📋 Drug Information
| Generic Name(s) | Atracurium besilate |
| Brand Name | Atracurium Besilate Injection |
| Manufacturer | Cachet Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Skeletal muscle relaxant- Peripherally acting |
| Route of Administration | Intravenous |
| Storage | Store as directed on the product label. Typically, atracurium injection should be refrigerated at 2–8°C (36–46°F) and protected from light. Do not freeze. Once removed from refrigeration, it should be used within a specified period as per manufacturer instructions. Do not use if the solution is discolored or contains particulate matter. |
| Shelf Life | Not established from the available information. Refer to the product label for the expiration date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Atracurium is a non-depolarizing neuromuscular blocking agent. It competitively antagonizes acetylcholine at nicotinic acetylcholine receptors located on the motor endplate of skeletal muscle. By binding to these receptors without activating them, it prevents acetylcholine from depolarizing the muscle fiber, thereby blocking neuromuscular transmission and producing skeletal muscle relaxation. This effect can be reversed by increasing the concentration of acetylcholine at the neuromuscular junction (e.g., with neostigmine) or by spontaneous recovery as the drug is eliminated.
Mechanism Steps
💡 How to Take atb 25mg/ml injection
Strength: 25 mg/mL
Dosage Information
| Adult Dosage | Dosage must be individualized by a qualified anesthesiologist based on the patient's weight, clinical condition, surgical requirements, and response. A typical intubating dose is in the range of 0.4–0.5 mg/kg intravenously, but this is not a universal recommendation. Maintenance doses may be given as needed. Continuous infusion may be used. The dose should be titrated to effect using neuromuscular monitoring. This information is educational and not a prescription. |
| Pediatric Dosage | Not established from the available information. Pediatric dosing must be determined by a qualified pediatric anesthesiologist based on weight, age, and clinical status. Do not use without specialist supervision. |
| Elderly Dosage | Elderly patients may have altered sensitivity to neuromuscular blockers. Doses should be individualized and titrated carefully with neuromuscular monitoring. Not established from the available information for specific dose adjustments. |
| Renal Impairment | Atracurium's elimination is largely independent of renal function, so dose adjustment is generally not required in renal impairment. However, clinical monitoring is advised, and the dose should be titrated to effect. |
| Hepatic Impairment | Atracurium's elimination is largely independent of hepatic function, so dose adjustment is generally not required in hepatic impairment. However, clinical monitoring is advised, and the dose should be titrated to effect. |
| Maximum Daily Dose | Not established from the available information. The maximum dose is determined by clinical response and the need to avoid prolonged blockade. Doses should be individualized by a qualified clinician. |
Dosage Timeline
⚠️ Side Effects of atb 25mg/ml injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Minor | ||
| Minor | ||
| Minor | ||
| Minor | ||
| Minor |
🚨 Major Interactions
- Inhalational anesthetics (e.g., isoflurane, sevoflurane)
- Aminoglycoside antibiotics (e.g., gentamicin, neomycin)
- Magnesium sulfate
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Calcium channel blockers
- Lithium
🍷 Alcohol Interaction
Alcohol is not typically relevant in the acute perioperative setting where atracurium is used. Chronic alcohol use may alter hepatic function and potentially affect the metabolism of some drugs, but atracurium's degradation is largely independent of liver function. No direct food or alcohol interaction is established.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to atracurium or benzylisoquinolinium compounds.","Use in patients without access to facilities for intubation, artificial ventilation, and oxygen therapy.","Administration by untrained personnel."]
⚠️ Warnings & Precautions
[{"warning":"Respiratory paralysis","reason":"Atracurium causes complete paralysis of respiratory muscles.","action":"Ensure immediate availability of ventilation support; monitor until full recovery."},{"warning":"Anaphylaxis","reason":"Rare but life-threatening allergic reactions can occur.","action":"Be prepared to treat anaphylaxis promptly; monitor for signs."},{"warning":"Histamine release","reason":"Can cause hypotension, tachycardia, flushing, bronchospasm.","action":"Administer slowly; monitor vital signs; treat symptoms as needed."},{"warning":"Prolonged blockade","reason":"May occur with overdosage, drug interactions, or in certain patients.","action":"Monitor neuromuscular function; use reversal agents if appropriate; do not extubate until recovery."},{"warning":"Use in intensive care","reason":"Prolonged infusion may lead to tolerance, prolonged recovery, or critical illness polyneuropathy.","action":"Use only when necessary; monitor closely; consider alternative agents."}]
🤱 Lactation Safety
Not established from the available information. It is not known whether atracurium is excreted in human milk. Because it is used in the perioperative setting and has a short duration, exposure to a breastfeeding infant is likely minimal, but caution is advised. Breastfeeding may be resumed when the mother is stable and able, as per clinician advice.
💊 Overdose Management
Overdose of atracurium leads to prolonged neuromuscular blockade and respiratory paralysis. There is no specific antidote for atracurium itself, but the effects can be reversed with acetylcholinesterase inhibitors (e.g., neostigmine) once spontaneous recovery begins. Management includes immediate discontinuation of the drug, maintenance of a patent airway, and continued mechanical ventilation until full recovery of neuromuscular function. Cardiovascular and respiratory support should be provided as needed. In case of suspected overdose, seek emergency medical care immediately. Do not attempt to manage at home.
⏰ Missed Dose
Atracurium is administered by healthcare professionals in a controlled setting; missed doses are not applicable to patient self-administration. If a scheduled dose during a procedure is missed, the anesthesiologist will determine the appropriate action based on the patient's condition and surgical requirements.
Additional Safety Advice
This medicine must be given only by a qualified anesthesiologist or clinician trained in the use of neuromuscular blocking agents, in a setting equipped for intubation, artificial ventilation, oxygen therapy, and immediate management of anaphylaxis. It must never be self-administered. The patient's neuromuscular function, heart rate, blood pressure, oxygen saturation, and body temperature should be monitored throughout. A peripheral nerve stimulator should be used to assess the degree of block and recovery. Reversal agents (such as neostigmine, usually with an anticholinergic) should be available, and the decision to reverse and extubate must be individualized. Caution is needed in patients with known hypersensitivity to atracurium or benzylisoquinolinium compounds, in those with asthma or a history of severe allergic reactions, and in patients with significant cardiovascular disease, electrolyte disturbances, or neuromuscular disorders. The medicine should be stored as directed on the label and used only if the solution is clear and the container is intact.
🔄 Substitutes for atb 25mg/ml injection
View AllAlternative brands with exact same active ingredient:
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atrager 25mg/ml injectionZydus Cadila ₹100.83 33.3% COSTLIER
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crimat 25mg/ml injectionMiracalus Pharma Pvt Ltd ₹118.00 56% COSTLIER
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atracade 25mg/ml injectionBharat Serums & Vaccines Ltd ₹120.20 59% COSTLIER
-
Artacil 25mg/ml InjectionNeon Laboratories Ltd ₹120.70 59.6% COSTLIER
-
tracrium 25mg/ml injectionGlaxo SmithKline Pharmaceuticals Ltd ₹126.23 66.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Atracurium is a painkiller.
Fact: Atracurium is a muscle relaxant; it has no pain-relieving properties. It is used alongside anesthetics. - Myth: Atracurium can be taken orally.
Fact: Atracurium is given intravenously only; it is not effective orally. - Myth: Atracurium is safe to use without monitoring.
Fact: Atracurium requires continuous monitoring of neuromuscular function and vital signs because it can cause paralysis and serious cardiovascular effects.
🔄 Alternative Options
Generic Alternatives
- Atracurium besylate injection
Brand Alternatives
- Tracrium