AB-Flo-N Tablet: Complete Guide to Uses, Side Effects, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, or throat
- Difficulty breathing or sudden worsening of breathing
- Severe rash, blistering, or peeling skin
- Fast, irregular, or pounding heartbeat
- Seizures or unusual muscle twitching
- Blood in vomit or stool
- Severe abdominal pain
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is aphyren-n tablet used for?
This medicine is a combination of Acebrophylline 100 mg and Acetylcysteine 600 mg used to treat respiratory conditions like COPD and chronic bronchitis. It works by opening the airways and thinning thick mucus, making it easier to breathe and cough out sputum. It is not a rescue inhaler for sudden breathing attacks.
- Generic Name: Acebrophylline + Acetylcysteine
- Manufacturer: La Renon Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 aphyren-n tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसीब्रोफिलिन 100 मिलीग्राम और एसिटाइलसिस्टीन 600 मिलीग्राम का संयोजन है। इसका उपयोग मुख्य रूप से सीओपीडी, क्रोनिक ब्रोंकाइटिस, और बलगम वाले दमा जैसी श्वसन संबंधी समस्याओं में किया जाता है। यह दवा श्वास नलियों को फैलाकर सांस लेने में आसानी करती है और गाढ़े बलगम को पतला करके बाहर निकालने में मदद करती है। यह दवा अचानक होने वाले गंभीर दमा के दौरे के लिए नहीं है। इसे डॉक्टर के बताए अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, पेट में असहजता, सिरदर्द, चक्कर आना और हल्की नींद आना शामिल हैं। कुछ लोगों को दिल की धड़कन तेज होना, बेचैनी या हल्का कंपन महसूस हो सकता है। गंभीर दुष्प्रभाव बहुत कम होते हैं, लेकिन अगर चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई, त्वचा पर गंभीर दाने, या दिल की धड़कन अनियमित हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर खाने के बाद। टैबलेट को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। निर्धारित मात्रा से अधिक न लें। शराब का सेवन न करें। अगर आपको दिल, किडनी, लिवर, थायरॉइड, मिर्गी या पेट के अल्सर की समस्या है, तो डॉक्टर को पहले बताएं। गर्भवती और स्तनपान कराने वाली महिलाएं डॉक्टर की सलाह के बिना इसका उपयोग न करें। दवा को ठंडी और सूखी जगह पर रखें।
💊 aphyren-n tablet Uses & Benefits
[{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Helps relieve bronchospasm and thin thick mucus, making breathing easier and reducing cough severity in patients with COPD.","evidence":"Well-established"},{"condition":"Chronic bronchitis","description":"Used to loosen thick bronchial secretions and improve airway clearance in chronic bronchitis.","evidence":"Well-established"},{"condition":"Bronchial asthma with mucus hypersecretion","description":"May be added to standard asthma therapy to help manage thick mucus and mild bronchospasm, but it is not a replacement for inhaled corticosteroids or rescue inhalers.","evidence":"Moderate"},{"condition":"Productive cough with thick sputum","description":"Acetylcysteine thins mucus while acebrophylline helps open airways, making it easier to cough out sputum.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Post-operative pulmonary complications prevention","description":"Sometimes used to improve mucus clearance after surgery in patients at risk of lung complications.","evidence":"Limited"},{"condition":"Bronchiectasis with thick secretions","description":"May be used to help clear thick secretions in bronchiectasis, though evidence is limited.","evidence":"Limited"}]
Primary treatment for: Chronic obstructive pulmonary disease (COPD)
Also treats: Chronic bronchitis, Bronchial asthma with mucus hypersecretion, Productive cough with thick sputum
📋 Drug Information
| Generic Name(s) | Acebrophylline + Acetylcysteine |
| Brand Name | Ab-Flo-N Tablet |
| Manufacturer | La Renon Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Mucolytic and Bronchodilator |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Acebrophylline is a xanthine derivative that inhibits phosphodiesterase enzymes, leading to increased cyclic AMP levels in airway smooth muscle cells. This causes bronchodilation and also reduces inflammation by inhibiting the release of inflammatory mediators from mast cells and neutrophils. Acetylcysteine is a mucolytic agent that breaks disulfide bonds in mucus glycoproteins, reducing mucus viscosity and elasticity. This makes thick secretions easier to clear from the airways. Together, they improve airflow and mucus clearance in respiratory conditions.
Mechanism Steps
💡 How to Take aphyren-n tablet
Strength: Each tablet contains Acebrophylline 100 mg and Acetylcysteine 600 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally one to two times daily, or as directed by your doctor. The exact dose and frequency depend on the condition being treated, its severity, and your overall health. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Take the tablet with food to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially fast heartbeat, dizziness, and stomach upset. Dose adjustment may be necessary based on kidney and liver function. Consult your doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, the dose may need to be reduced. Consult your doctor for appropriate dosing based on creatinine clearance. |
| Hepatic Impairment | In patients with hepatic impairment, the dose may need to be reduced. Consult your doctor for appropriate dosing based on liver function tests. |
| Maximum Daily Dose | The maximum recommended daily dose is two tablets (200 mg acebrophylline and 1200 mg acetylcysteine) per day, or as prescribed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of aphyren-n tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Nitroglycerin | Major | |
| Carbamazepine | Major | |
| Theophylline | Moderate | |
| Beta-blockers | Moderate | |
| Ciprofloxacin | Moderate | |
| Activated charcoal | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Nitroglycerin
- Carbamazepine
⚡ Moderate Interactions
- Theophylline
- Beta-blockers
- Ciprofloxacin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and stomach irritation. It may also worsen the underlying respiratory condition and increase the risk of liver problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to acebrophylline, acetylcysteine, or any component of the formulation","Active peptic ulcer disease","Severe liver disease","Severe kidney disease","Uncontrolled cardiac arrhythmias","Acute severe asthma attack (not a rescue medication)","Children under 12 years of age (safety and efficacy not established)"]
⚠️ Warnings & Precautions
["This medicine is not a rescue inhaler and should not be used for sudden severe breathing difficulty.","Use with caution in patients with heart disease, high blood pressure, thyroid disorders, epilepsy, or peptic ulcer.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Do not exceed the prescribed dose; higher doses can cause serious side effects.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep out of reach of children.","Do not use after the expiry date."]
🤱 Lactation Safety
It is not known whether acebrophylline and acetylcysteine are excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a breastfeeding woman. Consult your doctor before use.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, restlessness, fast heartbeat, seizures, and low blood pressure. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be given if the patient presents early. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually after food to reduce stomach upset. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Swallow it whole with a glass of water. Do not take more than the recommended dose because higher doses can increase the risk of nausea, fast heartbeat, and seizures. Avoid alcohol while taking this medicine because it can worsen drowsiness and stomach irritation. If you have heart disease, high blood pressure, thyroid problems, epilepsy, liver disease, kidney disease, or peptic ulcer, tell your doctor before starting this medicine. Do not stop this medicine suddenly without consulting your doctor, especially if you have been taking it for a long time. Keep all follow-up appointments and report any new or worsening symptoms. This medicine may cause dizziness or drowsiness in some people, so avoid driving or operating heavy machinery until you know how it affects you. Pregnant and breastfeeding women should use this medicine only if clearly advised by a doctor. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially fast heartbeat, dizziness, and stomach upset. Dose adjustment may be necessary based on kidney and liver function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks and may recommend alternative treatments.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to prevent pulmonary complications in patients at risk. However, consult your surgeon and doctor before starting or continuing this medicine after surgery, as it may interact with other medications.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may cause dry mouth or interact with local anesthetics. Your dentist may recommend taking a break or adjusting the dose.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fast heartbeat. Avoid strenuous exercise until you know how the medicine affects you. If you experience dizziness, chest pain, or severe breathlessness during exercise, stop and consult your doctor. Gentle activities like walking and breathing exercises are usually safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take regular breaks and stay hydrated. Inform your employer if you have a respiratory condition that may require accommodations.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects such as allergic reactions, seizures, or irregular heartbeat, stop the medicine and seek immediate medical attention. Your doctor may adjust the dose or switch to another medicine based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of liver and kidney function, especially in patients with pre-existing liver or kidney disease. It is generally well tolerated, but prolonged use of acebrophylline may lead to tolerance or increased side effects. Regular follow-up with your doctor is important to assess the continued need for this medicine and to monitor for any adverse effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Inhaled medications like salbutamol or ipratropium can provide rapid relief of bronchospasm and are often used alongside oral medicines.
Evidence: Well-establishedTechniques like postural drainage and percussion help clear mucus from the airways.
Evidence: Well-establishedInhaling steam can help loosen thick mucus and soothe irritated airways.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients with chronic respiratory conditions like COPD are advised to receive annual influenza vaccination and pneumococcal vaccination as per their doctor's recommendation. This medicine does not interact with vaccines, but consult your doctor about the best timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a doctor's note if you are carrying more than a personal supply. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your doses at the same intervals as prescribed; consult your doctor if you need to adjust the schedule. Check the customs regulations of your destination country regarding prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Bronchodilation may begin within 30 to 60 minutes, but the full benefits for mucus clearance may take several days of regular use.
A: Yes, take it with food to reduce stomach upset and nausea.
A: Common side effects include nausea, vomiting, stomach discomfort, headache, and dizziness. These usually improve with continued use.
A: The safety of this medicine during pregnancy is not well established. Use it only if clearly advised by your doctor.
A: Avoid alcohol as it can increase drowsiness, dizziness, and stomach irritation.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for aphyren-n tablet
View AllAlternative brands with exact same active ingredient:
-
nobro 100mg/600mg tabletIndiabulls pharmaceutical ltd ₹93.75 58.7% CHEAPER
-
stayhappi acebrophylline+acetylcysteine 100mg/600mg tabletSarvagunaushdhi Pvt Ltd ₹98.44 56.6% CHEAPER
-
placklin plus 100mg/600mg tabletPlacker Life Sciences ₹103.13 54.5% CHEAPER
-
acedril forte 100mg/600mg tabletIntra Labs India Pvt Ltd ₹131.25 42.1% CHEAPER
-
resebron plus 100mg/600mg tabletInvision Medi Sciences Pvt Ltd ₹131.83 41.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used as a rescue inhaler during an asthma attack.
Fact: This medicine is not a rescue medication. It is used for maintenance therapy. For sudden severe breathing difficulty, use your prescribed rescue inhaler and seek emergency help. - Myth: It is safe to take extra doses for faster relief.
Fact: Taking more than the prescribed dose can cause serious side effects like seizures and irregular heartbeat. Always follow your doctor's instructions. - Myth: This medicine can cure asthma permanently.
Fact: This medicine helps control symptoms but does not cure asthma. Asthma management requires a comprehensive plan including inhaled medications and trigger avoidance.
🔄 Alternative Options
Generic Alternatives
- Acebrophylline 100 mg + Acetylcysteine 600 mg tablet
Brand Alternatives
- AB-Flo-N Tablet
- Mucolite Tablet
- Broncholyte Tablet