Anxidep Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Severe allergic reaction (rash, swelling of face or throat)
- Irregular or fast heartbeat
- Confusion, hallucinations, or extreme agitation
- Fever with muscle stiffness or sweating
- Yellowing of skin or eyes
- Unusual bleeding or bruising
- Seizures
If experiencing severe symptoms, call emergency services immediately.
What is anxidep tablet used for?
This medicine is a combination of diazepam and imipramine used for short-term treatment of anxiety with depressive symptoms. It works by calming the brain and balancing mood chemicals. It is not for everyone and requires a prescription.
- Generic Name: Diazepam (2.5mg) + Imipramine (25mg)
- Manufacturer: Mayflower India
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 anxidep tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डायजेपाम और इमिप्रामाइन का संयोजन है, जिसका उपयोग चिंता और अवसाद के लक्षणों के अल्पकालिक उपचार के लिए किया जाता है। यह मस्तिष्क को शांत करने और मूड को संतुलित करने में मदद करती है। यह केवल डॉक्टर के पर्चे पर ही ली जानी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, कब्ज और थकान शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, अनियमित दिल की धड़कन, भ्रम और दौरे पड़ सकते हैं। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। शराब का सेवन बिल्कुल न करें। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको इसका असर पता न चल जाए। अचानक दवा बंद न करें। नियमित जांच के लिए डॉक्टर के पास जाएँ।
💊 anxidep tablet Uses & Benefits
[{"condition":"Anxiety with depressive symptoms","description":"This combination may be used for short-term relief of anxiety that occurs alongside mild to moderate depression, when a doctor decides that both components are needed.","evidence":"Limited"},{"condition":"Mixed anxiety-depressive disorder","description":"Sometimes prescribed when a patient has features of both anxiety and depression, though evidence for this specific combination is not robust.","evidence":"Limited"}]
Off-label uses: [{"condition":"Insomnia with anxiety","description":"The diazepam component may help with sleep, but this is not a standard approved use and carries risks of dependence.","evidence":"Limited"}]
Primary treatment for: Anxiety with depressive symptoms
Also treats: Mixed anxiety-depressive disorder, Insomnia with anxiety
📋 Drug Information
| Generic Name(s) | Diazepam (2.5mg) + Imipramine (25mg) |
| Brand Name | anxidep tablet |
| Manufacturer | Mayflower India |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Diazepam enhances the inhibitory neurotransmitter GABA at GABA-A receptors, producing anxiolytic, sedative, muscle relaxant, and anticonvulsant effects. Imipramine inhibits the reuptake of serotonin and norepinephrine in the brain, increasing their availability and helping to improve mood and reduce anxiety over time. The combination is intended to provide rapid anxiety relief from diazepam while imipramine addresses underlying depressive symptoms, though the rationale for a fixed-dose combination is debated.
Mechanism Steps
💡 How to Take anxidep tablet
Strength: Tablet containing Diazepam 2.5 mg and Imipramine 25 mg.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Typically, one tablet is taken one to three times daily, but the exact dose and frequency should be determined by your doctor. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of diazepam and imipramine. Lower doses are usually recommended, and close monitoring for sedation, falls, and confusion is necessary. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in renal impairment. Dose adjustment may be needed based on clinical response and renal function. Consult your doctor. |
| Hepatic Impairment | Use with caution in hepatic impairment. Lower doses may be required. Regular monitoring of liver function is advised. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose should not exceed the limit set by your doctor. Typically, the maximum daily dose of diazepam is 30 mg and imipramine is 150 mg, but this combination should not exceed the prescribed amount. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of anxidep tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Opioids | Major | |
| SSRIs | Major | |
| CYP2D6 inhibitors | Moderate | |
| CYP3A4 inhibitors | Moderate | |
| Anticholinergics | Moderate | |
| Cimetidine | Minor | |
| Oral contraceptives | Minor | |
| Alcohol | Major | |
| Grapefruit juice | Moderate |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- CNS depressants (e.g., opioids, alcohol, barbiturates)
- SSRIs (e.g., fluoxetine, sertraline)
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., quinidine, paroxetine)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- Anticholinergic drugs (e.g., benztropine, diphenhydramine)
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. It can dangerously increase sedation, impair breathing, and worsen dizziness, and it may also increase the risk of liver damage.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to diazepam, imipramine, or any component","Concurrent use of MAO inhibitors","Acute narrow-angle glaucoma","Urinary retention","Severe hepatic impairment","Recent myocardial infarction","Children under 12 years","Pregnancy and breastfeeding"]
⚠️ Warnings & Precautions
["May cause drowsiness and impair ability to drive or operate machinery.","Avoid alcohol and other CNS depressants.","Do not stop abruptly; taper under medical supervision.","May cause dependence and withdrawal symptoms.","Use with caution in elderly and debilitated patients.","May worsen depression and increase suicidal thoughts; monitor closely.","Can cause anticholinergic effects; use with caution in patients with BPH or glaucoma.","May interact with many drugs; always inform your doctor."]
🤱 Lactation Safety
Both diazepam and imipramine are excreted in breast milk and may cause sedation and other effects in the infant. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.
💊 Overdose Management
Overdose can cause severe drowsiness, confusion, coma, respiratory depression, seizures, and cardiac arrhythmias. Seek emergency medical help immediately. Treatment is supportive and may include activated charcoal, gastric lavage, and monitoring in an intensive care setting. There is no specific antidote for imipramine; sodium bicarbonate may be used for cardiac toxicity.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Avoid alcohol completely while taking this medicine, as it can increase sedation and dangerous side effects. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially MAO inhibitors, pain relievers, and blood thinners. Do not stop this medicine suddenly, as withdrawal symptoms may occur. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight. Regular follow-up with your doctor is essential to monitor your response and adjust the dose if needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of sedation, dizziness, falls, and confusion. Lower doses are recommended, and close monitoring is essential. Regular review of the need for continued treatment is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both diazepam and imipramine may pose risks to the fetus. Alternative treatments may be considered.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and increase sedation. Your doctor may advise you to stop it temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with local anesthetics and sedatives used in dentistry, increasing the risk of excessive sedation.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your coordination. Avoid activities that require alertness, such as driving or operating machinery, until you know how it affects you. Light exercise like walking is generally safe, but consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness and impair your ability to drive or operate machinery. It may affect your concentration and reaction time. Discuss with your doctor about work adjustments if your job involves operating heavy machinery or driving. Avoid making important decisions until you know how the medicine affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will decide when and how to stop based on your condition and response. Abrupt discontinuation can cause withdrawal symptoms such as anxiety, insomnia, and seizures. Always taper gradually under medical supervision.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to dependence on diazepam and withdrawal symptoms upon discontinuation. Imipramine may cause weight gain, sexual dysfunction, and cardiac effects with prolonged use. Regular monitoring of liver function, blood counts, and ECG may be required. The need for continued treatment should be reassessed periodically by your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A talking therapy that can help manage anxiety and depression without medication.
Evidence: Well-establishedAlternative antidepressants with a better safety profile for long-term use.
Evidence: Well-establishedRegular exercise, healthy diet, and stress reduction techniques can complement treatment.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccinations while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check local customs regulations regarding controlled substances before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Diazepam works within 30-60 minutes for anxiety, but imipramine may take 2-4 weeks for full antidepressant effect.
A: No, stopping suddenly can cause withdrawal symptoms. Your doctor will taper the dose gradually.
A: It can interact with many medicines. Always inform your doctor about all other medicines you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for anxidep tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: It is not a sleeping pill; it is a combination of an anxiolytic and an antidepressant, used for specific conditions. - Myth: You can stop this medicine anytime.
Fact: Stopping suddenly can cause withdrawal symptoms; always taper under medical supervision. - Myth: It is safe to drink alcohol with this medicine.
Fact: Alcohol increases sedation and dangerous side effects; it should be avoided.
🔄 Alternative Options
Generic Alternatives
- Diazepam + Imipramine (generic)