Antiflam 400 mg/650 mg Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is antiflam 400 mg/650 mg tablet used for?
This medicine is a combination of ibuprofen (400 mg) and paracetamol (650 mg) used for short-term relief of moderate to severe pain and fever. It works by reducing inflammation and pain signals in the body. Take it with food to avoid stomach upset, and do not exceed 3 tablets in 24 hours.
- Generic Name: Ibuprofen (400mg) + Paracetamol (650mg)
- Manufacturer: Klar Sehen Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 antiflam 400 mg/650 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इबुप्रोफेन 400 मिलीग्राम और पैरासिटामोल 650 मिलीग्राम का संयोजन है। इसका उपयोग मध्यम से गंभीर दर्द और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सिरदर्द, मासिक धर्म के दर्द, और गठिया से जुड़े दर्द में राहत देती है। यह सूजन को कम करने और दर्द को शांत करने में मदद करती है। इसे भोजन के साथ लेना चाहिए ताकि पेट में जलन न हो।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, दस्त, कब्ज, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति, और हृदय संबंधी घटनाएं शामिल हो सकती हैं। यदि आपको कोई गंभीर लक्षण दिखाई दे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन या दूध के साथ लें ताकि पेट में जलन न हो। खाली पेट न लें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव और यकृत की क्षति का खतरा बढ़ सकता है। निर्धारित खुराक से अधिक न लें। यदि आपको पेट अल्सर, गुर्दे की बीमारी, यकृत की बीमारी, हृदय रोग या अस्थमा है तो डॉक्टर से परामर्श करें। बुखार के लिए 3 दिन से अधिक और दर्द के लिए 10 दिन से अधिक इस दवा का उपयोग न करें।
💊 antiflam 400 mg/650 mg tablet Uses & Benefits
[{"condition":"Musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and bones, such as back pain, sprains, and strains.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides effective relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after surgery.","evidence":"Well-established"},{"condition":"Headache","description":"Relieves tension headaches and mild migraines.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to its paracetamol content.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Reduces pain and improves joint mobility in osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps manage pain and inflammation in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes used off-label for preventing migraines, but evidence is limited.","evidence":"Limited"},{"condition":"Sore throat","description":"May be used for symptomatic relief of sore throat pain, though not a primary indication.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Fever, Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Ibuprofen (400mg) + Paracetamol (650mg) |
| Brand Name | antiflam 400 mg/650 mg tablet |
| Manufacturer | Klar Sehen Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Ibuprofen is a non-selective cyclooxygenase (COX) inhibitor that reversibly blocks both COX-1 and COX-2 enzymes, leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol, although its exact mechanism is not fully understood, primarily acts centrally to inhibit prostaglandin synthesis in the brain and may also activate descending serotonergic pathways, resulting in analgesia and antipyresis. The combination provides additive pain relief through different pathways.
Mechanism Steps
💡 How to Take antiflam 400 mg/650 mg tablet
Strength: Each tablet contains Ibuprofen 400 mg and Paracetamol 650 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain or fever. Do not exceed 3 tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Take with food or milk to reduce stomach upset. Do not use for more than 3 days for fever or more than 10 days for pain without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney impairment. Use the lowest effective dose for the shortest duration. Consult a doctor for appropriate dosing. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose adjustment may be necessary. Consult a doctor for appropriate dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose adjustment may be necessary. Consult a doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum daily dose is 3 tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of antiflam 400 mg/650 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Aspirin
- Other NSAIDs
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- Corticosteroids
- SSRIs
- Alcohol
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Concurrent use increases the risk of gastrointestinal bleeding, ulcers, and liver damage, especially with paracetamol. Even moderate alcohol consumption can potentiate these risks.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to ibuprofen, paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic reaction after taking aspirin or other NSAIDs","Active or history of peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe kidney impairment","Severe liver impairment","Third trimester of pregnancy","Children under 12 years of age"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration of treatment.","Use with caution in elderly patients due to increased risk of side effects.","Consult your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma.","Do not use for more than 3 days for fever or more than 10 days for pain without medical advice.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Keep out of reach of children."]
🤱 Lactation Safety
Ibuprofen and paracetamol are excreted in breast milk in small amounts. They are generally considered compatible with breastfeeding when used at recommended doses for short periods. Consult your doctor before use.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding, kidney failure, and central nervous system effects due to ibuprofen. Symptoms of overdose include nausea, vomiting, abdominal pain, drowsiness, and confusion. If you suspect an overdose, seek emergency medical attention immediately. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine with food or milk to reduce the risk of stomach irritation. Do not take it on an empty stomach. Avoid alcohol while taking this medicine, as it can increase the risk of stomach bleeding and liver damage. Do not exceed the recommended dose or duration of treatment. If you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma, consult your doctor before taking this medicine. Do not use this medicine for more than 3 days for fever or more than 10 days for pain without medical advice. Keep out of reach of children. Store at room temperature away from moisture and heat. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like ibuprofen may affect ovulation and are generally avoided during pregnancy, especially in the third trimester.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but it should be used with caution after surgery due to the risk of bleeding and kidney problems. Follow your surgeon's instructions.
🦷 Dental Procedures
This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain while taking this medicine. Listen to your body and rest if needed. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain or fever persists beyond the recommended duration, if you experience any serious side effects, or if you develop new symptoms. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of liver and kidney function, blood counts, and blood pressure is recommended for prolonged use. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation.
Evidence: Well-establishedMay provide pain relief for some individuals.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking the medicine as prescribed, but adjust the timing gradually to the new local schedule. Check the customs regulations of your destination country regarding prescription medications. Always keep the medicine in your carry-on luggage to avoid loss or exposure to extreme temperatures.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine typically starts relieving pain within 30 to 60 minutes after taking it.
A: No, it should be taken with food or milk to reduce the risk of stomach upset.
A: Do not take it with other NSAIDs or paracetamol-containing products without consulting your doctor, as it may increase the risk of side effects.
A: Consult your doctor before taking this medicine during pregnancy, especially in the third trimester.
A: Do not use for more than 3 days for fever or more than 10 days for pain without medical advice.
🤔 Common Patient Concerns
🔄 Substitutes for antiflam 400 mg/650 mg tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is completely safe and can be taken long-term without any risk.
Fact: Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. It should be used for the shortest duration necessary. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol increases the risk of liver damage and gastrointestinal bleeding when taken with this medicine. It should be avoided. - Myth: This medicine can be taken on an empty stomach without any issues.
Fact: Taking this medicine on an empty stomach increases the risk of stomach upset and gastrointestinal irritation. It should be taken with food.
🔄 Alternative Options
Generic Alternatives
- Ibuprofen 400 mg + Paracetamol 650 mg tablet
Brand Alternatives
- Combiflam
- Brufen Plus
- Ibugesic Plus
- Flexon
- Doloflam