blomig p 10 mg/5 mg/325 mg tablet - Domperidone (10mg) + Flunarizine (5mg) medicine

Blomig P 10 mg/5 mg Tablet: Complete Medicine Guide

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🏭 Klar Sehen Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for migraine prophylaxis and vertigo; well-established for Domperidone as antiemetic.
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Irregular heartbeat or palpitations
  • Severe dizziness or fainting
  • Involuntary muscle movements or stiffness
  • Signs of allergic reaction such as swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Severe abdominal pain
  • Persistent depression or mood changes

If experiencing severe symptoms, call emergency services immediately.

What is blomig p 10 mg/5 mg/325 mg tablet used for?

This medicine is a combination of Domperidone and Flunarizine used to prevent migraines and treat vertigo. It works by reducing nausea and stabilizing blood vessels in the brain. It is usually taken once daily at bedtime.

  • Generic Name: Domperidone + Flunarizine
  • Manufacturer: Klar Sehen Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 blomig p 10 mg/5 mg/325 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन और फ्लुनारिज़ीन का संयोजन है, जिसका उपयोग माइग्रेन के दौरों को रोकने और चक्कर आने (वर्टिगो) के इलाज के लिए किया जाता है। यह मतली और उल्टी को कम करने में मदद करती है और मस्तिष्क की रक्त वाहिकाओं को स्थिर करती है। इसे आमतौर पर रात को सोने से पहले एक बार लिया जाता है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुँह सूखना, थकान और वजन बढ़ना शामिल हैं। कुछ लोगों को बेचैनी या मन में परिवर्तन भी हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको अनियमित दिल की धड़कन, मांसपेशियों में अकड़न, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। इसे लेते समय गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको लीवर, किडनी या हृदय की समस्या है, तो डॉक्टर को बताएं। दवा को बच्चों की पहुंच से दूर रखें और सूखी जगह पर कमरे के तापमान पर स्टोर करें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 blomig p 10 mg/5 mg/325 mg tablet Uses & Benefits

[{"condition":"Migraine prophylaxis","description":"This medicine is used to reduce the frequency and severity of migraine attacks in adults.","evidence":"Well-established"},{"condition":"Vertigo","description":"It helps relieve dizziness and balance disturbances associated with vestibular disorders.","evidence":"Moderate"},{"condition":"Nausea and vomiting","description":"The Domperidone component helps control nausea and vomiting, especially when associated with migraine.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Gastroparesis","description":"Domperidone alone is sometimes used off-label to improve gastric emptying in diabetic gastroparesis, but the combination is not standard for this.","evidence":"Limited"}]

Primary treatment for: Migraine

Also treats: Vertigo, Nausea and vomiting

📋 Drug Information

Generic Name(s)Domperidone + Flunarizine
Brand NameBlomig P 10 mg/5 mg/325 mg Tablet
ManufacturerKlar Sehen Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassAntiemetic + Calcium Channel Blocker
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at bedtime to minimize daytime drowsiness.
2
Avoid driving or operating heavy machinery until you know how this medicine affects you.
3
Do not consume alcohol while taking this medicine as it can increase sedation.
4
Inform your doctor if you have a history of heart rhythm problems or liver disease.
5
Do not stop taking this medicine abruptly without consulting your doctor.
6
Keep a headache diary to track the frequency and severity of migraines.
7
Report any unusual muscle movements or mood changes to your doctor immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Migraine headaches
This medicine is commonly prescribed for migraine prevention.
Likely Use
✅
Vertigo
This medicine helps relieve dizziness and balance issues.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed from the gastrointestinal tract after oral administration, with peak plasma levels occurring within 30 to 60 minutes. Flunarizine is well absorbed orally, with peak plasma concentrations reached in 2 to 4 hours. Food may slightly delay the absorption of Domperidone but does not significantly affect the extent of absorption.
DistributionDomperidone is widely distributed in the body but does not readily cross the blood-brain barrier. Flunarizine is highly lipophilic and distributes extensively into tissues, including the central nervous system, and has a large volume of distribution.
Protein BindingDomperidone is approximately 91-93% bound to plasma proteins. Flunarizine is about 90% bound to plasma proteins.
MetabolismDomperidone undergoes extensive first-pass metabolism in the liver via CYP3A4 and CYP1A2 enzymes. Flunarizine is metabolized in the liver, primarily by CYP2D6 and CYP3A4.
Half-LifeDomperidone has an elimination half-life of approximately 7-9 hours in healthy individuals. Flunarizine has a long elimination half-life of about 18-23 days, which allows for once-daily dosing.
ExcretionDomperidone is excreted mainly in the feces (about 66%) and urine (about 33%) as metabolites. Flunarizine is excreted primarily in the feces via bile, with a small amount in urine.
BioavailabilityDomperidone has a low oral bioavailability of about 13-17% due to extensive first-pass metabolism. Flunarizine has a bioavailability of approximately 80-90%.
Onset of ActionDomperidone's antiemetic effect begins within 30-60 minutes after oral administration. Flunarizine's prophylactic effect for migraine may take several weeks to become fully apparent.
Peak Plasma TimeDomperidone: 0.5-1 hour. Flunarizine: 2-4 hours.
Duration of ActionDomperidone's antiemetic effect lasts about 6-8 hours. Flunarizine's effect is long-lasting due to its long half-life, providing 24-hour coverage for migraine prophylaxis.

How It Works

This medicine combines two active ingredients with distinct mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) and in the gastrointestinal tract, thereby reducing nausea and vomiting and enhancing gastric motility. Flunarizine is a selective calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells and neurons, which helps prevent vasospasm and reduces neuronal excitability, contributing to migraine prophylaxis. Together, they address both the nausea and the vascular/neurological components of migraine and vertigo.

Mechanism Steps

1
Domperidone blocks peripheral dopamine D2 receptors: Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, which reduces nausea and vomiting and promotes gastric emptying.
2
Flunarizine blocks calcium channels: Flunarizine inhibits the influx of calcium ions into vascular smooth muscle and neurons, leading to vasodilation and reduced neuronal excitability.
3
Combined effect on migraine and vertigo: The combined actions help prevent migraine attacks by stabilizing blood vessels and reducing nausea, and alleviate vertigo by improving vestibular function.

💡 How to Take blomig p 10 mg/5 mg/325 mg tablet

Strength: Each immediate-release tablet contains Domperidone 10 mg and Flunarizine 5 mg.

1Swallow the tablet whole with a glass of water.
2Take it at bedtime to reduce daytime drowsiness.
3You may take it with or without food, but taking it with food may reduce stomach upset.
4Do not crush, chew, or break the tablet.
5Follow your doctor's instructions exactly.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once daily, preferably at bedtime to minimize daytime drowsiness. However, the exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and extrapyramidal symptoms. Use with caution and lower doses may be considered as advised by a clinician.
Renal ImpairmentUse with caution in patients with severe renal impairment. Dose adjustment may be necessary as advised by a clinician.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be required. Contraindicated in severe hepatic impairment.
Maximum Daily DoseThe maximum recommended daily dose is one tablet (Domperidone 10 mg + Flunarizine 5 mg). Do not exceed this dose unless specifically instructed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels and side effects.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of blomig p 10 mg/5 mg/325 mg tablet

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If persistent, consult your doctor.
Dry mouth (Common (5-10%))
Sip water frequently. Usually resolves on its own.
Weight gain (Common (5-10%))
Monitor your weight and diet. Consult your doctor if concerned.
Fatigue (Common (5-10%))
Get adequate rest. If severe, consult your doctor.

🚨 Serious Side Effects

Extrapyramidal symptoms (involuntary movements, rigidity) (Rare (<0.1%))
Seek immediate medical attention if you experience muscle stiffness, tremors, or difficulty moving.
Cardiac arrhythmias (irregular heartbeat) (Rare (<0.1%))
Seek immediate medical attention if you feel palpitations, dizziness, or fainting.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Call emergency services if you experience swelling of face, lips, throat, or difficulty breathing.

⚠️ Rare Side Effects

Depression
Consult your doctor if you feel persistently sad or lose interest in activities.
Galactorrhea (breast milk secretion)
Consult your doctor for evaluation.
Gynecomastia (breast enlargement in men)
Consult your doctor if you notice breast tenderness or swelling.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Clarithromycin Major
Amiodarone Major
Benzodiazepines Moderate
Opioids Moderate
Atropine Moderate
Grapefruit juice Minor

🚨 Major Interactions

  • Ketoconazole, itraconazole, clarithromycin
  • QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)

⚡ Moderate Interactions

  • Anticholinergic drugs (e.g., atropine, benztropine)
  • CNS depressants (e.g., benzodiazepines, opioids)

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and impair your ability to drive or operate machinery. It may also worsen the side effects of Flunarizine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Domperidone or Flunarizine","Severe hepatic impairment","Prolonged QT interval or history of torsades de pointes","Concomitant use with strong CYP3A4 inhibitors","Parkinson's disease","Gastrointestinal obstruction, perforation, or bleeding"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Use with caution in elderly patients due to increased risk of extrapyramidal symptoms.","Do not use for longer than prescribed without medical review.","Inform your doctor if you have liver, kidney, or heart disease.","May increase risk of falls in elderly due to dizziness."]

🤱 Lactation Safety

Domperidone is excreted in breast milk and may cause side effects in the infant. Flunarizine is also excreted in breast milk. This medicine is not recommended during breastfeeding unless specifically advised by a doctor.

💊 Overdose Management

Overdose may cause drowsiness, extrapyramidal symptoms, and cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1 hour of ingestion. Monitor ECG and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness. Avoid alcohol while taking this medicine because it can increase drowsiness and dizziness. Inform your doctor if you have liver, kidney, or heart problems, or if you have Parkinson's disease. Do not take this medicine for longer than your doctor has advised without a review. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use it after the expiry date.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of extrapyramidal symptoms, drowsiness, and falls. Use with caution and monitor closely.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor to discuss the risks and benefits of this medicine. It may need to be stopped or switched to a safer alternative.

🏥 Post-Surgery Considerations

Consult your doctor before resuming this medicine after surgery, especially if you have been advised to avoid certain medications.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine, as it may interact with certain anesthetics or medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Maintain a regular sleep schedule.
🥗
Identify and avoid migraine triggers such as certain foods, stress, and lack of sleep.
😴
Stay hydrated throughout the day.
💧
Practice relaxation techniques like yoga or meditation.
🧘
Exercise regularly, but avoid strenuous activities during migraine attacks.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel dizzy or drowsy. Take precautions to prevent falls. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include magnesium-rich foods like leafy greens and nuts.
Avoid processed foods and artificial sweeteners.
Limit caffeine and alcohol.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, which may affect your ability to drive or operate machinery. It is best to take it at bedtime. Avoid tasks requiring alertness until you know how it affects you.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects or if your doctor decides to discontinue, follow their guidance for tapering if necessary.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to weight gain, depression, and extrapyramidal symptoms due to Flunarizine. Regular monitoring by a doctor is recommended. Do not use for prolonged periods without medical review.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help with vestibular rehabilitation for vertigo.

Evidence: Well-established
Biofeedback and relaxation techniques

May help reduce migraine frequency.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are known. However, consult your doctor before any vaccination while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your dose at the same local time as prescribed, preferably at bedtime. Keep enough supply for the entire trip. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with frequent migraines
She was prescribed this medicine for migraine prevention. After taking it at bedtime for 4 weeks, she noticed a significant reduction in the number of migraine attacks. She experienced mild drowsiness initially, which improved after a few days. She was advised to avoid alcohol and driving at night.
💡 Lesson: Consistent bedtime dosing and avoiding alcohol help manage side effects and improve outcomes.
👤 A 60-year-old man with vertigo
He started this medicine for dizziness and balance problems. Within 2 weeks, his vertigo episodes decreased. He was monitored for extrapyramidal symptoms due to his age. He was advised to rise slowly from sitting or lying positions to avoid falls.
💡 Lesson: Elderly patients should be monitored closely for side effects and take precautions to prevent falls.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The antiemetic effect of Domperidone starts within 30-60 minutes, but the full migraine prophylactic effect of Flunarizine may take several weeks to become apparent.

Q: Can I take this medicine during pregnancy?

A: Consult your doctor before taking this medicine during pregnancy. The safety has not been fully established.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for blomig p 10 mg/5 mg/325 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure migraines permanently.
    Fact: It helps prevent migraines but does not cure them. Lifestyle changes and trigger avoidance are also important.
  • Myth: It is safe to take without a prescription.
    Fact: This is a prescription medicine and should only be taken under medical supervision.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Flunarizine combination generics may be available.

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Domperidone 10 mg + Flunarizine 5 mg","uses":"Migraine prophylaxis, vertigo","notes":"Combination provides antiemetic and prophylactic effects."},{"medicine":"Flunarizine alone","composition":"Flunarizine 5 mg/10 mg","uses":"Migraine prophylaxis, vertigo","notes":"No antiemetic effect."}]

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