angiblock retard 20mg tablet - Nifedipine (20mg) medicine

Angiblock Retard 20mg Tablet - Uses, Price, Side Effects

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🏭 Alkem Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is angiblock retard 20mg tablet used for?

Angiblock Retard 20mg Tablet contains Nifedipine, a calcium channel blocker used to treat high blood pressure and angina (chest pain). It works by relaxing blood vessels, improving blood flow, and reducing the heart's workload. This helps lower blood pressure and prevent angina attacks.

  • Generic Name: Nifedipine
  • Manufacturer: Alkem Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 angiblock retard 20mg tablet Uses & Benefits

Hypertension, chronic stable angina, vasospastic angina (Prinzmetal's angina), Raynaud's phenomenon

Off-label uses: Preterm labor (tocolysis), high-altitude pulmonary edema, anal fissures (topical)

📋 Drug Information

Generic Name(s)Nifedipine
Brand NameAngiblock 5mg Capsule
ManufacturerAlkem Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassCalcium channel blockers- Dihydropyridines (DHP)
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed from the gastrointestinal tract after oral administration
DistributionDistributed widely throughout the body; crosses the blood-brain barrier and placenta
Protein Binding92-98% bound to plasma proteins
MetabolismExtensively metabolized in the liver via CYP3A4 to inactive metabolites
Half-Life2-5 hours (immediate release)
ExcretionPrimarily renal (70-80% as metabolites); 15% fecal
Bioavailability45-56% (due to first-pass metabolism)
Onset of Action20-30 minutes (immediate release)
Peak Plasma Time0.5-2 hours (immediate release)
Duration of Action6-8 hours (immediate release)

How It Works

Inhibits calcium ion influx across cardiac and smooth muscle cells, leading to vasodilation and reduced myocardial oxygen demand

Mechanism Steps

1Binds to L-type calcium channels in vascular smooth muscle and cardiac muscle
2Inhibits calcium influx into cells
3Reduces intracellular calcium concentration
4Decreases smooth muscle contraction, leading to vasodilation
5Reduces peripheral vascular resistance and blood pressure
6Increases coronary blood flow and reduces myocardial oxygen demand

💡 How to Take angiblock retard 20mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of angiblock retard 20mg tablet

✅ Common Side Effects

Peripheral edema
Headache
Dizziness
Flushing
Palpitations
Nausea
Constipation

🚨 Serious Side Effects

Severe hypotension
Myocardial infarction
Heart failure exacerbation
Arrhythmias
Stevens-Johnson syndrome
Gingival hyperplasia

⚠️ Rare Side Effects

Hepatotoxicity
Agranulocytosis
Leukopenia
Gynecomastia
Photosensitivity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Beta-blockers Moderate Increased risk of hypotension and heart failure
Cimetidine Moderate Increased nifedipine levels
Grapefruit juice Major Increased nifedipine concentration and toxicity

🚨 Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
  • CYP3A4 inducers (e.g., rifampin, phenytoin)
  • Beta-blockers
  • Digoxin
  • Magnesium sulfate (IV)

⚡ Moderate Interactions

  • Antihypertensives
  • Cimetidine
  • Grapefruit juice
  • Quinidine
  • Theophylline

🍷 Alcohol Interaction

May enhance hypotensive effect; avoid excessive alcohol

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to nifedipine, cardiogenic shock, severe aortic stenosis, unstable angina (except under special circumstances), within 4 weeks of myocardial infarction

🤱 Lactation Safety

Excreted in breast milk; use with caution, monitor infant for hypotension

💊 Overdose Management

Activated charcoal, gastric lavage, IV fluids, calcium gluconate or calcium chloride, vasopressors for hypotension, atropine for bradycardia

⏰ Missed Dose

Take as soon as remembered unless close to next dose; do not double dose

🔄 Substitutes for angiblock retard 20mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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