Ethyol 500mg Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness, fainting, or blurred vision
- Chest pain, palpitations, or difficulty breathing
- Swelling of the face, lips, tongue, or throat
- Severe nausea and vomiting that does not stop
- Muscle cramps, twitching, or tingling around the mouth
- Rash, blisters, or peeling skin
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is amiphos 500mg injection used for?
This medicine is an injectable cytoprotective agent containing amifostine 500 mg. It is used to reduce kidney damage from cisplatin chemotherapy and dry mouth from radiation therapy in certain cancers. It is given intravenously by a healthcare professional before cancer treatment.
- Generic Name: Amifostine (500mg)
- Manufacturer: Dabur India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amiphos 500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एमिफोस्टीन 500 मिलीग्राम इंजेक्शन के रूप में उपलब्ध है। इसका उपयोग कीमोथेरेपी और रेडिएशन थेरेपी के दौरान स्वस्थ ऊतकों को होने वाले नुकसान को कम करने के लिए किया जाता है। यह विशेष रूप से सिस्प्लाटिन कीमोथेरेपी से होने वाली किडनी की क्षति और सिर और गर्दन के कैंसर के रेडिएशन से होने वाले मुंह सूखने को कम करने में मदद करती है। यह दवा कैंसर का इलाज नहीं है, बल्कि कैंसर उपचार के दौरान होने वाले दुष्प्रभावों से बचाव करती है। यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल में नस के माध्यम से दी जाती है। इसे घर पर स्वयं न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, चेहरे पर गर्मी लगना, चक्कर आना, नींद आना, छींक आना और रक्तचाप में कमी शामिल हैं। ये आमतौर पर इंजेक्शन के दौरान या तुरंत बाद होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में बहुत कम रक्तचाप, एलर्जी प्रतिक्रिया, त्वचा पर गंभीर दाने और कैल्शियम की कमी शामिल हो सकती है। अगर आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या बहुत अधिक चक्कर आना महसूस हो, तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में प्रशिक्षित स्वास्थ्य कर्मचारी द्वारा दी जानी चाहिए। इंजेक्शन के दौरान और बाद में आपके रक्तचाप की निगरानी की जाएगी। अगर आपको पहले कभी कम रक्तचाप, हृदय रोग, गुर्दे की समस्या या एमिफोस्टीन से एलर्जी हुई है, तो डॉक्टर को बताएं। इंजेक्शन से पहले पर्याप्त पानी पिएं। चक्कर या नींद आने पर वाहन न चलाएं। कोई भी नई दवा, सप्लीमेंट या हर्बल उत्पाद लेने से पहले डॉक्टर से पूछें। गर्भवती होने, गर्भधारण की योजना बनाने या स्तनपान कराने के बारे में डॉक्टर को बताएं।
💊 amiphos 500mg injection Uses & Benefits
[{"condition":"Reduction of cisplatin-induced nephrotoxicity in advanced ovarian cancer","description":"This medicine is used to reduce kidney damage caused by cisplatin chemotherapy in patients with advanced ovarian cancer.","evidence":"Well-established"},{"condition":"Reduction of cisplatin-induced nephrotoxicity in non-small cell lung cancer","description":"This medicine is used to reduce kidney damage caused by cisplatin chemotherapy in patients with non-small cell lung cancer.","evidence":"Well-established"},{"condition":"Reduction of xerostomia (dry mouth) from radiation therapy for head and neck cancer","description":"This medicine may be used to reduce dry mouth caused by radiation therapy to the head and neck region.","evidence":"Moderate"},{"condition":"Reduction of mucositis from chemotherapy or radiation","description":"This medicine may help reduce mouth sores and throat inflammation caused by cancer treatments.","evidence":"Limited"}]
Off-label uses: [{"condition":"Reduction of bone marrow suppression from chemotherapy","description":"Sometimes used off-label to reduce low blood counts caused by chemotherapy.","evidence":"Limited"},{"condition":"Protection against radiation injury in non-cancer settings","description":"Investigated for protecting normal tissues from radiation exposure, but not standard practice.","evidence":"Investigational"}]
Primary treatment for: Cancer (used as supportive care during chemotherapy or radiation)
Also treats: Ovarian cancer, Non-small cell lung cancer, Head and neck cancer
📋 Drug Information
| Generic Name(s) | Amifostine (500mg) |
| Brand Name | amiphos 500mg injection |
| Manufacturer | Dabur India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Cytoprotective agents- Kidney & Salivary gland |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store this medicine in its original carton at room temperature between 20°C and 25°C (68°F to 77°F). Protect from light. Do not freeze. Keep out of reach of children. Once reconstituted, the solution should be used as directed by the healthcare professional. Do not use if the solution is discolored or contains particles. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture when stored as directed. Check the expiry date on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a thiophosphate prodrug that is converted by alkaline phosphatase enzymes into an active free thiol metabolite. The active metabolite acts as a scavenger of reactive oxygen species and reactive electrophiles generated by chemotherapy and radiation. It also binds to and inactivates harmful metabolites of drugs like cisplatin. Because normal tissues have higher alkaline phosphatase activity and higher pH compared to tumor tissues, the active metabolite is preferentially generated in normal tissues, providing selective protection. This helps reduce damage to normal cells, especially in the kidneys, bone marrow, and salivary glands, without significantly reducing the anti-cancer effects of chemotherapy or radiation.
Mechanism Steps
💡 How to Take amiphos 500mg injection
Strength: This medicine is available as a sterile lyophilized powder for injection containing 500 mg of amifostine per vial. It is reconstituted with sterile water or normal saline before intravenous infusion.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 500 mg given as a single intravenous infusion over 15 minutes, starting 30 minutes before chemotherapy. For radiation therapy, the dose may be 200 mg to 340 mg per day, given as a short infusion before radiation. The exact dose and schedule depend on the type of cancer treatment, your kidney function, and your overall health. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-administer this medicine. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Blood pressure should be monitored closely. Dose adjustment may be needed based on kidney function and overall health. Your doctor will decide the appropriate dose for you. |
| Renal Impairment | In patients with kidney impairment, the dose of this medicine may need to be reduced. For patients with a creatinine clearance less than 60 mL/min, a lower dose may be recommended. Your doctor will adjust the dose based on your kidney function tests. |
| Hepatic Impairment | No specific dose adjustment is established for patients with liver impairment. However, liver function should be monitored. Your doctor will decide if any dose change is needed. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is 500 mg for chemotherapy protection and up to 340 mg for radiation protection. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amiphos 500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Antihypertensives | Major | |
| Nephrotoxic drugs | Major | |
| Cisplatin | Moderate | |
| Anticoagulants | Moderate | |
| Antihistamines | Minor | |
| Sedatives | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Antihypertensive medicines (e.g., beta-blockers, ACE inhibitors, calcium channel blockers)
- Other nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, NSAIDs)
⚡ Moderate Interactions
- Cisplatin
- Anticoagulants (e.g., warfarin, heparin)
🍷 Alcohol Interaction
Avoid drinking alcohol while receiving this medicine. Alcohol can worsen dizziness, drowsiness, and low blood pressure. It may also increase the risk of stomach upset and dehydration.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to amifostine or any component of this medicine","Severe hypotension (low blood pressure)","Dehydration","Use in patients receiving chemotherapy for other than approved indications, unless directed by a specialist"]
⚠️ Warnings & Precautions
["This medicine can cause severe low blood pressure. Blood pressure must be monitored closely during and after infusion.","Allergic reactions, including anaphylaxis, can occur. Emergency equipment should be available.","Patients should be well hydrated before receiving this medicine.","Avoid use in patients with severe kidney disease unless the benefit outweighs the risk.","This medicine may cause drowsiness or dizziness. Avoid driving or operating machinery until you know how it affects you.","Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Do not receive this medicine if you have an active infection or are severely ill, unless cleared by your doctor."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment with this medicine. Talk to your doctor about the best way to feed your baby during treatment.
💊 Overdose Management
Overdose of this medicine is unlikely because it is given by healthcare professionals. If an overdose occurs, it may cause severe low blood pressure, nausea, vomiting, and dizziness. Treatment is supportive and includes stopping the infusion, giving intravenous fluids, and monitoring vital signs. There is no specific antidote. Contact your doctor or emergency services immediately if you suspect an overdose.
⏰ Missed Dose
This medicine is given in a hospital or clinic setting by a healthcare professional. If you miss an appointment for your infusion, contact your doctor or clinic as soon as possible to reschedule. Do not try to take this medicine on your own. Your treatment schedule will be adjusted by your healthcare team.
Additional Safety Advice
This medicine must only be given by a trained healthcare professional in a hospital or clinic setting. You will be monitored for blood pressure changes and allergic reactions during and after the infusion. Tell your doctor if you have ever had low blood pressure, heart problems, kidney problems, or an allergic reaction to amifostine. Drink fluids as advised before your treatment unless told otherwise. Avoid driving or operating heavy machinery if you feel dizzy or drowsy after the infusion. Do not take any new medicines, supplements, or herbal products without asking your doctor, as some may interact with this medicine. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before receiving this medicine. Keep all follow-up appointments and blood tests as scheduled.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Blood pressure should be monitored closely. Dose adjustment may be needed based on kidney function and overall health. Your doctor will decide the appropriate dose for you.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, talk to your doctor before receiving this medicine. This medicine should be used during pregnancy only if clearly needed. Effective contraception should be used during treatment and for a period after treatment as advised by your doctor.
🏥 Post-Surgery Considerations
If you have recently had surgery, tell your doctor before receiving this medicine. Your doctor will assess your overall health and decide if any precautions are needed. This medicine is usually given as part of cancer treatment, so your surgical team and oncology team will coordinate your care.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine before any dental procedure. This medicine can cause low blood pressure and dizziness, so your dentist may take precautions. Good oral hygiene is important during cancer treatment to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting on the day of your infusion, especially if you feel dizzy or tired. Light activity like walking is fine if you feel up to it. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may feel tired or dizzy after the infusion, so it is best to take the rest of the day off from work. Avoid driving or operating heavy machinery until you feel normal. Most people can resume their normal activities the next day, but this depends on how you feel and your cancer treatment schedule.
🛑 When to Stop This Medicine
This medicine is given under medical supervision, so you should not stop it on your own. Your doctor will decide when to stop based on your treatment plan, response, and side effects. If you experience severe side effects, your doctor may stop the infusion or adjust the dose. Always consult your doctor before stopping any treatment.
📅 Long-Term Use Effects
Long-term effects of this medicine are not well established because it is usually given for a limited period during cancer treatment. It is not intended for long-term use. Patients should be monitored for kidney function, blood pressure, and blood counts during treatment. If you receive multiple cycles, your doctor will assess the benefits and risks regularly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Drinking plenty of fluids before and after chemotherapy can help protect kidneys.
Evidence: Well-establishedGood oral hygiene and saliva substitutes can help manage dry mouth from radiation.
Evidence: Well-establishedOther cytoprotective agents like mesna or dexrazoxane may be used for specific toxicities.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Talk to your doctor about vaccinations before starting cancer treatment. Live vaccines should be avoided during chemotherapy or radiation. Inactivated vaccines may be given, but their effectiveness can be reduced. Your doctor will advise you on the best vaccination schedule.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic, so you will not need to travel with it. If you are traveling for treatment, carry a copy of your prescription and medical records. Keep your appointment schedule handy. Inform your doctor if you plan to travel, as your treatment schedule may need adjustment. Always carry your emergency contact information and a list of your medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working soon after the infusion, typically within 15 to 30 minutes. It is given before chemotherapy or radiation to provide protection during treatment.
A: This medicine is given as an intravenous infusion by a healthcare professional in a hospital or clinic. It is not taken at home.
A: Common side effects include nausea, vomiting, flushing, dizziness, drowsiness, sneezing, and low blood pressure. These usually improve after the infusion.
A: You should avoid driving or operating machinery if you feel dizzy or drowsy after the infusion. Arrange for someone else to drive you home.
A: This medicine should be used during pregnancy only if clearly needed. Tell your doctor if you are pregnant or planning pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for amiphos 500mg injection
View AllAlternative brands with exact same active ingredient:
-
natfost 500mg injectionNatco Pharma Ltd ₹87.52 95.4% CHEAPER
-
cytofos 500mg injectionSun Pharmaceutical Industries Ltd ₹937.50 50.9% CHEAPER
-
amiget 500mg injectionGLS Pharma Ltd. ₹1,687.50 11.6% CHEAPER
-
chemophos 500mg injectionCytogen Pharmaceuticals India Pvt Ltd ₹1,861.88 2.5% CHEAPER
-
m-fost 500mg injectionShantha Biotech ₹2,343.75 22.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure cancer.
Fact: This medicine does not treat cancer. It is used to protect normal tissues from the side effects of chemotherapy or radiation. - Myth: This medicine can be taken as a pill at home.
Fact: This medicine is given only by intravenous infusion in a hospital or clinic setting. - Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for people with severe low blood pressure, dehydration, or allergy to amifostine.
🔄 Alternative Options
Generic Alternatives
- Amifostine
Brand Alternatives
- Ethyol