Adnexa 10mg Injection (Epirubicin): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Chest pain or pressure
- Shortness of breath or swelling of the legs
- Fever with chills or feeling very unwell
- Unusual bruising or bleeding
- Severe mouth sores that make eating or drinking difficult
- Pain or burning at the injection site
- Yellowing of the eyes or skin
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is anthracin 10mg injection used for?
This medicine is an intravenous chemotherapy injection containing epirubicin, used to treat several types of cancer under the care of an oncology specialist. It works by damaging the DNA of cancer cells so they cannot divide and grow.
- Generic Name: Epirubicin
- Manufacturer: Dabur India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 anthracin 10mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एपिरुबिसिन नामक कीमोथेरेपी दवा है, जो इंजेक्शन के रूप में नस के जरिए दी जाती है। इसका उपयोग स्तन कैंसर, लिम्फोमा, ल्यूकीमिया और पेट, फेफड़े, अंडाशय तथा मूत्राशय के कुछ कैंसर के इलाज में किया जाता है। यह कैंसर कोशिकाओं की वृद्धि और विभाजन को रोककर उन्हें नष्ट करने में मदद करती है। यह दवा केवल कैंसर रोग विशेषज्ञ की देखरेख में अस्पताल या कैंसर केंद्र में ही दी जानी चाहिए। मरीज को अपने आप यह इंजेक्शन नहीं लगाना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, भूख कम लगना, मुंह में छाले, बाल झड़ना, थकान और खून की कोशिकाओं की संख्या घटना शामिल हैं। इंजेक्शन के बाद पेशाब का रंग एक-दो दिन के लिए लाल हो सकता है, जो सामान्य है। गंभीर दुष्प्रभावों में दिल की मांसपेशियों को नुकसान, गंभीर संक्रमण और खून बहने की समस्या हो सकती है। सीने में दर्द, सांस फूलना, तेज बुखार, असामान्य खून बहना या इंजेक्शन की जगह पर जलन होने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्यकर्मी द्वारा अस्पताल या कैंसर केंद्र में ही दी जानी चाहिए। इलाज से पहले और दौरान खून की जांच तथा दिल की जांच कराना जरूरी है। गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं को यह दवा नहीं दी जानी चाहिए, जब तक विशेषज्ञ टीम फायदे और नुकसान को देखकर फैसला न करे। इलाज के दौरान शराब न पिएं और संक्रमण वाले लोगों से दूरी बनाए रखें। बुखार, ठंड लगना, खून बहना या सांस फूलने पर तुरंत डॉक्टर से संपर्क करें।
💊 anthracin 10mg injection Uses & Benefits
[{"condition":"Breast cancer","description":"Used as part of combination chemotherapy regimens for early and advanced breast cancer.","evidence":"Well-established"},{"condition":"Non-Hodgkin lymphoma","description":"Included in some multi-drug regimens for treating certain lymphomas.","evidence":"Well-established"},{"condition":"Acute leukaemia","description":"Used in selected treatment protocols for acute leukaemias under specialist care.","evidence":"Well-established"},{"condition":"Gastric cancer","description":"Used in some chemotherapy combinations for stomach cancer.","evidence":"Moderate"},{"condition":"Ovarian cancer","description":"Used in selected regimens for ovarian cancer.","evidence":"Moderate"},{"condition":"Bladder cancer","description":"Given intravenously in some treatment plans for bladder cancer.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Soft tissue sarcoma","description":"Sometimes used in specialist regimens for certain sarcomas.","evidence":"Limited"},{"condition":"Hepatocellular carcinoma","description":"Occasionally used in selected liver cancer treatment protocols.","evidence":"Limited"}]
Primary treatment for: Breast cancer
Also treats: Non-Hodgkin lymphoma, Acute leukaemia, Gastric cancer, Ovarian cancer, Bladder cancer
📋 Drug Information
| Generic Name(s) | Epirubicin |
| Brand Name | Alrubicin |
| Manufacturer | Dabur India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkaloids-cytotoxic agents |
| Route of Administration | Intravenous |
| Storage | Store this medicine in its original packaging in a refrigerator at 2 to 8 degrees Celsius, protected from light. Do not freeze. Keep out of reach of children. Once prepared, the injection should be used as directed by the hospital pharmacy. |
| Shelf Life | The shelf life is usually stated on the pack and is commonly 24 to 36 months from the date of manufacture when stored as recommended. Always check the expiry date before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine belongs to the anthracycline class of anticancer antibiotics. Its active ingredient, epirubicin, works by inserting itself between the base pairs of DNA and by interfering with the enzyme topoisomerase II. This blocks the copying and repair of DNA, which stops cancer cells from dividing and leads to their death. Because cancer cells divide more often than most normal cells, they are more affected by this medicine, although normal tissues that divide quickly, such as bone marrow, hair follicles, and the lining of the mouth and gut, can also be affected.
Mechanism Steps
💡 How to Take anthracin 10mg injection
Strength: Injection, 10 mg
Dosage Information
| Adult Dosage | The dose of this medicine is decided by an oncology specialist and is based on the type of cancer, the treatment plan, body surface area, blood counts, heart function, liver function, and kidney function. It is given by intravenous injection or infusion, usually in cycles with rest periods in between. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Patients should never adjust the dose themselves. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Older adults may be more sensitive to the side effects of this medicine, especially effects on the heart, bone marrow, and general strength. Doses are usually adjusted by the treating oncologist after checking heart, liver, and kidney function. |
| Renal Impairment | Patients with kidney problems may need lower doses or extra monitoring because this medicine is partly removed by the kidneys. Dose adjustments must be made by the treating specialist. |
| Hepatic Impairment | Patients with liver problems may need lower doses because this medicine is broken down in the liver. Liver function tests are used to guide dose adjustments, which must be made by the treating specialist. |
| Maximum Daily Dose | The maximum total dose is decided by the treating oncologist and depends on the treatment plan and the total lifetime dose limit for anthracyclines. It is not a fixed daily dose for home use. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of anthracin 10mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Live vaccines | Major | |
| Other anthracyclines | Major | |
| Cimetidine | Moderate | |
| Liver enzyme affecting medicines | Moderate |
🚨 Major Interactions
- Other anthracyclines or related heart-damaging medicines
- Live vaccines
- Cytotoxic chemotherapy medicines
⚡ Moderate Interactions
- Warfarin and other blood thinners
- Medicines that affect the liver
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it can increase the risk of liver problems, stomach upset, and worsening of general tiredness. Patients should discuss any alcohol use with their cancer care team.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe heart disease or recent heart attack","Very low blood cell counts not due to cancer","Active serious infection","Severe liver problems","Previous severe allergic reaction to anthracyclines","Pregnancy, unless the specialist team decides it is necessary","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine must be given only by a trained healthcare professional.","Heart function should be checked before and during treatment.","Blood counts should be monitored regularly.","Avoid live vaccines during treatment.","Use effective contraception during treatment and for a period advised by your doctor.","Report fever, unusual bleeding, chest pain, or breathlessness immediately.","Avoid alcohol during treatment.","Tell your doctor about all other medicines and supplements you take."]
🤱 Lactation Safety
This medicine passes into breast milk and may harm a breastfed baby. Breastfeeding should be stopped before treatment begins and should not be restarted until the doctor says it is safe.
💊 Overdose Management
Overdose of this medicine can cause severe bone marrow suppression, heart damage, and other serious toxicities. There is no specific antidote. Treatment is supportive and may include hospital admission, blood transfusions, antibiotics, and close monitoring of heart, liver, and kidney function. Any suspected overdose should be treated as a medical emergency.
⏰ Missed Dose
This medicine is given by a healthcare professional in a hospital or clinic, so a missed dose is unlikely to happen at home. If an appointment is missed, contact your cancer care team as soon as possible to reschedule. Do not try to catch up with extra doses on your own.
Additional Safety Advice
This medicine must be given only by a trained healthcare professional in a setting equipped to manage chemotherapy reactions. Patients should not attempt to self-administer this injection. Before each dose, blood tests and a heart check may be needed, and patients should attend all scheduled monitoring visits. Women who could become pregnant should use effective contraception during treatment and for a period advised by their doctor, and men should also follow contraception advice. Breastfeeding should be stopped before treatment begins. Patients should avoid close contact with people who have active infections and should report any fever, chills, or feeling unwell immediately. Alcohol should be avoided because it can worsen liver and stomach effects. Patients should not receive live vaccines during treatment without medical advice.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the side effects of this medicine, especially heart damage, bone marrow suppression, and tiredness. Heart, liver, and kidney function should be checked carefully, and doses may need to be adjusted by the treating oncologist.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Women who could become pregnant should use effective contraception during treatment and for a period advised by their doctor. Men should also follow contraception advice. If you are planning a pregnancy, discuss it with your cancer team before starting or after completing treatment.
🏥 Post-Surgery Considerations
After surgery, this medicine may be given as part of adjuvant chemotherapy to reduce the risk of cancer returning. The timing of treatment after surgery is decided by the cancer team, and wound healing, blood counts, and general health are checked before starting.
🦷 Dental Procedures
Tell your dentist that you are receiving this medicine before any dental procedure. Chemotherapy can increase the risk of infection and bleeding, so dental work may need to be planned around treatment cycles and blood counts. Good mouth care is important during treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Gentle activity such as short walks can help with tiredness, but avoid strenuous exercise during treatment cycles, especially if you feel weak, dizzy, or breathless. Always check with your cancer team before starting or changing an exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause tiredness, nausea, and a higher risk of infection, which may affect your ability to work during treatment cycles. Many patients need time off or reduced hours. Avoid driving or operating heavy machinery if you feel dizzy, tired, or unwell. Discuss your work schedule with your cancer team so that treatment and rest can be planned safely.
🛑 When to Stop This Medicine
This medicine should only be stopped on the advice of your cancer specialist. Treatment may be stopped or changed if serious side effects such as heart damage, severe bone marrow suppression, or severe allergic reactions occur. Never stop treatment on your own, because doing so can reduce the chance of controlling the cancer.
📅 Long-Term Use Effects
Long-term use of this medicine is limited by the total lifetime dose because of the risk of heart damage. Patients who receive this medicine need regular heart check-ups and long-term follow-up with their cancer team. There is also a small risk of developing a second cancer many years later. Blood counts, liver function, and kidney function may need to be checked periodically after treatment ends.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines such as doxorubicin or daunorubicin may be used in some treatment plans.
Evidence: Well-establishedSome patients may receive chemotherapy combinations that do not include anthracyclines, depending on the cancer type and heart risk.
Evidence: Well-establishedAnti-sickness medicines, blood transfusions, and growth factor injections can help manage side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be given during treatment with this medicine because of the increased risk of serious infection. Inactivated vaccines may be given, but the response may be weaker. Discuss all vaccinations with your cancer team and follow their advice on timing.
📦 Storage Guide
✅ DO
Store in the refrigerator at 2 to 8 degrees Celsius
❌ DON'T
Do not freeze the injection
✅ DO
Keep in the original packaging, protected from light
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
This medicine is given in a hospital or cancer clinic, so travel usually needs to be planned around treatment cycles. If you must travel, carry a copy of your prescription and treatment summary, keep the medicine in its original packaging if you are carrying it, and follow the storage instructions of your hospital pharmacy. Check airline and customs rules for carrying prescription medicines, and inform your cancer team before planning any long trip so that monitoring and treatment schedules can be adjusted safely.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is given by a trained healthcare professional as an intravenous injection or infusion in a hospital or cancer clinic.
A: The schedule is decided by your oncologist and is usually given in cycles with rest periods in between.
A: Watch for fever, unusual bleeding or bruising, chest pain, breathlessness, and swelling of the legs, and report these to your care team immediately.
A: Avoid driving if you feel tired, dizzy, or unwell after treatment. Ask your doctor for advice based on how you feel.
A: No. Breastfeeding should be stopped before treatment begins because this medicine can pass into breast milk and harm the baby.
🤔 Common Patient Concerns
🔄 Substitutes for anthracin 10mg injection
View AllAlternative brands with exact same active ingredient:
-
epineon 10mg injectionNeon Laboratories Ltd ₹169.77 1024.3% COSTLIER
-
epithra 10mg injectionGlenmark Pharmaceuticals Ltd ₹251.00 1562.3% COSTLIER
-
innorubicin 10mg injectionInnova Formulations Pvt Ltd ₹255.37 1591.2% COSTLIER
-
erubin 10mg injectionRPG Life Sciences Ltd ₹258.00 1608.6% COSTLIER
-
biorubin 10mg injectionBiochem Pharmaceutical Industries ₹264.15 1649.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home like a normal tablet.
Fact: This medicine is an intravenous chemotherapy injection and must be given by a trained healthcare professional in a hospital or clinic. - Myth: Hair loss from this medicine is permanent.
Fact: Hair usually grows back after treatment is completed, although it may take several months. - Myth: Reddish urine after this medicine means internal bleeding.
Fact: Reddish urine is a harmless and expected effect of the medicine and usually clears within a day or two. - Myth: This medicine can be stopped without telling the doctor.
Fact: Treatment should only be changed or stopped after discussion with the cancer care team.
🔄 Alternative Options
Generic Alternatives
- Epirubicin injection
Brand Alternatives
- Adnexa 10mg injection