cytofos 500mg injection

4.6 (9 reviews)

Amifostine (500mg)

🏭 Sun Pharmaceutical Industries Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is cytofos 500mg injection used for?

Amiget 500mg Injection (Amifostine) is used to treat BLOOD RELATED. It contains Amifostine (500mg), which Amifostine is a prodrug that is dephosphorylated to active free thiol metabolite. Always consult your doctor before use. Take as prescribed.

Generic Name: Amifostine
Manufacturer: Sun Pharmaceutical Industries Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 cytofos 500mg injection Uses & Benefits

Reduction of cumulative renal toxicity from cisplatin; reduction of xerostomia from radiation therapy for head and neck cancer; reduction of hematologic toxicity from cyclophosphamide.

Off-label uses: Prevention of radiation-induced mucositis; protection against ototoxicity from cisplatin.

📋 Drug Information

Generic Name(s)	Amifostine
Brand Name	Amiget 500mg Injection
Manufacturer	Sun Pharmaceutical Industries Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	BLOOD RELATED
Action Class	Cytoprotective agents- Kidney & Salivary gland
Route of Administration	Intravenous infusion
Storage	Store at 20-25°C (68-77°F); protect from light; reconstituted solution stable for 24 hours at room temperature.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in rapid distribution; no oral absorption due to first-pass metabolism.

DistributionWidely distributed to tissues, including kidneys, liver, and bone marrow; crosses placenta.

Protein BindingLow (<10%)

MetabolismRapidly dephosphorylated by alkaline phosphatase to active free thiol metabolite (WR-1065); further metabolism to disulfides.

Half-LifeApproximately 8 minutes for amifostine; active metabolite half-life ~1 hour.

ExcretionRenal excretion of metabolites; small amount unchanged in urine.

BioavailabilityNot applicable (IV administration); oral bioavailability negligible.

Onset of ActionImmediate (minutes) after IV infusion.

Peak Plasma TimeEnd of infusion (peak concentration).

Duration of ActionProtective effect lasts 2-4 hours after infusion.

How It Works

Amifostine is a prodrug that is dephosphorylated to active free thiol metabolite (WR-1065) which scavenges free radicals and detoxifies reactive metabolites of chemotherapy and radiation.

Mechanism Steps

1Amifostine is administered intravenously as a prodrug.

2Rapidly dephosphorylated by alkaline phosphatase on cell membranes to active free thiol metabolite WR-1065.

3WR-1065 enters normal cells more readily than tumor cells due to higher alkaline phosphatase activity and lower pH in normal tissues.

💡 How to Take cytofos 500mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of cytofos 500mg injection

✅ Common Side Effects

Nausea
Vomiting
Hypotension
Flushing
Chills
Dizziness

🚨 Serious Side Effects

Severe hypotension
Allergic reactions (anaphylaxis)
Stevens-Johnson syndrome
Toxic epidermal necrolysis

⚠️ Rare Side Effects

Seizures
Arrhythmias
Hypocalcemia
Rhabdomyolysis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Cisplatin	Major	Reduces cisplatin-induced nephrotoxicity and ototoxicity.
Cyclophosphamide	Major	Reduces cyclophosphamide-induced hemorrhagic cystitis.
Radiation therapy	Major	Reduces radiation-induced xerostomia and mucositis.
Antihypertensives	Moderate	May potentiate hypotensive effect; monitor blood pressure.
Calcium channel blockers	Moderate	May increase risk of hypotension.

🚨 Major Interactions

Cisplatin
Cyclophosphamide
Radiation therapy

⚡ Moderate Interactions

Antihypertensives
Calcium channel blockers

ℹ️ Minor Interactions

None documented

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to amifostine or aminothiol compounds; patients with hypotension or dehydration.

📊 Monitoring Parameters

Blood pressure (before and during infusion), renal function, serum electrolytes, complete blood count.

🤱 Lactation Safety

Unknown if excreted in breast milk; caution advised.

💊 Overdose Management

Monitor for hypotension, nausea, vomiting; supportive care; no specific antidote.

⏰ Missed Dose

Administer as soon as possible if within 1 hour of scheduled time; otherwise skip and resume next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for cytofos 500mg injection

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Alternative brands with exact same active ingredient (Amifostine (500mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026