ANC 9 Tablet: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or wheezing
- Severe skin rash or hives
- Chest pain or irregular heartbeat
- Unusual bleeding or bruising
- Yellowing of eyes or skin
- Severe headache with vision changes
- Persistent vomiting or diarrhea
If experiencing severe symptoms, call emergency services immediately.
What is ambifol-dha soft gelatin capsule used for?
This medicine is a combination of L-Methyl Folate (1 mg) and Methylcobalamin (1500 mcg), used to treat or prevent deficiency of these vitamins. It supports red blood cell production, nerve health, and normal cell division. It is taken orally once daily with a meal, as prescribed by a doctor.
- Generic Name: L-Methyl Folate + Methylcobalamin
- Manufacturer: Dewcare Concept Pvt.Ltd.
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ambifol-dha soft gelatin capsule के बारे में (Hindi Summary)
उपयोग: यह दवा विटामिन बी9 और बी12 की कमी को पूरा करने के लिए दी जाती है। इसमें एल-मिथाइल फोलेट और मिथाइलकोबालामिन होते हैं, जो शरीर में सीधे उपयोग हो सकते हैं। यह लाल रक्त कोशिकाओं के निर्माण, तंत्रिका तंत्र की सेहत और कोशिका विभाजन में मदद करती है। गर्भावस्था में यह शिशु के मस्तिष्क और रीढ़ की हड्डी के विकास के लिए महत्वपूर्ण है। जिन लोगों में इन विटामिनों की कमी है, उन्हें थकान, कमजोरी, हाथ-पैर में झनझनाहट और मुंह के छाले हो सकते हैं। यह दवा उन लक्षणों को सुधारने में मदद करती है।
साइड इफेक्ट्स: इस दवा से आमतौर पर हल्के दुष्प्रभाव हो सकते हैं जैसे जी मिचलाना, पेट में गड़बड़ी, या सिरदर्द। कुछ लोगों को भूख में बदलाव महसूस हो सकता है। गंभीर दुष्प्रभाव बहुत कम होते हैं, लेकिन अगर चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई, या त्वचा पर चकत्ते दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट खराब न हो और अवशोषण बेहतर हो। अगर आपको किडनी या लीवर की बीमारी है, या किसी भी चीज़ से एलर्जी है, तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर की सलाह जरूर लें। शराब न पिएं क्योंकि इससे विटामिन का अवशोषण कम होता है। दवा को ठंडी और सूखी जगह पर रखें, धूप से बचाएं, और बच्चों की पहुंच से दूर रखें।
💊 ambifol-dha soft gelatin capsule Uses & Benefits
[{"condition":"Folate deficiency","description":"This medicine provides the active form of folate to correct low folate levels, which can cause anemia, fatigue, and mouth sores.","evidence":"Well-established"},{"condition":"Vitamin B12 deficiency","description":"Methylcobalamin helps treat B12 deficiency, which can lead to nerve damage, anemia, and cognitive issues.","evidence":"Well-established"},{"condition":"MTHFR gene mutation support","description":"People with MTHFR gene variations may have difficulty converting folic acid to its active form; L-Methyl Folate bypasses this step.","evidence":"Moderate"},{"condition":"Pregnancy nutritional support","description":"Adequate folate and B12 are essential for fetal neural tube development and maternal health.","evidence":"Well-established"},{"condition":"Hyperhomocysteinemia","description":"This medicine helps lower elevated homocysteine levels, which are linked to cardiovascular and neurological risks.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Depression adjunct","description":"Sometimes used as an add-on to antidepressants, especially in people with low folate or B12.","evidence":"Limited"},{"condition":"Diabetic neuropathy","description":"Methylcobalamin may help reduce nerve pain in diabetic patients, though evidence is mixed.","evidence":"Limited"},{"condition":"Cognitive decline","description":"May be used to support brain health in elderly with vitamin deficiencies, but not proven to prevent dementia.","evidence":"Limited"}]
Primary treatment for: Vitamin B9 and B12 deficiency
Also treats: MTHFR gene mutation, Pregnancy nutritional support, Hyperhomocysteinemia, Diabetic neuropathy, Megaloblastic anemia
📋 Drug Information
| Generic Name(s) | L-Methyl Folate + Methylcobalamin |
| Brand Name | Aftron Tablet |
| Manufacturer | Dewcare Concept Pvt.Ltd. |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | VITAMINS MINERALS NUTRIENTS |
| Action Class | Vitamins and Nutrients |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. WHO recommends adequate folate and B12 intake for all age groups, but specific product recommendations are not available. |
| ICMR Guideline | Not established from the available information. ICMR recommends daily allowance of folate and B12, but specific product recommendations are not available. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by supplying the body with already-active forms of folate and vitamin B12. L-Methyl Folate is the primary circulating form of folate and acts as a cofactor for enzymes involved in DNA synthesis, repair, and methylation. It helps convert homocysteine to methionine, which is important for many biochemical reactions. Methylcobalamin is a coenzyme for methionine synthase and methylmalonyl-CoA mutase, enzymes that are critical for nerve myelin maintenance and red blood cell production. Together, they support normal cell division, nerve function, and blood formation.
Mechanism Steps
💡 How to Take ambifol-dha soft gelatin capsule
Strength: Tablet: L-Methyl Folate 1 mg + Methylcobalamin 1500 mcg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet once daily, preferably with a meal, or as prescribed by your doctor. The dose may be adjusted based on your specific vitamin levels and medical condition. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients can usually take the same adult dose, but they may be more sensitive to side effects. Regular monitoring of vitamin levels and kidney function is advised. Consult a doctor for personalized dosing. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. However, in severe kidney disease, consult your doctor as accumulation may occur. Monitoring of vitamin levels is recommended. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. In severe liver disease, consult your doctor before use. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (1 mg L-Methyl Folate + 1500 mcg Methylcobalamin) unless otherwise prescribed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ambifol-dha soft gelatin capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | |
| Phenytoin | Major | |
| Sulfasalazine | Moderate | |
| Metformin | Moderate | |
| Antacids | Minor | |
| Colchicine | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Methotrexate
- Phenytoin
⚡ Moderate Interactions
- Sulfasalazine
- Metformin
🍷 Alcohol Interaction
Alcohol can reduce the absorption of both L-Methyl Folate and Methylcobalamin and worsen deficiency. It is best to avoid alcohol while taking this medicine. If you drink, limit intake and inform your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to L-Methyl Folate, Methylcobalamin, or any excipient","Untreated vitamin B12 deficiency with neurological signs (folate alone may mask B12 deficiency)","Leber's disease (hereditary optic nerve atrophy) - Methylcobalamin may worsen","Use with caution in patients with polycythemia vera"]
⚠️ Warnings & Precautions
["Do not use this medicine to treat undiagnosed anemia without medical evaluation.","Folate supplementation can mask vitamin B12 deficiency; always check B12 levels.","If you have kidney or liver disease, use only under medical supervision.","Inform your doctor if you are taking methotrexate, phenytoin, or sulfasalazine.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose.","Keep out of reach of children.","If pregnant or breastfeeding, consult your doctor before use."]
🤱 Lactation Safety
L-Methyl Folate and Methylcobalamin are safe during breastfeeding when taken at recommended doses. They pass into breast milk and are beneficial for the infant. Consult your doctor for proper dosage.
💊 Overdose Management
This medicine contains water-soluble vitamins. Overdose is unlikely to cause serious harm, but may cause nausea, stomach upset, or diarrhea. If you suspect a large overdose, contact your doctor or a poison control center immediately. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose on your own. Swallow the tablet whole with a glass of water, preferably with a meal to improve absorption and reduce stomach upset. If you have kidney disease, liver disease, or a history of allergies, tell your doctor before starting this medicine. Do not take this medicine if you have a known allergy to any of its ingredients. If you are pregnant or planning to become pregnant, discuss with your doctor before use. If you are breastfeeding, consult your doctor to ensure it is safe for your baby. Avoid alcohol while taking this medicine, as it can interfere with vitamin absorption. Keep all follow-up appointments and get your vitamin levels checked as advised. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children. Do not use it after the expiry date.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced absorption of vitamins and may need higher doses or alternative routes. Regular monitoring of B12 and folate levels is important. They may also be more prone to drug interactions, so review all medications with a doctor.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, start this medicine only after consulting your doctor. Adequate folate and B12 are crucial before conception to prevent neural tube defects. Your doctor may recommend a specific dose and duration.
🏥 Post-Surgery Considerations
After surgery, your doctor may prescribe this medicine to support healing and prevent deficiency, especially if you have difficulty eating. Follow your surgeon's instructions regarding when to resume oral intake.
🦷 Dental Procedures
No specific precautions for dental procedures. Inform your dentist about all medicines you take. If you are due for surgery, discuss with your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions while taking this medicine. However, if you have neuropathy or balance issues due to deficiency, avoid high-impact activities until symptoms improve. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to work or drive. If you experience dizziness or drowsiness (rare), avoid driving or operating heavy machinery until you know how it affects you.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or allergic reactions, stop immediately and seek medical help. Your doctor will advise when to stop based on your vitamin levels and condition.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when taken as prescribed. It helps maintain normal vitamin levels and prevents deficiency-related complications. Regular monitoring of blood levels is recommended to avoid excessive intake. There is no known risk of toxicity with recommended doses.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Increasing intake of folate and B12 rich foods can help mild deficiencies.
Evidence: Well-establishedFolic acid and cyanocobalamin are alternative forms, but may require conversion in the body.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interaction with vaccines. You can receive vaccinations while taking this medicine. Inform your healthcare provider about all supplements you take.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, continue taking it at your usual time or adjust gradually. Check customs regulations for carrying prescription medicines. Always carry enough supply for your trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within a few days to weeks, but it may take several months to fully correct a deficiency. Follow your doctor's advice for monitoring.
A: It is best taken with food to improve absorption and reduce stomach upset. If you must take it without food, do so but monitor for nausea.
A: Yes, when taken under medical supervision. Folate and B12 are essential during pregnancy. Do not self-medicate; consult your doctor for the right dose.
🤔 Common Patient Concerns
🔄 Substitutes for ambifol-dha soft gelatin capsule
View AllAlternative brands with exact same active ingredient:
-
davaindia l-methyl folate+methylcobalamin+pyridoxal-5-phasphate 1mg/1500mcg/0.5mg tabletDavaindia Generic Pharmacy ₹50.00 69.3% CHEAPER
-
desifol-plus tabletSyndicate Life Sciences Pvt Ltd ₹83.44 48.9% CHEAPER
-
foligram tabletGrawish Pharma Pvt Ltd ₹92.81 43.1% CHEAPER
-
smartfol tabletMedgrow Health Care ₹102.19 37.4% CHEAPER
-
foliboon tabletMeckley Life Sciences Pvt Ltd ₹106.88 34.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure all types of anemia.
Fact: It only helps anemia caused by folate or B12 deficiency. Other types of anemia need different treatments. - Myth: More is always better for vitamins.
Fact: High doses can cause side effects and mask other deficiencies. Take only as prescribed. - Myth: This medicine is only for pregnant women.
Fact: It is for anyone with folate or B12 deficiency, including men, children, and elderly.
🔄 Alternative Options
Generic Alternatives
- L-Methyl Folate + Methylcobalamin tablets from other manufacturers
Brand Alternatives
- Not applicable. This is a generic product.