ambifol-dha soft gelatin capsule - L-Methyl Folate (1mg) + Methylcobalamin (1500mcg) medicine

Ambifol-DHA Soft Gelatin Capsule - Uses, Price, Side Effects

4.6 (19 reviews)
๐Ÿญ Dewcare Concept Pvt.Ltd. ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 21, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 21, 2026

What is ambifol-dha soft gelatin capsule used for?

Ambifol-DHA soft gelatin capsule is a nutritional supplement containing L-Methyl Folate (1mg) and Methylcobalamin (1500mcg). It is used to treat and prevent folic acid and vitamin B12 deficiencies, which can cause anemia and nerve damage. L-Methyl Folate supports red blood cell formation and DNA synthesis, while Methylcobalamin helps maintain healthy nerve cells and myelin sheath. This combination is especially beneficial for individuals with malabsorption issues or those on certain medications.

  • Generic Name: L-Methyl Folate + Methylcobalamin
  • Manufacturer: Dewcare Concept Pvt.Ltd.
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š ambifol-dha soft gelatin capsule Uses & Benefits

Treatment of folate deficiency, vitamin B12 deficiency, hyperhomocysteinemia, and as adjunct in depression or cognitive decline.

Off-label uses: Adjunct for depression, Cognitive decline, Peripheral neuropathy

๐Ÿ“‹ Drug Information

Generic Name(s)L-Methyl Folate + Methylcobalamin
Brand NameAftron Tablet
ManufacturerDewcare Concept Pvt.Ltd.
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassVITAMINS MINERALS NUTRIENTS
Action ClassVitamins and Nutrients
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed in the gastrointestinal tract; L-methyl folate is absorbed via folate transporters, methylcobalamin via intrinsic factor-dependent mechanism.
DistributionDistributed throughout the body; crosses the blood-brain barrier.
Protein BindingL-methyl folate: ~50% bound to plasma proteins; methylcobalamin: bound to transcobalamins.
MetabolismL-methyl folate is metabolized in the liver; methylcobalamin is converted to other cobalamin forms.
Half-LifeL-methyl folate: ~3-4 hours; methylcobalamin: ~6 days (plasma).
ExcretionRenal excretion of metabolites; bile for cobalamin.
BioavailabilityHigh oral bioavailability for both components.
Onset of ActionWithin hours to days for folate; days to weeks for cobalamin.
Peak Plasma TimeL-methyl folate: 1-2 hours; methylcobalamin: 8-12 hours.
Duration of ActionSeveral hours for folate; days for cobalamin.

How It Works

Provides active folate and vitamin B12 to support homocysteine metabolism, DNA synthesis, and neuronal function.

Mechanism Steps

1L-methyl folate enters cells via folate receptors and is converted to active folate cofactors.
2Methylcobalamin binds to intrinsic factor in stomach, absorbed in ileum, and enters circulation bound to transcobalamin.
3Both act as cofactors in homocysteine remethylation to methionine.

๐Ÿ’ก How to Take ambifol-dha soft gelatin capsule

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of ambifol-dha soft gelatin capsule

โœ… Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Insomnia

๐Ÿšจ Serious Side Effects

  • Allergic reactions
  • Peripheral neuropathy (rare)

โš ๏ธ Rare Side Effects

  • Seizures
  • Hypersensitivity reactions

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Levodopa Moderate Decreased effectiveness of levodopa
Chloramphenicol Moderate Reduced response to vitamin B12
Colchicine Moderate Decreased absorption of vitamin B12

๐Ÿšจ Major Interactions

  • Methotrexate
  • Phenytoin
  • Primidone
  • Pyrimethamine
  • Trimethoprim

โšก Moderate Interactions

  • Oral contraceptives
  • Antacids
  • H2 blockers
  • Proton pump inhibitors
  • Metformin

โ„น๏ธ Minor Interactions

  • Cholestyramine
  • Colchicine
  • Neomycin
  • Nitrous oxide

๐Ÿฝ๏ธ Food Interactions

Alcohol, Folate-rich foods may reduce absorption of other drugs

๐Ÿท Alcohol Interaction

Alcohol may decrease folate absorption and increase requirements.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity to any component; pernicious anemia (unless cyanocobalamin is used).

๐Ÿ“Š Monitoring Parameters

Serum folate, vitamin B12, homocysteine levels; CBC.

๐Ÿคฑ Lactation Safety

Safe; excreted in breast milk in small amounts.

๐Ÿ’Š Overdose Management

Generally safe; supportive care. No specific antidote.

โฐ Missed Dose

Take as soon as remembered; skip if almost time for next dose. Do not double.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

๐Ÿ”— View Profile

โญ User Reviews

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.

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