combee-l tablet
What is combee-l tablet used for?
Bandhan (Ethinyl Estradiol + Levonorgestrel) is used to treat GYNAECOLOGICAL. It contains Ethinyl Estradiol (0.03mg) + Levonorgestrel (0.15mg), which Suppresses ovulation via inhibition of gonadotropin release; increases cervical . Always consult your doctor before use. Take as prescribed.
- Generic Name: Ethinyl Estradiol + Levonorgestrel
- Manufacturer: Dewcare Concept Pvt.Ltd.
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ combee-l tablet Uses & Benefits
Oral contraception, regulation of menstrual cycles, treatment of acne (off-label), emergency contraception (as dedicated product)
Off-label uses: Acne vulgaris, hirsutism, dysmenorrhea, endometriosis, menstrual migraine prophylaxis
๐ Drug Information
| Generic Name(s) | Ethinyl Estradiol + Levonorgestrel |
| Brand Name | Bandhan |
| Manufacturer | Dewcare Concept Pvt.Ltd. |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Combined Oral Contraceptive |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Suppresses ovulation via inhibition of gonadotropin release; increases cervical mucus viscosity and alters endometrial lining
Mechanism Steps
๐ก How to Take combee-l tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of combee-l tablet
โ Common Side Effects
- Nausea
- Headache
- Breast tenderness
- Weight changes
- Mood changes
- Irregular bleeding
- Spotting
๐จ Serious Side Effects
- Thromboembolism
- Myocardial infarction
- Stroke
- Hypertension
- Liver tumors
- Gallbladder disease
- Depression
โ ๏ธ Rare Side Effects
- Chloasma
- Hepatic adenoma
- Pancreatitis
- Optic neuritis
- Retinal thrombosis
- Hemolytic uremic syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Rifampin | Major | Reduced contraceptive efficacy |
| Carbamazepine | Major | Reduced contraceptive efficacy |
| St. John's Wort | Major | Reduced contraceptive efficacy |
| Amoxicillin | Moderate | Possible reduced efficacy |
| Grapefruit juice | Moderate | Increased estrogen levels |
๐จ Major Interactions
- Rifampin
- Rifabutin
- Carbamazepine
- Phenytoin
- Barbiturates
- St. John's Wort
- Griseofulvin
- Topiramate
- Modafinil
- Aprepitant
โก Moderate Interactions
- Amoxicillin
- Tetracycline
- Doxycycline
- Clarithromycin
- Fluconazole
- Itraconazole
- Ketoconazole
- Atorvastatin
- Rosuvastatin
- Cyclosporine
- Theophylline
- Corticosteroids
- Tizanidine
- Selegiline
- Lamotrigine
- Morphine
- Salicylates
- Temazepam
- Midazolam
- Omeprazole
- Cimetidine
- Acetaminophen
- Ascorbic acid
- Tocopherol
- Grapefruit juice
โน๏ธ Minor Interactions
- Caffeine
- Theophylline
- Metoprolol
- Propranolol
- Prednisolone
- Prednisone
- Methylprednisolone
- Clofibric acid
- Paracetamol
- Morphine
- Temazepam
- Midazolam
- Omeprazole
- Cimetidine
- Acetaminophen
- Ascorbic acid
- Tocopherol
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase ethinyl estradiol levels; high-fat meals may increase absorption
๐ท Alcohol Interaction
No direct interaction, but alcohol may impair judgment and compliance
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Pregnancy, history of thromboembolic disorders, cerebrovascular disease, coronary artery disease, known or suspected breast cancer, estrogen-dependent neoplasia, undiagnosed abnormal genital bleeding, liver tumors or active liver disease, hypersensitivity to components
๐ Monitoring Parameters
Blood pressure, liver function, signs of thromboembolism, menstrual patterns, pregnancy test if indicated
๐คฑ Lactation Safety
Use with caution; may reduce milk production; small amounts excreted in breast milk
๐ Overdose Management
May cause nausea, vomiting, withdrawal bleeding; treatment is symptomatic and supportive
โฐ Missed Dose
If missed one pill, take as soon as remembered; if missed two or more, use backup contraception and consult package insert
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Good quality medicine. Satisfied with the outcome.
This medicine was effective for me. I followed the doctor's advice.
This medicine was effective for me. I followed the doctor's advice.
This medicine was effective for me. I followed the doctor's advice.
Good quality medicine. Satisfied with the outcome.