alpha d3 0.5mcg capsule - Alfacalcidol (0.5mcg) medicine

alpha d3 0.5mcg capsule

4.4 (13 reviews)
๐Ÿญ Glaxo SmithKline Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿคฐ Pregnancy Category A ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is alpha d3 0.5mcg capsule used for?

Alphadol (Alfacalcidol) is used to treat VITAMINS MINERALS NUTRIENTS. It contains Alfacalcidol (0.5mcg), which Alfacalcidol is a prodrug that is hydroxylated in the liver to form calcitriol, . Always consult your doctor before use. Take as prescribed.

  • Generic Name: Alfacalcidol
  • Manufacturer: Glaxo SmithKline Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š alpha d3 0.5mcg capsule Uses & Benefits

Osteoporosis, renal osteodystrophy, hypoparathyroidism, rickets, osteomalacia.

Off-label uses: Psoriasis, autoimmune diseases (limited evidence).

๐Ÿ“‹ Drug Information

Generic Name(s)Alfacalcidol
Brand NameAlphadol
ManufacturerGlaxo SmithKline Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassVITAMINS MINERALS NUTRIENTS
Action ClassVitamins
Route of AdministrationOral
StorageStore at room temperature (15-30ยฐC), protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract.
DistributionDistributed widely in tissues; stored in fat and muscle.
Protein BindingApproximately 99% bound to plasma proteins, mainly vitamin D-binding protein.
MetabolismConverted in the liver to 1,25-dihydroxyvitamin D3 (calcitriol) via 25-hydroxylation.
Half-LifeApproximately 2-3 hours for alfacalcidol; calcitriol half-life is about 5-8 hours.
ExcretionExcreted primarily in bile and feces; less than 1% excreted in urine.
BioavailabilityHigh oral bioavailability (approximately 80-100%).
Onset of ActionWithin 2-6 hours after oral administration.
Peak Plasma TimePeak plasma concentration of calcitriol reached within 8-18 hours.
Duration of ActionUp to 24 hours.

How It Works

Alfacalcidol is a prodrug that is hydroxylated in the liver to form calcitriol, which binds to vitamin D receptors (VDR) in target tissues, regulating calcium and phosphate homeostasis.

Mechanism Steps

1Alfacalcidol is absorbed in the intestine.
2Converted to calcitriol in the liver via 25-hydroxylation.
3Calcitriol binds to vitamin D receptors (VDR) in target cells.

๐Ÿ’ก How to Take alpha d3 0.5mcg capsule

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of alpha d3 0.5mcg capsule

โœ… Common Side Effects

  • Hypercalcemia
  • Hypercalciuria
  • Nausea
  • Vomiting
  • Constipation
  • Headache

๐Ÿšจ Serious Side Effects

  • Severe hypercalcemia
  • Arrhythmias
  • Renal impairment
  • Bone pain

โš ๏ธ Rare Side Effects

  • Allergic reactions
  • Metastatic calcification

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Thiazide diuretics Major Increased risk of hypercalcemia
Cardiac glycosides Major Increased risk of arrhythmias due to hypercalcemia
Cholestyramine Major Reduced absorption of alfacalcidol
Phenytoin Moderate Reduced efficacy of alfacalcidol
Corticosteroids Moderate Reduced calcium absorption

๐Ÿšจ Major Interactions

  • Thiazide diuretics
  • Cardiac glycosides (e.g., digoxin)
  • Cholestyramine
  • Colestipol
  • Orlistat
  • Mineral oil

โšก Moderate Interactions

  • Phenytoin
  • Phenobarbital
  • Carbamazepine
  • Corticosteroids
  • Rifampin
  • Isoniazid

โ„น๏ธ Minor Interactions

  • Magnesium-containing antacids
  • Aluminum-containing antacids
  • Calcium supplements

๐Ÿฝ๏ธ Food Interactions

May be taken with or without food; high-fiber diets may reduce absorption.

๐Ÿท Alcohol Interaction

No significant interaction reported.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypercalcemia, hypercalciuria, vitamin D toxicity, known hypersensitivity.

๐Ÿ“Š Monitoring Parameters

Serum calcium, phosphate, alkaline phosphatase, and renal function periodically.

๐Ÿคฑ Lactation Safety

Excreted in breast milk; caution advised.

๐Ÿ’Š Overdose Management

Discontinue drug; treat hypercalcemia with hydration, loop diuretics, corticosteroids, and calcitonin if severe.

โฐ Missed Dose

Take as soon as remembered; if close to next dose, skip missed dose. Do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for alpha d3 0.5mcg capsule

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Alternative brands with exact same active ingredient (Alfacalcidol (0.5mcg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Found this to be a helpful product. Good results.

Happy Patient Jul 10, 2026

Found this to be a helpful product. Good results.

Certified Buyer Jul 10, 2026

Found this to be a helpful product. Good results.

Trusted Reviewer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

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