Levosulpiride Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with muscle rigidity or confusion
- Involuntary repetitive movements of face or tongue
- Palpitations or fainting
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is alevo 12.5mg injection used for?
Levosulpiride injection is used to treat nausea, vomiting, and gastric motility disorders. It works by blocking dopamine receptors in the brain and gut. It is given by a healthcare professional.
- Generic Name: Levosulpiride
- Manufacturer: Ikon Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 alevo 12.5mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा मतली, उल्टी और पेट की गड़बड़ी जैसे अपच, पेट फूलना और गैस्ट्रोपैरेसिस के इलाज के लिए इस्तेमाल की जाती है। यह डोपामाइन रिसेप्टर्स को ब्लॉक करके काम करती है, जिससे उल्टी और मतली कम होती है और पेट की गतिशीलता बढ़ती है। यह इंजेक्शन के रूप में डॉक्टर या नर्स द्वारा दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, मुंह सूखना और कब्ज शामिल हैं। कभी-कभी मांसपेशियों में अकड़न या कंपन हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यदि आपको तेज बुखार, मांसपेशियों में अकड़न, या दिल की धड़कन तेज होना महसूस हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा दी जानी चाहिए। खुद से इंजेक्शन न लगाएं। यदि आपको हृदय रोग, मिर्गी, या गुर्दे या यकृत की समस्या है तो डॉक्टर को बताएं। इस दवा को लेने के दौरान वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं।
💊 alevo 12.5mg injection Uses & Benefits
[{"condition":"Nausea and vomiting","description":"This medicine is effective in controlling nausea and vomiting of various causes, including chemotherapy-induced and postoperative nausea.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"It helps relieve symptoms such as bloating, early satiety, and upper abdominal discomfort by promoting gastric emptying.","evidence":"Well-established"},{"condition":"Diabetic gastroparesis","description":"This medicine improves gastric motility and reduces symptoms of delayed stomach emptying in diabetic patients.","evidence":"Moderate"},{"condition":"Depression","description":"In some countries, levosulpiride is used as an adjunct in the treatment of depression, particularly when associated with somatic symptoms.","evidence":"Limited"}]
Off-label uses: [{"condition":"Premature ejaculation","description":"Levosulpiride has been studied off-label for premature ejaculation due to its dopamine antagonist properties.","evidence":"Limited"},{"condition":"Anxiety","description":"Sometimes used off-label for anxiety, but evidence is not robust.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting
Also treats: Functional dyspepsia, Diabetic gastroparesis, Depression
📋 Drug Information
| Generic Name(s) | Levosulpiride |
| Brand Name | Aurlev 75 Tablet |
| Manufacturer | Ikon Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Atypical Antipsychotics |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store below 25°C, protected from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Levosulpiride is a selective dopamine D2 receptor antagonist that acts primarily in the central nervous system. It blocks dopamine receptors in the chemoreceptor trigger zone and the vomiting center, thereby exerting antiemetic effects. Additionally, it enhances gastrointestinal motility by antagonizing dopamine receptors in the gut, leading to improved gastric emptying and intestinal transit. Its antipsychotic and antidepressant effects are thought to be mediated by modulation of dopaminergic pathways in the brain.
Mechanism Steps
💡 How to Take alevo 12.5mg injection
Strength: Levosulpiride 12.5 mg/ml injection
Dosage Information
| Adult Dosage | The usual adult dose of levosulpiride injection is 25 mg to 50 mg administered intramuscularly or intravenously, once or twice daily, depending on the indication and severity of symptoms. For nausea and vomiting, a single dose of 25 mg may be sufficient. For functional dyspepsia, 25 mg twice daily may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of levosulpiride, especially extrapyramidal symptoms and sedation. Start with a lower dose and titrate slowly. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, the elimination half-life of levosulpiride is prolonged. Dose reduction may be necessary. Consult a clinician for individualized dosing. |
| Hepatic Impairment | Levosulpiride undergoes minimal hepatic metabolism, so dose adjustment may not be necessary in hepatic impairment. However, caution is advised. Consult a clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 100 mg, but this should not be exceeded without specialist advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of alevo 12.5mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Metoclopramide | Major | |
| Levodopa | Major | |
| Amiodarone | Major | |
| Diazepam | Moderate | |
| Lisinopril | Moderate |
🚨 Major Interactions
- Other dopamine antagonists (e.g., metoclopramide, haloperidol)
- Levodopa
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
⚡ Moderate Interactions
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
- Antihypertensives
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine as it can potentiate the sedative and CNS depressant effects, leading to increased drowsiness, dizziness, and impaired motor skills.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to levosulpiride or any component of the formulation","Pheochromocytoma","Epilepsy","Severe cardiovascular disorders (e.g., recent myocardial infarction, heart failure)","Concomitant use with levodopa","Prolactin-dependent tumors (e.g., pituitary adenoma, breast cancer)"]
⚠️ Warnings & Precautions
["Use with caution in elderly patients due to increased risk of extrapyramidal symptoms and falls.","Avoid in patients with Parkinson's disease as it may worsen symptoms.","May impair ability to drive or operate machinery; advise caution.","Use with caution in patients with renal impairment; dose adjustment may be needed.","May cause QT prolongation; avoid in patients with long QT syndrome.","Not recommended for use in children unless prescribed by a specialist.","Avoid alcohol consumption during treatment."]
🤱 Lactation Safety
Levosulpiride is excreted in breast milk. Breastfeeding is not recommended while receiving this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of levosulpiride may cause severe extrapyramidal symptoms, sedation, hypotension, and QT prolongation. There is no specific antidote. Treatment is supportive and symptomatic, including monitoring of vital signs, ECG, and management of extrapyramidal symptoms with anticholinergic drugs if necessary. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
Since this medicine is usually administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your healthcare provider for guidance. Do not attempt to self-administer an extra dose.
Additional Safety Advice
This medicine should only be administered by a healthcare professional. Do not self-administer. Inform your doctor if you have a history of heart problems, epilepsy, or kidney or liver disease. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not consume alcohol while receiving this medicine, as it can increase drowsiness and dizziness. Your doctor may monitor your heart rhythm and kidney function during treatment. If you are pregnant or breastfeeding, consult your doctor before receiving this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of extrapyramidal symptoms, sedation, and falls. Use with caution and start with a lower dose. Monitor renal function regularly.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. The safety profile in pregnancy is not well established, and alternative treatments may be considered.
🏥 Post-Surgery Considerations
Levosulpiride injection is often used postoperatively for nausea and vomiting. It should be administered by healthcare professionals. Monitor for excessive sedation and extrapyramidal symptoms.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may interact with anesthetics or cause dry mouth, affecting dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise immediately after receiving this injection, as it may cause dizziness or hypotension. Light activity is fine once you feel stable.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, affecting your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause extrapyramidal symptoms that can impact fine motor skills.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects like neuroleptic malignant syndrome or tardive dyskinesia, seek immediate medical attention and discontinuation may be advised.
📅 Long-Term Use Effects
Long-term use of levosulpiride may increase the risk of tardive dyskinesia and other extrapyramidal symptoms. Regular monitoring for movement disorders is recommended. It may also cause hyperprolactinemia, leading to breast enlargement or galactorrhea. Periodic assessment of renal function is advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Small, frequent meals and avoiding trigger foods can help manage dyspepsia.
Evidence: Well-establishedMay help reduce nausea and vomiting in some patients.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Keep a copy of your prescription with you. Store it at room temperature, away from direct sunlight and moisture. If traveling across time zones, consult your doctor for dose timing adjustments. Declare it at customs if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The antiemetic effect typically begins within 30 minutes to 1 hour after injection.
A: Consult your doctor. The safety of levosulpiride in pregnancy is not well established.
A: Common side effects include drowsiness, dizziness, headache, and dry mouth.
🤔 Common Patient Concerns
🔄 Substitutes for alevo 12.5mg injection
View AllAlternative brands with exact same active ingredient:
-
neopride injectionIntas Pharmaceuticals Ltd ₹86.72 63.6% COSTLIER
-
levazeo 12.5mg/ml injectionTorrent Pharmaceuticals Ltd ₹215.63 306.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Levosulpiride injection is a painkiller.
Fact: Levosulpiride is not a painkiller; it is used for nausea, vomiting, and gastric motility disorders. - Myth: Levosulpiride injection can be self-administered.
Fact: This injection must be given by a healthcare professional only.
🔄 Alternative Options
Generic Alternatives
- Levosulpiride injection (generic)
Brand Alternatives
- Levosulpiride 12.5mg/ml injection by various manufacturers