Levosulpiride Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with muscle rigidity and confusion
- Irregular heartbeat or palpitations
- Severe allergic reaction with swelling of face or throat
- Involuntary movements of face, tongue, or limbs
- Yellowing of skin or eyes
- Decreased urine output
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is neopride injection used for?
Levosulpiride injection is a prokinetic and antipsychotic medicine used to treat nausea, vomiting, and certain stomach and mental health conditions. It works by blocking dopamine receptors in the brain and gut. It is given by a healthcare professional as an intramuscular or intravenous injection.
- Generic Name: Levosulpiride (12.5mg/ml)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 neopride injection के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से उल्टी और मतली के इलाज के लिए दी जाती है। यह पेट की समस्याओं जैसे अपच, गैस्ट्रोपैरेसिस में भी फायदेमंद है। कुछ मानसिक बीमारियों जैसे सिज़ोफ्रेनिया में भी इसका उपयोग किया जाता है। यह इंजेक्शन के रूप में डॉक्टर या नर्स द्वारा दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, मुँह सूखना, कब्ज या दस्त शामिल हैं। कभी-कभी हाथ-पैरों में कंपन, अकड़न या बेचैनी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन अगर तेज़ बुखार, मांसपेशियों में अकड़न, बेहोशी या दिल की धड़कन तेज़ हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: यह दवा सिर्फ डॉक्टर की देखरेख में ही दी जानी चाहिए। इलाज के दौरान शराब न पिएं और वाहन न चलाएं। अपने डॉक्टर को अपनी सभी दवाओं और बीमारियों के बारे में बताएं। गुर्दे या लीवर की बीमारी हो तो विशेष सावधानी बरतें। बिना डॉक्टर की सलाह के दवा न रोकें।
💊 neopride injection Uses & Benefits
[{"condition":"Nausea and vomiting","description":"This medicine is effective in controlling nausea and vomiting of various origins, including chemotherapy-induced, postoperative, and drug-induced emesis.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"It helps relieve symptoms such as postprandial fullness, early satiety, and epigastric pain by accelerating gastric emptying.","evidence":"Well-established"},{"condition":"Diabetic gastroparesis","description":"Levosulpiride improves gastric motility and reduces symptoms of delayed gastric emptying in diabetic patients.","evidence":"Moderate"},{"condition":"Schizophrenia","description":"Used as an antipsychotic for acute and chronic schizophrenia, particularly for negative symptoms.","evidence":"Moderate"},{"condition":"Depression with somatic symptoms","description":"Sometimes used as an adjunct in depression with prominent gastrointestinal complaints.","evidence":"Limited"}]
Off-label uses: [{"condition":"Premature ejaculation","description":"Levosulpiride has been studied off-label for premature ejaculation due to its prolactin-lowering effect.","evidence":"Limited"},{"condition":"Tourette syndrome","description":"Occasionally used off-label for tic disorders, but evidence is insufficient.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting
Also treats: Functional dyspepsia, Diabetic gastroparesis, Schizophrenia
📋 Drug Information
| Generic Name(s) | Levosulpiride (12.5mg/ml) |
| Brand Name | neopride injection |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Atypical Antipsychotics |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Levosulpiride is a selective dopamine D2 receptor antagonist that primarily acts on the chemoreceptor trigger zone and the gastrointestinal tract. By blocking D2 receptors, it prevents dopamine-mediated nausea and vomiting and enhances gastric motility. It also acts as a partial agonist at serotonin 5-HT4 receptors, which further promotes gastrointestinal propulsion. Its antipsychotic effect is attributed to D2 receptor blockade in the mesolimbic pathway.
Mechanism Steps
💡 How to Take neopride injection
Strength: 12.5 mg/ml injection, available in 2 ml ampoules (25 mg per ampoule).
Dosage Information
| Adult Dosage | The usual adult dose for nausea and vomiting is 25 mg (2 ml) by intramuscular injection, which may be repeated after 6 to 8 hours if needed. For functional dyspepsia, 25 mg intramuscularly once daily is often used. For schizophrenia, doses may range from 50 to 200 mg per day by intramuscular or intravenous injection, divided into 2 to 3 doses. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of levosulpiride, especially extrapyramidal symptoms and sedation. Start with the lowest effective dose and titrate slowly. Renal function should be assessed before dosing. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate renal impairment (creatinine clearance 30-60 ml/min), dose reduction may be necessary. In severe renal impairment (creatinine clearance < 20 ml/min), levosulpiride is contraindicated. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment, but use with caution and monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 200 mg per day for psychiatric indications. For gastrointestinal indications, the maximum is 50 mg per day. Doses above these are not recommended. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of neopride injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Metoclopramide | Major | |
| Amiodarone | Major | |
| Levodopa | Major | |
| Benzodiazepines | Moderate | |
| Antihypertensives | Moderate | |
| Anticholinergics | Moderate | |
| Diuretics | Minor | |
| Antacids | Minor | |
| SSRIs | Moderate | |
| Opioids | Moderate |
🚨 Major Interactions
- Other dopamine antagonists (e.g., metoclopramide, haloperidol)
- QT-prolonging drugs (e.g., amiodarone, sotalol, moxifloxacin)
- Levodopa
⚡ Moderate Interactions
- Antihypertensives
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
- Anticholinergics
🍷 Alcohol Interaction
Alcohol should be strictly avoided while receiving this medicine because it can potentiate central nervous system depression, leading to excessive drowsiness, dizziness, and impaired coordination. It may also increase the risk of orthostatic hypotension and falls.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to levosulpiride or any component of the formulation","Pheochromocytoma","Epilepsy","Breast cancer","Severe renal impairment (creatinine clearance < 20 ml/min)","Concomitant use with levodopa","QT interval prolongation or congenital long QT syndrome"]
⚠️ Warnings & Precautions
["Administer only under medical supervision with resuscitation facilities available.","May cause sedation; avoid driving or operating machinery until effects are known.","Use with caution in elderly patients due to increased risk of extrapyramidal symptoms.","Monitor for neuroleptic malignant syndrome; discontinue immediately if suspected.","Avoid in patients with Parkinson's disease as it may worsen symptoms.","Use with caution in patients with cardiovascular disease or electrolyte imbalances.","Do not use in children unless specifically prescribed by a pediatrician."]
🤱 Lactation Safety
Levosulpiride is excreted in breast milk. Breastfeeding is not recommended during treatment. Consult your doctor for alternative options.
💊 Overdose Management
Overdose may cause severe extrapyramidal symptoms, sedation, hypotension, and QT prolongation. There is no specific antidote. Treatment is supportive and symptomatic, including monitoring of vital signs, ECG, and electrolytes. Activated charcoal may be considered if ingestion was oral, but this is an injectable form. Hemodialysis is not effective in removing levosulpiride. Contact a poison control center for guidance.
⏰ Missed Dose
This medicine is administered by a healthcare professional, so missed doses are unlikely. If you miss a scheduled injection, contact your doctor or nurse to reschedule as soon as possible. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional in a setting equipped to manage anaphylactic reactions. Inform your doctor about all medications you are taking, especially antihypertensives, antidepressants, and drugs that prolong the QT interval. Avoid alcohol and other central nervous system depressants during treatment as they can enhance sedation. Do not drive or operate heavy machinery until you know how this medicine affects you. Use with caution in elderly patients and those with renal or hepatic impairment. Regular monitoring of blood pressure, heart rate, and extrapyramidal symptoms is recommended. Do not use this medicine for longer than prescribed without medical review.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to extrapyramidal symptoms, sedation, and orthostatic hypotension. Use with caution and monitor closely. Dose reduction may be necessary.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It is not recommended during pregnancy unless clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used postoperatively for nausea and vomiting. Monitor for excessive sedation and respiratory depression, especially if combined with other sedatives.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may interact with anesthetics and increase sedation. Dose adjustments may be needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise immediately after injection as it may worsen dizziness or hypotension. Light activity is fine once you feel stable.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, affecting your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also cause sedation, so plan your work accordingly.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects like involuntary movements, high fever, or irregular heartbeat, seek immediate medical attention and your doctor may decide to stop the medicine.
📅 Long-Term Use Effects
Long-term use of levosulpiride injection may increase the risk of tardive dyskinesia, neuroleptic malignant syndrome, and metabolic changes. Regular monitoring of extrapyramidal symptoms, prolactin levels, and cardiac function is recommended. Periodic review of the need for continued therapy is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
If oral therapy is feasible, tablets like ondansetron or domperidone may be used.
Evidence: Well-establishedMay help with mild nausea but not a substitute for medical treatment.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interaction with vaccines is known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store below 30°C in a dry place
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in a cool, dry place away from direct sunlight. If traveling across time zones, consult your doctor for dose adjustments. Declare it at customs if required. Do not pack it in checked luggage; keep it in carry-on with proper documentation.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It starts working within 30 minutes after intramuscular injection and within 5-10 minutes after intravenous injection.
A: No, it must be administered by a healthcare professional in a clinical setting.
A: Safety in pregnancy is not established. Use only if clearly needed and after consulting your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for neopride injection
View AllAlternative brands with exact same active ingredient:
-
alevo 12.5mg injectionIkon Remedies Pvt Ltd ₹53.00 38.9% CHEAPER
-
levazeo 12.5mg/ml injectionTorrent Pharmaceuticals Ltd ₹215.63 148.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Levosulpiride injection is a painkiller.
Fact: It is not a painkiller; it is used for nausea, vomiting, and certain gastrointestinal and psychiatric conditions. - Myth: Levosulpiride injection can be self-administered at home.
Fact: It must be given by a healthcare professional in a clinical setting. - Myth: Levosulpiride injection is safe for everyone.
Fact: It is contraindicated in certain conditions like pheochromocytoma, epilepsy, and breast cancer.
🔄 Alternative Options
Generic Alternatives
- Levosulpiride injection (generic)
Brand Alternatives
- Levazeo 12.5mg/ml injection