Doxolin 400mg Tablet (Doxofylline): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Fast, irregular, or fluttering heartbeat
- Chest pain or pressure
- Severe dizziness or fainting
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing that is getting worse
- Seizure or uncontrolled shaking
- Severe nausea or vomiting that prevents you from keeping fluids down
- Yellowing of the skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is adiphylin 400mg tablet used for?
This medicine contains Doxofylline 400 mg, an oral bronchodilator used to relax airway muscles and improve breathing in asthma and COPD. It is taken as prescribed, usually two or three times a day, and is not meant for sudden severe attacks.
- Generic Name: Doxofylline
- Manufacturer: Biosans Lifecare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 adiphylin 400mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डॉक्सोफिलिन 400 मिलीग्राम की एक टैबलेट है, जिसका उपयोग अस्थमा और क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिजीज जैसी सांस की बीमारियों में किया जाता है। यह श्वास नलियों की मांसपेशियों को ढीला करके सांस लेना आसान बनाती है। यह दवा अचानक होने वाले तेज अस्थमा अटैक के लिए नहीं है, इसलिए ऐसे समय में अपने रेस्क्यू इनहेलर का ही उपयोग करें। इसे डॉक्टर की सलाह के अनुसार ही लें और दिन में दो या तीन बार ले सकते हैं। खाने के बाद लेने से पेट की जलन कम हो सकती है। धूम्रपान, शराब और अधिक चाय-कॉफी से बचें क्योंकि इनसे धड़कन और बेचैनी बढ़ सकती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, पेट में असहजता, सिरदर्द, बेचैनी और धड़कन तेज होना शामिल हैं। ये आमतौर पर हल्के होते हैं और शरीर के अभ्यस्त होने पर कम हो जाते हैं। कभी-कभी दिल की धड़कन अनियमित हो सकती है, सीने में दर्द, चक्कर आना, कंपन या एलर्जी जैसी गंभीर समस्या हो सकती है। अगर सांस लेने में तकलीफ, होठों या चेहरे पर सूजन, बेहोशी या तेज अनियमित धड़कन हो तो तुरंत डॉक्टर से मिलें। अपनी मर्जी से दवा की मात्रा न बढ़ाएं।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, खाने के बाद लेना बेहतर होता है। टैबलेट को पानी के साथ पूरा निगलें, चबाएं नहीं। अचानक तेज अस्थमा अटैक में इसका उपयोग न करें। अपनी सभी दवाओं की जानकारी डॉक्टर को दें, खासकर एंटीबायोटिक और दिल की दवाएं। शराब न पिएं और चाय-कॉफी कम करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। दवा को ठंडी, सूखी जगह पर मूल डिब्बे में रखें और बच्चों से दूर रखें।
💊 adiphylin 400mg tablet Uses & Benefits
[{"condition":"Bronchial asthma","description":"Used as add-on maintenance therapy to relax airway smooth muscles and reduce wheezing and breathlessness in patients whose asthma is not fully controlled by inhaled medicines.","evidence":"Established"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Helps improve airflow and reduce breathlessness in stable COPD when used as part of a comprehensive treatment plan.","evidence":"Established"},{"condition":"Chronic bronchitis","description":"May ease cough and sputum-related breathing difficulty in chronic bronchitis as an adjunct to other treatments.","evidence":"Limited"},{"condition":"Bronchospasm associated with respiratory infections","description":"Sometimes used short-term to relieve bronchospasm during respiratory infections, but only under medical supervision.","evidence":"Limited"}]
Off-label uses: [{"condition":"Diaphragmatic weakness in neuromuscular disorders","description":"Occasionally used off-label to improve diaphragm contractility, but evidence is not strong enough for routine use.","evidence":"Limited"},{"condition":"Apnea of prematurity","description":"Methylxanthines have been studied for apnea of prematurity, but Doxofylline is not standard therapy and should not be used without specialist guidance.","evidence":"Limited"}]
Primary treatment for: Bronchial asthma
Also treats: Chronic obstructive pulmonary disease (COPD), Chronic bronchitis
📋 Drug Information
| Generic Name(s) | Doxofylline |
| Brand Name | Amril Plus 400mg Tablet |
| Manufacturer | Biosans Lifecare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Theophylline & its derivatives |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep the tablets in their original container and out of reach of children. |
| Shelf Life | Refer to the expiry date printed on the pack. Do not use the tablets after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Doxofylline is a methylxanthine bronchodilator that inhibits phosphodiesterase enzymes, mainly phosphodiesterase 4, inside airway smooth muscle cells. This inhibition raises cyclic adenosine monophosphate levels, which relaxes bronchial smooth muscle and widens the airways. Doxofylline also blocks adenosine receptors to a lesser extent than older methylxanthines, which may explain its better tolerability. In addition, it reduces the release of inflammatory mediators from mast cells and other immune cells, and it may improve the strength of diaphragm contraction. These combined actions lead to easier breathing, less wheezing, and better airflow in people with asthma and COPD.
Mechanism Steps
💡 How to Take adiphylin 400mg tablet
Strength: Immediate-release tablet, 400 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 400 mg taken two or three times a day, but the exact dose and frequency depend on your condition, response to treatment, and other medicines you take. Some doctors start with a lower dose and increase it gradually. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may need a lower dose because Doxofylline is cleared more slowly with age. The dose must be individualized by a qualified clinician based on kidney and liver function, other medicines, and overall health. |
| Renal Impairment | Doxofylline is excreted mainly by the kidneys, so people with kidney disease may need a lower dose. The dose must be individualized by a qualified clinician based on kidney function tests. |
| Hepatic Impairment | Doxofylline is metabolized in the liver, so people with liver disease may need a lower dose. The dose must be individualized by a qualified clinician based on liver function tests. |
| Maximum Daily Dose | The maximum daily dose is usually 1200 mg, but this must be confirmed by your doctor. Do not exceed the dose prescribed for you. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of adiphylin 400mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Erythromycin | Major | |
| Propranolol | Major | |
| Cimetidine | Moderate | |
| Phenytoin | Moderate | |
| Rifampicin | Moderate | |
| Theophylline | Moderate | |
| Caffeine | Minor | |
| Oral contraceptives | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Ciprofloxacin
- Erythromycin
- Propranolol and other non-selective beta-blockers
⚡ Moderate Interactions
- Cimetidine
- Phenytoin
- Rifampicin
- Theophylline or aminophylline
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase the risk of dizziness, palpitations, and stomach upset. Alcohol may also worsen dehydration and make side effects like restlessness and headache more likely.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to Doxofylline or any ingredient in the tablet","Recent heart attack","Serious heart rhythm problems such as fast or irregular heartbeat","Severe liver disease","Severe kidney disease without specialist supervision","Children below the age for which safety and effectiveness are established","Breastfeeding without medical advice"]
⚠️ Warnings & Precautions
["Do not use this medicine to treat a sudden severe asthma attack; use your rescue inhaler as prescribed.","Tell your doctor if you have heart disease, high blood pressure, liver disease, kidney disease, or diabetes.","Avoid drinking alcohol and limit caffeine while taking this medicine.","Do not increase the dose on your own, because higher doses increase the risk of heart rhythm problems and seizures.","Tell your doctor about all other medicines you take, including antibiotics and heart medicines.","Use with caution in elderly patients, who may be more sensitive to side effects.","Stop the medicine and seek medical help if you develop a severe rash, swelling, or difficulty breathing."]
🤱 Lactation Safety
It is not known whether Doxofylline passes into breast milk in significant amounts. Breastfeeding mothers should consult their doctor before using this medicine, and the doctor will decide whether to continue breastfeeding or change the medicine.
💊 Overdose Management
Overdose of Doxofylline can cause severe nausea, vomiting, restlessness, palpitations, irregular heartbeat, seizures, and low blood pressure. If you suspect an overdose, stop the medicine and seek emergency medical care immediately. Treatment is supportive and may include monitoring of heart rhythm, blood pressure, and breathing, along with medicines to control seizures or heart rhythm problems if they occur. Do not try to treat an overdose at home.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, with or without food, but taking it after a meal may reduce stomach upset. Swallow the tablet whole with a glass of water; do not crush or chew it unless your doctor or pharmacist says it is acceptable. Do not take more than the prescribed dose, and do not use this medicine to treat a sudden severe asthma attack. Keep regular follow-up appointments so your doctor can check your breathing, heart rate, and blood levels of the medicine if needed. Tell your doctor about all other medicines you take, especially antibiotics, heart medicines, and medicines for depression, because Doxofylline can interact with them. Avoid alcohol and reduce caffeine intake while taking this medicine, as both can increase restlessness and palpitations. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before using this medicine. Store the tablets in their original container at room temperature, away from moisture and direct sunlight, and keep them out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially palpitations, dizziness, and restlessness. Kidney and liver function often decline with age, so a lower dose may be needed. Regular follow-up and monitoring of heart rate and breathing are important.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, talk to your doctor before continuing this medicine. The safety of this medicine in pregnancy is not fully established, and your doctor may switch you to a safer alternative or adjust the dose based on your condition.
🏥 Post-Surgery Considerations
Tell your surgeon and anaesthetist that you are taking this medicine before any surgery. It may affect heart rate and breathing during anaesthesia, and your doctor may advise you to stop it temporarily or adjust the dose.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can increase heart rate, and some dental medicines may interact with it. Your dentist may take extra precautions if you have heart or breathing problems.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular physical activity is good for your lungs, but avoid exercising in very cold, dusty, or polluted air. Warm up slowly and use your rescue inhaler before exercise if your doctor has advised it. If you feel breathless, dizzy, or have palpitations while exercising, stop and rest. Contact your doctor if these symptoms do not settle.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine usually does not stop you from working, but it can cause dizziness, restlessness, or palpitations in some people. If you feel dizzy or your heart is racing, avoid driving or operating heavy machinery until you feel normal. Tell your employer or supervisor about your breathing condition if your work involves dust, fumes, or heavy physical exertion.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your breathing control and overall health. If you develop serious side effects such as irregular heartbeat, chest pain, or a severe allergic reaction, stop the medicine and seek medical help immediately.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well tolerated when taken at the prescribed dose, but regular follow-up is important. Your doctor may check your heart rate, breathing, and liver and kidney function if you have other health conditions. Long-term use does not usually cause addiction, but it should not be stopped suddenly without medical advice. If you notice persistent palpitations, sleep problems, or mood changes, tell your doctor so the dose can be reviewed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Inhaled medicines such as salbutamol or formoterol are often preferred for quick relief and maintenance because they act directly on the airways.
Evidence: Well-establishedThese reduce airway inflammation and are a cornerstone of asthma maintenance therapy.
Evidence: Well-establishedA structured exercise and education program can improve breathing capacity and quality of life in COPD.
Evidence: Well-establishedTechniques such as pursed-lip breathing and diaphragmatic breathing can help reduce breathlessness.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with asthma or COPD should stay up to date with influenza and pneumococcal vaccines as advised by their doctor. There is no known interaction between this medicine and routine vaccines, but tell your healthcare provider about all medicines you take before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription, especially when travelling internationally. Keep enough supply for your entire trip plus a few extra days in case of delays. Store it in a cool, dry place away from direct sunlight and do not leave it in a hot car. If you are crossing time zones, ask your doctor how to adjust the timing of your doses. Check local customs rules for carrying prescription medicines and keep the prescription in English if possible.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It usually starts working within 30 to 60 minutes after a dose, but the full benefit may take a few hours. It is a maintenance medicine, so regular use is needed for lasting control of symptoms.
A: Yes, you can take it with or without food. Taking it after a meal may reduce stomach upset and nausea.
A: Do not stop this medicine suddenly without talking to your doctor, because your breathing symptoms may worsen. Your doctor will decide if and when to stop it.
A: The safety of this medicine in pregnancy is not fully established. Use it only if your doctor clearly advises it after weighing the benefits and risks.
A: Some antibiotics, such as ciprofloxacin and erythromycin, can increase the levels of this medicine and the risk of side effects. Always tell your doctor about all medicines you take.
🤔 Common Patient Concerns
🔄 Substitutes for adiphylin 400mg tablet
View AllAlternative brands with exact same active ingredient:
-
ventidox 400 mg tabletMankind Pharma Ltd ₹13.36 82.2% CHEAPER
-
microphylline tabletMicro Labs Ltd ₹16.69 77.7% CHEAPER
-
doxopil 400mg tabletPsychotropics India Ltd ₹17.58 76.6% CHEAPER
-
davaindia doxofylline 400mg tabletDavaindia Generic Pharmacy ₹30.00 60% CHEAPER
-
doxiba 400 mg tabletFDC Ltd ₹30.94 58.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used as a rescue inhaler during a severe asthma attack.
Fact: This medicine is a maintenance bronchodilator and is not meant for sudden severe attacks. Use your rescue inhaler as prescribed. - Myth: Taking a higher dose will give faster relief.
Fact: Taking more than the prescribed dose increases the risk of palpitations, nausea, and seizures without giving faster relief. - Myth: This medicine can be stopped as soon as breathing improves.
Fact: Do not stop this medicine without talking to your doctor, because stopping suddenly may worsen your breathing symptoms. - Myth: This medicine is safe for everyone with breathing problems.
Fact: People with serious heart rhythm problems, recent heart attack, or severe liver or kidney disease may not be able to take this medicine.
🔄 Alternative Options
Generic Alternatives
- Doxofylline 400 mg tablet
Brand Alternatives
- Doxolin 400mg tablet