adilid plus 100mg/325mg tablet - Uses, Price, Side Effects & Substitutes
What is adilid plus 100mg/325mg tablet used for?
AP 100mg/325mg Tablet (Nimesulide + Paracetamol) is used to treat PAIN ANALGESICS. It contains Nimesulide (100mg) + Paracetamol (325mg), which Nimesulide selectively inhibits COX-2, reducing prostaglandin synthesis; Paracet. Always consult your doctor before use. Take as prescribed.
- Generic Name: Nimesulide + Paracetamol
- Manufacturer: Adison Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ adilid plus 100mg/325mg tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Nimesulide + Paracetamol |
| Brand Name | AP 100mg/325mg Tablet |
| Manufacturer | Adison Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Nimesulide selectively inhibits COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in the CNS, reducing pain and fever
Mechanism Steps
๐ก How to Take adilid plus 100mg/325mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of adilid plus 100mg/325mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Dizziness
- Somnolence
- Diarrhea
๐จ Serious Side Effects
- Hepatotoxicity
- Gastrointestinal bleeding
- Stevens-Johnson syndrome
- Renal failure
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Anaphylaxis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Lithium | Major | Increased lithium levels |
| Aspirin | Major | Increased risk of gastrointestinal ulceration |
| Other NSAIDs | Major | Additive gastrointestinal and renal toxicity |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- Aspirin
- Other NSAIDs
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Anticoagulants
- Corticosteroids
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
๐ฝ๏ธ Food Interactions
Food may delay absorption; avoid alcohol
๐ท Alcohol Interaction
Increased risk of hepatotoxicity and gastrointestinal bleeding
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active peptic ulcer, severe hepatic/renal impairment, third trimester pregnancy, lactation, children <12 years (Nimesulide)
๐ Monitoring Parameters
Liver function, renal function, blood pressure, signs of bleeding
๐คฑ Lactation Safety
Paracetamol is safe; Nimesulide is contraindicated
๐ Overdose Management
Activated charcoal, N-acetylcysteine for paracetamol overdose; supportive care
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose