Lupihist Plus Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, tongue, or throat.
- Severe drowsiness, confusion, or unresponsiveness.
- Irregular heartbeat, palpitations, or chest pain.
- Seizures or convulsions.
- Blood in vomit or stool, or severe abdominal pain.
- Yellowing of the skin or eyes, or dark urine.
- Inability to pass urine.
- High fever with rash or unusual bruising.
If experiencing severe symptoms, call emergency services immediately.
What is anadryl syrup used for?
This medicine is an oral syrup combining citric acid and diphenhydramine, used to relieve allergy symptoms such as sneezing, runny nose, and itchy eyes. Diphenhydramine blocks histamine and causes drowsiness, while citric acid soothes the throat. It should be taken as directed, and alcohol must be avoided.
- Generic Name: Citric Acid (NA) + Diphenhydramine (NA)
- Manufacturer: Adison Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 anadryl syrup के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से एलर्जी के लक्षणों जैसे छींक आना, नाक बहना, आंखों में खुजली और पानी आना, और गले में खुजली को कम करने के लिए दी जाती है। इसमें डिफेनहाइड्रामाइन नाम का एंटीहिस्टामिन होता है जो शरीर में हिस्टामिन के प्रभाव को रोकता है, जिससे एलर्जी के लक्षण कम होते हैं। साथ ही इसमें सिट्रिक एसिड होता है जो गले को आराम देता है। यह दवा मोशन सिकनेस (सफर में उल्टी-जी मिचलाना) और सर्दी-जुकाम के लक्षणों में भी राहत दे सकती है। ध्यान रखें कि यह दवा नींद ला सकती है, इसलिए इसे लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें। शराब के साथ इसका सेवन बिल्कुल न करें।
साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधला दिखना, कब्ज और पेट में गड़बड़ी शामिल हैं। कुछ लोगों को सिरदर्द या बेचैनी भी हो सकती है। गंभीर दुष्प्रभाव बहुत कम होते हैं, लेकिन अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, दिल की धड़कन अनियमित होना, या दौरा पड़ना जैसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, और मात्रा से ज्यादा न लें। यह दवा नींद ला सकती है, इसलिए गाड़ी चलाने या मशीन चलाने से बचें। शराब, नींद की गोलियां या अन्य शांत करने वाली दवाओं के साथ इसका सेवन न करें। अगर आपको ग्लूकोमा, प्रोस्टेट की समस्या, पेशाब में रुकावट, दिल, लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के इसका इस्तेमाल न करें। बच्चों को डॉक्टर की सलाह के बिना न दें।
💊 anadryl syrup Uses & Benefits
[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itchy nose, and itchy or watery eyes caused by seasonal or year-round allergies.","evidence":"Well-established"},{"condition":"Urticaria (hives)","description":"Reduces itching and skin rash associated with allergic reactions.","evidence":"Well-established"},{"condition":"Common cold symptoms","description":"May help dry up a runny nose and reduce sneezing, though it does not treat the underlying infection.","evidence":"Established for symptom relief"},{"condition":"Motion sickness","description":"Diphenhydramine can reduce nausea, vomiting, and dizziness associated with motion sickness.","evidence":"Well-established"},{"condition":"Cough due to allergy","description":"May soothe cough related to postnasal drip or allergic throat irritation.","evidence":"Limited"}]
Off-label uses: [{"condition":"Insomnia","description":"Sometimes used for short-term sleep aid because of its sedating effect, but this is not a primary approved use.","evidence":"Limited"},{"condition":"Nausea and vomiting in pregnancy","description":"Occasionally used under medical supervision, but safety must be confirmed by a clinician.","evidence":"Limited"},{"condition":"Anxiety-related sleep disturbance","description":"May be used off-label for sedation in some clinical settings, but not as a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Allergic rhinitis
Also treats: Urticaria, Common cold, Motion sickness, Allergic cough
📋 Drug Information
| Generic Name(s) | Citric Acid (NA) + Diphenhydramine (NA) |
| Brand Name | anadryl syrup |
| Manufacturer | Adison Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. Keep the bottle tightly closed and out of the reach of children. |
| Shelf Life | Typically 24 months from the date of manufacture, but refer to the expiry date printed on the package. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different roles. Diphenhydramine is a first-generation antihistamine that competitively blocks histamine H1 receptors in the brain and peripheral tissues, which reduces allergy symptoms such as sneezing, itching, and runny nose, and also causes sedation because it crosses the blood-brain barrier. Citric acid is an acidifier that lowers the pH of the formulation, which can help soothe the throat and may act as a mild preservative and flavoring agent. Together, these ingredients provide symptomatic relief of allergic and cold-related symptoms, with diphenhydramine providing the main pharmacological effect.
Mechanism Steps
💡 How to Take anadryl syrup
Strength: Oral syrup. The strength is not specified in the provided information. Typically, diphenhydramine syrup contains 12.5 mg per 5 mL. Refer to the product label for exact strength.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mL to 20 mL (containing 12.5 mg to 25 mg of diphenhydramine per 5 mL, depending on the product) taken every 4 to 6 hours as needed for symptoms, not to exceed 6 doses in 24 hours. However, the exact dose depends on the indication, severity of symptoms, age, weight, kidney and liver function, and other medicines being taken. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate beyond the recommended duration. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Diphenhydramine dosing in children is weight-based and must be determined by a healthcare professional. Do not give this medicine to children under 2 years of age without medical advice. |
| Elderly Dosage | Older adults are more sensitive to the sedative and anticholinergic effects of diphenhydramine. The dose should be reduced, and the medicine should be used with caution. Dose must be individualized by a qualified clinician based on renal and hepatic function, and the lowest effective dose should be used for the shortest duration. |
| Renal Impairment | In patients with kidney impairment, the half-life of diphenhydramine may be prolonged. Dose reduction or longer dosing intervals may be necessary. Consult a clinician for individualized dosing. |
| Hepatic Impairment | In patients with liver disease, diphenhydramine metabolism may be reduced, increasing the risk of side effects. Dose reduction is advised. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose of diphenhydramine for adults is generally 300 mg per day, but this should not be exceeded. For this syrup, follow the label instructions and do not exceed 6 doses in 24 hours. Individual maximum dose must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of anadryl syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Opioids | Major | |
| Benzodiazepines | Major | |
| MAOIs | Major | |
| Tricyclic antidepressants | Major | |
| Antihypertensives | Moderate | |
| Anticholinergics | Moderate | |
| CNS stimulants | Moderate | |
| Metoclopramide | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Alcohol
- Opioid pain relievers (e.g., codeine, morphine)
- Benzodiazepines and other sedatives (e.g., diazepam, alprazolam)
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants (e.g., amitriptyline)
⚡ Moderate Interactions
- Antihypertensive medicines
- Anticholinergic medicines (e.g., oxybutynin, benztropine)
- CNS stimulants (e.g., methylphenidate)
- Metoclopramide
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine because it significantly increases the sedative and central nervous system depressant effects of diphenhydramine. This combination can lead to excessive drowsiness, impaired coordination, difficulty breathing, and increased risk of accidents. If you have consumed alcohol, do not take this medicine until the effects have worn off, and consult your doctor if you have any concerns.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to diphenhydramine, citric acid, or any component of the formulation","Narrow-angle glaucoma","Urinary retention or bladder neck obstruction","Severe liver disease","Neonates and premature infants","Breastfeeding without medical advice","Concurrent use with MAO inhibitors"]
⚠️ Warnings & Precautions
["May cause marked drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not consume alcohol or take other sedatives while using this medicine.","Use with caution in patients with asthma, chronic obstructive pulmonary disease, or sleep apnea.","Use with caution in older adults due to increased risk of confusion, falls, and urinary retention.","May cause dry mouth, constipation, and blurred vision due to anticholinergic effects.","Do not use for longer than recommended without consulting a doctor.","Keep out of reach of children; accidental overdose can be dangerous.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
Diphenhydramine passes into breast milk and may cause drowsiness or irritability in a breastfed infant. It is generally recommended to use with caution and to monitor the infant for sedation. Consult your doctor before using this medicine while breastfeeding, and consider timing doses to minimize infant exposure.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, hallucinations, seizures, irregular heartbeat, difficulty breathing, and coma. If you suspect an overdose, seek emergency medical attention immediately. Do not try to induce vomiting unless instructed by a medical professional. Treatment is supportive and may include activated charcoal, intravenous fluids, and medications to control seizures or heart rhythm abnormalities. Always bring the medicine container to the hospital.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as directed by your doctor or as stated on the label, and do not exceed the recommended dose. Because this medicine commonly causes drowsiness, avoid driving, operating heavy machinery, or performing tasks that require alertness until you know how it affects you. Do not drink alcohol or take other sedatives, sleeping pills, or anti-anxiety medicines while using this product, as the combination can cause dangerous sedation. Tell your doctor about all other medicines you take, especially antidepressants, opioid pain relievers, muscle relaxants, and medicines for blood pressure or seizures. Use caution if you have asthma, glaucoma, an enlarged prostate, difficulty urinating, heart disease, liver disease, or kidney disease. Do not use this medicine for longer than recommended without consulting a clinician, and keep it out of the reach of children. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more sensitive to the sedative and anticholinergic effects of diphenhydramine, including confusion, dry mouth, constipation, urinary retention, and increased risk of falls. The dose should be reduced, and the medicine should be used with caution. Second-generation antihistamines may be safer alternatives. Consult a doctor before use.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, consult your doctor before using this medicine. Diphenhydramine is generally considered acceptable when clearly needed, but it should be used at the lowest effective dose for the shortest duration. Discuss all options with your healthcare provider.
🏥 Post-Surgery Considerations
After surgery, the use of this medicine should be discussed with your surgeon or anesthesiologist, as it can interact with anesthetic agents and other postoperative medications, increasing sedation and respiratory depression. Do not take it without medical advice during the postoperative period.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It can cause dry mouth, which may affect dental work, and it may interact with sedatives or anesthetics used during the procedure. Your dentist may advise you to stop it temporarily or adjust the dose.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your coordination and balance. Avoid strenuous exercise, driving, or operating machinery until you know how the medicine affects you. If you exercise, do so with caution and stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine commonly causes drowsiness, which can significantly impact your ability to drive, operate machinery, or perform tasks requiring alertness. It is best to take it when you do not need to be fully alert, such as at bedtime. Inform your employer if your job involves operating heavy equipment. Avoid making important decisions until you know how the medicine affects you.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects such as difficulty breathing, irregular heartbeat, or severe drowsiness. Do not stop suddenly if you have been using it for a long time without medical advice, as withdrawal symptoms may occur.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of diphenhydramine can lead to tolerance, dependence, and increased risk of cognitive impairment, especially in older adults. It may also cause persistent dry mouth, constipation, and urinary retention. Regular monitoring of liver and kidney function may be advised if used for extended periods. Consult your doctor if you need to use this medicine for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Reducing exposure to allergens such as pollen, dust mites, and pet dander can help prevent symptoms.
Evidence: Well-establishedRinsing the nasal passages with saline can reduce congestion and allergy symptoms.
Evidence: Well-establishedMedicines like cetirizine or loratadine cause less drowsiness and may be preferred for daytime use.
Evidence: Well-establishedThese are effective for moderate to severe allergic rhinitis and are often first-line treatment.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider that you are taking this medicine. It is generally safe to continue, but your doctor may advise timing adjustments based on your overall health.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container with cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it in a cool, dry place, away from direct sunlight, and do not leave it in a hot car. If you are crossing time zones, continue taking your doses at the same intervals as prescribed, but consult your doctor if you are unsure. Check customs regulations for carrying medicines into your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 15 to 30 minutes after you take it, with peak effects in about 1 to 2 hours.
A: The effects generally last about 4 to 6 hours, but drowsiness may persist longer in some people.
A: It is intended for short-term use. Do not use it for more than 7 days without consulting your doctor.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Pediatric dosing is not established from available information. Consult a pediatrician before giving this medicine to a child.
A: Do not take other antihistamines or sedatives without consulting your doctor, as the combination can increase drowsiness and other side effects.
🤔 Common Patient Concerns
🔄 Substitutes for anadryl syrup
View AllAlternative brands with exact same active ingredient:
-
aldryl syrupAlkem Laboratories Ltd ₹11.60 84.5% CHEAPER
-
agidril syrupInd Swift Laboratories Ltd ₹11.70 84.4% CHEAPER
-
maxodyl syrupAbbott ₹11.72 84.4% CHEAPER
-
koncidryl syrupConcept Pharmaceuticals Ltd ₹12.30 83.6% CHEAPER
-
q coril syrupSyncom Formulations I Limited ₹17.47 76.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the sedative effects and can cause dangerous drowsiness and breathing problems. - Myth: This medicine can be used for long-term allergy control.
Fact: It is intended for short-term relief. Long-term use should be under medical supervision. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with certain conditions like glaucoma, urinary retention, or severe liver disease. - Myth: More medicine means faster relief.
Fact: Taking more than the recommended dose increases the risk of serious side effects without providing better relief.
🔄 Alternative Options
Generic Alternatives
- Diphenhydramine syrup
- Citric acid and diphenhydramine oral solution
Brand Alternatives
- Lupihist Plus Syrup