actibro dm syrup - Phenylephrine (5mg) + Chlorpheniramine Maleate (2mg) medicine

Actibro DM Syrup - Uses, Price, Side Effects

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๐Ÿญ Astopic Lifescience ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 30, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 30, 2026

What is actibro dm syrup used for?

Actibro DM Syrup is a combination medicine used for the relief of cold and allergy symptoms such as nasal congestion, sneezing, and runny nose. It contains Phenylephrine (a decongestant) and Chlorpheniramine Maleate (an antihistamine). Phenylephrine works by narrowing blood vessels in the nasal passages to reduce congestion, while Chlorpheniramine blocks histamine to alleviate allergic reactions.

  • Generic Name: Phenylephrine + Chlorpheniramine Maleate
  • Manufacturer: Astopic Lifescience
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š actibro dm syrup Uses & Benefits

Allergic rhinitis, Common cold, Sinusitis

๐Ÿ“‹ Drug Information

Generic Name(s)Phenylephrine + Chlorpheniramine Maleate
Brand NameAscoril D Plus Syrup Sugar Free
ManufacturerAstopic Lifescience
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassDecongestant + Antihistamine
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from gastrointestinal tract
DistributionDistributes widely; crosses blood-brain barrier
Protein BindingPhenylephrine: low; Chlorpheniramine: 70%
MetabolismPhenylephrine: hepatic (MAO); Chlorpheniramine: hepatic (CYP450)
Half-LifePhenylephrine: 2-3 hours; Chlorpheniramine: 12-15 hours
ExcretionRenal (urine)
BioavailabilityPhenylephrine: ~38%; Chlorpheniramine: ~25-50%
Onset of ActionPhenylephrine: 15-30 min; Chlorpheniramine: 30-60 min
Peak Plasma TimePhenylephrine: 1-2 hours; Chlorpheniramine: 2-6 hours
Duration of ActionPhenylephrine: 4-6 hours; Chlorpheniramine: 4-6 hours

How It Works

Phenylephrine: alpha-1 adrenergic agonist causing vasoconstriction; Chlorpheniramine: H1 receptor antagonist blocking histamine effects

Mechanism Steps

1Phenylephrine binds to alpha-1 adrenergic receptors on vascular smooth muscle
2Causes vasoconstriction in nasal mucosa, reducing congestion
3Chlorpheniramine blocks H1 receptors on blood vessels and respiratory epithelium

๐Ÿ’ก How to Take actibro dm syrup

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of actibro dm syrup

โœ… Common Side Effects

  • Drowsiness
  • Dry mouth
  • Nausea
  • Dizziness
  • Headache

๐Ÿšจ Serious Side Effects

  • Hypertension
  • Arrhythmias
  • Seizures
  • Urinary retention

โš ๏ธ Rare Side Effects

  • Allergic reactions
  • Thrombocytopenia
  • Hallucinations

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Hypertensive crisis
Beta-blockers Moderate Reduced antihypertensive effect
CNS depressants Moderate Increased sedation

๐Ÿšจ Major Interactions

  • MAOIs
  • Beta-blockers
  • Tricyclic antidepressants

โšก Moderate Interactions

  • Antihypertensives
  • Sympathomimetics
  • CNS depressants

โ„น๏ธ Minor Interactions

  • Antacids
  • Caffeine

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase chlorpheniramine levels

๐Ÿท Alcohol Interaction

Increased CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Moderate
Pregnancy
Category C

๐Ÿšซ Contraindications

Hypertension, Hyperthyroidism, Diabetes, Glaucoma, MAOI use, Severe coronary artery disease

๐Ÿ“Š Monitoring Parameters

Blood pressure, Heart rate, CNS effects

๐Ÿคฑ Lactation Safety

Caution; may be excreted in breast milk

๐Ÿ’Š Overdose Management

Symptomatic and supportive; may include activated charcoal, benzodiazepines for seizures

โฐ Missed Dose

Take as soon as remembered; skip if near next dose; do not double

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 30, 2026

๐Ÿ”— View Profile

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