actfit-p 50mg/500mg tablet - Diclofenac (50mg) + Paracetamol (500mg) medicine

AT SP Tablet: Complete Guide to Uses, Dosage, and Safety

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🏭 Santiago Lifesciences Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Diclofenac is generally avoided during the third trimester due to risk of premature closure of the ductus arteriosus. Paracetamol is considered relatively safe during pregnancy when used at recommended doses. Consult your doctor before taking this medicine during pregnancy. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for short-term acute pain relief.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual tiredness or pale skin

If experiencing severe symptoms, call emergency services immediately.

What is actfit-p 50mg/500mg tablet used for?

This medicine is a combination of Diclofenac 50 mg and Paracetamol 500 mg used for short-term relief of acute pain and inflammation. It works by reducing pain and swelling. Take it with food, do not exceed 3 tablets in 24 hours, and avoid alcohol.

  • Generic Name: Diclofenac + Paracetamol
  • Manufacturer: Santiago Lifesciences Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 actfit-p 50mg/500mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डाइक्लोफेनाक 50 मिलीग्राम और पैरासिटामोल 500 मिलीग्राम का संयोजन है। इसका उपयोग तीव्र दर्द और सूजन के इलाज के लिए किया जाता है, जैसे मांसपेशियों में दर्द, दांत दर्द, मासिक धर्म में ऐंठन, और सर्जरी के बाद का दर्द। यह दर्द को कम करने और सूजन को कम करने में मदद करती है। इसे भोजन के साथ लें और 24 घंटे में 3 गोलियों से अधिक न लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, पेट दर्द, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, लीवर की क्षति, गुर्दे की समस्या और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, उल्टी में खून, या गंभीर पेट दर्द हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को हमेशा भोजन या दूध के साथ लें। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको पेट अल्सर, गुर्दे या लीवर की बीमारी, या दिल की बीमारी है, तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 actfit-p 50mg/500mg tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after surgical procedures.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Reduces menstrual cramps and associated pain.","evidence":"Well-established"},{"condition":"Acute gout","description":"Helps relieve pain and inflammation during acute gout attacks.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not a first-line treatment.","evidence":"Limited"},{"condition":"Osteoarthritis flare-ups","description":"May be used short-term for osteoarthritis pain exacerbations, though not for long-term management.","evidence":"Limited"}]

Primary treatment for: Acute pain and inflammation

Also treats: Musculoskeletal pain, Post-operative pain, Dental pain, Dysmenorrhea, Acute gout

📋 Drug Information

Generic Name(s)Diclofenac + Paracetamol
Brand NameAt Sp Tablet
ManufacturerSantiago Lifesciences Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to reduce stomach upset.
2
Do not exceed the recommended dose of 3 tablets in 24 hours.
3
Avoid alcohol while taking this medicine to prevent stomach bleeding and liver damage.
4
Do not take other paracetamol-containing products simultaneously to avoid overdose.
5
Consult your doctor if pain persists beyond 7 days or worsens.
6
Report any signs of bleeding, such as black stools or easy bruising, immediately.
7
Use the lowest effective dose for the shortest duration, especially if you are elderly or have kidney or liver problems.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Acute joint pain
This medicine is commonly prescribed for this.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary
Dental pain
This medicine is effective for dental pain.
Likely Use
Menstrual cramps
This medicine is used for dysmenorrhea.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac is rapidly absorbed from the gastrointestinal tract after oral administration. Paracetamol is also rapidly and completely absorbed from the gastrointestinal tract. Food may delay the absorption of diclofenac but does not significantly reduce the extent of absorption.
DistributionDiclofenac is highly bound to plasma proteins and distributes into synovial fluid, where it can persist for longer periods. Paracetamol distributes widely into most body tissues, with a volume of distribution of approximately 0.9 L/kg.
Protein BindingDiclofenac is approximately 99% bound to plasma proteins, primarily albumin. Paracetamol is only about 10-25% bound to plasma proteins.
MetabolismDiclofenac is metabolized in the liver by cytochrome P450 enzymes, primarily CYP2C9, to several metabolites. Paracetamol is metabolized in the liver primarily by glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is normally detoxified by glutathione.
Half-LifeThe elimination half-life of diclofenac is approximately 1-2 hours. The elimination half-life of paracetamol is approximately 2-3 hours.
ExcretionDiclofenac is excreted primarily in the urine and bile as metabolites. Paracetamol is excreted in the urine as glucuronide and sulfate conjugates.
BioavailabilityThe oral bioavailability of diclofenac is approximately 50-60% due to first-pass metabolism. The oral bioavailability of paracetamol is approximately 80-90%.
Onset of ActionThe onset of analgesic effect for this combination is typically within 30-60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations of diclofenac are reached approximately 1-2 hours after oral administration. Peak plasma concentrations of paracetamol are reached within 30-60 minutes.
Duration of ActionThe duration of analgesic effect is approximately 4-6 hours, which determines the typical dosing interval of every 6-8 hours as needed.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Diclofenac is a non-steroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and may also modulate pain perception through other pathways. The combination provides enhanced analgesic and anti-inflammatory effects compared to either agent alone.

Mechanism Steps

1
Diclofenac inhibits COX enzymes: Diclofenac binds to and reversibly inhibits cyclooxygenase-1 and cyclooxygenase-2 enzymes, blocking the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: This inhibition decreases the production of prostaglandins, prostacyclin, and thromboxane, which are key mediators of inflammation, pain, and fever.
3
Paracetamol acts centrally: Paracetamol inhibits prostaglandin synthesis in the central nervous system and may also activate descending inhibitory pain pathways.
4
Combined analgesic effect: The combination of peripheral anti-inflammatory action from diclofenac and central analgesic action from paracetamol results in enhanced pain relief.

💡 How to Take actfit-p 50mg/500mg tablet

Strength: Tablet containing Diclofenac 50 mg and Paracetamol 500 mg.

1Take this medicine orally with a full glass of water.
2Take with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Do not lie down immediately after taking the tablet.
5Follow the prescribed dosing schedule exactly.

Dosage Information

Adult DosageThe usual adult dose is one tablet (Diclofenac 50 mg + Paracetamol 500 mg) taken orally every 6 to 8 hours as needed for pain, not to exceed 3 tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose or duration of treatment without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose reduction may be necessary. Avoid use in severe renal impairment (eGFR <30 mL/min). Consult a doctor for dose adjustment.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid use in severe hepatic impairment. Consult a doctor for dose adjustment.
Maximum Daily DoseMaximum daily dose is 3 tablets (Diclofenac 150 mg + Paracetamol 1500 mg) in 24 hours. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of stomach bleeding and liver damage.
Grapefruit
Avoid
May increase drug levels and side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of actfit-p 50mg/500mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk. If nausea persists, consult your doctor.
Stomach pain or indigestion (Common (5-10%))
Take with food. Avoid alcohol. If pain is severe or persistent, consult your doctor.
Headache (Common (5-10%))
Usually resolves on its own. Stay hydrated. Consult doctor if severe or persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Drowsiness (Common (5-10%))
Avoid driving or operating machinery. Consult doctor if persistent.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or tarry stools, vomiting blood, or severe abdominal pain.
Liver damage (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, or persistent nausea.
Kidney problems (Rare (<0.1%))
Seek immediate medical attention if you notice decreased urine output or swelling in legs.
Severe allergic reaction (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, or throat, difficulty breathing, or severe rash.
Cardiovascular events (Rare (<0.1%))
Seek immediate medical attention if you experience chest pain, shortness of breath, or sudden weakness.

⚠️ Rare Side Effects

Stevens-Johnson syndrome
Seek immediate medical attention if you develop a painful rash with blisters or peeling skin.
Aplastic anemia
Seek immediate medical attention if you experience unusual tiredness, pale skin, or frequent infections.
Pancreatitis
Seek immediate medical attention if you experience severe upper abdominal pain radiating to the back.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Methotrexate Major
ACE inhibitors Major
Diuretics Major
Corticosteroids Moderate
SSRIs Moderate
Lithium Moderate
Cyclosporine Moderate
Digoxin Moderate

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, naproxen)
  • Methotrexate
  • ACE inhibitors and ARBs
  • Diuretics

⚡ Moderate Interactions

  • Corticosteroids
  • SSRIs
  • Lithium
  • Cyclosporine
  • Digoxin

🍷 Alcohol Interaction

Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can potentiate liver damage, especially with paracetamol. It may also increase drowsiness and dizziness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to diclofenac, paracetamol, or any component of the formulation.","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.","Active or history of recurrent peptic ulcer or gastrointestinal bleeding.","Severe heart failure, ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease.","Severe hepatic impairment or active liver disease.","Severe renal impairment (eGFR

⚠️ Warnings & Precautions

["Take with food or milk to reduce gastrointestinal irritation.","Avoid alcohol consumption while taking this medicine.","Do not exceed the recommended dose or duration of treatment.","Use with caution in elderly patients due to increased risk of side effects.","Inform your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not use for more than 7 days without medical advice.","Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]

🤱 Lactation Safety

Diclofenac and paracetamol are excreted in breast milk in small amounts. Short-term use is generally considered compatible with breastfeeding, but consult your doctor before use.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding, kidney failure, and central nervous system effects due to diclofenac. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours of ingestion, N-acetylcysteine for paracetamol toxicity, and supportive care. Monitor liver and kidney function, and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Always take this medicine with food or milk to reduce the risk of stomach upset. Do not exceed the recommended dose or duration of treatment. Avoid drinking alcohol while taking this medicine, as it can increase the risk of stomach bleeding and liver damage. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. If you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma, inform your doctor before taking this medicine. This medicine may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you. Do not use this medicine for more than 7 days without medical advice. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Keep this medicine out of the reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Diclofenac may affect ovulation and is not recommended during the third trimester. Paracetamol is generally considered safe but should be used at the lowest effective dose for the shortest time.

🏥 Post-Surgery Considerations

This medicine may be prescribed for post-operative pain. Follow your surgeon's instructions carefully. Do not exceed the recommended dose. Inform your surgeon if you experience any unusual symptoms.

🦷 Dental Procedures

This medicine can be used for dental pain. Inform your dentist if you are taking this medicine before any dental procedure. It may increase bleeding risk during dental surgery.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming or walking.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods in your diet, such as omega-3 rich fish and fruits.
🧘
Get adequate sleep to aid recovery.
🌞
Stay well hydrated throughout the day.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may increase pain while taking this medicine. Gentle stretching and low-impact exercises are generally safe. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include omega-3 rich foods like salmon, flaxseeds, and walnuts.
Reduce processed food intake.
Stay well hydrated.
Avoid alcohol.
Eat a balanced diet rich in fruits and vegetables.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your pain persists beyond 7 days, worsens, or if you experience any serious side effects such as stomach bleeding, allergic reactions, or signs of liver or kidney problems. Do not stop abruptly if you have been taking it for a prolonged period without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney damage, liver damage, and cardiovascular events. It is not recommended for chronic use. Regular monitoring of liver and kidney function, blood counts, and blood pressure is advised if prolonged use is necessary. Consult your doctor for alternative treatments if you need long-term pain management.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve mobility.

Evidence: Well-established
Hot and cold therapy

Applying heat or cold packs can help reduce pain and inflammation.

Evidence: Well-established
Acupuncture

May provide pain relief for some individuals.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If crossing time zones, continue your regular dosing schedule as prescribed. Check customs regulations for carrying prescription medicines. Keep a list of your medications and allergies with you.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 30-year-old woman with severe menstrual cramps
Used this medicine for dysmenorrhea and experienced relief within 1 hour. She was advised to take it with food and not to exceed 3 tablets per day. She reported no side effects.
💡 Lesson: This medicine provides effective short-term relief for menstrual pain when taken as directed.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30-60 minutes after taking it.

Q: Can I take this medicine on an empty stomach?

A: No, it is best to take this medicine with food or milk to reduce the risk of stomach upset.

Q: How many tablets can I take in a day?

A: Do not exceed 3 tablets in 24 hours unless directed by your doctor.

Q: Is it safe to take this medicine during pregnancy?

A: Consult your doctor before taking this medicine during pregnancy, especially in the third trimester.

Q: Can I take this medicine with other painkillers?

A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor, as it can increase the risk of side effects.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for actfit-p 50mg/500mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken long-term for chronic pain.
    Fact: This medicine is intended for short-term use only. Long-term use increases the risk of serious side effects.
  • Myth: It is safe to take this medicine on an empty stomach.
    Fact: Taking this medicine on an empty stomach increases the risk of stomach upset and bleeding. Always take it with food.
  • Myth: This medicine is safe to take with other painkillers.
    Fact: Combining with other NSAIDs or paracetamol-containing products can lead to overdose and serious side effects.

🔄 Alternative Options

Generic Alternatives

  • Diclofenac 50 mg + Paracetamol 500 mg tablet (generic)

Brand Alternatives

  • Not established from the available information.

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Diclofenac 50 mg + Paracetamol 500 mg","onset":"30-60 minutes","duration":"4-6 hours","notes":"Combination provides both anti-inflammatory and analgesic effects."},{"medicine":"Aceclofenac + Paracetamol","composition":"Aceclofenac 100 mg + Paracetamol 325 mg","onset":"30-60 minutes","duration":"4-6 hours","notes":"Similar efficacy, may have better GI tolerability."},{"medicine":"Ibuprofen + Paracetamol","composition":"Ibuprofen 400 mg + Paracetamol 500 mg","onset":"30-60 minutes","duration":"4-6 hours","notes":"Alternative combination with similar effects."}]

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