acostin forte 2miu injection - Uses, Price, Side Effects & Substitutes
What is acostin forte 2miu injection used for?
Acostin 1 Million IU Injection (Colistimethate Sodium) is used to treat GASTRO INTESTINAL. It contains Colistimethate Sodium (2Million IU), which Disrupts bacterial cell membrane integrity by binding to lipopolysaccharides and. Always consult your doctor before use. Take as prescribed.
- Generic Name: Colistimethate Sodium
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ acostin forte 2miu injection Uses & Benefits
Treatment of multidrug-resistant Gram-negative infections (e.g., Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae); used in cystic fibrosis exacerbations.
Off-label uses: Nebulized therapy for ventilator-associated pneumonia; topical use for wound infections.
๐ Drug Information
| Generic Name(s) | Colistimethate Sodium |
| Brand Name | Acostin 1 Million IU Injection |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Cell membrane active agent |
| Route of Administration | Intravenous (IV) or intramuscular (IM); also via nebulization for respiratory infections. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Disrupts bacterial cell membrane integrity by binding to lipopolysaccharides and phospholipids, leading to increased permeability and cell death.
Mechanism Steps
๐ก How to Take acostin forte 2miu injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of acostin forte 2miu injection
โ Common Side Effects
- Nephrotoxicity (increased creatinine)
- Neurotoxicity (paresthesias, dizziness, vertigo)
- Gastrointestinal disturbances (nausea, vomiting)
๐จ Serious Side Effects
- Acute kidney injury
- Neuromuscular blockade leading to respiratory depression
- Seizures
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Cardiotoxicity (arrhythmias)
- Pseudomembranous colitis
- Superinfection
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Neuromuscular blocking agents | Major | Enhanced neuromuscular blockade, respiratory depression |
| Aminoglycosides | Major | Increased nephrotoxicity and ototoxicity |
| Vancomycin | Major | Increased nephrotoxicity |
| Cyclosporine | Major | Increased nephrotoxicity |
| Tacrolimus | Major | Increased nephrotoxicity |
| Amphotericin B | Major | Increased nephrotoxicity |
| Cisplatin | Major | Increased nephrotoxicity and ototoxicity |
| Loop diuretics | Major | Increased nephrotoxicity and ototoxicity |
| Cephalosporins | Moderate | Increased nephrotoxicity |
| Penicillins | Moderate | Possible additive nephrotoxicity |
| NSAIDs | Moderate | Increased risk of renal impairment |
| ACE inhibitors | Moderate | Increased risk of renal impairment |
| Antacids | Minor | No significant interaction |
| Probenecid | Minor | May reduce renal excretion of colistin |
๐จ Major Interactions
- Neuromuscular blocking agents
- Aminoglycosides
- Vancomycin
- Cyclosporine
- Tacrolimus
- Amphotericin B
- Cisplatin
- Loop diuretics
โก Moderate Interactions
- Cephalosporins
- Penicillins
- NSAIDs
- ACE inhibitors
โน๏ธ Minor Interactions
- Antacids
- Probenecid
๐ฝ๏ธ Food Interactions
No significant food interactions (parenteral).
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to colistimethate or colistin; myasthenia gravis (relative).
๐ Monitoring Parameters
Renal function (serum creatinine, BUN, urine output), electrolytes, neuromuscular function, signs of neurotoxicity (paresthesias, dizziness, seizures).
๐คฑ Lactation Safety
Excreted in breast milk; caution advised.
๐ Overdose Management
Supportive care; hemodialysis may remove colistin; monitor renal function and neuromuscular status.
โฐ Missed Dose
Administer as soon as remembered; if close to next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for acostin forte 2miu injection
View AllAlternative brands with exact same active ingredient (Colistimethate Sodium (2Million IU)):
-
guficol 2miu injectionGufic Bioscience Ltd โน899.00 41.4% CHEAPER
-
hopstin forte 2million iu injectionMicro Labs Ltd โน942.77 38.6% CHEAPER
-
coly suz 2miu injectionSuzan Pharma โน1,149.00 25.1% CHEAPER
-
ivistin ds injectionConverge Biotech โน1,285.00 16.3% CHEAPER
-
Tinmax 2Million IU InjectionLemford Biotech Pvt Ltd โน1,300.00 15.3% CHEAPER
-
sudostar 2miu injectionLupin Ltd โน1,315.00 14.3% CHEAPER
-
unilistin forte injectionUnited Biotech Pvt Ltd โน1,328.58 13.4% CHEAPER
-
critimycin 2miu injectionTorrent Pharmaceuticals Ltd โน1,396.88 9% CHEAPER
-
coligetz 2miu injectionAlniche Life Sciences Pvt Ltd โน1,399.00 8.8% CHEAPER
-
elistin forte injectionSamarth Life Sciences Pvt Ltd โน1,450.00 5.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.