Acostin 1Million IU Injection - Uses, Price, Side Effects
What is acostin 1million iu injection used for?
Acostin 1Million IU Injection contains Colistimethate Sodium, a polymyxin antibiotic used to treat serious infections caused by multidrug-resistant Gram-negative bacteria. It works by disrupting the bacterial cell membrane, leading to cell death. It is typically administered intravenously or intramuscularly under medical supervision.
- Generic Name: Colistimethate Sodium
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ acostin 1million iu injection Uses & Benefits
Treatment of multidrug-resistant Gram-negative infections (e.g., Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae); used in cystic fibrosis exacerbations.
Off-label uses: Nebulized therapy for ventilator-associated pneumonia; topical use for wound infections.
๐ Drug Information
| Generic Name(s) | Colistimethate Sodium |
| Brand Name | Acostin 1 Million IU Injection |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Cell membrane active agent |
| Route of Administration | Intravenous (IV) or intramuscular (IM); also via nebulization for respiratory infections. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Disrupts bacterial cell membrane integrity by binding to lipopolysaccharides and phospholipids, leading to increased permeability and cell death.
Mechanism Steps
๐ก How to Take acostin 1million iu injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of acostin 1million iu injection
โ Common Side Effects
- Nephrotoxicity (increased creatinine)
- Neurotoxicity (paresthesias, dizziness, vertigo)
- Gastrointestinal disturbances (nausea, vomiting)
๐จ Serious Side Effects
- Acute kidney injury
- Neuromuscular blockade leading to respiratory depression
- Seizures
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Cardiotoxicity (arrhythmias)
- Pseudomembranous colitis
- Superinfection
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | Increased nephrotoxicity and ototoxicity |
| Neuromuscular blocking agents | Major | Enhanced neuromuscular blockade |
| Cephalosporins | Moderate | Increased nephrotoxicity risk |
๐จ Major Interactions
- Neuromuscular blocking agents
- Aminoglycosides
- Vancomycin
- Cyclosporine
- Tacrolimus
- Amphotericin B
- Cisplatin
- Loop diuretics
โก Moderate Interactions
- Cephalosporins
- Penicillins
- NSAIDs
- ACE inhibitors
โน๏ธ Minor Interactions
- Antacids
- Probenecid
๐ฝ๏ธ Food Interactions
No significant food interactions (parenteral).
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to colistimethate or colistin; myasthenia gravis (relative).
๐ Monitoring Parameters
Renal function (serum creatinine, BUN, urine output), electrolytes, neuromuscular function, signs of neurotoxicity (paresthesias, dizziness, seizures).
๐คฑ Lactation Safety
Excreted in breast milk; caution advised.
๐ Overdose Management
Supportive care; hemodialysis may remove colistin; monitor renal function and neuromuscular status.
โฐ Missed Dose
Administer as soon as remembered; if close to next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for acostin 1million iu injection
View AllAlternative brands with exact same active ingredient (Colistimethate Sodium (1Million IU)):
-
guficol 1million iu injectionGufic Bioscience Ltd โน499.00 38.4% CHEAPER
-
colicraft 1million iu injectionUnited Biotech Pvt Ltd โน594.30 26.7% CHEAPER
-
zycolis 1million iu injectionSinsan Pharmaceuticals โน623.07 23.1% CHEAPER
-
coly-suz 1miu injectionSuzan Pharma โน649.00 19.9% CHEAPER
-
Tinmax 1Million IU InjectionLemford Biotech Pvt Ltd โน700.00 13.6% CHEAPER
-
colirem 1million iu injectionIndoco Remedies Ltd โน721.60 11% CHEAPER
-
coligetz 1 miu injectionAlniche Life Sciences Pvt Ltd โน749.06 7.6% CHEAPER
-
d mithate 1miu injectionDr. Edwin Lab โน750.00 7.5% CHEAPER
-
zolistin 1miu injectionLG Lifesciences โน760.00 6.2% CHEAPER
-
sudostar 1miu injectionLupin Ltd โน767.50 5.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.