Clot-XL 500 Tablet (Tranexamic Acid Injection): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden shortness of breath or chest pain
- Swelling, pain, or redness in one leg
- Severe headache with vision changes
- Convulsions or loss of consciousness
- Decreased urine output or swelling in legs
- Severe allergic reaction (rash, itching, swelling of face/lips/throat)
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is axamic 500mg injection used for?
This medicine is an antifibrinolytic injection used to control excessive bleeding. It works by preventing the breakdown of blood clots. It is given intravenously by a healthcare professional in a hospital setting.
- Generic Name: Tranexamic Acid
- Manufacturer: Axis Life Science Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 axamic 500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा ट्रैनेक्सैमिक एसिड का इंजेक्शन है, जिसका उपयोग अत्यधिक रक्तस्राव को नियंत्रित करने के लिए किया जाता है। यह सर्जरी, आघात, भारी मासिक धर्म, और नाक से खून आने जैसी स्थितियों में उपयोग की जाती है। यह खून के थक्के को टूटने से रोकती है और रक्तस्राव को कम करती है। यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा दी जाती है। इसे घर पर स्वयं न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें रक्त के थक्के बनना, एलर्जी प्रतिक्रिया, दौरे पड़ना, और दृष्टि में बदलाव शामिल हो सकते हैं। यदि आपको सांस लेने में कठिनाई, सीने में दर्द, या पैर में सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा दी जानी चाहिए। इसे स्वयं न लें। यदि आपको रक्त के थक्के, गुर्दे की बीमारी, या दौरे की समस्या है, तो अपने डॉक्टर को बताएं। इस दवा को लेने से पहले अपने डॉक्टर को सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। शराब का सेवन न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। इस दवा को लेने के बाद गाड़ी न चलाएं। किसी भी असामान्य लक्षण की रिपोर्ट तुरंत करें।
💊 axamic 500mg injection Uses & Benefits
- [{"condition":"Heavy menstrual bleeding (menorrhagia)","description":"This medicine is used to reduce heavy menstrual bleeding in women with regular cycles.
- It helps decrease blood loss and improve quality of life.","evidence":"Well-established"},{"condition":"Surgical bleeding","description":"This medicine is used to prevent or reduce bleeding during and after various surgical procedures, including cardiac, orthopedic, and dental surgeries.","evidence":"Well-established"},{"condition":"Trauma-related bleeding","description":"This medicine is used in trauma patients to reduce bleeding and improve survival when given early after injury.","evidence":"Well-established"},{"condition":"Epistaxis (nosebleeds)","description":"This medicine can be used to control severe or recurrent nosebleeds, especially in patients with bleeding disorders.","evidence":"Moderate"},{"condition":"Hematuria (blood in urine)","description":"This medicine may be used to reduce bleeding in the urinary tract, but it should be used with caution due to the risk of clot formation in the urinary tract.","evidence":"Limited"}]
Off-label uses: [{"condition":"Melasma","description":"Topical or oral tranexamic acid is sometimes used off-label to treat melasma, a skin condition causing dark patches. However, this injection form is not typically used for melasma.","evidence":"Limited"},{"condition":"Hereditary angioedema","description":"This medicine may be used off-label to prevent attacks of hereditary angioedema, a rare genetic disorder causing swelling.","evidence":"Limited"}]
Primary treatment for: Excessive bleeding
Also treats: Heavy menstrual bleeding, Surgical bleeding, Trauma, Epistaxis
📋 Drug Information
| Generic Name(s) | Tranexamic Acid |
| Brand Name | Armril Injection IP |
| Manufacturer | Axis Life Science Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Antifibrinolytic |
| Route of Administration | Intravenous |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization (WHO) recommends the use of tranexamic acid for the treatment of postpartum hemorrhage and for trauma patients with significant bleeding. It is included in the WHO Model List of Essential Medicines. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) has guidelines for the use of tranexamic acid in various conditions, including trauma and obstetric hemorrhage. Consult local guidelines for specific recommendations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking the binding of plasminogen to fibrin, thereby preventing the conversion of plasminogen to plasmin. Plasmin is an enzyme that breaks down blood clots. By inhibiting plasmin, this medicine helps stabilize blood clots and reduces bleeding. It does not promote new clot formation but protects existing clots from premature breakdown.
Mechanism Steps
💡 How to Take axamic 500mg injection
Strength: Injection: 500mg in 5mL (100mg/mL)
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, patient's age, weight, renal function, and clinical condition. For heavy menstrual bleeding, a common dose is 1g (1000mg) intravenously every 6-8 hours for up to 5 days. For surgical bleeding, doses range from 500mg to 1g before, during, or after surgery. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and require dose adjustment. Use with caution and monitor renal function. |
| Renal Impairment | In patients with renal impairment, dose reduction is necessary. For serum creatinine 1.4-2.8 mg/dL, dose is 10 mg/kg IV every 8 hours. For serum creatinine 2.8-5.7 mg/dL, dose is 10 mg/kg IV every 12 hours. For serum creatinine >5.7 mg/dL, dose is 10 mg/kg IV every 24 hours. For patients on dialysis, dose is 10 mg/kg IV after each dialysis session. |
| Hepatic Impairment | No specific dose adjustment is required for hepatic impairment, as this medicine is minimally metabolized by the liver. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the indication and renal function. In general, doses up to 4g per day have been used. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of axamic 500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Heparin | Major | |
| Aminocaproic acid | Major | |
| Hormonal contraceptives | Major | |
| Alteplase | Moderate | |
| NSAIDs | Moderate | |
| Penicillins | Minor |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin, heparin)
- Antifibrinolytics (e.g., aminocaproic acid)
- Hormonal contraceptives
⚡ Moderate Interactions
- Thrombolytic agents (e.g., alteplase)
- NSAIDs
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness and gastrointestinal bleeding when used with this medicine. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active thromboembolic disease (e.g., deep vein thrombosis, pulmonary embolism)","History of thrombosis or thromboembolism","Severe renal impairment (eGFR < 30 mL/min/1.73 m²)","Subarachnoid hemorrhage","Hypersensitivity to tranexamic acid"]
⚠️ Warnings & Precautions
["Use with caution in patients with a history of thrombosis or risk factors for thrombosis.","Dose adjustment required in renal impairment.","May cause seizures, especially with high doses or in patients with renal impairment.","Visual disturbances may occur; periodic eye examinations recommended for long-term use.","Avoid concomitant use with antifibrinolytics or hormonal contraceptives.","Not recommended for use in patients with hematuria of upper urinary tract origin due to risk of clot formation.","Use with caution in patients with disseminated intravascular coagulation (DIC)."]
🤱 Lactation Safety
This medicine is excreted in breast milk at low concentrations. It is generally considered safe during breastfeeding, but consult your doctor.
💊 Overdose Management
Overdose of this medicine may increase the risk of thrombosis. There is no specific antidote. Treatment is supportive and symptomatic. In case of overdose, discontinue the medicine and monitor for signs of thrombosis. Hemodialysis may be considered to remove the drug in severe cases.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a controlled setting. Missed doses are unlikely. If a dose is missed, inform your healthcare provider. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be given only by a qualified healthcare professional. Do not attempt to self-administer. Inform your doctor if you have a history of blood clots, kidney disease, or seizures. Your doctor may adjust the dose or monitor you closely. Before receiving this medicine, tell your doctor about all other medicines you are taking, especially blood thinners, hormonal contraceptives, and other antifibrinolytic agents. Avoid alcohol while receiving this medicine as it may increase the risk of dizziness. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor. Do not drive or operate heavy machinery immediately after receiving this medicine, as it may cause dizziness. Report any unusual symptoms, such as leg pain, swelling, chest pain, or difficulty breathing, immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function and are at higher risk of side effects. Dose adjustment and close monitoring are recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before receiving this medicine. It is Pregnancy Category B and should be used only if clearly needed.
🏥 Post-Surgery Considerations
This medicine is often used during surgery to reduce bleeding. After surgery, monitor for signs of thrombosis and follow your surgeon's instructions.
🦷 Dental Procedures
This medicine may be used before dental procedures in patients with bleeding disorders to reduce bleeding. Inform your dentist if you are receiving this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase the risk of bleeding or injury while receiving this medicine. Consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness. Avoid driving or operating heavy machinery until you know how it affects you. It is usually given in a hospital setting, so work impact is minimal.
🛑 When to Stop This Medicine
This medicine is stopped when the bleeding is controlled or as directed by your doctor. Do not stop without consulting your healthcare provider.
📅 Long-Term Use Effects
Long-term use of this medicine is not common as it is typically used for short durations. Prolonged use may increase the risk of thrombosis and visual disturbances. Periodic monitoring of renal function and eye examinations may be required for extended therapy. Consult your doctor for regular check-ups if long-term use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antifibrinolytic that can be used as an alternative.
Evidence: Well-establishedA hemostatic agent that can be used for capillary bleeding.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is given in a hospital setting, so travel advice is limited. If you are prescribed this medicine for home use (unlikely), carry it in its original packaging with a copy of your prescription. Store at room temperature and protect from light. When traveling, keep it in your carry-on luggage. Inform security personnel that you are carrying a prescription medicine. Check customs regulations for your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within minutes after intravenous administration.
A: It is given as an intravenous injection by a healthcare professional.
A: Common side effects include nausea, vomiting, diarrhea, and dizziness.
A: It is Pregnancy Category B. Use only if clearly needed, as advised by your doctor.
A: No, this medicine must be administered by a healthcare professional in a medical setting.
🤔 Common Patient Concerns
🔄 Substitutes for axamic 500mg injection
View AllAlternative brands with exact same active ingredient:
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proklot 500mg tabletPrescription Medicines Pvt Ltd ₹12.86 15.3% CHEAPER
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redotrex 500mg injectionLeeford Healthcare Ltd ₹20.58 35.6% COSTLIER
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gynae pil 500mg tabletPsychotropics India Ltd ₹25.05 65% COSTLIER
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wistran 500mg injectionWisdom Pharma Pvt. Ltd ₹27.75 82.8% COSTLIER
-
Tranee 500mg InjectionInd Swift Laboratories Ltd ₹28.00 84.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home for minor bleeding.
Fact: This medicine is an injection that must be given by a healthcare professional in a medical setting. - Myth: This medicine is safe for everyone.
Fact: This medicine is contraindicated in patients with active blood clots or severe kidney problems. - Myth: This medicine can be used to treat all types of bleeding.
Fact: This medicine is specific for certain types of bleeding and should only be used under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Tranexamic Acid Injection
Brand Alternatives
- Clot-XL 500 Tablet