Metrogyl Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, or throat or difficulty breathing
- Seizures or sudden confusion
- Numbness, tingling, or weakness in the hands or feet
- Yellowing of the skin or eyes or dark urine
- Severe abdominal pain or persistent vomiting
- Unusual bruising or bleeding
- Fast heartbeat with flushing and severe nausea after alcohol
If experiencing severe symptoms, call emergency services immediately.
What is zoacide 500mg infusion used for?
This medicine is a metronidazole injection used to treat serious anaerobic bacterial and protozoal infections when oral therapy is not possible. It works by damaging the DNA of susceptible organisms. It is given by a healthcare professional and must not be self-administered.
- Generic Name: Metronidazole (500mg)
- Manufacturer: Wockhardt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zoacide 500mg infusion के बारे में (Hindi Summary)
उपयोग: यह दवा मेट्रोनिडाजोल का इंजेक्शन है, जिसका उपयोग गंभीर एनारोबिक बैक्टीरिया और कुछ परजीवी संक्रमणों के इलाज के लिए किया जाता है, जब मुँह से दवा लेना संभव न हो। यह पेट, पेल्विस, फेफड़ों और अन्य अंगों के संक्रमण में दी जाती है। यह दवा संक्रमण पैदा करने वाले कीटाणुओं का डीएनए खराब करके उन्हें मार देती है। यह केवल डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में ही दी जाती है। इसे घर पर खुद से नहीं लगाया जाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, मुँह में धातु जैसा स्वाद, सिरदर्द और इंजेक्शन लगाने की जगह पर दर्द शामिल हैं। कुछ लोगों को चक्कर आना, पेट खराब होना या पेशाब का रंग गहरा होना भी महसूस हो सकता है। गंभीर दुष्प्रभाव कम होते हैं, लेकिन एलर्जी, दौरे, हाथ-पैरों में झुनझुनी या खून से जुड़ी समस्याएँ हो सकती हैं। शराब के साथ इस दवा का सेवन करने पर तेज प्रतिक्रिया हो सकती है। कोई भी गंभीर लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इसे घर पर खुद से न लगाएं। अगर आपको मेट्रोनिडाजोल या किसी अन्य दवा से एलर्जी है, तो डॉक्टर को पहले बताएं। अपनी सभी दवाओं की जानकारी डॉक्टर को दें, खासकर खून पतला करने वाली दवाएं, लिथियम और दौरे की दवाएं। इलाज के दौरान और आखिरी खुराक के 48 घंटे बाद तक शराब बिल्कुल न लें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। झुनझुनी, भ्रम या दौरे जैसे लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
💊 zoacide 500mg infusion Uses & Benefits
[{"condition":"Intra-abdominal infections","description":"Used to treat serious abdominal infections caused by anaerobic bacteria, often in combination with other antibiotics.","evidence":"Well-established"},{"condition":"Pelvic inflammatory disease","description":"Used as part of combination therapy for pelvic infections in women, especially when anaerobic coverage is needed.","evidence":"Well-established"},{"condition":"Aspiration pneumonia and lung abscess","description":"Provides anaerobic coverage in serious lung infections that may follow aspiration.","evidence":"Well-established"},{"condition":"Trichomoniasis","description":"Used when oral therapy is not feasible for this sexually transmitted protozoal infection.","evidence":"Well-established"},{"condition":"Amoebiasis","description":"Used for severe intestinal or liver amoebic infections when intravenous therapy is required.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Used for giardiasis when oral treatment cannot be given.","evidence":"Well-established"},{"condition":"Bacterial vaginosis","description":"Used in some cases when oral or topical therapy is not suitable.","evidence":"Established"},{"condition":"Surgical prophylaxis","description":"Sometimes used to prevent anaerobic infection during colorectal or gynecological surgery.","evidence":"Established"}]
Off-label uses: [{"condition":"Helicobacter pylori eradication","description":"Sometimes included in combination regimens for H. pylori when intravenous therapy is needed, though oral therapy is standard.","evidence":"Limited"},{"condition":"Rosacea","description":"Oral or topical metronidazole is used for rosacea, but the injectable form is not standard for this condition.","evidence":"Limited"},{"condition":"Crohn's disease","description":"Occasionally used for perianal complications, but evidence is limited and it is not a standard treatment.","evidence":"Limited"}]
Primary treatment for: Anaerobic bacterial infections
Also treats: Intra-abdominal infections, Pelvic inflammatory disease, Aspiration pneumonia, Trichomoniasis, Amoebiasis, Giardiasis
📋 Drug Information
| Generic Name(s) | Metronidazole (500mg) |
| Brand Name | zoacide 500mg infusion |
| Manufacturer | Wockhardt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | 5-Nitroimidazole (Antiprotozoal & Antibacterial) |
| Route of Administration | Parenteral |
| Storage | Store this medicine below 30 degrees Celsius, protected from light. Do not freeze. Keep it in its original packaging until use. Once prepared for infusion, use according to the instructions provided by the healthcare facility. |
| Shelf Life | The shelf life is typically 24 to 36 months from the date of manufacture, depending on the specific product. Always check the expiry date on the label before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a nitroimidazole antimicrobial that works by entering susceptible anaerobic bacteria and protozoa. Inside these organisms, the nitro group of metronidazole is reduced by ferredoxin-like electron transport proteins that are present only in anaerobic organisms. This reduction creates reactive intermediates that bind to and damage DNA, causing strand breakage and preventing further DNA synthesis. As a result, the microorganisms cannot multiply and are killed. Because this activation occurs only in low-oxygen environments, the medicine is selective for anaerobic organisms and has little effect on normal human cells.
Mechanism Steps
💡 How to Take zoacide 500mg infusion
Strength: This medicine is supplied as a 500 mg sterile injection for parenteral use.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, severity of infection, age, weight, kidney function, and liver function. For serious anaerobic infections, a common adult dose is 500 mg given intravenously every 8 hours. For some infections, a loading dose may be used. The duration of treatment depends on the infection and clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Older adults may be more sensitive to the side effects of this medicine, especially dizziness, confusion, and nerve-related effects. Kidney and liver function should be checked before and during treatment, and the dose may need to be adjusted. Discuss all medicines and health conditions with the treating doctor. |
| Renal Impairment | In people with severe kidney impairment, this medicine may accumulate, and dose adjustment may be considered, especially for prolonged treatment. For short courses, many clinicians do not adjust the dose. Your doctor will decide based on your kidney function and the infection being treated. |
| Hepatic Impairment | In people with severe liver disease, this medicine is metabolized more slowly, and dose reduction may be needed. Your doctor may monitor liver function and adjust the dose accordingly. Avoid alcohol completely. |
| Maximum Daily Dose | The maximum daily dose is determined by the treating clinician based on the infection and the patient's condition. In adults, doses above 4 grams per day are not usually recommended. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zoacide 500mg infusion
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Lithium | Major | |
| Disulfiram | Major | |
| Phenytoin | Moderate | |
| Carbamazepine | Moderate | |
| Cimetidine | Moderate | |
| Cyclosporine | Moderate | |
| Oral contraceptives | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin and other oral anticoagulants
- Alcohol
- Lithium
- Disulfiram
⚡ Moderate Interactions
- Phenytoin
- Carbamazepine
- Cimetidine
- Cyclosporine
🍷 Alcohol Interaction
Alcohol must be completely avoided while receiving this medicine and for at least 48 hours after the last dose. Combining them can cause a disulfiram-like reaction with flushing, severe nausea, vomiting, headache, and a fast heartbeat. In some cases, the reaction can be severe and require medical attention.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to metronidazole or other nitroimidazole medicines","Use of disulfiram within the past two weeks","Alcohol consumption during treatment and for at least 48 hours after the last dose","First trimester of pregnancy unless clearly necessary and advised by a doctor","Severe liver disease without dose adjustment and monitoring"]
⚠️ Warnings & Precautions
["This medicine must be given by a healthcare professional and is not for self-administration.","Avoid alcohol completely during treatment and for at least 48 hours after the last dose.","Tell your doctor about all medicines you take, especially blood thinners, lithium, and seizure medicines.","Report numbness, tingling, confusion, or seizures immediately.","Use with caution in people with severe liver disease or severe kidney disease.","Prolonged use may increase the risk of nerve-related side effects and blood disorders.","If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor."]
🤱 Lactation Safety
This medicine passes into breast milk. For a single dose, some experts advise interrupting breastfeeding for 12 to 24 hours to reduce infant exposure. For longer courses, discuss with your doctor whether to continue breastfeeding or use an alternative. Always follow the advice of your treating clinician.
💊 Overdose Management
Overdose with this medicine is rare because it is given by healthcare professionals. Symptoms of overdose may include nausea, vomiting, dizziness, and in severe cases, seizures or nerve problems. Treatment is supportive and includes monitoring of vital signs, blood counts, and neurological status. There is no specific antidote. If an overdose is suspected, seek emergency medical care immediately.
⏰ Missed Dose
Because this medicine is given by a healthcare professional, missed doses are managed by the clinical team. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not try to catch up by taking extra doses on your own. The healthcare team will adjust the schedule based on your condition.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a clinical setting. Do not attempt to self-administer this injection. Inform your doctor if you are allergic to metronidazole or any other medicine. Tell your doctor about all other medicines you take, especially blood thinners such as warfarin, lithium, and medicines for seizures. Avoid all alcohol during treatment and for at least 48 hours after the last dose, because a severe reaction can occur. If you are pregnant, planning pregnancy, or breastfeeding, discuss the risks and benefits with your doctor before receiving this medicine. Report any numbness, tingling, confusion, or seizures immediately. Your doctor may monitor your blood counts and liver function if treatment is prolonged.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more likely to experience dizziness, confusion, and nerve-related side effects. Kidney and liver function should be checked, and the dose may need adjustment. Monitor for falls and confusion during treatment.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this medicine with your doctor before starting treatment. It should be used during pregnancy only when clearly needed. If you become pregnant while receiving this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine is sometimes used after surgery to prevent or treat anaerobic infections. It is given by the healthcare team, and the dose and duration depend on the type of surgery and your condition. Follow your surgeon's instructions about activity, diet, and follow-up.
🦷 Dental Procedures
This medicine is not commonly used for routine dental procedures. If you have a dental infection that requires anaerobic coverage, your dentist or doctor will decide the best treatment. Tell your dentist about all medicines you are taking, especially blood thinners.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you are recovering from a serious infection. Light activity such as walking may be helpful once you feel better. If you feel dizzy or weak, do not drive or operate machinery. Ask your doctor when it is safe to return to your normal exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need time off work during treatment. You may feel tired or dizzy, so avoid driving or operating heavy machinery until you feel normal. Discuss your work schedule with your doctor and plan for rest during recovery.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. The treating doctor will decide when to stop based on your clinical response and the infection being treated. If you develop serious side effects such as seizures, severe allergic reaction, or nerve symptoms, the doctor may stop the medicine immediately and change the treatment plan.
📅 Long-Term Use Effects
Prolonged use of this medicine may increase the risk of peripheral neuropathy, blood disorders, and liver problems. If treatment lasts longer than 10 days, your doctor may monitor blood counts, liver function, and neurological symptoms. Long-term use should be avoided unless clearly necessary, and the need for continued treatment should be reviewed regularly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used once you can take medicines by mouth and your doctor decides it is safe to switch.
Evidence: Well-establishedAlternatives such as clindamycin or a beta-lactam/beta-lactamase inhibitor may be used depending on the infection and allergy history.
Evidence: Well-establishedDrainage of abscesses or surgical removal of infected tissue is often needed along with antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no known interaction between this medicine and routine vaccines. If you need a vaccine, discuss the timing with your doctor, especially if you are unwell with an active infection.
📦 Storage Guide
✅ DO
Store below 30 degrees Celsius
❌ DON'T
Do not freeze the injection
✅ DO
Keep in the original packaging
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from direct sunlight
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic, so travel planning should be discussed with your doctor. If you need to continue treatment while traveling, carry a copy of your prescription and a letter from your doctor explaining the medicine and the reason for it. Keep the injection in its original packaging and store it below 30 degrees Celsius, away from direct sunlight. Check the expiry date before use. If you are crossing time zones, ask your doctor how to adjust the dosing schedule. Carry enough supply for the entire trip and keep it in your hand luggage if flying.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement in fever and pain may begin within 24 to 48 hours, but full recovery depends on the infection and may take several days.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: No, alcohol must be avoided completely during treatment and for at least 48 hours after the last dose.
A: It should be used during pregnancy only when clearly needed. Discuss the risks and benefits with your doctor.
A: Tell the healthcare professional immediately. They may slow the infusion and check your vital signs.
🤔 Common Patient Concerns
🔄 Substitutes for zoacide 500mg infusion
View AllAlternative brands with exact same active ingredient:
-
metrodac 500mg infusionCadila Pharmaceuticals Ltd ₹9.96 7.8% CHEAPER
-
metrocip 500mg infusionCipla Ltd ₹10.25 5.1% CHEAPER
-
meterkem 500mg infusionGeneral Pharmaceuticals Pvt Ltd ₹11.70 8.3% COSTLIER
-
metro 500mg infusionVenus Remedies Ltd ₹12.08 11.9% COSTLIER
-
metron 500mg infusionAlkem Laboratories Ltd ₹12.20 13% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home by injection.
Fact: This medicine must be given by a healthcare professional in a clinical setting. - Myth: It is safe to drink alcohol while receiving this medicine.
Fact: Alcohol must be avoided completely during treatment and for at least 48 hours after the last dose. - Myth: This medicine works for all types of infections.
Fact: This medicine is effective only against certain anaerobic bacteria and protozoa, not against all infections.
🔄 Alternative Options
Generic Alternatives
- Metronidazole injection 500 mg
Brand Alternatives
- Metrogyl Injection
- Metronidazole Injection