zacpar 50mg/500mg tablet - Aceclofenac (50mg) + Paracetamol (500mg) medicine

Zumo Syrup: Complete Medicine Guide

No reviews yet
🏭 Multilax Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Use only if clearly needed and prescribed by a doctor. Avoid in the third trimester due to risk of premature closure of ductus arteriosus. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for short-term pain relief.
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is zacpar 50mg/500mg tablet used for?

This medicine is a combination of Aceclofenac and Paracetamol used for short-term relief of pain, inflammation, and fever. It works by reducing prostaglandins. Take it with food, avoid alcohol, and do not exceed the prescribed dose.

  • Generic Name: Aceclofenac (50mg) + Paracetamol (500mg)
  • Manufacturer: Multilax Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 zacpar 50mg/500mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एसिटोक्लोफेनाक और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार से राहत के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत के दर्द, सर्जरी के बाद के दर्द और गठिया के दर्द में प्रभावी है। यह दवा सूजन को कम करने और दर्द को शांत करने में मदद करती है। इसे भोजन के साथ लें और शराब से बचें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, एलर्जी प्रतिक्रिया, गुर्दे की समस्या और यकृत विषाक्तता शामिल हो सकते हैं। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें। यदि आपको पेट में अल्सर, गुर्दे या यकृत की बीमारी, उच्च रक्तचाप या हृदय की समस्या है तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 zacpar 50mg/500mg tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to its paracetamol content.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"May be used for short-term relief of pain and stiffness in osteoarthritis.","evidence":"Established"},{"condition":"Rheumatoid arthritis","description":"Provides symptomatic relief of pain and inflammation in rheumatoid arthritis.","evidence":"Established"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain.","evidence":"Limited"}]

Primary treatment for: Pain and inflammation

Also treats: Fever, Osteoarthritis, Rheumatoid arthritis, Dental pain, Post-operative pain

📋 Drug Information

Generic Name(s)Aceclofenac (50mg) + Paracetamol (500mg)
Brand Namezacpar 50mg/500mg tablet
ManufacturerMultilax Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine with food to minimize gastrointestinal side effects.
2
Assess renal and hepatic function before starting therapy, especially in elderly patients.
3
Avoid concurrent use with other NSAIDs or paracetamol-containing products.
4
Monitor for signs of gastrointestinal bleeding, especially in patients with a history of ulcers.
5
Limit the duration of therapy to the shortest time necessary to control symptoms.
6
Counsel patients to avoid alcohol while taking this medicine.
7
Consider alternative analgesics in patients with cardiovascular risk factors.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
✅
Fever
This medicine contains paracetamol which reduces fever.
Likely Use
✅
Dental pain
This medicine is effective for dental pain.
Likely Use
❌
Headache
This medicine is not a primary headache treatment.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAceclofenac is rapidly absorbed after oral administration, with peak plasma concentrations reached in about 1.25 to 3 hours. Paracetamol is also rapidly absorbed, with peak levels occurring within 0.5 to 2 hours. Food may delay absorption but does not significantly reduce the extent.
DistributionAceclofenac is highly protein-bound and distributes well into synovial fluid. Paracetamol distributes widely into most body tissues, with a volume of distribution of about 0.95 L/kg.
Protein BindingAceclofenac is approximately 99% bound to plasma proteins. Paracetamol is about 10-25% bound to plasma proteins.
MetabolismAceclofenac is metabolized in the liver primarily by CYP2C9 to 4'-hydroxyaceclofenac and other metabolites. Paracetamol is metabolized in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is detoxified by glutathione.
Half-LifeThe elimination half-life of Aceclofenac is approximately 4 hours. Paracetamol has a half-life of about 2 to 3 hours.
ExcretionAceclofenac and its metabolites are excreted mainly in urine. Paracetamol is excreted in urine as glucuronide and sulfate conjugates.
BioavailabilityThe oral bioavailability of Aceclofenac is about 80-100%. Paracetamol has an oral bioavailability of about 80-90%.
Onset of ActionPain relief typically begins within 30 minutes to 1 hour after oral administration.
Peak Plasma TimeAceclofenac peak plasma time is 1.25 to 3 hours; Paracetamol peak plasma time is 0.5 to 2 hours.
Duration of ActionThe analgesic effect lasts approximately 4 to 6 hours.

How It Works

This medicine combines two active ingredients. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase (COX) enzymes, leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, resulting in analgesic and antipyretic effects. The combination provides enhanced pain relief through complementary mechanisms.

Mechanism Steps

1
Inhibition of cyclooxygenase enzymes: Aceclofenac inhibits COX-1 and COX-2 enzymes, reducing the conversion of arachidonic acid to prostaglandins.
2
Reduced prostaglandin synthesis: Decreased prostaglandin levels lead to less inflammation, pain, and fever.
3
Central analgesic action of paracetamol: Paracetamol acts on the central nervous system to increase the pain threshold and reduce fever.
4
Combined effect: The two ingredients work together to provide stronger pain relief than either alone.

💡 How to Take zacpar 50mg/500mg tablet

Strength: Each 5 mL of syrup contains Aceclofenac 50 mg and Paracetamol 500 mg.

1Shake the bottle well before use.
2Use a measuring cup or spoon to measure the correct dose.
3Take the medicine with food or milk to reduce stomach upset.
4Swallow the syrup directly or mix with a small amount of water if desired.
5Do not exceed the recommended dose.
6Wash the measuring cup after each use.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 mL (2 teaspoons) two to three times daily, or as prescribed by your doctor. The dose may vary depending on the condition being treated, severity of pain, and individual response. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney impairment. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with kidney impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with liver impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum daily dose of this medicine is 30 mL (6 teaspoons) per day, providing 300 mg Aceclofenac and 3000 mg Paracetamol. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding and liver toxicity.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of zacpar 50mg/500mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk. If persists, consult doctor.
Vomiting (Common (5-10%))
Stay hydrated. Consult doctor if severe.
Stomach pain (Common (5-10%))
Take with food. Avoid alcohol. Consult doctor if severe.
Indigestion (Common (5-10%))
Take with food. Antacids may help. Consult doctor if persistent.
Headache (Common (5-10%))
Usually resolves. Consult doctor if severe or persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Drowsiness (Common (5-10%))
Avoid driving. Consult doctor if persistent.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Peptic ulcer (Rare (<0.1%))
Report persistent stomach pain to your doctor.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Call emergency services if you experience swelling of face, lips, throat, or difficulty breathing.
Kidney impairment (Rare (<0.1%))
Report decreased urine output or swelling to your doctor.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue.
Cardiovascular events (Rare (<0.1%))
Seek immediate care for chest pain, shortness of breath, or weakness.

⚠️ Rare Side Effects

Blood disorders (e.g., agranulocytosis, thrombocytopenia)
Report unusual bleeding, bruising, or infections.
Stevens-Johnson syndrome
Seek immediate medical attention for rash, blisters, or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Corticosteroids Major
Methotrexate Major
Lithium Major
ACE inhibitors Moderate
Diuretics Moderate
SSRIs Moderate
Antacids Minor
Cholestyramine Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, naproxen)
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Beta-blockers
  • SSRIs

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and may enhance liver toxicity, especially due to the paracetamol component.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to Aceclofenac, Paracetamol, or any other NSAID","Active peptic ulcer or history of recurrent ulcers","Severe heart failure","Severe kidney impairment","Severe liver impairment","Third trimester of pregnancy","Children under 12 years (unless prescribed)","Patients with aspirin-sensitive asthma"]

⚠️ Warnings & Precautions

["Take with food to reduce stomach upset.","Avoid alcohol.","Do not exceed recommended dose.","Use with caution in elderly patients.","Monitor for signs of bleeding.","Consult doctor if symptoms persist beyond 7 days.","Do not use in patients with dehydration or hypovolemia.","May impair ability to drive or operate machinery."]

🤱 Lactation Safety

Aceclofenac and paracetamol are excreted in breast milk in small amounts. Consult your doctor before use. Generally considered safe for short-term use, but monitor infant for any adverse effects.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding due to Aceclofenac. Seek immediate medical attention. Treatment includes gastric lavage, activated charcoal, and administration of N-acetylcysteine for paracetamol toxicity. Supportive care for NSAID toxicity.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding. Do not take other NSAIDs or paracetamol-containing products simultaneously to prevent overdose. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, high blood pressure, or heart problems. Do not drive or operate heavy machinery if you feel dizzy or drowsy. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.

🤰 Pregnancy Planning (TTC)

Consult your doctor before taking this medicine if you are planning pregnancy. Avoid use in the third trimester.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain, but consult your surgeon before taking it, especially if you are on other medications.

🦷 Dental Procedures

This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.
🌞
Stay hydrated.

🏋️ Exercise Considerations

Avoid strenuous exercise while taking this medicine, especially if you have joint pain or inflammation. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Avoid alcohol

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, or if you experience any severe side effects such as stomach pain, black stools, or allergic reactions.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of kidney and liver function is recommended. Use the lowest effective dose for the shortest duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot/cold therapy

May help reduce pain and inflammation.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 30-year-old woman with acute dental pain
Took this medicine for severe toothache before a dental procedure. Experienced relief within 30 minutes. Was advised to avoid alcohol and take with food.
💡 Lesson: This medicine provides rapid relief for acute dental pain when taken as directed.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30 minutes to 1 hour after taking it.

Q: Can I take it on an empty stomach?

A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.

Q: Is it safe to take with other painkillers?

A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor, as it may increase the risk of side effects.

Q: How long can I take this medicine?

A: This medicine is for short-term use only. Consult your doctor if you need it for more than 7 days.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for zacpar 50mg/500mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe to take without a prescription.
    Fact: This medicine is a prescription drug and should only be taken under medical supervision.
  • Myth: This medicine can be taken long-term for chronic pain.
    Fact: It is intended for short-term use only. Long-term use requires medical supervision.
  • Myth: It is safe to take this medicine with alcohol.
    Fact: Alcohol increases the risk of stomach bleeding and liver toxicity.

🔄 Alternative Options

Generic Alternatives

  • Aceclofenac + Paracetamol syrup

Brand Alternatives

  • Zumo syrup

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredients":"Aceclofenac 50 mg + Paracetamol 500 mg per 5 mL","route":"Oral","common_use":"Pain, inflammation, fever"},{"medicine":"Ibuprofen + Paracetamol","active_ingredients":"Ibuprofen 100 mg + Paracetamol 162.5 mg per 5 mL","route":"Oral","common_use":"Pain, fever"},{"medicine":"Diclofenac + Paracetamol","active_ingredients":"Diclofenac 50 mg + Paracetamol 500 mg","route":"Oral","common_use":"Pain, inflammation"}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory