xom-d capsule sr - Domperidone (30mg) + Omeprazole (40mg) medicine

Ezimoz-SD Capsule SR: Complete Medicine Guide

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🏭 Novogen Captab 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for the combination in GERD with delayed gastric emptying; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Oct 21, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in vomit or black, tarry stools
  • Severe abdominal pain or persistent vomiting
  • Chest pain, palpitations, or difficulty breathing
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes (jaundice)
  • Decreased urine output or swelling in legs
  • Uncontrollable muscle spasms or involuntary movements

If experiencing severe symptoms, call emergency services immediately.

What is xom-d capsule sr used for?

This medicine is a combination of Domperidone 30 mg and Omeprazole 40 mg used to treat acid reflux and poor stomach emptying. It works by reducing stomach acid and improving gut movement. It is available by prescription only.

  • Generic Name: Domperidone (30mg) + Omeprazole (40mg)
  • Manufacturer: Novogen Captab
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 xom-d capsule sr के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन 30 मिलीग्राम और ओमेप्राज़ोल 40 मिलीग्राम का संयोजन है। इसका उपयोग एसिड रिफ्लक्स (जीईआरडी), अपच, और पेट के खाली होने में देरी से जुड़ी समस्याओं के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट की गति को बढ़ाती है, जिससे जलन, उल्टी, और पेट फूलने में राहत मिलती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।

साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, सिरदर्द, दस्त, पेट दर्द, और जी मिचलाना शामिल हैं। कुछ लोगों को नींद या चक्कर आ सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अनियमित दिल की धड़कन, स्तनों में सूजन या स्राव, और गंभीर एलर्जी प्रतिक्रियाएँ हो सकती हैं। लंबे समय तक उपयोग से मैग्नीशियम और विटामिन बी12 की कमी हो सकती है। कोई भी असामान्य लक्षण दिखने पर डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। कैप्सूल को चबाएं या तोड़ें नहीं, पूरा निगल लें। इसे खाली पेट, भोजन से 30-60 मिनट पहले लेना सबसे अच्छा है। इस दवा के साथ शराब न लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। यदि आपको हृदय, यकृत, या गुर्दे की बीमारी है, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के लंबे समय तक न लें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 xom-d capsule sr Uses & Benefits

[{"condition":"Gastroesophageal reflux disease (GERD) with delayed gastric emptying","description":"Reduces acid reflux and improves stomach emptying, relieving heartburn, regurgitation, and bloating.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps with symptoms like upper abdominal pain, early satiety, and postprandial fullness.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with acid-related disorders","description":"Domperidone reduces nausea by improving gastric motility, while omeprazole reduces acid irritation.","evidence":"Moderate"},{"condition":"Gastroparesis (diabetic or idiopathic)","description":"May improve gastric emptying and reduce symptoms of nausea, vomiting, and bloating.","evidence":"Limited"}]

Off-label uses: [{"condition":"Refractory nausea in palliative care","description":"Sometimes used off-label for nausea not responding to other treatments.","evidence":"Limited"}]

Primary treatment for: Gastroesophageal reflux disease (GERD) with delayed gastric emptying

Also treats: Functional dyspepsia, Gastroparesis, Nausea and vomiting associated with acid-related disorders

📋 Drug Information

Generic Name(s)Domperidone (30mg) + Omeprazole (40mg)
Brand Namexom-d capsule sr
ManufacturerNovogen Captab
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine on an empty stomach, at least 30 to 60 minutes before breakfast, for best results.
2
Do not crush or chew the capsule; swallow it whole with water.
3
Avoid alcohol and grapefruit juice while taking this medicine.
4
Do not drive or operate heavy machinery until you know how this medicine affects you.
5
Report any palpitations, dizziness, or fainting immediately, as this medicine can affect heart rhythm.
6
Do not take this medicine for longer than prescribed without consulting your doctor.
7
If you have kidney or liver problems, inform your doctor before starting this medicine.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Heartburn
This medicine is commonly prescribed for acid reflux.
Likely Use
✅
Bloating and early satiety
Helps with delayed gastric emptying.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary
❌
Headache
Not a primary treatment for headache.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed after oral administration, with peak plasma levels occurring within 30 to 60 minutes. Omeprazole is also rapidly absorbed, with peak plasma concentrations achieved within 1 to 2 hours. The presence of food may delay the absorption of omeprazole but does not significantly affect the extent of absorption. Domperidone absorption is slightly reduced when taken with food.
DistributionDomperidone is widely distributed in tissues but does not readily cross the blood-brain barrier. It is highly protein-bound (approximately 91-93%). Omeprazole is distributed into gastric parietal cells and is about 95% protein-bound. Both drugs have large volumes of distribution.
Protein BindingDomperidone: approximately 91-93% bound to plasma proteins. Omeprazole: approximately 95% bound to plasma proteins.
MetabolismDomperidone undergoes extensive first-pass metabolism in the liver and intestinal wall via CYP3A4 and CYP1A2 enzymes. Omeprazole is metabolized in the liver by CYP2C19 and CYP3A4 enzymes. Genetic polymorphisms in CYP2C19 can affect omeprazole metabolism.
Half-LifeDomperidone: approximately 7-9 hours in healthy individuals. Omeprazole: approximately 0.5-1 hour, but the duration of acid suppression is much longer due to irreversible binding.
ExcretionDomperidone is excreted mainly in the feces (approximately 66%) and urine (approximately 33%). Omeprazole is excreted primarily as metabolites in urine (approximately 80%) and feces (approximately 20%).
BioavailabilityDomperidone: approximately 15% due to extensive first-pass metabolism. Omeprazole: approximately 30-40% after a single dose, but increases with repeated dosing.
Onset of ActionDomperidone: within 30-60 minutes. Omeprazole: within 1 hour for acid suppression, but maximum effect may take 2-5 days of daily dosing.
Peak Plasma TimeDomperidone: 0.5-1 hour. Omeprazole: 1-2 hours.
Duration of ActionDomperidone: approximately 6-8 hours. Omeprazole: acid suppression lasts up to 24 hours despite a short plasma half-life.

How It Works

This medicine combines two active ingredients with complementary actions. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract. This enhances gastric motility and accelerates gastric emptying without significant central nervous system effects because it does not readily cross the blood-brain barrier. Omeprazole is a proton pump inhibitor that irreversibly inhibits the H+/K+ ATPase enzyme in gastric parietal cells, thereby suppressing both basal and stimulated gastric acid secretion. The combination addresses both acid hypersecretion and delayed gastric emptying, which often coexist in functional gastrointestinal disorders.

Mechanism Steps

1
Domperidone blocks peripheral dopamine D2 receptors: Domperidone antagonizes dopamine D2 receptors in the gastrointestinal tract and chemoreceptor trigger zone, which enhances gastric motility and reduces nausea.
2
Enhanced gastric emptying: By blocking D2 receptors, domperidone increases lower esophageal sphincter tone and promotes coordinated antroduodenal contractions, speeding up stomach emptying.
3
Omeprazole inhibits proton pumps: Omeprazole accumulates in the acidic environment of parietal cells and irreversibly binds to H+/K+ ATPase, blocking the final step of acid secretion.
4
Reduced gastric acid secretion: Inhibition of the proton pump decreases both basal and stimulated acid production, reducing esophageal irritation and reflux symptoms.
5
Combined therapeutic effect: The dual action addresses both acid hypersecretion and delayed gastric emptying, providing comprehensive relief for GERD and dyspepsia.

💡 How to Take xom-d capsule sr

Strength: Capsule containing Domperidone 30 mg and Omeprazole 40 mg.

1Take the capsule whole with a glass of water.
2Do not crush, chew, or open the capsule.
3Take it on an empty stomach, at least 30 to 60 minutes before a meal.
4If you have trouble swallowing, consult your doctor for alternative formulations.
5Follow your doctor's instructions regarding the duration of treatment.

Dosage Information

Adult DosageThe usual adult dose is one capsule taken orally once daily on an empty stomach, at least 30 to 60 minutes before breakfast. However, the exact dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to therapy. Do not self-adjust the dose. Follow your doctor's prescription exactly.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially cardiac arrhythmias and central nervous system effects. Use with caution and at the lowest effective dose. Dose adjustment may be necessary based on renal and hepatic function. Regular monitoring is recommended.
Renal ImpairmentUse with caution in patients with renal impairment. Dose reduction may be necessary. In severe renal impairment, domperidone is contraindicated. Consult your doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be necessary. In severe hepatic impairment, domperidone is contraindicated. Consult your doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is one capsule (Domperidone 30 mg + Omeprazole 40 mg) per day. Do not exceed this dose without medical advice.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take on an empty stomach
Food may delay absorption of omeprazole and reduce efficacy.
Grapefruit
Avoid
May increase omeprazole levels and side effects.
Alcohol
Avoid
Increases stomach acid and risk of drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of xom-d capsule sr

✅ Common Side Effects

Dry mouth (Common (1-10%))
Sip water frequently. Chew sugar-free gum. Consult doctor if persistent.
Headache (Common (1-10%))
Rest and stay hydrated. Use over-the-counter pain relief if needed, but consult your doctor first.
Diarrhea (Common (1-10%))
Stay hydrated. Avoid fatty or spicy foods. Consult doctor if diarrhea persists beyond 48 hours.
Abdominal pain (Common (1-10%))
Take with food if not contraindicated. Apply a warm compress. Consult doctor if severe.
Nausea (Common (1-10%))
Take with a small snack. Avoid strong odors. Consult doctor if vomiting occurs.

🚨 Serious Side Effects

Irregular heartbeat (QT prolongation) (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, dizziness, or fainting.
Breast enlargement or discharge (galactorrhea) (Uncommon (0.1-1%))
Consult your doctor. Dose adjustment or discontinuation may be needed.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency help if you have swelling of face, lips, throat, or difficulty breathing.
Clostridium difficile-associated diarrhea (Rare (<0.1%))
Report persistent diarrhea, abdominal pain, or fever to your doctor immediately.
Hypomagnesemia (low magnesium) (Rare (<0.1%))
Report muscle cramps, tremors, or irregular heartbeat. Blood tests may be needed.

⚠️ Rare Side Effects

Tardive dyskinesia
Report involuntary movements to your doctor immediately.
Acute interstitial nephritis
Seek medical attention if you notice decreased urine output or swelling.
Cutaneous lupus erythematosus
Report skin rash, especially on sun-exposed areas, to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Clopidogrel Major
Warfarin Moderate
Diazepam Moderate
Phenytoin Moderate
Atazanavir Moderate
Antacids Minor
Sucralfate Minor
Methotrexate Major
Amiodarone Major

🚨 Major Interactions

  • Ketoconazole, itraconazole, clarithromycin, ritonavir
  • QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
  • Clopidogrel
  • Methotrexate

⚡ Moderate Interactions

  • Warfarin
  • Diazepam
  • Phenytoin
  • Atazanavir, nelfinavir

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase stomach acid, worsen reflux symptoms, and increase the risk of drowsiness and dizziness from domperidone. It may also increase the risk of liver toxicity.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to domperidone, omeprazole, or any component of the formulation","Gastrointestinal obstruction, perforation, or bleeding","Prolactin-releasing pituitary tumor (prolactinoma)","Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)","Concomitant use with QT-prolonging drugs","Severe hepatic impairment","Moderate or severe renal impairment","Cardiac disease such as heart failure, coronary artery disease, or arrhythmias","Hypokalemia or hypomagnesemia","Use in children under 12 years or weighing less than 35 kg"]

⚠️ Warnings & Precautions

["Domperidone should be used at the lowest effective dose for the shortest duration due to risk of cardiac arrhythmias.","Avoid use in patients with risk factors for QT prolongation, such as electrolyte imbalances, bradycardia, or family history of long QT syndrome.","Omeprazole may increase the risk of bone fractures with long-term use; consider calcium and vitamin D supplementation.","Long-term use of omeprazole may lead to hypomagnesemia; monitor magnesium levels periodically.","Omeprazole may mask symptoms of gastric cancer; ensure appropriate evaluation before starting therapy.","Use with caution in patients with hepatic impairment; dose adjustment may be required.","Use with caution in elderly patients due to increased risk of side effects and drug interactions.","Do not use for longer than 8 weeks without re-evaluation by a doctor."]

🤱 Lactation Safety

Domperidone passes into breast milk and may cause side effects in the infant. Omeprazole also passes into breast milk but is considered compatible with breastfeeding. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause drowsiness, extrapyramidal symptoms, and QT prolongation. There is no specific antidote. Treatment is supportive and symptomatic. Gastric lavage may be considered if within 1 hour of ingestion. Monitor ECG and electrolytes. Contact a poison control center or emergency department immediately.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush or chew the capsule; swallow it whole. It is best taken on an empty stomach, at least 30 to 60 minutes before a meal, but follow your doctor's specific instructions. Avoid alcohol while taking this medicine as it can worsen stomach irritation and increase drowsiness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have heart problems, liver disease, or kidney disease. Do not take this medicine for longer than prescribed without medical supervision. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of cardiac arrhythmias, electrolyte imbalances, and drug interactions. Use with caution and at the lowest effective dose. Regular monitoring of ECG, magnesium, and renal function is advised.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Both domperidone and omeprazole should be used with caution during pregnancy. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Use with caution after surgery, especially if you have had gastrointestinal surgery. Consult your surgeon before taking this medicine.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine. It may increase the risk of bleeding during dental procedures. Your dentist may recommend temporary discontinuation or monitoring.

💚 Lifestyle Tips for Better Results

🏃
Eat smaller, more frequent meals.
🥗
Avoid lying down for at least 2 hours after eating.
😴
Elevate the head of your bed by 6-8 inches.
💧
Maintain a healthy weight.
🧘
Avoid trigger foods like spicy, fatty, and acidic foods.
🌞
Quit smoking and limit alcohol.
🚭
Manage stress through relaxation techniques.

🏋️ Exercise Considerations

Avoid vigorous exercise immediately after taking this medicine, especially if you experience dizziness or drowsiness. Light to moderate exercise is generally safe. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include high-fiber foods like fruits, vegetables, and whole grains.
Eat lean proteins.
Avoid caffeine, chocolate, and mint.
Limit fatty and fried foods.
Stay hydrated with water.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause dry mouth, so keep water handy. Generally, it does not significantly impact daily activities if taken as prescribed.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects, contact your doctor immediately. Your doctor may adjust the dose or switch to another medicine.

📅 Long-Term Use Effects

Long-term use of omeprazole may lead to low magnesium levels, vitamin B12 deficiency, increased risk of bone fractures, and gastrointestinal infections. Domperidone long-term use may cause hyperprolactinemia and cardiac arrhythmias. Regular monitoring and periodic review are recommended. Do not use for more than 8 weeks without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet changes, weight loss, and elevating the head of the bed can help manage GERD.

Evidence: Well-established
Other prokinetics

Metoclopramide or erythromycin may be used as alternatives, but have their own side effects.

Evidence: Moderate
Surgery

Fundoplication may be considered for severe GERD not responding to medicines.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, omeprazole may reduce the effectiveness of the oral typhoid vaccine. Consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light and moisture. If traveling across time zones, continue taking it once daily as prescribed; adjust timing gradually. Check customs regulations for carrying prescription medicines. Keep enough supply for your trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic acid reflux and bloating
Ravi had been suffering from heartburn and a feeling of fullness after meals for months. His doctor prescribed this medicine. Within a week, his heartburn reduced significantly, and he felt less bloated. He was advised to take it before breakfast and avoid late-night meals. He also started walking daily.
💡 Lesson: Taking the medicine as prescribed and making lifestyle changes like avoiding late meals and exercising can greatly improve symptoms.
👤 A 60-year-old woman with diabetic gastroparesis
Mrs. Sharma had diabetes and often felt nauseous and full after small meals. Her doctor added this medicine to her regimen. She noticed gradual improvement in her appetite and less nausea. She was monitored for heart rhythm and magnesium levels.
💡 Lesson: Regular monitoring is important, especially in elderly patients with other health conditions, to ensure safety and effectiveness.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Domperidone starts working within 30-60 minutes, while omeprazole may take 1-4 days for full acid suppression.

Q: Can I take it with other medicines?

A: It can interact with several medicines. Always inform your doctor about all medicines you take.

Q: Is it safe during pregnancy?

A: Consult your doctor. It should be used only if clearly needed.

Q: What if I miss a dose?

A: Take it as soon as you remember, but skip if it's almost time for the next dose. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for xom-d capsule sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any stomach pain.
    Fact: This medicine is specifically for acid reflux and delayed gastric emptying. It is not a general painkiller and should only be used as prescribed.
  • Myth: It is safe to take this medicine indefinitely.
    Fact: Long-term use should be avoided unless prescribed. Regular monitoring is required for potential side effects like low magnesium and bone fractures.
  • Myth: You can stop taking this medicine as soon as you feel better.
    Fact: Always complete the prescribed course and consult your doctor before stopping, as symptoms may rebound.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Omeprazole capsules (various manufacturers)

Brand Alternatives

  • Ezimoz-SD Capsule SR

📊 Comparison with Similar Medicines

[{"medicine":"Domperidone + Omeprazole","composition":"Domperidone 30 mg + Omeprazole 40 mg","release_type":"Immediate release","frequency":"Once daily","notes":"Combines prokinetic and PPI."},{"medicine":"Domperidone + Pantoprazole","composition":"Domperidone 30 mg + Pantoprazole 40 mg","release_type":"Immediate release","frequency":"Once daily","notes":"Pantoprazole has fewer CYP2C19 interactions."},{"medicine":"Domperidone + Rabeprazole","composition":"Domperidone 30 mg + Rabeprazole 20 mg","release_type":"Immediate release","frequency":"Once daily","notes":"Rabeprazole has faster onset of acid suppression."}]

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