voglikem-m 0.3 tablet sr - Metformin (500mg) + Voglibose (0.3mg) medicine

Agivog M 0.3 Tablet SR: Complete Guide to Uses, Side Effects, and Safety

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🏭 Alkem Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for metformin; voglibose has established evidence in Asian populations.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Rapid breathing or difficulty breathing
  • Severe muscle pain or weakness
  • Extreme fatigue or unusual drowsiness
  • Persistent vomiting or severe abdominal pain
  • Signs of hypoglycemia: shakiness, sweating, confusion, rapid heartbeat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is voglikem-m 0.3 tablet sr used for?

This medicine is a combination of Metformin and Voglibose used to treat type 2 diabetes. It helps control both fasting and post-meal blood sugar levels when taken with meals as prescribed.

  • Generic Name: Metformin (500mg) + Voglibose (0.3mg)
  • Manufacturer: Alkem Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 voglikem-m 0.3 tablet sr के बारे में (Hindi Summary)

उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। इसमें मेटफॉर्मिन और वोग्लिबोज दो दवाएं होती हैं जो मिलकर खाने के बाद और खाली पेट दोनों समय ब्लड शुगर को कंट्रोल करने में मदद करती हैं। यह दवा उन वयस्कों के लिए है जिनका शुगर सिर्फ डाइट और एक्सरसाइज से कंट्रोल नहीं हो पाता। इसे डॉक्टर की सलाह से खाने के साथ लेना चाहिए।

साइड इफेक्ट्स: इस दवा के आम साइड इफेक्ट्स में पेट में गैस, सूजन, दस्त, जी मिचलाना और पेट में असहजता शामिल हैं। ये आमतौर पर कुछ समय में कम हो जाते हैं। कभी-कभी मुंह में धातु जैसा स्वाद आ सकता है। गंभीर लेकिन दुर्लभ साइड इफेक्ट्स में लैक्टिक एसिडोसिस और गंभीर हाइपोग्लाइसीमिया हो सकते हैं। अगर सांस लेने में तकलीफ, बहुत ज्यादा कमजोरी या पेट में तेज दर्द हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार खाने के साथ लें। खाना न छोड़ें, खासकर अगर आप इंसुलिन या सल्फोनिलयूरिया भी ले रहे हैं। शराब का सेवन न करें या बहुत कम करें। किडनी या लिवर की बीमारी हो तो डॉक्टर को बताएं। नियमित रूप से ब्लड शुगर की जांच कराएं। डॉक्टर की सलाह के बिना दवा बंद या डोज न बदलें। सर्जरी या स्कैन से पहले डॉक्टर को इस दवा के बारे में जरूर बताएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 voglikem-m 0.3 tablet sr Uses & Benefits

[{"condition":"Type 2 Diabetes Mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes, particularly when postprandial hyperglycemia is prominent.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Prediabetes","description":"Sometimes prescribed off-label to delay progression to type 2 diabetes in high-risk individuals, but this is not a standard approved use.","evidence":"Limited"},{"condition":"Polycystic Ovary Syndrome (PCOS)","description":"Metformin component may be used off-label for insulin resistance in PCOS, but the combination with voglibose is not standard for this indication.","evidence":"Limited"}]

Primary treatment for: Type 2 Diabetes Mellitus

Also treats: Prediabetes, Metabolic syndrome

📋 Drug Information

Generic Name(s)Metformin (500mg) + Voglibose (0.3mg)
Brand Namevoglikem-m 0.3 tablet sr
ManufacturerAlkem Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI DIABETIC
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture, or as printed on the packaging.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with meals to reduce gastrointestinal side effects and enhance voglibose efficacy.
2
Monitor blood glucose regularly, especially when combined with insulin or sulfonylureas.
3
Assess renal function before starting and at least annually thereafter.
4
Advise patients to avoid excessive alcohol intake to prevent lactic acidosis.
5
Temporarily discontinue before iodinated contrast imaging procedures.
6
Educate patients on recognizing symptoms of hypoglycemia and lactic acidosis.
7
Consider vitamin B12 supplementation if long-term metformin use is anticipated.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

High blood sugar after meals
This medicine is commonly prescribed for postprandial hyperglycemia in type 2 diabetes.
Likely Use
Fever
This medicine is not a fever reducer.
Not Primary
Chronic joint pain
This medicine is not indicated for pain relief.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMetformin is slowly and incompletely absorbed from the gastrointestinal tract, with bioavailability of about 50-60%. Voglibose is poorly absorbed systemically, with less than 2% of an oral dose reaching the bloodstream; it acts locally in the gut.
DistributionMetformin is widely distributed to body tissues, including liver, kidney, and gastrointestinal tract. It does not bind significantly to plasma proteins. Voglibose has negligible systemic distribution due to its minimal absorption.
Protein BindingMetformin: negligible plasma protein binding. Voglibose: not established from the available information.
MetabolismMetformin is not metabolized in the liver and is excreted unchanged in urine. Voglibose is minimally absorbed and primarily metabolized in the gastrointestinal tract by intestinal bacteria, with some metabolites excreted in feces.
Half-LifeMetformin: approximately 6.2 hours from plasma and about 17.6 hours from whole blood. Voglibose: not established from the available information.
ExcretionMetformin is excreted unchanged in urine via active tubular secretion and glomerular filtration. Voglibose is mainly excreted in feces as unchanged drug and metabolites.
BioavailabilityMetformin: 50-60%. Voglibose: less than 2% (systemic).
Onset of ActionMetformin: blood glucose-lowering effect may take several days to weeks to become apparent. Voglibose: reduces postprandial glucose within hours of intake, but overall glycemic improvement takes days to weeks.
Peak Plasma TimeMetformin: 2-3 hours after oral dose. Voglibose: not established from the available information due to poor systemic absorption.
Duration of ActionMetformin: approximately 24 hours with immediate-release formulations. Voglibose: effect on postprandial glucose lasts for the duration of carbohydrate digestion, typically a few hours after a meal.

How It Works

This medicine combines two oral antidiabetic agents with complementary mechanisms. Metformin decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Voglibose inhibits alpha-glucosidase enzymes in the intestinal brush border, delaying the digestion of complex carbohydrates into monosaccharides and thereby reducing postprandial blood glucose peaks. The combination addresses both fasting and post-meal hyperglycemia.

Mechanism Steps

1
Metformin activates AMPK: Metformin enters hepatocytes and activates AMP-activated protein kinase (AMPK), which leads to reduced expression of gluconeogenic enzymes and decreased hepatic glucose output.
2
Improved peripheral insulin sensitivity: Metformin enhances insulin-mediated glucose uptake in skeletal muscle and adipose tissue, increasing glucose utilization.
3
Voglibose inhibits alpha-glucosidase: Voglibose competitively inhibits alpha-glucosidase enzymes in the small intestine, preventing the breakdown of disaccharides and complex carbohydrates into absorbable monosaccharides.
4
Reduced postprandial glucose rise: Due to delayed carbohydrate digestion, glucose absorption is slowed, resulting in a lower and more gradual rise in blood glucose after meals.

💡 How to Take voglikem-m 0.3 tablet sr

Strength: Tablet containing Metformin 500 mg and Voglibose 0.3 mg.

1Take this medicine orally with a full glass of water.
2Take it with meals to reduce stomach upset and improve effectiveness.
3Swallow the tablet whole; do not crush or chew.
4Follow your doctor's prescribed schedule exactly.
5Do not skip meals while on this medicine.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally with meals, typically once or twice daily as prescribed by your doctor. The dose may be adjusted based on blood glucose levels, renal function, and tolerability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may require lower doses due to reduced renal function. Renal function should be assessed before and during treatment. Dose must be individualized by a qualified clinician.
Renal ImpairmentMetformin is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). In moderate renal impairment (eGFR 30-45), use with caution and consider dose reduction. Voglibose dose adjustment in renal impairment is not established. Consult your doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with liver disease due to increased risk of lactic acidosis. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose of metformin is 2000-2550 mg depending on formulation; voglibose maximum is 0.9 mg per day (0.3 mg three times daily). However, this fixed-dose combination should not exceed the prescribed strength. Follow your doctor's advice.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With meals
Take with meals
Reduces stomach upset and allows voglibose to act on dietary carbohydrates.
Alcohol
Avoid
Increases risk of lactic acidosis and hypoglycemia.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of voglikem-m 0.3 tablet sr

✅ Common Side Effects

Flatulence (Common (10-30%))
Usually reduces over time. Avoid gas-producing foods and take with meals.
Abdominal bloating (Common (10-20%))
Take with meals and avoid overeating. Consult doctor if persistent.
Diarrhea (Common (10-20%))
Stay hydrated. If severe or persistent, consult your doctor.
Nausea (Common (5-10%))
Take with food. Usually resolves with continued use.
Metallic taste (Uncommon (1-5%))
Usually temporary. Chewing sugar-free gum may help.

🚨 Serious Side Effects

Lactic acidosis (Rare (<0.1%))
Seek immediate medical attention if you experience rapid breathing, severe muscle pain, extreme fatigue, or stomach pain.
Severe hypoglycemia (Rare when used alone; higher if combined with insulin or sulfonylureas)
If you experience shakiness, sweating, confusion, or rapid heartbeat, consume fast-acting sugar and seek medical help.
Vitamin B12 deficiency (Uncommon with long-term use)
Periodic monitoring of B12 levels is advised. Supplement if deficient.

⚠️ Rare Side Effects

Hepatitis
Report yellowing of eyes or skin, dark urine, or right upper abdominal pain immediately.
Severe allergic reactions
Seek emergency care if you develop rash, swelling of face/lips/throat, or difficulty breathing.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Iodinated contrast media Major
Alcohol Major
Insulin Major
Sulfonylureas Major
Diuretics Moderate
Corticosteroids Moderate
Cimetidine Moderate
Digoxin Minor
Warfarin Minor

🚨 Major Interactions

  • Iodinated contrast media
  • Alcohol
  • Insulin or sulfonylureas

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Corticosteroids
  • Cationic drugs (e.g., cimetidine, amiloride)

🍷 Alcohol Interaction

Alcohol should be avoided or limited while taking this medicine because it can increase the risk of lactic acidosis and hypoglycemia. It may also worsen gastrointestinal side effects.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR

⚠️ Warnings & Precautions

["Lactic acidosis is a rare but serious complication; discontinue and seek immediate medical help if suspected.","Avoid excessive alcohol intake.","Temporarily discontinue before iodinated contrast imaging procedures.","Use with caution in elderly patients and those with renal impairment.","Monitor blood glucose regularly, especially when combined with insulin or sulfonylureas.","Voglibose may cause hypoglycemia when used with other antidiabetic agents; treat with glucose, not sucrose, if hypoglycemia occurs.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]

🤱 Lactation Safety

Metformin is excreted in breast milk in small amounts and is generally considered compatible with breastfeeding. Voglibose is not established for use during lactation. Consult your doctor before breastfeeding while on this medicine.

💊 Overdose Management

Overdose may cause hypoglycemia, lactic acidosis, or severe gastrointestinal symptoms. Seek immediate medical attention. Treatment is supportive and symptomatic, including monitoring of vital signs, blood glucose, and electrolytes. Hemodialysis may be considered for metformin overdose in severe cases.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember if it is less than half the dosing interval away. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor, usually with meals to reduce stomach upset and improve effectiveness. Do not skip meals while on this medicine, especially if you are also taking insulin or sulfonylureas, as this can increase the risk of low blood sugar. Avoid excessive alcohol consumption because it can increase the risk of lactic acidosis and low blood sugar. Inform your doctor if you have kidney or liver problems, as dose adjustments may be needed. Regularly monitor your blood sugar levels as advised. Do not stop or change the dose without consulting your doctor. If you are scheduled for surgery or a contrast-enhanced imaging procedure, inform your doctor because this medicine may need to be temporarily stopped. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of renal impairment and lactic acidosis. Renal function should be assessed before and during treatment. Dose adjustments may be necessary.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor. Metformin may be continued in some cases, but voglibose is not recommended during pregnancy. Your doctor will decide the safest treatment option.

🏥 Post-Surgery Considerations

This medicine may need to be temporarily stopped before surgery due to the risk of lactic acidosis, especially if contrast agents or dehydration are involved. Follow your surgeon's and doctor's instructions.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. If you are unable to eat normally after the procedure, consult your doctor about dose adjustments to avoid hypoglycemia.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to improve insulin sensitivity.
🥗
Engage in regular physical activity, such as brisk walking or swimming.
😴
Follow a balanced diet rich in fiber and low in refined sugars.
💧
Monitor your blood sugar levels regularly as advised.
🧘
Get adequate sleep and manage stress effectively.
🌞
Avoid smoking and limit alcohol consumption.

🏋️ Exercise Considerations

Exercise is encouraged, but be aware that intense exercise can lower blood sugar. Monitor your glucose levels before and after exercise, and carry fast-acting sugar in case of hypoglycemia.

🥗 Diet Recommendations

Include high-fiber foods like whole grains, vegetables, and legumes.
Limit intake of refined carbohydrates and sugary beverages.
Eat small, frequent meals to help control blood sugar.
Stay well hydrated with water.
Include lean proteins and healthy fats.

💼 Impact on Daily Work & Life

This medicine generally does not impair your ability to work or drive. However, if you experience hypoglycemia, avoid driving or operating heavy machinery until your blood sugar normalizes. Inform your employer about your condition if necessary.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience serious side effects like lactic acidosis or severe hypoglycemia, seek immediate medical attention and follow your doctor's advice on discontinuation.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to vitamin B12 deficiency due to metformin. Regular monitoring of B12 levels and renal function is advised. Gastrointestinal side effects often diminish over time. The combination helps maintain long-term glycemic control and may reduce the risk of diabetes-related complications when used consistently with lifestyle modifications.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet and exercise are foundational for managing type 2 diabetes and can complement or reduce the need for medication.

Evidence: Well-established
Other oral antidiabetic agents

Depending on your condition, your doctor may consider other classes like DPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no specific vaccine interactions with this medicine. However, people with diabetes should stay up to date with recommended vaccinations, including influenza and pneumococcal vaccines.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times gradually in consultation with your doctor. Keep enough supply for the entire trip and carry it in hand luggage. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 52-year-old man with type 2 diabetes and post-meal sugar spikes
He was prescribed this medicine after his post-meal glucose remained high despite metformin alone. He took it with breakfast and dinner as advised. Within a month, his post-meal sugar levels improved significantly, and he experienced only mild flatulence initially, which subsided.
💡 Lesson: Taking this medicine with meals improves tolerability and effectiveness, especially for post-meal glucose control.
👤 A 60-year-old woman with type 2 diabetes and mild renal impairment
Her doctor adjusted her dose and monitored her kidney function regularly. She was advised to avoid alcohol and stay hydrated. She maintained good glycemic control without any serious side effects.
💡 Lesson: Regular monitoring of renal function and adherence to lifestyle advice are crucial when using this medicine in older adults.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within hours to reduce post-meal glucose, but full effects on overall blood sugar control may take several days to weeks.

Q: Can I take this medicine if I have kidney disease?

A: It depends on the severity of kidney disease. Your doctor will assess your renal function and may adjust the dose or choose an alternative.

Q: What should I do if I experience low blood sugar?

A: If you experience symptoms of hypoglycemia, consume fast-acting sugar like glucose tablets or fruit juice, and inform your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for voglikem-m 0.3 tablet sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure diabetes.
    Fact: This medicine helps manage blood sugar but does not cure diabetes. Lifestyle changes and ongoing treatment are essential.
  • Myth: You can stop taking this medicine once your sugar levels are normal.
    Fact: Blood sugar levels may normalize due to the medicine. Stopping it without medical advice can cause sugar levels to rise again.
  • Myth: This medicine causes kidney damage.
    Fact: Metformin does not cause kidney damage, but it should be used with caution in people with existing kidney problems.

🔄 Alternative Options

Generic Alternatives

  • Metformin 500 mg + Voglibose 0.3 mg tablet (generic)

Brand Alternatives

  • Agivog M 0.3 Tablet SR

📊 Comparison with Similar Medicines

[{"medicine":"Metformin + Voglibose","key_difference":"Targets both fasting and postprandial glucose; low hypoglycemia risk."},{"medicine":"Metformin + Glimepiride","key_difference":"Sulfonylurea increases insulin secretion; higher hypoglycemia risk."},{"medicine":"Metformin + Sitagliptin","key_difference":"DPP-4 inhibitor; weight neutral; low hypoglycemia risk."}]

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