venphylin-m tablet sr - Acebrophylline (200mg) + Montelukast (10mg) medicine

Glemont-A Tablet SR: Complete Medicine Guide

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🏭 Leeford Healthcare Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Consult your doctor before use. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for COPD and asthma; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or severe asthma attack
  • Swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Severe abdominal pain
  • Irregular heartbeat or palpitations
  • Suicidal thoughts or severe mood changes
  • Seizures

If experiencing severe symptoms, call emergency services immediately.

What is venphylin-m tablet sr used for?

This medicine is a combination of Acebrophylline and Montelukast used to treat COPD and asthma. It works by relaxing airways and reducing inflammation. It is not for sudden breathing attacks.

  • Generic Name: Acebrophylline (200mg) + Montelukast (10mg)
  • Manufacturer: Leeford Healthcare Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 venphylin-m tablet sr के बारे में (Hindi Summary)

उपयोग: यह दवा एसब्रोफिलिन और मॉन्टेलुकास्ट का संयोजन है, जिसका उपयोग सीओपीडी और अस्थमा के इलाज के लिए किया जाता है। यह श्वास नलियों को फैलाकर और सूजन कम करके सांस लेने में मदद करती है। यह तुरंत अस्थमा के दौरे के लिए नहीं है।

साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, मतली, पेट दर्द, दस्त और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, लीवर की समस्या, मूड में बदलाव या अनियमित दिल की धड़कन हो सकती है। कोई भी असामान्य लक्षण दिखने पर डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। गोली को चबाएं या तोड़ें नहीं, पूरा निगल लें। शराब से बचें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर को बताएं। अचानक सांस फूलने पर इसका उपयोग न करें, रेस्क्यू इनहेलर पास रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 venphylin-m tablet sr Uses & Benefits

[{"condition":"Chronic Obstructive Pulmonary Disease (COPD)","description":"Helps relieve bronchospasm, reduce mucus production, and improve lung function in patients with COPD.","evidence":"Well-established"},{"condition":"Asthma","description":"Used as add-on therapy to control asthma symptoms and prevent exercise-induced bronchoconstriction.","evidence":"Well-established"},{"condition":"Bronchitis","description":"May help in chronic bronchitis by reducing airway inflammation and mucus.","evidence":"Limited"}]

Off-label uses: [{"condition":"Allergic rhinitis","description":"Montelukast component may help allergic rhinitis, but combination is not standard.","evidence":"Limited"}]

Primary treatment for: Chronic Obstructive Pulmonary Disease (COPD)

Also treats: Asthma, Chronic bronchitis

📋 Drug Information

Generic Name(s)Acebrophylline (200mg) + Montelukast (10mg)
Brand Namevenphylin-m tablet sr
ManufacturerLeeford Healthcare Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each evening for best results.
2
Do not use this medicine for sudden breathing difficulty; always keep a rescue inhaler.
3
Inform your doctor if you experience mood changes, depression, or sleep disturbances.
4
Avoid alcohol and other sedatives while taking this medicine.
5
Do not stop this medicine abruptly without consulting your doctor.
6
Report any yellowing of eyes or skin, dark urine, or severe stomach pain immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic cough with mucus
This medicine is commonly prescribed for COPD and chronic bronchitis.
Likely Use
✅
Wheezing and breathlessness
Used for asthma and COPD.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAcebrophylline is rapidly absorbed from the gastrointestinal tract after oral administration. Montelukast is also well absorbed orally, with a bioavailability of approximately 64% for the 10 mg tablet. Food does not significantly affect the absorption of either component.
DistributionBoth drugs are highly protein-bound. Acebrophylline is distributed widely in body tissues, including the lungs. Montelukast is more than 99% bound to plasma proteins and has a small volume of distribution.
Protein BindingAcebrophylline: approximately 60-70% bound to plasma proteins. Montelukast: more than 99% bound to plasma proteins.
MetabolismAcebrophylline is metabolized in the liver via oxidation and demethylation. Montelukast is extensively metabolized in the liver by cytochrome P450 enzymes, primarily CYP2C8 and CYP3A4.
Half-LifeAcebrophylline: approximately 3-5 hours. Montelukast: approximately 2.7-5.5 hours in healthy adults.
ExcretionAcebrophylline and its metabolites are excreted mainly in urine. Montelukast is excreted primarily in bile and feces, with a small amount in urine.
BioavailabilityAcebrophylline: Not established from the available information. Montelukast: approximately 64% for the 10 mg tablet.
Onset of ActionAcebrophylline: bronchodilation begins within 30-60 minutes. Montelukast: onset of action for asthma control may take hours to days, but some effect on exercise-induced bronchoconstriction occurs within 2 hours.
Peak Plasma TimeAcebrophylline: 1-2 hours. Montelukast: 3-4 hours for the 10 mg tablet.
Duration of ActionAcebrophylline: approximately 6-8 hours. Montelukast: approximately 24 hours, allowing once-daily dosing.

How It Works

This medicine combines two active ingredients with complementary actions. Acebrophylline is a xanthine derivative that inhibits phosphodiesterase enzymes, increasing cyclic AMP levels in bronchial smooth muscle, leading to relaxation and bronchodilation. It also reduces mucus viscosity and improves mucociliary clearance. Montelukast is a selective leukotriene receptor antagonist that blocks cysteinyl leukotriene receptors in the airways, preventing leukotriene-mediated bronchoconstriction, inflammation, and mucus secretion. Together, they provide bronchodilation and anti-inflammatory effects.

Mechanism Steps

1
Acebrophylline inhibits phosphodiesterase: Acebrophylline blocks phosphodiesterase enzymes, increasing cyclic AMP in bronchial smooth muscle cells, which causes muscle relaxation and bronchodilation.
2
Acebrophylline reduces mucus viscosity: It improves mucociliary clearance by making mucus less thick, making it easier to cough out.
3
Montelukast blocks leukotriene receptors: Montelukast selectively antagonizes CysLT1 receptors, preventing leukotrienes from causing bronchoconstriction and inflammation.
4
Combined bronchodilation and anti-inflammation: The two actions together relax airways and reduce swelling, leading to easier breathing.

💡 How to Take venphylin-m tablet sr

Strength: Sustained-release tablet containing Acebrophylline 200 mg and Montelukast 10 mg.

1Swallow the tablet whole with a glass of water.
2Do not crush, chew, or break the tablet.
3Take it at the same time each day, preferably in the evening.
4Can be taken with or without food.
5If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose is one tablet (Acebrophylline 200 mg + Montelukast 10 mg) taken orally once daily, preferably in the evening. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients, but use with caution due to potential reduced hepatic and renal function. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo specific dose adjustment is established. Use with caution in patients with renal impairment. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with mild to moderate hepatic impairment. Contraindicated in severe hepatic impairment. Dose must be individualized by a qualified clinician.
Maximum Daily DoseOne tablet (Acebrophylline 200 mg + Montelukast 10 mg) per day. Do not exceed.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Can take with or without food
Food does not significantly affect absorption.
Grapefruit juice
Avoid
May increase montelukast levels.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours since missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours since missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of venphylin-m tablet sr

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent or severe.
Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if it continues.
Stomach pain (Common (5-10%))
Take with meals. If pain is severe, contact your doctor.
Diarrhea (Common (5-10%))
Stay hydrated. Consult doctor if diarrhea persists more than 2 days.
Skin rash (Uncommon (1-5%))
Stop the medicine and consult your doctor if rash appears.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, throat, or difficulty breathing.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe abdominal pain immediately.
Neuropsychiatric events (Uncommon (1-5%))
Montelukast may cause mood changes, depression, or suicidal thoughts. Contact your doctor if you notice any behavior changes.
Palpitations or irregular heartbeat (Rare (<0.1%))
Seek medical attention if you feel rapid or irregular heartbeat.

⚠️ Rare Side Effects

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
Report symptoms like fever, rash, joint pain, or numbness to your doctor immediately.
Seizures
Seek emergency medical help if seizures occur.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Rifampicin Major
Warfarin Major
Gemfibrozil Moderate
Salbutamol Moderate
Antacids Minor

🚨 Major Interactions

  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
  • Warfarin

⚡ Moderate Interactions

  • CYP2C8 inhibitors (e.g., gemfibrozil)
  • Beta-agonists (e.g., salbutamol)

🍷 Alcohol Interaction

Alcohol may increase drowsiness, dizziness, and stomach irritation. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to acebrophylline, montelukast, or any component of the formulation","Children under 15 years of age (safety and efficacy not established)","Acute bronchospasm requiring rescue therapy","Severe hepatic impairment","Pregnancy and breastfeeding unless clearly needed and advised by doctor"]

⚠️ Warnings & Precautions

["Do not use for acute asthma attacks; always carry a rescue inhaler.","Montelukast may cause neuropsychiatric events; monitor for mood changes.","Use with caution in patients with liver or kidney disease.","Avoid alcohol and other CNS depressants.","Do not crush or chew sustained-release tablets.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]

🤱 Lactation Safety

Not established from the available information. Montelukast is excreted in breast milk; caution is advised. Consult your doctor.

💊 Overdose Management

Seek emergency medical attention. Symptoms of overdose may include nausea, vomiting, palpitations, and seizures. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the sustained-release tablet; swallow it whole with water. Avoid alcohol while taking this medicine as it may increase drowsiness and stomach irritation. Inform your doctor if you have liver or kidney disease, or if you are pregnant or breastfeeding. Do not use this medicine for sudden breathing difficulty; always keep a rescue inhaler handy. Store at room temperature away from moisture and heat. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to side effects. Use with caution and monitor renal and hepatic function.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy. This medicine should be used during pregnancy only if clearly needed.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist about this medicine. It may interact with other medications used during surgery.

🦷 Dental Procedures

Inform your dentist about this medicine. No specific precautions are established, but maintain good oral hygiene.

💚 Lifestyle Tips for Better Results

🏃
Avoid smoking and exposure to secondhand smoke.
🥗
Stay up to date with vaccinations (flu, pneumonia).
😴
Practice breathing exercises as advised.
💧
Maintain a healthy weight.
🧘
Avoid known allergens and pollutants.

🏋️ Exercise Considerations

Exercise may trigger asthma in some patients. Use your rescue inhaler as advised before exercise. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits and vegetables.
Stay hydrated to help thin mucus.
Limit processed foods and excess salt.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience serious side effects, contact your doctor immediately.

📅 Long-Term Use Effects

Long-term use may require periodic monitoring of liver function and mood changes. Montelukast has been associated with neuropsychiatric events. Regular follow-up with your doctor is recommended.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Inhaled corticosteroids

Common alternative for asthma control.

Evidence: Well-established
Pulmonary rehabilitation

Exercise and education program for COPD.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Ensure you are up to date with influenza and pneumococcal vaccines, as respiratory infections can worsen COPD and asthma.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, consult your doctor about adjusting the timing. Keep enough supply for the entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with COPD
He was prescribed this medicine as part of his COPD management. After a few weeks, he noticed fewer episodes of breathlessness and less coughing. He learned to take it regularly and keep his rescue inhaler handy.
💡 Lesson: Consistent use of controller medications can significantly improve quality of life in COPD.
👤 A 32-year-old woman with asthma
She started this medicine for asthma control. She initially experienced mild headache but it resolved. She was advised to avoid alcohol and to report any mood changes. Her asthma symptoms improved over time.
💡 Lesson: Patience and adherence are key; side effects often diminish with time.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Acebrophylline starts working within 30-60 minutes, but Montelukast may take several days to show full effect. Maximum benefit may take a few weeks.

Q: Can I take it with other asthma medicines?

A: Yes, but inform your doctor about all medicines you take to avoid interactions.

Q: Is it safe during pregnancy?

A: Consult your doctor. Safety is not well established.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for venphylin-m tablet sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can replace your rescue inhaler.
    Fact: No, it is a controller medicine and cannot provide immediate relief during an acute attack.
  • Myth: You can stop taking it once you feel better.
    Fact: You should complete the prescribed course and consult your doctor before stopping.

🔄 Alternative Options

Generic Alternatives

  • Acebrophylline + Montelukast combination generics may be available.

Brand Alternatives

  • Glemont-A Tablet SR

📊 Comparison with Similar Medicines

[{"medicine":"Glemont-A Tablet SR","composition":"Acebrophylline 200 mg + Montelukast 10 mg","uses":"COPD, asthma","notes":"Sustained release"},{"medicine":"Montelukast + Levocetirizine","composition":"Montelukast 10 mg + Levocetirizine 5 mg","uses":"Allergic rhinitis, asthma","notes":"Immediate release"}]

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