Sildenafil 20mg Tablet: Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Chest pain or pressure that may indicate a heart attack
- Sudden vision loss in one or both eyes
- Sudden hearing loss or ringing in the ears
- Erection lasting more than 4 hours
- Severe dizziness or fainting
- Signs of an allergic reaction such as rash, itching, swelling of the face, lips, or throat
- Yellowing of the skin or eyes (jaundice)
If experiencing severe symptoms, call emergency services immediately.
What is vasosure tablet used for?
This medicine contains sildenafil 20 mg, a PDE5 inhibitor used to treat pulmonary arterial hypertension (PAH). It works by relaxing blood vessels in the lungs, lowering blood pressure and improving exercise capacity. It is taken three times a day and must not be used with nitrates.
- Generic Name: Sildenafil (20mg)
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 vasosure tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सिल्डेनाफिल 20 मिलीग्राम युक्त है और फुफ्फुसीय धमनी उच्च रक्तचाप (पल्मोनरी आर्टेरियल हाइपरटेंशन) के इलाज के लिए उपयोग की जाती है। यह फेफड़ों की रक्त वाहिकाओं को फैलाकर रक्तचाप को कम करती है, जिससे सांस लेने में आसानी होती है और व्यायाम करने की क्षमता बढ़ती है। यह दवा डॉक्टर के निर्देशानुसार दिन में तीन बार लेनी चाहिए। इसे नाइट्रेट या रियोसिगुआट के साथ कभी नहीं लेना चाहिए क्योंकि इससे खतरनाक रूप से रक्तचाप गिर सकता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चेहरे पर लालिमा, अपच, नाक बंद होना और चक्कर आना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में अचानक रक्तचाप गिरना, लंबे समय तक इरेक्शन बने रहना, दृष्टि में अचानक कमी या सुनने में कमी शामिल हैं। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर दिन में तीन बार। इसे नाइट्रेट या रियोसिगुआट के साथ न लें। शराब का सेवन कम करें क्योंकि इससे चक्कर आ सकते हैं। यदि आपको सीने में दर्द, सांस लेने में तकलीफ, अचानक दृष्टि जाना या 4 घंटे से अधिक इरेक्शन हो तो तुरंत आपातकालीन चिकित्सा सहायता लें। इस दवा को बच्चों की पहुंच से दूर रखें।
💊 vasosure tablet Uses & Benefits
- [{"condition":"Pulmonary arterial hypertension (PAH)","description":"This medicine is used to improve exercise capacity and delay clinical worsening in adults with pulmonary arterial hypertension (WHO Group I).
- It helps lower pulmonary artery pressure and improves blood flow through the lungs.","evidence":"Well-established"},{"condition":"Erectile dysfunction","description":"Sildenafil is also approved for erectile dysfunction at higher strengths (50 mg and 100 mg).
- The 20 mg tablet strength is not typically used for this indication, but the active ingredient is the same.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Raynaud's phenomenon","description":"Sometimes prescribed off-label to improve blood flow to the fingers and toes in people with Raynaud's phenomenon.","evidence":"Limited"},{"condition":"High-altitude pulmonary edema prevention","description":"Occasionally used off-label to prevent high-altitude pulmonary edema in susceptible individuals.","evidence":"Limited"}]
Primary treatment for: Pulmonary arterial hypertension
Also treats: Erectile dysfunction (at higher doses)
📋 Drug Information
| Generic Name(s) | Sildenafil (20mg) |
| Brand Name | vasosure tablet |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | SEX STIMULANTS REJUVENATORS |
| Action Class | Phosphodiesterase-V inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Do not refrigerate. Keep in the original container, tightly closed. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | The World Health Organization (WHO) recognizes PDE5 inhibitors, including sildenafil, as a treatment option for pulmonary arterial hypertension (Group I). Guidelines recommend it for patients with WHO functional class II or III PAH to improve exercise capacity and symptoms. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for the management of pulmonary arterial hypertension include PDE5 inhibitors as part of targeted therapy. However, specific recommendations should be followed as per the latest ICMR guidelines and specialist advice. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively inhibiting the enzyme phosphodiesterase type 5 (PDE5). In the lungs, PDE5 is responsible for breaking down cyclic guanosine monophosphate (cGMP), a molecule that relaxes smooth muscle cells in blood vessels. By blocking PDE5, this medicine increases cGMP levels, leading to relaxation and widening of the pulmonary blood vessels. This reduces pulmonary vascular resistance and lowers blood pressure in the lungs, which reduces the workload on the right side of the heart and improves blood flow. The same mechanism also affects blood vessels in other parts of the body, which explains some of the side effects such as headache and flushing.
Mechanism Steps
💡 How to Take vasosure tablet
Strength: Immediate-release tablet, 20 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for pulmonary arterial hypertension is 20 mg taken orally three times a day, approximately 4 to 6 hours apart, with or without food. For patients with severe hepatic impairment or those taking CYP3A4 inhibitors, a lower dose may be recommended. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. Do not adjust the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based solely on age. However, elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Dose should be individualized by a qualified clinician based on renal and hepatic function and concomitant medications. |
| Renal Impairment | No dose adjustment is needed for patients with mild to moderate renal impairment (creatinine clearance 30-80 mL/min). In patients with severe renal impairment (creatinine clearance <30 mL/min), the clearance of this medicine may be reduced. A lower starting dose may be considered, and dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No dose adjustment is needed for patients with mild to moderate hepatic impairment (Child-Pugh class A and B). In patients with severe hepatic impairment (Child-Pugh class C), the clearance of this medicine is reduced. A lower starting dose of 20 mg once daily may be considered, and dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose for pulmonary arterial hypertension is 20 mg three times a day (total 60 mg per day). Higher doses are not recommended for this indication. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of vasosure tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Nitrates | Major | |
| Riociguat | Major | |
| Ketoconazole | Major | |
| Ritonavir | Major | |
| Alpha-blockers | Moderate | |
| Amlodipine | Moderate | |
| Rifampin | Moderate | |
| Carbamazepine | Moderate | |
| Grapefruit juice | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Nitrates (e.g., nitroglycerin, isosorbide mononitrate)
- Riociguat
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin)
⚡ Moderate Interactions
- Alpha-blockers (e.g., doxazosin, terazosin)
- Antihypertensives (e.g., amlodipine, losartan)
- CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
🍷 Alcohol Interaction
Alcohol can increase the risk of low blood pressure, dizziness, and fainting when taken with this medicine. It is advisable to limit or avoid alcohol while taking this medicine, especially if you have a history of low blood pressure or heart problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Concurrent use of nitrates in any form (e.g., nitroglycerin, isosorbide mononitrate)","Concurrent use of riociguat","Known hypersensitivity to sildenafil or any component of the tablet","Previous episode of non-arteritic anterior ischemic optic neuropathy (NAION) while taking a PDE5 inhibitor"]
⚠️ Warnings & Precautions
["Cardiovascular risk: This medicine can cause hypotension. Assess cardiovascular status before starting treatment.","Priapism: Prolonged erections lasting more than 4 hours require immediate medical attention.","Visual effects: Sudden vision loss may occur. Stop the medicine and seek medical help immediately.","Hearing loss: Sudden decrease or loss of hearing has been reported. Stop the medicine and consult your doctor.","Combination with other PDE5 inhibitors: Do not take with other PDE5 inhibitors or riociguat.","Hepatic impairment: Dose adjustment may be needed in severe hepatic impairment.","Renal impairment: Dose adjustment may be needed in severe renal impairment.","Alcohol: May increase the risk of hypotension.","Driving and operating machinery: May cause dizziness; avoid if affected."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose with this medicine may cause severe hypotension, syncope, and priapism. There is no specific antidote. Treatment should be supportive and symptomatic. If overdose occurs, contact a poison control center or emergency room immediately. Hemodialysis is not expected to be effective in removing this medicine because it is highly protein-bound.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually three times a day, with or without food. Do not change the dose or stop taking it without talking to your doctor first. Avoid drinking large amounts of alcohol, as it can increase the risk of low blood pressure and dizziness. Do not take this medicine with nitrates, riociguat, or any medicine that contains nitrates, as this can cause a dangerous drop in blood pressure. Tell all your healthcare providers that you are taking this medicine, especially before any surgery or dental procedure. If you experience chest pain, shortness of breath, sudden vision loss, or an erection lasting more than four hours, seek emergency medical help immediately. Keep this medicine out of reach of children and store it at room temperature away from moisture and heat. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Monitor blood pressure regularly and adjust dose as needed. No specific dose adjustment is recommended based solely on age, but individualization is important.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conceiving. This medicine is Pregnancy Category B, but its safety in pregnancy is not fully established. Your doctor will weigh the benefits and risks and may adjust your treatment plan.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with certain anesthetic agents and cause hypotension. Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dizziness or hypotension during the procedure. Your dentist may take precautions such as monitoring your blood pressure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is beneficial for pulmonary arterial hypertension, but you should avoid strenuous activities that cause severe breathlessness or chest pain. Start slowly and gradually increase activity as tolerated. Always consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or visual changes in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal daily activities, but you should pace yourself and avoid overexertion. Inform your employer about your condition if needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as sudden vision loss, hearing loss, or prolonged erection, stop the medicine and seek immediate medical attention. Your doctor may adjust or discontinue treatment based on your response and side effects.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well-tolerated. Regular monitoring of blood pressure, heart function, and symptoms is recommended. Some patients may develop tolerance, but this is not common. Long-term use may be associated with an increased risk of NAION, but this is rare. Regular follow-up with your specialist is important to assess the ongoing benefit and adjust treatment as needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another class of oral medicines for PAH, such as bosentan or ambrisentan.
Evidence: Well-establishedMedicines like epoprostenol or iloprost, often used for more severe PAH.
Evidence: Well-establishedDiet, exercise, and stress management can complement medical therapy.
Evidence: Supportive💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with pulmonary arterial hypertension are at higher risk of respiratory infections, so vaccinations against influenza and pneumococcal disease are recommended as per standard guidelines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and avoid direct sunlight. If crossing time zones, continue taking the medicine at the same intervals as prescribed, but consult your doctor for specific advice. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 to 60 minutes, but the full benefits for pulmonary arterial hypertension may take several weeks to become noticeable.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: Avoid nitrates, riociguat, and large amounts of alcohol. Also avoid grapefruit juice as it can increase the levels of this medicine.
🤔 Common Patient Concerns
🔄 Substitutes for vasosure tablet
View AllAlternative brands with exact same active ingredient:
-
sildaflow 20mg tabletMankind Pharma Ltd ₹100.00 72.3% CHEAPER
-
pulmoday 20mg tabletAprica Pharmaceuticals Pvt Ltd ₹155.36 57% CHEAPER
-
esylnafil 20mg tabletTruecure Healthcare Private Limited ₹180.00 50.2% CHEAPER
-
pah 20 tabletMSN Laboratories ₹292.59 19.1% CHEAPER
-
penegra pah tabletZydus Cadila ₹300.00 17% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is only for erectile dysfunction.
Fact: This medicine is approved for pulmonary arterial hypertension at the 20 mg strength. Higher strengths are used for erectile dysfunction. - Myth: This medicine can be taken with nitrates for chest pain.
Fact: This medicine must never be taken with nitrates due to the risk of severe hypotension. - Myth: This medicine is a cure for pulmonary arterial hypertension.
Fact: This medicine helps manage the condition but does not cure it. It is part of a comprehensive treatment plan.
🔄 Alternative Options
Generic Alternatives
- Sildenafil 20 mg tablet
Brand Alternatives
- Revatio