avanair 100 tablet - Avanafil (100mg) medicine

avanair 100 tablet

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🏭 Cipla Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is avanair 100 tablet used for?

This medicine contains Avanafil (100mg) and is used to treat SEX STIMULANTS REJUVENATORS. Inhibits PDE5, increasing cGMP levels in corpus cavernosum, leading to smooth muscle relaxation and . Always consult your doctor before use.

  • Generic Name: Avanafil
  • Manufacturer: Cipla Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 avanair 100 tablet Uses & Benefits

Treatment of erectile dysfunction.

Off-label uses: Pulmonary arterial hypertension (not approved); Raynaud's phenomenon.

📋 Drug Information

Generic Name(s)Avanafil
Brand NameAvanair 100 Tablet
ManufacturerCipla Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassSEX STIMULANTS REJUVENATORS
Action ClassPhosphodiesterase-5 (PDE5) Inhibitor
Route of AdministrationOral
StorageStore at 20-25°C (68-77°F); protect from moisture and light.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentration achieved within 30-45 minutes under fasting conditions.
DistributionVolume of distribution approximately 2.5 L/kg; extensively distributed to tissues.
Protein BindingApproximately 99% bound to plasma proteins.
MetabolismPrimarily metabolized by CYP3A4 and to a lesser extent by CYP2C9; major metabolites are inactive.
Half-LifeApproximately 5 hours.
ExcretionPrimarily excreted in feces (approximately 63%) and urine (approximately 21%) as metabolites.
BioavailabilityApproximately 15% under fasting conditions; reduced with high-fat meal.
Onset of ActionAs early as 15 minutes; effective within 30 minutes.
Peak Plasma Time30-45 minutes under fasting conditions.
Duration of ActionUp to 6 hours.

How It Works

Inhibits PDE5, increasing cGMP levels in corpus cavernosum, leading to smooth muscle relaxation and increased blood flow.

Mechanism Steps

1Sexual stimulation releases nitric oxide (NO) in corpus cavernosum.
2NO activates guanylate cyclase, increasing cGMP levels.
3cGMP causes smooth muscle relaxation and increased blood flow into the penis.
4Avanafil inhibits PDE5, preventing cGMP degradation.
5Elevated cGMP enhances and prolongs smooth muscle relaxation.
6Result: improved erectile function.

💡 How to Take avanair 100 tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of avanair 100 tablet

✅ Common Side Effects

Headache
Flushing
Nasal congestion
Back pain
Myalgia
Dyspepsia

🚨 Serious Side Effects

Priapism
Sudden hearing loss
Non-arteritic anterior ischemic optic neuropathy (NAION)
Hypotension
Myocardial infarction

⚠️ Rare Side Effects

Seizures
Prolonged erection
Allergic reactions
Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Nitrates Major Severe hypotension, syncope, myocardial infarction
Riociguat Major Severe hypotension
Ketoconazole Major Increased avanafil exposure
Ritonavir Major Increased avanafil exposure
Alpha-blockers Moderate Orthostatic hypotension
Antihypertensives Moderate Additive hypotensive effect
Rifampin Moderate Decreased avanafil efficacy
Erythromycin Moderate Increased avanafil exposure
Grapefruit juice Minor Slight increase in avanafil levels
Antacids Minor Possible reduced absorption

🚨 Major Interactions

  • Nitrates
  • Nitric oxide donors
  • Guanylate cyclase stimulators (e.g., riociguat)
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)

⚡ Moderate Interactions

  • Alpha-blockers
  • Antihypertensives
  • CYP3A4 inducers (e.g., rifampin)
  • Moderate CYP3A4 inhibitors (e.g., erythromycin)

🍷 Alcohol Interaction

May increase risk of hypotension and dizziness; avoid excessive alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Concomitant use with nitrates or nitric oxide donors; hypersensitivity; severe hepatic impairment; hypotension; recent stroke or myocardial infarction; use of guanylate cyclase stimulators.

🤱 Lactation Safety

Not indicated for women; excretion in breast milk unknown.

💊 Overdose Management

Supportive measures; monitor blood pressure; consider activated charcoal if recent ingestion.

⏰ Missed Dose

Take as needed; do not take more than once daily.

🔄 Substitutes for avanair 100 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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