ND-HEP Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain or swelling
- Vomiting blood or black, tarry stools
- Difficulty breathing or swelling of face, lips, or throat
- Decreased urine output or extreme fatigue
- Persistent high fever with chills
If experiencing severe symptoms, call emergency services immediately.
What is urdohep sl 140 mg/300 mg tablet used for?
This medicine is a combination of Silymarin and Ursodeoxycholic Acid used to support liver health in chronic liver conditions. It works by protecting liver cells from damage and improving bile flow. It is available as a tablet and is taken orally with meals.
- Generic Name: Silymarin (140mg) + Ursodeoxycholic Acid (300mg)
- Manufacturer: Macleods Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 urdohep sl 140 mg/300 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सिलिमारिन और अर्सोडीऑक्सीकोलिक एसिड का संयोजन है, जिसका उपयोग लीवर से जुड़ी समस्याओं जैसे फैटी लीवर, क्रोनिक हेपेटाइटिस और पित्त नली के रोगों में सहायक उपचार के रूप में किया जाता है। यह लीवर की कोशिकाओं को नुकसान से बचाती है और पित्त के प्रवाह को सुधारती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, दस्त, पेट में असहजता या कब्ज शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको त्वचा या आंखों में पीलापन, गंभीर पेट दर्द, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। इसे चबाएं या तोड़ें नहीं। इस दवा को लेते समय शराब का सेवन पूरी तरह बंद कर दें। नियमित रूप से लीवर फंक्शन टेस्ट करवाते रहें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 urdohep sl 140 mg/300 mg tablet Uses & Benefits
[{"condition":"Non-alcoholic fatty liver disease (NAFLD)","description":"This medicine is used as an adjunct to lifestyle modifications to improve liver enzyme levels and reduce hepatic steatosis in NAFLD.","evidence":"Moderate"},{"condition":"Chronic hepatitis","description":"It may be prescribed as supportive therapy in chronic hepatitis B or C alongside specific antiviral treatment to improve liver function.","evidence":"Limited"},{"condition":"Cholestatic liver disorders","description":"Ursodeoxycholic acid component helps in conditions like primary biliary cholangitis by improving bile flow and reducing bile acid toxicity.","evidence":"Well-established for ursodeoxycholic acid alone"},{"condition":"Drug-induced liver injury","description":"Sometimes used to support liver recovery after hepatotoxic drug exposure, but evidence is not robust.","evidence":"Limited"}]
Off-label uses: [{"condition":"Gallstone dissolution","description":"Ursodeoxycholic acid alone is used off-label for dissolving cholesterol gallstones in selected patients, but the combination with silymarin is not standard for this purpose.","evidence":"Limited"},{"condition":"Alcoholic liver disease","description":"Silymarin has been studied for alcoholic hepatitis and cirrhosis, but evidence is inconclusive and combination use is not established.","evidence":"Insufficient"}]
Primary treatment for: Chronic liver disease
Also treats: Non-alcoholic fatty liver disease, Cholestatic liver disorders, Chronic hepatitis
📋 Drug Information
| Generic Name(s) | Silymarin (140mg) + Ursodeoxycholic Acid (300mg) |
| Brand Name | urdohep sl 140 mg/300 mg tablet |
| Manufacturer | Macleods Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary liver-protective actions. Silymarin acts by inhibiting lipid peroxidation, scavenging free radicals, and stabilizing hepatocyte membranes, thereby reducing liver cell damage. It also stimulates ribosomal RNA synthesis, promoting hepatocyte regeneration. Ursodeoxycholic Acid works by replacing toxic hydrophobic bile acids in the bile acid pool, reducing cholestasis and protecting cholangiocytes from bile acid-induced injury. It also has immunomodulatory effects and reduces apoptosis of hepatocytes.
Mechanism Steps
💡 How to Take urdohep sl 140 mg/300 mg tablet
Strength: Each tablet contains Silymarin 140 mg and Ursodeoxycholic Acid 300 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily, or as directed by your physician. The dose may be adjusted based on the specific liver condition, its severity, and your response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is established, but elderly patients should be monitored for liver and kidney function. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. Use with caution and monitor renal function. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution under medical supervision. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is not established from available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of urdohep sl 140 mg/300 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cyclosporine | Major | |
| Antacids (aluminum) | Moderate | |
| Cholestyramine | Moderate | |
| Ciprofloxacin | Moderate | |
| Oral contraceptives | Minor | |
| Alpha-blockers | Minor |
🚨 Major Interactions
- Warfarin
- Cyclosporine
⚡ Moderate Interactions
- Antacids containing aluminum
- Cholestyramine
- Ciprofloxacin
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Alcohol can worsen liver damage, reduce the effectiveness of the treatment, and increase the risk of gastrointestinal side effects. If you consume alcohol regularly, discuss this with your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to silymarin, ursodeoxycholic acid, or any component of the formulation.","Complete biliary obstruction.","Acute liver failure.","Severe pancreatic disease.","Active peptic ulcer disease."]
⚠️ Warnings & Precautions
["Use with caution in patients with chronic liver disease and portal hypertension.","May cause diarrhea; monitor fluid intake.","Avoid alcohol consumption.","Not recommended for children unless prescribed by a pediatrician.","Elderly patients may require dose adjustment based on liver and kidney function.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Do not exceed the recommended dose."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
There is no specific antidote for overdose. In case of suspected overdose, seek immediate medical attention. Treatment is symptomatic and supportive. Gastric lavage may be considered if ingestion is recent. Monitor liver and kidney function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Swallow the tablet whole with a glass of water; do not crush or chew it. It is best taken with meals to enhance absorption and reduce stomach upset. Avoid alcohol completely while on this medicine, as alcohol can worsen liver damage and reduce the effectiveness of treatment. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially those that affect the liver. Regular monitoring of liver function tests is essential during treatment. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects. Monitor liver and kidney function regularly. Dose adjustment may be needed based on individual response.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. The safety of this combination during pregnancy is not well established.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist about this medicine before any surgery. It may need to be temporarily stopped or adjusted based on your liver function.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. No specific precautions are usually needed, but it is important for your dentist to know your medication history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions are associated with this medicine. However, if you have advanced liver disease, consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to work or drive. However, if you experience dizziness or fatigue, avoid driving or operating heavy machinery until you feel better.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or your condition worsens, contact your doctor immediately. Your doctor will decide whether to continue, adjust, or stop the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored by a doctor. Regular liver function tests are recommended to assess efficacy and detect any potential issues. It may be continued as long as the underlying condition requires treatment and no adverse effects occur.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are cornerstone for managing fatty liver disease.
Evidence: Well-establishedAgents like ademetionine or essential phospholipids may be used in some liver conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, patients with chronic liver disease should receive hepatitis A and B vaccines as recommended by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, continue taking it at your usual times; no specific adjustments are needed. Check customs regulations for carrying prescription medicines. Keep enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several weeks to months to see improvement in liver function tests. Symptomatic relief may occur earlier.
A: Consult your doctor before combining with other liver medicines, as interactions may occur.
A: Pediatric dosing is not established. Consult a pediatrician.
🤔 Common Patient Concerns
🔄 Substitutes for urdohep sl 140 mg/300 mg tablet
View AllAlternative brands with exact same active ingredient:
-
tyrin-forte 140mg/300mg tabletTested & Trusted Pharma Pvt Ltd ₹178.13 40.6% CHEAPER
-
udisil tabletICI Healthcare Pvt Ltd ₹281.25 6.3% CHEAPER
-
vadliv sl 140mg/300mg tabletBiosys Medisciences ₹317.81 5.9% COSTLIER
-
udc-sm 140mg/300mg tabletGlobus Remedies Ltd ₹318.75 6.3% COSTLIER
-
ursodox plus tabletSignova Pharma Pvt Ltd ₹326.00 8.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure all liver diseases.
Fact: This medicine is a supportive treatment and does not cure underlying liver diseases. It should be used as part of a comprehensive treatment plan. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can worsen liver damage and should be strictly avoided while on this medicine. - Myth: More is better; I can double the dose for faster results.
Fact: Taking more than the prescribed dose can increase side effects and is not more effective. Always follow your doctor's prescription.
🔄 Alternative Options
Generic Alternatives
- Silymarin 140 mg + Ursodeoxycholic Acid 300 mg tablet (various manufacturers)
Brand Alternatives
- ND-HEP Tablet