Epitero 50 Injection (Epirubicin 50 mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Fever of 38°C or higher, or chills, which may indicate infection.
- Chest pain, breathlessness, or swelling of the legs, which may indicate heart problems.
- Unusual bruising or bleeding that will not stop.
- Severe mouth sores that make it hard to eat or drink.
- Pain, burning, or redness at the injection site.
- Sudden swelling of the face, lips, or throat, or difficulty breathing.
- Yellowing of the skin or eyes, or dark urine.
- A big drop in urine output or sudden swelling of the legs and face.
If experiencing severe symptoms, call emergency services immediately.
What is Torrence 50mg Injection used for?
This medicine is a prescription chemotherapy injection containing epirubicin 50 mg. It is given into a vein by a healthcare professional to treat several types of cancer, including breast cancer, lymphoma, and leukaemia. It works by damaging the DNA of cancer cells so they cannot divide. It can cause heart and bone marrow side effects, so regular monitoring is needed.
- Generic Name: Epirubicin (50mg)
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Torrence 50mg Injection के बारे में (Hindi Summary)
उपयोग: यह दवा एपिरुबिसिन 50 मिलीग्राम इंजेक्शन है, जिसका उपयोग कैंसर के इलाज के लिए किया जाता है। यह स्तन कैंसर, लिम्फोमा, ल्यूकीमिया, पेट के कैंसर, फेफड़ों के कैंसर, अंडाशय के कैंसर और मूत्राशय के कैंसर में दी जाती है। यह दवा कैंसर कोशिकाओं के डीएनए को नुकसान पहुंचाकर उन्हें बढ़ने और बढ़ने से रोकती है। यह दवा केवल डॉक्टर या प्रशिक्षित नर्स द्वारा नस में इंजेक्शन के रूप में दी जाती है। इलाज के दौरान दिल, खून और लीवर की निगरानी की जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, भूख न लगना, मुंह में छाले, बाल झड़ना, थकान और खून की कोशिकाओं में कमी शामिल हैं। कुछ लोगों का पेशाब एक-दो दिन के लिए लाल या नारंगी दिख सकता है, जो सामान्य है। गंभीर दुष्प्रभावों में दिल की मांसपेशियों को नुकसान, बुखार के साथ सफेद रक्त कोशिकाओं में भारी कमी, गंभीर संक्रमण और गंभीर रक्तस्राव शामिल हैं। अगर सीने में दर्द, सांस लेने में तकलीफ, पैरों में सूजन, बुखार, असामान्य चोट या खून आना हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इलाज से पहले अपने डॉक्टर को दिल की बीमारी, लीवर की बीमारी, पहले हुई रेडियोथेरेपी और किसी भी संक्रमण के बारे में बताएं। इलाज के दौरान खून, लीवर, किडनी और दिल की जांच नियमित रूप से करवानी चाहिए। गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं को यह दवा नहीं दी जानी चाहिए। इलाज के दौरान शराब न पिएं और लाइव वैक्सीन न लगवाएं।
💊 Torrence 50mg Injection Uses & Benefits
[{"condition":"Breast cancer","description":"Used as part of combination chemotherapy for early and advanced breast cancer, often after surgery to reduce the risk of recurrence.","evidence":"Well-established"},{"condition":"Non-Hodgkin lymphoma","description":"Included in multi-drug regimens for several types of lymphoma, including diffuse large B-cell lymphoma.","evidence":"Well-established"},{"condition":"Acute leukaemia","description":"Used in combination regimens for acute lymphoblastic leukaemia and acute myeloid leukaemia.","evidence":"Well-established"},{"condition":"Gastric cancer","description":"Used in combination chemotherapy for advanced or operable stomach cancer.","evidence":"Established"},{"condition":"Small cell lung cancer","description":"Part of combination chemotherapy for extensive-stage small cell lung cancer.","evidence":"Established"},{"condition":"Ovarian cancer","description":"Used in some combination regimens for ovarian cancer, especially when platinum agents are included.","evidence":"Established"},{"condition":"Bladder cancer","description":"Given as part of chemotherapy for advanced or muscle-invasive bladder cancer.","evidence":"Established"},{"condition":"Soft tissue sarcoma","description":"Used in selected combination regimens for advanced soft tissue sarcomas.","evidence":"Limited"}]
Off-label uses: [{"condition":"Hepatocellular carcinoma","description":"Sometimes used in transarterial chemoembolization or combination regimens for liver cancer.","evidence":"Limited"},{"condition":"Thymic carcinoma","description":"Occasionally included in combination chemotherapy for advanced thymic tumours.","evidence":"Limited"},{"condition":"Kaposi sarcoma","description":"Rarely used in selected patients when other treatments are not suitable.","evidence":"Limited"}]
Primary treatment for: Breast cancer
Also treats: Non-Hodgkin lymphoma, Acute leukaemia, Gastric cancer, Small cell lung cancer, Ovarian cancer, Bladder cancer
📋 Drug Information
| Generic Name(s) | Epirubicin (50mg) |
| Brand Name | Torrence 50mg Injection |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | vial of 1 Injection (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store this medicine in its original container in a refrigerator at 2–8°C, protected from light. Do not freeze. Follow the storage instructions on the label and any instructions given by the pharmacy. |
| Shelf Life | The shelf life is usually 24 months from the date of manufacture when stored as directed. Once the vial is opened or reconstituted, use it within the time specified by the manufacturer and the hospital pharmacy. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine belongs to the anthracycline class of chemotherapy agents. It works in two main ways: it intercalates between the base pairs of DNA, which physically blocks the enzymes that copy and repair DNA, and it stabilises the complex between DNA and topoisomerase II, trapping the enzyme and causing permanent DNA breaks. These actions stop cancer cells from dividing and trigger programmed cell death. The medicine also generates free radicals that damage cell membranes and DNA, which adds to its anti-cancer effect but also explains some of its toxicity to the heart.
Mechanism Steps
💡 How to Take Torrence 50mg Injection
Strength: Injection, 50 mg
Dosage Information
| Adult Dosage | The dose of this medicine is decided by an oncology specialist and is based on the type of cancer, the stage of disease, the treatment regimen, the patient's body surface area, and how well the liver, kidneys, and bone marrow are working. It is usually given as a single intravenous injection or infusion every three weeks, often as part of a combination of several chemotherapy medicines. The total lifetime dose is limited to reduce the risk of heart damage. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Older adults may be more sensitive to the side effects of this medicine, especially heart toxicity and bone marrow suppression. The doctor will assess heart, liver, kidney, and bone marrow function before deciding the dose, and may reduce the dose or choose a different treatment if needed. |
| Renal Impairment | Kidney function should be checked before treatment. Dose adjustment is usually not needed for mild kidney impairment, but caution is advised in moderate to severe kidney disease. The doctor will decide the dose based on kidney function and the overall treatment plan. |
| Hepatic Impairment | This medicine is metabolised in the liver, and the dose may need to be reduced in patients with liver impairment. Liver function tests are checked before and during treatment, and the doctor will adjust the dose based on the results. |
| Maximum Daily Dose | The maximum dose is determined by the treating oncologist based on body surface area and the total lifetime limit to reduce heart toxicity. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Torrence 50mg Injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Doxorubicin | Major | |
| Trastuzumab | Major | |
| Live vaccines | Major | |
| Paclitaxel | Major | |
| Cimetidine | Moderate | |
| Warfarin | Moderate | |
| Phenytoin | Moderate | |
| Other bone marrow suppressing medicines | Moderate | |
| Paracetamol | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Other anthracyclines (for example, doxorubicin or daunorubicin)
- Trastuzumab
- Live vaccines
- Paclitaxel
- Cimetidine
⚡ Moderate Interactions
- Warfarin and other blood thinners
- Other bone marrow suppressing medicines
- Radiotherapy to the chest
- Phenytoin
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. It can worsen nausea, mouth sores, and liver strain, and it may increase the risk of bleeding when blood counts are low. If you drink alcohol regularly, discuss this with your doctor before starting treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe heart disease or recent heart attack","Very low blood counts","Active serious infection","Severe liver impairment","Previous severe allergic reaction to epirubicin or other anthracyclines","Pregnancy or breastfeeding","Previous treatment with high total doses of anthracyclines"]
⚠️ Warnings & Precautions
["This medicine must only be given by a healthcare professional trained in chemotherapy.","Heart function should be checked before and during treatment.","Blood counts should be checked before each cycle.","Avoid live vaccines during treatment.","Use effective contraception during treatment and for a period afterwards.","Tell your doctor if you have liver or kidney problems.","Report any pain or burning at the injection site immediately.","Avoid alcohol during treatment."]
🤱 Lactation Safety
This medicine passes into breast milk and could harm a nursing baby. Breastfeeding should be stopped before treatment begins and should not be restarted until the doctor says it is safe.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. Overdose can cause severe bone marrow suppression, heart toxicity, and severe mouth and gut damage. Treatment is supportive and may include hospital admission, blood transfusions, antibiotics, and heart monitoring. If an overdose is suspected, contact emergency medical services immediately.
⏰ Missed Dose
This medicine is given by a healthcare professional, so a missed dose usually means a missed appointment. Contact your treatment centre as soon as possible to reschedule. Do not try to make up for a missed dose on your own, and do not take extra doses.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a setting where resuscitation equipment is available. Patients should tell their doctor about any heart problems, previous radiotherapy to the chest, liver disease, or current infections before receiving this medicine. Blood tests to check blood counts, liver function, and kidney function are usually done before each cycle, and heart function is checked with tests such as an echocardiogram or a MUGA scan before and during treatment. Because this medicine can harm an unborn baby, effective contraception is essential for both men and women during treatment and for a period afterwards as advised by the treating team. Breastfeeding should be stopped before treatment begins. Patients should avoid live vaccines during treatment and should not receive this medicine if they have a very low blood count or an active serious infection unless the doctor decides it is safe.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the side effects of this medicine, especially heart toxicity and bone marrow suppression. The doctor will check heart, liver, kidney, and bone marrow function before deciding the dose and may reduce it if needed.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Both men and women should use effective contraception during treatment and for a period afterwards as advised by their doctor. If you are planning a pregnancy, discuss it with your oncologist before starting treatment. Fertility counselling may be helpful before treatment begins.
🏥 Post-Surgery Considerations
This medicine is often given after surgery for breast cancer and some other cancers to reduce the risk of the cancer returning. Your doctor will decide the timing based on your recovery from surgery and the type of cancer.
🦷 Dental Procedures
Tell your dentist that you are receiving this medicine before any dental work. Chemotherapy can increase the risk of infection and bleeding, so dental procedures may need to be timed around your treatment cycles. Good mouth care is important during treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Gentle exercise such as walking or light stretching can help with tiredness and mood, but avoid strenuous activity when your blood counts are low or if you feel unwell. Talk to your doctor before starting any new exercise programme during chemotherapy.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause tiredness, nausea, and low blood counts, which may affect your ability to work during treatment. Many people need to take time off or reduce their working hours. Discuss your treatment schedule with your employer and plan rest periods. Avoid driving or operating machinery if you feel dizzy or unwell.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your oncologist will decide when to stop based on your response to treatment, side effects, and overall health. If you experience severe side effects such as heart problems, very low blood counts, or a severe allergic reaction, your doctor may stop or change the treatment. Always discuss any concerns with your care team before making changes.
📅 Long-Term Use Effects
Long-term effects of this medicine can include heart muscle damage that may lead to heart failure, a small risk of a secondary cancer such as leukaemia, and effects on fertility. Regular follow-up with your oncology team is important to monitor your heart, blood counts, and overall health. Some patients may experience persistent tiredness or changes in memory and concentration after chemotherapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the cancer type and stage, other chemotherapy agents or regimens may be used instead of or in addition to this medicine.
Evidence: Well-establishedSome cancers may be treated with targeted medicines that act on specific molecules in cancer cells.
Evidence: Well-establishedImmunotherapy medicines help the body's immune system fight cancer and may be an option for some patients.
Evidence: Well-establishedRadiotherapy may be used alone or with chemotherapy for certain cancers.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because of the risk of serious infection. Inactivated vaccines may be given, but the response may be reduced. Discuss any vaccinations with your doctor before receiving them.
📦 Storage Guide
✅ DO
Store in the refrigerator at 2–8°C
❌ DON'T
Do not freeze
✅ DO
Keep in the original container and carton
❌ DON'T
Do not transfer to another container
✅ DO
Protect from light
❌ DON'T
Do not leave in direct sunlight
✅ DO
Follow the hospital pharmacy's instructions for reconstituted solution
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
If you need to travel while receiving this medicine, carry it in its original packaging with the prescription and a letter from your doctor explaining what it is and why you need it. This medicine is usually stored in a refrigerator at 2–8°C, so use a cool bag or arrange with your treatment centre for proper storage during travel. Check the customs rules of your destination country for carrying prescription medicines. Plan your travel around your treatment schedule and discuss any time zone changes with your doctor.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is given by a healthcare professional as an injection into a vein, usually in the arm or through a central line. It is given slowly over several minutes.
A: The schedule depends on your treatment plan. It is often given once every three weeks, but your doctor will decide the exact schedule.
A: Common side effects include nausea, vomiting, hair loss, mouth sores, tiredness, and low blood counts. Your care team can help manage these.
A: This medicine can cause tiredness or dizziness. Do not drive or operate machinery if you feel unwell.
A: This medicine can harm an unborn baby. It should not be used during pregnancy unless the doctor decides the benefit clearly outweighs the risk. Use effective contraception during treatment.
🤔 Common Patient Concerns
🔄 Substitutes for Torrence 50mg Injection
View AllAlternative brands with exact same active ingredient:
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anthracin 50mg injectionDabur India Ltd ₹60.89 97.5% CHEAPER
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erubin 50mg injectionRPG Life Sciences Ltd ₹597.00 75.1% CHEAPER
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epineon 50mg injectionNeon Laboratories Ltd ₹637.63 73.4% CHEAPER
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biorubin 50mg injectionBiochem Pharmaceutical Industries ₹900.85 62.5% CHEAPER
-
innorubicin 50mg injectionInnova Formulations Pvt Ltd ₹931.83 61.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a tablet at home.
Fact: This medicine is an injection that must be given by a healthcare professional in a clinic or hospital. - Myth: Hair loss from this medicine is permanent.
Fact: Hair usually grows back after treatment is finished, although it may take several months. - Myth: This medicine is safe for everyone with cancer.
Fact: This medicine is not suitable for people with severe heart disease, very low blood counts, active serious infection, or severe liver problems. - Myth: You can stop this medicine whenever you feel better.
Fact: Stopping chemotherapy without medical advice can allow the cancer to return. Always discuss any changes with your oncologist.
🔄 Alternative Options
Generic Alternatives
- Epirubicin hydrochloride injection
Brand Alternatives
- Epitero 50 injection