Ibuprofen + Tizanidine Soft Gelatin Capsule: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit, or black tarry stools
- Severe abdominal pain or persistent vomiting
- Chest pain, shortness of breath, or difficulty breathing
- Severe headache with visual changes or confusion
- Sudden swelling of face, lips, tongue, or throat
- Yellowing of skin or eyes, or dark urine
- Decreased urine output or swelling in legs
- Unusual bruising or bleeding
- Severe dizziness or fainting
- Hallucinations or unusual behavior
If experiencing severe symptoms, call emergency services immediately.
What is Tidifen 400mg/2mg Tablet used for?
This medicine is a prescription combination of Ibuprofen 400 mg and Tizanidine 2 mg used for short-term relief of painful muscle spasms and musculoskeletal pain. It works by reducing inflammation and pain (ibuprofen) and relaxing muscles (tizanidine). It is usually taken two to three times daily with food. It can cause drowsiness and dizziness, so avoid driving. Do not use without a doctor's prescription.
- Generic Name: Ibuprofen (400mg) + Tizanidine (2mg)
- Manufacturer: Redson Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Tidifen 400mg/2mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इबुप्रोफेन 400 मिलीग्राम और टिज़ानिडीन 2 मिलीग्राम का संयोजन है। इसका उपयोग मांसपेशियों में ऐंठन और दर्द के इलाज के लिए किया जाता है, जैसे कि कमर दर्द, गर्दन दर्द, और चोट के बाद होने वाली मांसपेशियों की ऐंठन। यह दर्द और सूजन को कम करने के साथ-साथ मांसपेशियों को आराम देती है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा को लेते समय शराब का सेवन बिल्कुल न करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, थकान, जी मिचलाना, पेट दर्द, और कब्ज शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, गुर्दे की समस्या, यकृत की समस्या, और गंभीर एलर्जी प्रतिक्रिया शामिल हैं। यदि आपको काला या खूनी मल, खून की उल्टी, तेज पेट दर्द, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या पेशाब कम आना जैसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से मात्रा न बढ़ाएं। इसे भोजन या दूध के साथ लें। शराब का सेवन बिल्कुल न करें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं और मशीनरी न चलाएं। अचानक उठने से बचें क्योंकि इससे चक्कर आ सकते हैं। अपने डॉक्टर को अपनी सभी दवाओं और स्वास्थ्य समस्याओं के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 Tidifen 400mg/2mg Tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Short-term relief of pain and spasm in conditions such as back pain, neck pain, and myofascial pain syndrome.","evidence":"Well-established for short-term use"},{"condition":"Post-traumatic muscle spasm","description":"Used after injuries such as strains and sprains to reduce pain and muscle tightness.","evidence":"Commonly used, evidence from clinical experience"},{"condition":"Post-operative muscle spasm","description":"May be used short-term after certain surgeries to relieve muscle spasm and pain.","evidence":"Limited, individualized use"},{"condition":"Tension headache with muscle spasm","description":"May provide relief when headache is associated with neck and shoulder muscle spasm.","evidence":"Limited"}]
Off-label uses: [{"condition":"Fibromyalgia pain","description":"Sometimes used off-label for short-term relief of muscle pain and spasm in fibromyalgia.","evidence":"Limited"},{"condition":"Temporomandibular joint disorder","description":"May be used off-label for jaw muscle spasm and pain.","evidence":"Limited"}]
Primary treatment for: Musculoskeletal pain with muscle spasm
Also treats: Back pain, Neck pain, Myofascial pain syndrome, Post-traumatic muscle spasm, Post-operative muscle spasm
📋 Drug Information
| Generic Name(s) | Ibuprofen (400mg) + Tizanidine (2mg) |
| Brand Name | Tidifen 400mg/2mg Tablet |
| Manufacturer | Redson Laboratories Pvt Ltd |
| Packaging / Form | strip of 10 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Ibuprofen reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing the production of prostaglandins that mediate pain, inflammation, and fever. Tizanidine is a centrally acting alpha-2 adrenergic agonist that reduces the release of excitatory neurotransmitters from spinal interneurons, thereby decreasing muscle tone and spasm. The combination provides both anti-inflammatory analgesia and muscle relaxation.
Mechanism Steps
💡 How to Take Tidifen 400mg/2mg Tablet
Strength: Soft gelatin capsule containing Ibuprofen 400 mg and Tizanidine 2 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule taken orally two to three times daily as needed for pain and muscle spasm, or as directed by your doctor. The maximum recommended dose is generally one capsule three times daily, but this may vary. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Do not exceed the prescribed dose. Take with food or milk to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of this medicine, especially drowsiness, dizziness, and kidney effects. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Ibuprofen should be avoided in severe kidney disease (creatinine clearance <30 mL/min). Tizanidine dose may need reduction. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Tizanidine is extensively metabolized in the liver; dose reduction may be necessary. Ibuprofen should be avoided in severe liver disease. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is generally one capsule three times daily (1200 mg ibuprofen and 6 mg tizanidine), but this must be individualized by a qualified clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Tidifen 400mg/2mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Fluvoxamine | Major | |
| Ciprofloxacin | Major | |
| Aspirin | Major | |
| Benzodiazepines | Major | |
| Opioids | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| Methotrexate | Moderate |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs including aspirin
- CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
- Antihypertensives
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
⚡ Moderate Interactions
- Corticosteroids
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- ACE inhibitors and ARBs
- Lithium
- Methotrexate
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the sedative effects of tizanidine and the risk of gastrointestinal bleeding and ulceration from ibuprofen. It can also worsen dizziness and impair motor skills, increasing the risk of accidents.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or gastrointestinal bleeding","Severe kidney disease (e.g., creatinine clearance
⚠️ Warnings & Precautions
["May cause drowsiness and dizziness; avoid driving or operating machinery until you know how it affects you.","May cause low blood pressure; stand up slowly to avoid falls.","Do not use with other NSAIDs or alcohol.","Use with caution in the elderly due to increased risk of side effects.","May cause kidney or liver problems; periodic monitoring may be needed.","Do not stop suddenly if you have been on long-term therapy; consult your doctor.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","May interact with many medicines; always inform your doctor about all medications you take."]
🤱 Lactation Safety
Ibuprofen is considered compatible with breastfeeding as it passes into breast milk in small amounts. Tizanidine may pass into breast milk and could cause sedation in the infant. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose can cause severe drowsiness, dizziness, slow heart rate, low blood pressure, nausea, vomiting, abdominal pain, and gastrointestinal bleeding. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be used if presented early. Monitor vital signs, kidney and liver function, and manage complications.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it more often than directed. Take it with food or milk to reduce stomach upset. Avoid alcohol completely while taking this medicine because it increases drowsiness and the risk of stomach bleeding. Do not drive or operate heavy machinery until you know how this medicine affects you, as it can cause drowsiness and dizziness. Stand up slowly to avoid falls due to low blood pressure. Do not take other NSAIDs, aspirin, or blood thinners without consulting your doctor. Inform your doctor if you have kidney, liver, heart, or stomach problems, or if you are pregnant, planning pregnancy, or breastfeeding. Do not stop this medicine suddenly without medical advice, especially if you have been taking it for a long time. Keep all follow-up appointments and report any unusual symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of side effects from this medicine, including drowsiness, dizziness, low blood pressure, kidney problems, and gastrointestinal bleeding. Start with a lower dose and monitor closely. Regular monitoring of kidney and liver function, blood pressure, and blood counts is recommended. Avoid driving and activities requiring alertness until you know how the medicine affects you.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Ibuprofen may affect ovulation and is not recommended during the third trimester. Tizanidine has limited safety data in pregnancy. Your doctor may recommend alternative treatments. Use effective contraception while taking this medicine if you are of childbearing age and not planning pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used short-term after surgery to relieve muscle spasm and pain. However, it can increase bleeding risk and should be used with caution after surgical procedures. Inform your surgeon and anesthesiologist about all medicines you are taking. Do not start this medicine after surgery without your doctor's approval.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. Ibuprofen can increase bleeding risk during dental surgery. Tizanidine can cause drowsiness and dry mouth. Your dentist may recommend stopping the medicine temporarily or adjusting the dose. Do not stop without consulting your prescribing doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience drowsiness and dizziness, which can affect your coordination and balance. Avoid high-impact or strenuous exercises until you know how the medicine affects you. Gentle stretching and low-impact activities like walking or swimming are generally safe. Always warm up before exercise and stop if you feel dizzy or unwell. Consult your doctor or physiotherapist for an exercise plan tailored to your condition.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and low blood pressure, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves operating heavy equipment. Take frequent breaks if you have a desk job and practice good posture. Do not consume alcohol at work events while on this medicine.
🛑 When to Stop This Medicine
Stop this medicine and consult your doctor immediately if you experience serious side effects such as black or bloody stools, severe abdominal pain, chest pain, difficulty breathing, swelling of face or throat, yellowing of eyes or skin, or decreased urine output. Do not stop this medicine suddenly if you have been taking it for a long time, as it may cause withdrawal symptoms like increased muscle spasm, anxiety, and tremors. Always consult your doctor before stopping.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney problems, liver enzyme elevation, and cardiovascular events. Tizanidine can cause dependence and withdrawal symptoms if stopped suddenly. Regular monitoring of blood pressure, kidney and liver function, and blood counts is recommended for prolonged use. Use the lowest effective dose for the shortest duration possible.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and muscle spasm by improving strength, flexibility, and posture.
Evidence: Well-establishedApplying heat or cold packs to affected muscles can help reduce pain and spasm.
Evidence: Commonly used, evidence from clinical experienceMay provide relief for some patients with chronic musculoskeletal pain.
Evidence: LimitedRelaxation, meditation, and biofeedback may help reduce muscle tension and pain perception.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking. If you have a fever or acute illness, vaccination may be postponed until you recover.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless specified.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss and to maintain temperature control. Store at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking it at the same intervals as prescribed; consult your doctor if adjustments are needed. Check local customs regulations regarding prescription medicines before travel. Do not pack it in checked baggage if you need doses during the journey.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain and muscle spasm within 30 to 60 minutes after taking it. The effect may last for 4 to 6 hours.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset and heartburn.
A: No, alcohol should be completely avoided as it increases drowsiness, dizziness, and the risk of stomach bleeding.
A: This medicine is usually prescribed for short-term use, typically up to 7 days. Longer use requires medical supervision and monitoring.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how it affects you.
A: This medicine is not recommended during the third trimester of pregnancy. Consult your doctor if you are pregnant or planning pregnancy.
A: Do not take other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.
🤔 Common Patient Concerns
🔄 Substitutes for Tidifen 400mg/2mg Tablet
View AllAlternative brands with exact same active ingredient:
-
lumbril tabletYash Pharma Laboratories Pvt Ltd ₹19.29 54.3% CHEAPER
-
brufen mr soft gelatin capsuleAbbott ₹20.96 50.3% CHEAPER
-
Treza MR 400mg/2mg CapsuleDestin Laboratories Pvt Ltd ₹36.56 13.3% CHEAPER
-
bruzen mr 400mg/2mg tabletAbbott ₹39.38 6.7% CHEAPER
-
tizapam 400 mg/2 mg tabletEskag Pharma Pvt Ltd ₹49.69 17.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: This medicine is specifically for musculoskeletal pain with muscle spasm. It is not appropriate for all types of pain and should only be used as prescribed. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases the risk of drowsiness, dizziness, and stomach bleeding. It should be completely avoided. - Myth: This medicine is not habit-forming.
Fact: Tizanidine can cause dependence and withdrawal symptoms if stopped suddenly after long-term use. It should be tapered under medical supervision. - Myth: More medicine means faster relief.
Fact: Taking more than the prescribed dose increases the risk of serious side effects and does not provide faster relief.
🔄 Alternative Options
Generic Alternatives
- Ibuprofen + Tizanidine combination capsules (various manufacturers)
Brand Alternatives
- Brufen MR Soft Gelatin Capsule