R-Cin Capsule (Rifampicin 150mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Dark-colored urine or pale stools
- Severe abdominal pain, especially in the upper right area
- Persistent nausea and vomiting
- Unusual bruising or bleeding
- Fever, sore throat, or mouth ulcers
- Difficulty breathing or swelling of the face, lips, or throat
- Decreased urine output or swelling in the legs
- Severe headache with visual changes
- Confusion or mood changes
If experiencing severe symptoms, call emergency services immediately.
What is Ticin 150mg Tablet used for?
This medicine is an antibiotic used to treat tuberculosis, leprosy, and other mycobacterial infections. It works by stopping the bacteria from making proteins. It is always used in combination with other antibiotics to prevent resistance. Common side effects include nausea, vomiting, and orange-red discoloration of body fluids. Serious side effects include liver toxicity and severe allergic reactions. It should be taken on an empty stomach and alcohol should be avoided.
- Generic Name: Rifampicin (150mg)
- Manufacturer: Themis Medicare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Ticin 150mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा रिफैम्पिसिन नामक एंटीबायोटिक है, जिसका उपयोग मुख्य रूप से तपेदिक (टीबी), कुष्ठ रोग और अन्य माइकोबैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह बैक्टीरिया को प्रोटीन बनाने से रोककर उन्हें मार देती है। यह दवा हमेशा अन्य एंटीबायोटिक्स के साथ मिलाकर दी जाती है ताकि बैक्टीरिया में प्रतिरोध न विकसित हो। यह दवा खाली पेट लेनी चाहिए, आमतौर पर भोजन से 1 घंटा पहले या 2 घंटे बाद। इसके सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द और पेशाब का रंग नारंगी-लाल होना शामिल है। गंभीर दुष्प्रभावों में लीवर की समस्या और एलर्जी प्रतिक्रिया हो सकती है। इस दवा को लेते समय शराब का सेवन नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, भूख न लगना, सिरदर्द, चक्कर आना और पेशाब, पसीना व आंसू का रंग नारंगी-लाल होना शामिल है। यह रंग परिवर्तन हानिरहित है लेकिन कॉन्टैक्ट लेंस और कपड़ों पर दाग लगा सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन तुरंत डॉक्टर से संपर्क करने की आवश्यकता होती है। इनमें गंभीर एलर्जी प्रतिक्रिया (चकत्ते, सूजन, सांस लेने में कठिनाई), लीवर की समस्या (पीलिया, गहरे रंग का पेशाब), रक्त विकार (असामान्य रक्तस्राव या चोट लगना), और गुर्दे की समस्या शामिल हैं। यदि आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: इस दवा को शुरू करने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और दवाओं के बारे में बताएं। यह दवा कई अन्य दवाओं के साथ परस्पर क्रिया कर सकती है, इसलिए अपनी सभी दवाओं की सूची दें। इस दवा को लेते समय शराब का सेवन न करें क्योंकि इससे लीवर को नुकसान का खतरा बढ़ जाता है। यदि आप गर्भनिरोधक गोलियां ले रही हैं, तो अतिरिक्त गैर-हार्मोनल तरीका अपनाएं क्योंकि यह दवा उनकी प्रभावशीलता को कम कर सकती है। इस दवा से चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीनरी चलाने से बचें जब तक आप जान न लें कि यह आपको कैसे प्रभावित करती है। अपने डॉक्टर के सभी अपॉइंटमेंट्स पर जाएं और लीवर फंक्शन टेस्ट करवाएं।
💊 Ticin 150mg Tablet Uses & Benefits
[{"condition":"Tuberculosis (TB)","description":"This medicine is a first-line agent used in combination with other antitubercular drugs for the treatment of active TB and latent TB infection.","evidence":"Well-established"},{"condition":"Leprosy","description":"It is used as part of multidrug therapy for leprosy to kill Mycobacterium leprae.","evidence":"Well-established"},{"condition":"Atypical mycobacterial infections","description":"Used in combination regimens for infections caused by Mycobacterium avium complex and other atypical mycobacteria, especially in immunocompromised patients.","evidence":"Established"},{"condition":"Meningococcal carriers","description":"Used to eliminate Neisseria meningitidis from the nasopharynx in close contacts of patients with meningococcal disease.","evidence":"Well-established"},{"condition":"Staphylococcal infections","description":"Sometimes used in combination with other antibiotics for serious staphylococcal infections, including prosthetic joint infections.","evidence":"Limited"}]
Off-label uses: [{"condition":"Brucellosis","description":"Used in combination with doxycycline for the treatment of brucellosis, although this is not a primary labeled indication.","evidence":"Limited"},{"condition":"Legionnaires' disease","description":"Occasionally used in combination with other antibiotics for severe Legionella infections.","evidence":"Limited"}]
Primary treatment for: Tuberculosis
Also treats: Leprosy, Atypical mycobacterial infections, Meningococcal carriage, Staphylococcal infections
📋 Drug Information
| Generic Name(s) | Rifampicin (150mg) |
| Brand Name | Ticin 150mg Tablet |
| Manufacturer | Themis Medicare Ltd |
| Packaging / Form | strip of 10 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature, between 15°C and 30°C (59°F to 86°F). Keep it away from direct sunlight and moisture. Do not store it in the bathroom. Keep it in its original container, tightly closed. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the packaging before use. Do not use if expired. |
| WHO Guideline | The World Health Organization (WHO) recommends rifampicin as a first-line agent in the treatment of tuberculosis and leprosy. It is included in the WHO Model List of Essential Medicines. For tuberculosis, it is used in combination with other drugs in both intensive and continuation phases. For leprosy, it is part of multidrug therapy. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recommends rifampicin as part of the standard treatment regimen for tuberculosis in India, in accordance with national guidelines. It is also used in the treatment of leprosy as per national programs. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the activity of bacterial DNA-dependent RNA polymerase, an enzyme essential for the synthesis of RNA from DNA. By binding to the beta subunit of this enzyme, it blocks the elongation of RNA chains, thereby preventing the bacteria from producing proteins necessary for their survival and replication. This medicine is bactericidal, meaning it kills the bacteria. It is effective against a wide range of mycobacteria, including Mycobacterium tuberculosis, Mycobacterium leprae, and several other bacteria. Because bacteria can develop resistance if this medicine is used alone, it is always combined with other antibiotics in clinical practice.
Mechanism Steps
💡 How to Take Ticin 150mg Tablet
Strength: This medicine is available as a capsule containing 150 mg of rifampicin. It is an immediate-release formulation.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for tuberculosis is 10 mg per kg of body weight, up to a maximum of 600 mg, taken once daily on an empty stomach. For other infections, the dose may vary. For meningococcal carriers, the recommended dose is 600 mg twice daily for 2 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially liver toxicity. Dose adjustments may be necessary based on liver and kidney function. Close monitoring is recommended. |
| Renal Impairment | No specific dose adjustment is usually required for mild to moderate renal impairment. However, in severe renal impairment, caution is advised, and monitoring is recommended. Consult your doctor for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in severe liver disease. In patients with mild to moderate liver impairment, dose reduction may be necessary, and liver function should be monitored closely. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose for adults is 600 mg. For children, the maximum daily dose is not established from available information. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Ticin 150mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Oral contraceptives | Major | |
| Protease inhibitors | Major | |
| Azole antifungals | Major | |
| Corticosteroids | Moderate | |
| Phenytoin | Moderate | |
| Digoxin | Moderate | |
| Theophylline | Moderate | |
| Antacids | Minor | |
| Food | Minor |
🚨 Major Interactions
- Warfarin
- Oral contraceptives
- Protease inhibitors (e.g., ritonavir, saquinavir)
- Non-nucleoside reverse transcriptase inhibitors (e.g., nevirapine, efavirenz)
- Azole antifungals (e.g., ketoconazole, itraconazole)
- Calcium channel blockers (e.g., verapamil, diltiazem)
⚡ Moderate Interactions
- Corticosteroids (e.g., prednisone)
- Oral hypoglycemics (e.g., sulfonylureas)
- Phenytoin
- Digoxin
- Theophylline
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both alcohol and this medicine can stress the liver, and combining them increases the risk of liver damage. Alcohol may also worsen side effects such as dizziness and drowsiness. If you have a history of alcohol abuse, inform your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to rifampicin or other rifamycins","Severe liver disease or acute hepatitis","Concurrent use with certain protease inhibitors (e.g., saquinavir/ritonavir) due to significant drug interactions","Concurrent use with live bacterial vaccines (may reduce efficacy)"]
⚠️ Warnings & Precautions
["This medicine can cause liver toxicity; monitor liver function regularly.","It may cause orange-red discoloration of body fluids; this is harmless but can stain contact lenses and clothing.","This medicine can reduce the effectiveness of hormonal contraceptives; use backup contraception.","It may cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not use this medicine for minor infections; it is reserved for serious mycobacterial infections.","Complete the full course of therapy as prescribed, even if you feel better, to prevent resistance.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","This medicine can interact with many drugs; provide a complete list of medications to your doctor."]
🤱 Lactation Safety
This medicine is excreted in breast milk in small amounts. It is generally considered compatible with breastfeeding, but the infant should be monitored for potential side effects such as jaundice. The benefits of breastfeeding should be weighed against the potential risks. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine can cause nausea, vomiting, abdominal pain, headache, dizziness, and potentially liver damage. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if the overdose is recent. Monitor liver function and vital signs closely.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Before you start taking this medicine, tell your doctor if you are allergic to rifampicin or any other medicines. Inform your doctor about all your medical conditions, especially liver or kidney disease, diabetes, or a history of alcohol abuse. This medicine can interact with many other drugs, including birth control pills, blood thinners, and some HIV medications, so provide a complete list of your medications. While taking this medicine, your doctor will likely monitor your liver function through regular blood tests. Avoid alcohol consumption as it increases the risk of liver damage. If you are using hormonal contraceptives, use an additional non-hormonal method, as this medicine can make them less effective. This medicine may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you. Do not stop taking this medicine without consulting your doctor, even if you feel better, as stopping early can lead to resistance and treatment failure. Keep all appointments with your healthcare provider.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of this medicine, particularly liver toxicity and drug interactions. Liver and kidney function should be monitored closely. Dose adjustments may be necessary based on organ function. Elderly patients should also be monitored for falls due to dizziness. Always consult a doctor for personalized dosing and monitoring.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting or continuing this medicine. This medicine is classified as Pregnancy Category C and should be used during pregnancy only if clearly needed. Effective contraception is recommended while taking this medicine, as it can harm the fetus. If you become pregnant while taking this medicine, contact your doctor immediately.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It can interact with certain anesthetic agents and other medications used during surgery. Your doctor may need to adjust your treatment plan. Do not stop taking this medicine without consulting your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine can interact with certain antibiotics and anesthetics used in dentistry. It may also cause dry mouth or other oral side effects. Your dentist may need to take precautions or adjust your treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. If you experience dizziness, avoid activities that require mental alertness. Light to moderate exercise is generally safe, but listen to your body and rest if you feel unwell. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or headache, which can affect your ability to drive or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. The need for regular follow-up appointments and monitoring may require time off work. Discuss your treatment schedule with your employer to accommodate any necessary adjustments. Most people can continue their normal daily activities with some modifications.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping early can lead to treatment failure, relapse of the infection, and development of drug-resistant bacteria. If you experience severe side effects, contact your doctor immediately; they may adjust your treatment or switch you to a different medicine. Always complete the full course as prescribed.
📅 Long-Term Use Effects
Long-term use of this medicine is generally required for the treatment of tuberculosis and other mycobacterial infections. The main concern with long-term use is liver toxicity, which requires regular monitoring of liver function tests. Other potential long-term effects include blood disorders and drug interactions. It is important to attend all follow-up appointments and report any new symptoms to your doctor. With proper monitoring, the benefits of treatment usually outweigh the risks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For patients who cannot tolerate this medicine, alternative regimens may be used, but they are often less effective or have more side effects.
Evidence: Well-establishedAdequate nutrition can help support the immune system during treatment, but it is not a substitute for antibiotics.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines, such as the BCG vaccine. If you are scheduled to receive any live vaccine, inform your doctor that you are taking this medicine. In general, live vaccines should be avoided during treatment with this medicine. Inactivated vaccines are generally safe to administer.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust your dosing schedule gradually to maintain consistent intervals; consult your doctor for specific advice. Carry enough supply for your entire trip, plus extra in case of delays. Check customs regulations for carrying prescription medicines in your destination country. If you need refrigeration, use a cool pack, but this medicine typically does not require refrigeration.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within a few days, but it may take several weeks to months to fully treat the infection. For tuberculosis, you may start feeling better within a few weeks, but you must complete the full course as prescribed.
A: No, you must complete the full course of treatment as prescribed, even if you feel better. Stopping early can lead to the infection returning and the bacteria becoming resistant to the medicine.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
A: No, you should avoid alcohol while taking this medicine because it increases the risk of liver damage. Both alcohol and this medicine can stress the liver.
A: Yes, this medicine can reduce the effectiveness of birth control pills. You should use an additional non-hormonal method of contraception while taking this medicine.
A: This medicine is classified as Pregnancy Category C. It should be used during pregnancy only if clearly needed and under medical supervision. Consult your doctor for personalized advice.
A: It is best to take this medicine on an empty stomach, at least 1 hour before or 2 hours after a meal, because food reduces its absorption.
A: Common side effects include nausea, vomiting, abdominal pain, headache, dizziness, and orange-red discoloration of urine, sweat, and tears. These are usually mild and temporary.
🤔 Common Patient Concerns
🔄 Substitutes for Ticin 150mg Tablet
View AllAlternative brands with exact same active ingredient:
-
rifampila 150mg capsuleAlbert David Ltd ₹5.46 60.5% CHEAPER
-
rf 150mg tabletSunij Pharma Pvt Ltd ₹14.42 4.3% COSTLIER
-
Tibrif 150mg TabletAgron Remedies Pvt Ltd ₹18.75 35.6% COSTLIER
-
Rifacilin 150mg CapsulePCI Pharmaceuticals ₹23.44 69.5% COSTLIER
-
r-cin capsuleLupin Ltd ₹24.38 76.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once you feel better.
Fact: You must complete the full course as prescribed, even if you feel better, to prevent the infection from returning and to avoid resistance. - Myth: This medicine is safe to take with any other medication.
Fact: This medicine interacts with many drugs, including birth control pills, blood thinners, and HIV medications. Always inform your doctor about all medicines you take. - Myth: The orange-red color of urine is a sign of kidney damage.
Fact: This is a harmless and expected side effect of this medicine. It is not a sign of kidney damage. - Myth: This medicine can be taken with food to reduce stomach upset.
Fact: Food reduces the absorption of this medicine. It should be taken on an empty stomach for best effect.
🔄 Alternative Options
Generic Alternatives
- Rifampicin 150 mg capsule
Brand Alternatives
- R-Cin 150 mg capsule