Sizopin 25 Tablet (Clozapine 25mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever, sore throat, or mouth ulcers
- Chest pain or shortness of breath
- Fast or irregular heartbeat
- Severe abdominal pain or inability to pass stool
- Seizures or loss of consciousness
- Yellowing of skin or eyes
- Severe dizziness or fainting
- Uncontrolled muscle movements or rigidity
If experiencing severe symptoms, call emergency services immediately.
What is syclop 25mg tablet used for?
This medicine is a prescription antipsychotic containing clozapine 25 mg, used for treatment-resistant schizophrenia. It requires mandatory regular blood tests due to the risk of agranulocytosis. It is not a first-line treatment and must only be used under specialist supervision.
- Generic Name: Clozapine (25mg)
- Manufacturer: Micro Labs Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 syclop 25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोज़ापिन 25 मिलीग्राम की एक प्रिस्क्रिप्शन टैबलेट है, जिसका उपयोग उन मरीज़ों के इलाज के लिए किया जाता है जिन्हें सिज़ोफ्रेनिया है और जिन्होंने कम से कम दो अन्य एंटीसाइकोटिक दवाओं का पूरा असर नहीं दिखाया है। इसे ट्रीटमेंट-रेसिस्टेंट सिज़ोफ्रेनिया के लिए इस्तेमाल किया जाता है। यह दवा मस्तिष्क में डोपामाइन और सेरोटोनिन रिसेप्टर्स को ब्लॉक करके काम करती है, जिससे मतिभ्रम, भ्रम और सोचने-समझने की समस्याएँ कम होती हैं। यह दवा आत्महत्या के खतरे को भी कम कर सकती है। इस दवा को केवल एक विशेषज्ञ मनोचिकित्सक की देखरेख में ही शुरू किया जाना चाहिए। इस दवा को लेते समय नियमित रूप से खून की जाँच कराना अनिवार्य है, क्योंकि यह एक गंभीर रक्त विकार का कारण बन सकती है। इस दवा को अचानक बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह में लार बढ़ना, दिल की धड़कन तेज़ होना, कब्ज, मुँह सूखना, धुंधली दृष्टि और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में एग्रानुलोसाइटोसिस नामक एक गंभीर रक्त विकार, हृदय की मांसपेशियों में सूजन, दौरे, गंभीर कब्ज और न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम शामिल हैं। अगर आपको बुखार, गले में दर्द, मुँह में छाले, अत्यधिक थकान, सीने में दर्द, साँस लेने में कठिनाई या दिल की धड़कन तेज़ या अनियमित महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल एक योग्य मनोचिकित्सक की देखरेख में ही लें। नियमित रूप से खून की जाँच कराना अनिवार्य है, और यह जाँच इलाज बंद करने के बाद कम से कम चार सप्ताह तक जारी रखनी चाहिए। डॉक्टर की सलाह के बिना खुराक को कभी न बढ़ाएँ या कम न करें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक गाड़ी चलाने या भारी मशीनरी चलाने से बचें। बैठने या लेटने की स्थिति से धीरे-धीरे उठें। कब्ज से बचने के लिए भरपूर पानी पिएँ और रेशेदार भोजन खाएँ। इस दवा के साथ शराब का सेवन बिल्कुल न करें। इस दवा को अचानक बंद न करें।
💊 syclop 25mg tablet Uses & Benefits
[{"condition":"Treatment-resistant schizophrenia","description":"This medicine is indicated for patients with schizophrenia who have not responded adequately to at least two other antipsychotic medicines.","evidence":"Well-established"},{"condition":"Reduction of recurrent suicidal behaviour","description":"This medicine is used to reduce the risk of recurrent suicidal behaviour in patients with schizophrenia or schizoaffective disorder.","evidence":"Well-established"},{"condition":"Schizoaffective disorder","description":"This medicine may be used in patients with schizoaffective disorder who have not responded to other treatments.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Bipolar disorder with treatment resistance","description":"Sometimes prescribed off-label for patients with bipolar disorder who have not responded to standard mood stabilizers and antipsychotics.","evidence":"Limited"},{"condition":"Severe borderline personality disorder with self-harm","description":"Occasionally used off-label in specialist settings for severe self-harm behaviour, but evidence is limited and risks are significant.","evidence":"Limited"}]
Primary treatment for: Treatment-resistant schizophrenia
Also treats: Schizoaffective disorder, Recurrent suicidal behaviour in schizophrenia
📋 Drug Information
| Generic Name(s) | Clozapine (25mg) |
| Brand Name | syclop 25mg tablet |
| Manufacturer | Micro Labs Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Atypical Antipsychotics |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C. Keep it in the original container, tightly closed, away from direct sunlight and moisture. Do not store it in the bathroom. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization includes clozapine in its Essential Medicines List for the treatment of treatment-resistant schizophrenia. It recommends clozapine for patients who have not responded to at least two other antipsychotics. |
| ICMR Guideline | The Indian Council of Medical Research guidelines recommend clozapine for treatment-resistant schizophrenia with mandatory regular blood monitoring for agranulocytosis. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine exerts its antipsychotic effect primarily by blocking dopamine D4 receptors and serotonin 5-HT2A receptors in the brain. It also has antagonistic effects at adrenergic, cholinergic, and histaminergic receptors, which explains many of its side effects. Unlike typical antipsychotics, it has weak affinity for dopamine D2 receptors, which reduces the risk of movement disorders but increases the risk of metabolic and blood-related side effects.
Mechanism Steps
💡 How to Take syclop 25mg tablet
Strength: 25 mg immediate-release tablet
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. For treatment-resistant schizophrenia in adults, a typical starting dose is 12.5 mg once or twice daily, gradually increased over several weeks to a target dose of 300 to 450 mg per day, divided into two or three doses. The maximum daily dose is usually 900 mg. Dose increases should be gradual and guided by clinical response and tolerability. Regular blood tests are mandatory before and during treatment. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric psychiatrist for guidance. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially sedation, orthostatic hypotension, and anticholinergic effects. A lower starting dose and slower titration are recommended. Close monitoring for side effects is essential. |
| Renal Impairment | No specific dose adjustment is established for renal impairment, but this medicine should be used with caution in patients with severe kidney disease. Monitor closely for side effects. |
| Hepatic Impairment | This medicine is extensively metabolized in the liver. Patients with hepatic impairment may require lower doses and close monitoring. Dose adjustment should be individualized by a qualified clinician. |
| Maximum Daily Dose | 900 mg per day |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of syclop 25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Benzodiazepines | Major | |
| Fluvoxamine | Major | |
| Ciprofloxacin | Major | |
| Carbamazepine | Major | |
| Rifampicin | Major | |
| Fluoxetine | Moderate | |
| Lithium | Moderate | |
| Anticholinergics | Moderate | |
| Antihypertensives | Moderate | |
| Caffeine | Minor |
🚨 Major Interactions
- Clozapine and other antipsychotics
- Benzodiazepines
- CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
- CYP1A2 inducers (e.g., smoking, rifampicin)
- Carbamazepine
⚡ Moderate Interactions
- SSRIs (e.g., fluoxetine, paroxetine)
- Lithium
- Anticholinergics
- Antihypertensives
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase sedation, dizziness, and the risk of orthostatic hypotension. It may also worsen the cognitive and motor side effects of this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["History of severe blood disorders, including agranulocytosis","Uncontrolled epilepsy","Severe cardiac disease, including recent myocardial infarction","History of neuroleptic malignant syndrome","Severe liver disease","Concurrent use with carbamazepine or other medicines that cause bone marrow suppression","Known hypersensitivity to clozapine"]
⚠️ Warnings & Precautions
["This medicine can cause agranulocytosis, a potentially fatal blood disorder. Regular blood tests are mandatory.","This medicine can cause myocarditis, especially in the first two months of treatment. Report chest pain or shortness of breath immediately.","This medicine can cause seizures, particularly at higher doses. Use with caution in patients with a history of seizures.","This medicine can cause severe constipation that may progress to bowel obstruction. Monitor bowel habits closely.","This medicine can cause orthostatic hypotension. Rise slowly from sitting or lying positions.","This medicine can cause sedation and impair cognitive and motor function. Avoid driving or operating machinery until you know how it affects you.","This medicine can cause weight gain and metabolic changes. Monitor weight, blood glucose, and lipids regularly.","This medicine should not be stopped suddenly, as this can cause withdrawal symptoms and rapid relapse of psychosis."]
🤱 Lactation Safety
This medicine is excreted in breast milk and may cause serious adverse effects in the nursing infant, including sedation and blood dyscrasias. Breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative feeding options.
💊 Overdose Management
Overdose of this medicine can cause severe sedation, tachycardia, hypotension, seizures, and cardiac arrhythmias. There is no specific antidote. Treatment is supportive and symptomatic, including airway management, intravenous fluids, and monitoring in an intensive care setting. Contact a poison control centre or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than half the dosing interval has passed. If more than half the dosing interval has passed, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you miss more than two consecutive doses, contact your doctor before restarting, as dose adjustment may be needed.
Additional Safety Advice
This medicine must only be taken under the supervision of a qualified psychiatrist. Regular blood tests are mandatory to monitor white blood cell counts, and these tests must continue throughout treatment and for at least four weeks after stopping the medicine. Never increase or decrease the dose without medical advice. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness and dizziness. Rise slowly from a sitting or lying position to prevent falls due to low blood pressure. Drink plenty of fluids and eat high-fibre foods to prevent severe constipation. Avoid alcohol completely while taking this medicine. Inform all healthcare providers, including dentists and surgeons, that you are taking this medicine. Do not stop this medicine suddenly, as this can cause serious withdrawal effects.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative, hypotensive, and anticholinergic effects of this medicine. A lower starting dose and slower titration are recommended. Close monitoring for falls, confusion, and cardiac effects is essential. The risk of agranulocytosis is not age-dependent, so blood monitoring remains mandatory.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Your doctor may adjust your treatment plan. Close monitoring of both mother and baby is required.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine. It may interact with anaesthetic agents and increase the risk of hypotension and sedation. Your doctor may advise temporary dose adjustments or monitoring during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It can cause dry mouth, which may increase the risk of dental problems. It may also interact with certain medicines used in dental procedures. Maintain good oral hygiene and regular dental check-ups.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness, dizziness, and orthostatic hypotension. Avoid strenuous exercise or activities that require alertness until you know how this medicine affects you. Rise slowly from sitting or lying positions to prevent falls. Stay well hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and difficulty concentrating, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. You may need to adjust your work schedule or duties temporarily. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects such as severe blood disorders, myocarditis, or neuroleptic malignant syndrome, your doctor may decide to stop the medicine. Stopping suddenly can cause withdrawal symptoms and relapse of psychosis. Always follow your doctor's guidance on tapering.
📅 Long-Term Use Effects
Long-term use of this medicine requires ongoing monitoring for blood disorders, metabolic changes, and cardiac effects. Regular blood tests, weight checks, blood glucose, and lipid monitoring are essential. Patients may develop tolerance to some side effects, but the risk of agranulocytosis persists throughout treatment. Periodic review of the risk-benefit balance is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine in managing symptoms of schizophrenia.
Evidence: Well-establishedHelps patients and families understand the illness and improve adherence to treatment.
Evidence: Well-establishedRegular exercise, healthy diet, and stress management can improve overall well-being.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, because this medicine can affect white blood cells, live vaccines should be avoided if there is a risk of immunosuppression. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container, tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with a copy of your prescription. Carry enough supply for your entire trip, plus extra in case of delays. Keep it in your hand luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of your doses. Store it at room temperature and avoid exposing it to direct sunlight or moisture. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may begin to show some effects within a few days, but full therapeutic benefits may take several weeks to months. It is important to continue taking it as prescribed and attend regular follow-ups.
A: You will need regular blood tests to monitor your white blood cell count and absolute neutrophil count. These are mandatory weekly for the first 18 weeks, then at least monthly throughout treatment and for four weeks after stopping.
A: No, you must never stop this medicine suddenly. It must be tapered gradually under medical supervision to avoid withdrawal symptoms and relapse of psychosis.
A: This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor for individualized advice.
A: This medicine is excreted in breast milk and may cause serious adverse effects in the nursing infant. Breastfeeding is not recommended. Consult your doctor for alternative feeding options.
🤔 Common Patient Concerns
🔄 Substitutes for syclop 25mg tablet
View AllAlternative brands with exact same active ingredient:
-
cozacin 25mg tabletCinerea Biotech Pvt Ltd ₹14.06 53% COSTLIER
-
lozin 25mg tabletPifer Pharmaceuticals Pvt Ltd ₹14.53 58.1% COSTLIER
-
zopizone 25mg tabletKC Laboratories ₹14.86 61.7% COSTLIER
-
clozcare 25mg tabletLifecare Innovations Pvt Ltd ₹15.18 65.2% COSTLIER
-
clonex 25mg tabletTheo Pharma Pvt Ltd ₹15.80 71.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a first-line treatment for schizophrenia.
Fact: This medicine is reserved for treatment-resistant schizophrenia after other antipsychotics have failed. - Myth: This medicine is safe without blood tests.
Fact: Regular blood tests are mandatory because this medicine can cause a serious blood disorder called agranulocytosis. - Myth: This medicine can be stopped suddenly once symptoms improve.
Fact: This medicine must never be stopped suddenly. It must be tapered gradually under medical supervision. - Myth: This medicine is addictive.
Fact: This medicine is not addictive, but it can cause withdrawal symptoms if stopped suddenly.
🔄 Alternative Options
Generic Alternatives
- Clozapine 25 mg tablet
Brand Alternatives
- Sizopin 25 tablet