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cozacin 25mg tablet

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Clozapine (25mg)

🏭 Cinerea Biotech Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jul 4, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Jul 04, 2026

What is cozacin 25mg tablet used for?

Alkepin ODT 12.5mg Tablet (Clozapine) is used to treat NEURO CNS. It contains Clozapine (25mg), which Antagonism at dopamine D2 and serotonin 5-HT2A receptors; also blocks D1, D3, D4. Always consult your doctor before use. Take as prescribed.

Generic Name: Clozapine
Manufacturer: Cinerea Biotech Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 cozacin 25mg tablet Uses & Benefits

Treatment-resistant schizophrenia; reduction of suicidal behavior in schizophrenia or schizoaffective disorder; off-label: bipolar disorder, Parkinson's disease psychosis.

Off-label uses: Bipolar disorder (manic episodes), Parkinson's disease psychosis, Treatment-resistant depression, Autism spectrum disorder (agitation)

📋 Drug Information

Generic Name(s)	Clozapine
Brand Name	Alkepin ODT 12.5mg Tablet
Manufacturer	Cinerea Biotech Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	NEURO CNS
Action Class	Atypical Antipsychotics
Route of Administration	Oral (tablet, ODT, suspension).
Storage	Store at 20-25°C (68-77°F); protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; food does not significantly affect absorption.

DistributionWidely distributed; crosses blood-brain barrier; volume of distribution 4-7 L/kg.

Protein BindingApproximately 97% bound to plasma proteins (mainly albumin and alpha-1-acid glycoprotein).

MetabolismExtensively metabolized in the liver primarily by CYP1A2 and CYP3A4, with minor contributions from CYP2C19 and CYP2D6; major metabolites: norclozapine (active) and clozapine N-oxide.

Half-LifeApproximately 12 hours (range 6-26 hours) at steady state.

ExcretionApproximately 50% in urine (metabolites) and 30% in feces.

BioavailabilityApproximately 50-60% due to first-pass metabolism.

Onset of Action1-2 weeks for antipsychotic effect; may take several weeks for full effect.

Peak Plasma Time1.5-2.5 hours after oral administration.

Duration of ActionApproximately 12 hours (dosing interval).

How It Works

Antagonism at dopamine D2 and serotonin 5-HT2A receptors; also blocks D1, D3, D4, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, alpha-1, alpha-2, histamine H1, and muscarinic M1 receptors.

Mechanism Steps

1Blocks dopamine D2 receptors in mesolimbic pathway, reducing positive symptoms.

2Blocks serotonin 5-HT2A receptors in prefrontal cortex, improving negative symptoms and reducing extrapyramidal side effects.

3Antagonism at alpha-1 adrenergic receptors causes orthostatic hypotension.

💡 How to Take cozacin 25mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of cozacin 25mg tablet

✅ Common Side Effects

Sedation
Dizziness
Orthostatic hypotension
Tachycardia
Constipation
Weight gain
Hypersalivation
Fever
Headache
Nausea

🚨 Serious Side Effects

Agranulocytosis
Myocarditis
Cardiomyopathy
Seizures
Neuroleptic malignant syndrome
Pulmonary embolism
QT prolongation
Severe hypotension

⚠️ Rare Side Effects

Pancreatitis
Hepatitis
Interstitial nephritis
Thrombocytopenia
Eosinophilia
Priapism
Tardive dyskinesia (less common than typical antipsychotics)

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Fluvoxamine	Major	Increases clozapine levels (CYP1A2 inhibition); risk of toxicity.
Carbamazepine	Major	Decreases clozapine levels (CYP1A2 induction); may reduce efficacy.
Benzodiazepines	Major	Increased risk of respiratory depression, hypotension, and sedation.
Ciprofloxacin	Major	Increases clozapine levels (CYP1A2 inhibition); risk of toxicity.
Warfarin	Moderate	Increased bleeding risk (additive effect).

🚨 Major Interactions

CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
CYP1A2 inducers (e.g., carbamazepine, smoking)
Bone marrow suppressants (e.g., carbamazepine, chlorambucil)
Other drugs causing agranulocytosis (e.g., sulfonamides, pyrazolone analgesics)
Benzodiazepines (increased risk of respiratory depression and hypotension)

⚡ Moderate Interactions

Anticholinergic drugs (additive anticholinergic effects)
Antihypertensives (additive hypotension)
CNS depressants (e.g., alcohol, opioids)
Lithium (increased risk of neurotoxicity)
SSRIs (increased clozapine levels via CYP inhibition)

ℹ️ Minor Interactions

Caffeine (slight increase in clozapine levels)
Omeprazole (minor increase in clozapine levels)

🍽️ Food Interactions

No significant food interactions; avoid grapefruit juice (may increase levels).

🍷 Alcohol Interaction

Avoid alcohol; increased CNS depression and risk of hypotension.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to clozapine; history of clozapine-induced agranulocytosis or severe granulocytopenia; uncontrolled epilepsy; paralytic ileus; severe CNS depression; history of myocarditis or cardiomyopathy.

📊 Monitoring Parameters

CBC with differential (weekly for first 18 weeks, then every 2 weeks for 1 year, then monthly); LFTs; ECG; vital signs (especially orthostatic BP); blood glucose; lipid profile; weight; signs of myocarditis (chest pain, dyspnea, fever).

🤱 Lactation Safety

Not recommended; clozapine is excreted in breast milk; potential for agranulocytosis and sedation in

💊 Overdose Management

Supportive care; activated charcoal if recent ingestion; monitor for CNS depression, hypotension, respiratory depression, arrhythmias; no specific antidote.

⏰ Missed Dose

If missed, take as soon as remembered unless close to next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Jul 04, 2026

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🔄 Substitutes for cozacin 25mg tablet

View All

Alternative brands with exact same active ingredient (Clozapine (25mg)):

Medical Note: Always consult your doctor before switching medications.

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📌 Quick Facts

Storage	Store at 20-25°C (68-77°F); protect from light and moisture.
Route	Oral (tablet, ODT, suspension).
Pregnancy	Category A
Breastfeeding	Not recommended; clozapine is excreted in breast milk; potential for agranulocytosis and sedation in
Alcohol	Avoid alcohol; increased CNS depression and risk of hypotension.
Onset of Action	1-2 weeks for antipsychotic effect; may take several weeks for full effect.
Half-Life	Approximately 12 hours (range 6-26 hours) at steady state.
Prescription	✅ Required

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