Svnim P Suspension - Nimesulide (50mg) + Paracetamol (250mg) medicine

Lotherma N 50mg/250mg Tablet: Complete Guide to Uses, Dosage, and Safety

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🏭 Ecocare 📦 vial of 60 ml Suspension 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in acute pain; limited for long-term use due to safety concerns.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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When to Call Your Doctor IMMEDIATELY

  • Blood in vomit or black, tarry stools.
  • Severe abdominal pain or persistent vomiting.
  • Yellowing of skin or eyes, dark urine, or severe fatigue.
  • Decreased urine output or swelling in legs.
  • Chest pain, shortness of breath, or difficulty breathing.
  • Severe headache with visual changes.
  • Swelling of face, lips, or throat.
  • Unusual bruising or bleeding.

If experiencing severe symptoms, call emergency services immediately.

What is Svnim P Suspension used for?

This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It works by reducing prostaglandins that cause pain and swelling. It should be taken with food and not for more than 7-10 days without medical advice.

  • Generic Name: Nimesulide (50mg) + Paracetamol (250mg)
  • Manufacturer: Ecocare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 Svnim P Suspension के बारे में (Hindi Summary)

उपयोग: यह दवा नाइमसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और मासिक धर्म के दर्द में राहत देती है। इसे भोजन के साथ लेना चाहिए और बिना डॉक्टर की सलाह के 7-10 दिनों से अधिक नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें पेट में रक्तस्राव, लीवर की क्षति, गुर्दे की समस्या और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक या अवधि से अधिक न लें। इसे हमेशा भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न लें क्योंकि इससे पेट में रक्तस्राव और लीवर की क्षति का खतरा बढ़ सकता है। यदि आपको पेट के अल्सर, लीवर या गुर्दे की बीमारी है, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के 7-10 दिनों से अधिक इसका उपयोग न करें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 Svnim P Suspension Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain after dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after surgery.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to its paracetamol content.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis flare","description":"May be used short-term for osteoarthritis pain flares, but not for long-term management.","evidence":"Limited"}]

Primary treatment for: Acute pain and inflammation

Also treats: Fever, Dental pain, Post-operative pain, Musculoskeletal pain, Dysmenorrhea

📋 Drug Information

Generic Name(s)Nimesulide (50mg) + Paracetamol (250mg)
Brand NameSvnim P Suspension
ManufacturerEcocare
Packaging / Formvial of 60 ml Suspension (Allopathy)
Therapeutic Class
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine for the shortest duration possible, usually not exceeding 7-10 days.
2
Advise patients to take it with food to minimize gastrointestinal irritation.
3
Warn patients about the risk of liver damage and advise them to avoid alcohol.
4
Monitor liver and kidney function in patients requiring prolonged use.
5
Avoid prescribing to patients with a history of peptic ulcer, liver disease, or kidney disease.
6
Instruct patients to stop the medicine and report immediately if they experience signs of liver problems or severe stomach pain.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Acute musculoskeletal pain
This medicine is commonly prescribed for this.
Likely Use
✅
Dental pain
This medicine can provide short-term relief.
Likely Use
✅
Fever
Paracetamol component helps reduce fever.
Likely Use
❌
Chronic pain
Not recommended for long-term use due to safety concerns.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNimesulide is rapidly absorbed from the gastrointestinal tract after oral administration. Paracetamol is also rapidly and completely absorbed. Food may slightly delay absorption but does not significantly reduce the extent.
DistributionNimesulide is highly bound to plasma proteins and distributes well into tissues, including synovial fluid. Paracetamol distributes widely throughout most body tissues.
Protein BindingNimesulide is approximately 99% bound to plasma proteins. Paracetamol is about 10-25% bound to plasma proteins.
MetabolismNimesulide is extensively metabolized in the liver, primarily by CYP2C9, to several metabolites. Paracetamol is metabolized in the liver by conjugation and by CYP2E1 to a toxic intermediate (NAPQI), which is normally detoxified by glutathione.
Half-LifeThe elimination half-life of nimesulide is approximately 2-5 hours. Paracetamol has a half-life of about 2-3 hours.
ExcretionNimesulide metabolites are excreted mainly in urine and feces. Paracetamol metabolites are excreted primarily in urine.
BioavailabilityNimesulide oral bioavailability is about 80-90%. Paracetamol oral bioavailability is about 80-100%.
Onset of ActionPain relief typically begins within 30 to 60 minutes after oral administration.
Peak Plasma TimeNimesulide reaches peak plasma concentration in about 1.5 to 3 hours. Paracetamol peaks in about 0.5 to 2 hours.
Duration of ActionThe analgesic effect lasts approximately 4 to 6 hours, so dosing is usually every 6 to 8 hours as needed.

How It Works

This medicine combines two active ingredients. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Paracetamol works primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending pain pathways, leading to pain relief and fever reduction. Together, they provide synergistic analgesic and anti-inflammatory effects.

Mechanism Steps

1
COX-2 inhibition by nimesulide: Nimesulide selectively binds to and inhibits the COX-2 enzyme, blocking the conversion of arachidonic acid to prostaglandins.
2
Reduced prostaglandin synthesis: Decreased prostaglandin levels lead to less inflammation, pain, and fever.
3
Central action of paracetamol: Paracetamol acts on the central nervous system to inhibit prostaglandin synthesis and modulate pain perception.
4
Combined analgesic effect: The two ingredients work together to provide stronger pain relief than either alone.

💡 How to Take Svnim P Suspension

Strength: Tablet containing Nimesulide 50 mg and Paracetamol 250 mg.

1Take this medicine orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole. Do not crush or chew.
4Take it at the same times each day if prescribed regularly.
5Do not take more than the recommended dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally every 6 to 8 hours as needed for pain and fever. Do not exceed 3 tablets in 24 hours. The maximum duration of use without medical advice is 7 to 10 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. This medicine is not recommended for children under 12 years. Consult a pediatrician for appropriate pain and fever management in children.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentUse with caution in patients with kidney disease. Dose reduction may be necessary. Avoid use in severe kidney disease (creatinine clearance <30 mL/min). Consult your doctor for dose adjustment.
Hepatic ImpairmentUse with caution in patients with liver disease. Dose reduction and close monitoring of liver function are recommended. Avoid use in severe liver disease.
Maximum Daily DoseThe maximum daily dose is 3 tablets (150 mg nimesulide and 750 mg paracetamol) in 24 hours. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and gastrointestinal irritation.
Alcohol
Avoid
Increases risk of liver damage and gastrointestinal bleeding.
Caffeine
Limit
May increase stomach irritation.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of Svnim P Suspension

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Stomach pain (Common (5-10%))
Take with food or milk. Avoid alcohol. If pain is severe, contact your doctor.
Heartburn (Common (5-10%))
Take with food. Avoid spicy and fatty foods. Consult doctor if persistent.
Diarrhea (Common (5-10%))
Stay hydrated. If diarrhea is severe or persistent, consult your doctor.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or tarry stools, vomiting blood, or severe abdominal pain.
Liver damage (Rare (<0.1%))
Stop the medicine and seek immediate medical help if you experience yellowing of skin or eyes, dark urine, or severe fatigue.
Kidney problems (Rare (<0.1%))
Contact your doctor if you notice decreased urine output, swelling in legs, or sudden weight gain.
Severe allergic reaction (Rare (<0.1%))
Seek emergency care if you develop rash, itching, swelling of face, lips, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Blood disorders
Report unusual bruising, bleeding, or infections to your doctor immediately.
Severe skin reactions
Seek immediate medical attention if you develop a severe rash with blisters or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Methotrexate Major
ACE inhibitors Major
Diuretics Major
Corticosteroids Moderate
SSRIs Moderate
Lithium Moderate
Phenytoin Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, aspirin)
  • Methotrexate
  • ACE inhibitors and ARBs
  • Diuretics

⚡ Moderate Interactions

  • Corticosteroids
  • SSRIs
  • Lithium
  • Phenytoin

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially from paracetamol, and can increase the risk of gastrointestinal bleeding from nimesulide.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to nimesulide, paracetamol, or any other ingredient.","Active or history of peptic ulcer or gastrointestinal bleeding.","Severe liver disease or active liver disease.","Severe kidney disease (e.g., creatinine clearance

⚠️ Warnings & Precautions

["Do not exceed the recommended dose or duration of treatment.","Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not use for more than 7-10 days without medical advice.","Consult your doctor if you have a history of stomach ulcers, liver disease, kidney disease, or heart problems.","Stop the medicine and seek medical help if you experience signs of liver problems (yellowing of eyes or skin, dark urine, severe fatigue).","Do not take other medicines containing paracetamol or NSAIDs without consulting your doctor.","Use with caution in the elderly due to increased risk of side effects.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep out of reach of children."]

🤱 Lactation Safety

Not established from the available information. Nimesulide and paracetamol may pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and jaundice. If you suspect an overdose, seek emergency medical help immediately. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Always take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine because it can increase the risk of stomach bleeding and liver damage. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor. If you have a history of stomach ulcers, liver disease, kidney disease, or heart problems, inform your doctor before taking this medicine. Do not use this medicine for more than 7 to 10 days unless your doctor advises otherwise. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function closely.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for safer alternatives for pain relief.

🏥 Post-Surgery Considerations

This medicine may be used for short-term post-operative pain management under medical supervision. It should not be used for prolonged periods after surgery. Follow your surgeon's instructions.

🦷 Dental Procedures

This medicine can be used for short-term relief of dental pain, but it should not replace dental treatment. Inform your dentist if you are taking this medicine before any dental procedure.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints.
🥗
Engage in regular low-impact exercises like walking or swimming.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods such as fruits, vegetables, and omega-3 rich fish in your diet.
🧘
Get adequate sleep to aid recovery.
🌞
Stay well hydrated throughout the day.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that could worsen pain while taking this medicine. Gentle stretching and low-impact activities are generally safe. Consult your doctor before starting any new exercise routine.

🥗 Diet Recommendations

Include omega-3 rich foods like fish, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Eat plenty of fruits and vegetables.
Stay well hydrated.
Avoid alcohol.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Generally, it does not significantly interfere with daily activities if taken as prescribed.

🛑 When to Stop This Medicine

Stop taking this medicine if you experience any serious side effects such as severe stomach pain, black stools, yellowing of eyes or skin, decreased urine output, or allergic reactions. Also stop after the prescribed duration unless your doctor advises otherwise. Do not stop abruptly if you are on a prescribed regimen without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine can lead to serious complications such as liver damage, kidney impairment, gastrointestinal bleeding, and increased cardiovascular risk. It is not intended for chronic use. Regular monitoring of liver and kidney function is advised if prolonged use is unavoidable. Always consult a doctor before using it for more than 7-10 days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help manage chronic pain and improve mobility.

Evidence: Well-established
Hot and cold therapy

Applying heat or cold packs can relieve localized pain and inflammation.

Evidence: Moderate
Acupuncture

May provide pain relief for some individuals.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. This medicine does not interact with vaccines, but consult your doctor if you are scheduled for vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If traveling across time zones, adjust dosing times gradually. Check customs regulations for carrying prescription medicines. Do not take more than the recommended dose during travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute lower back pain
He was prescribed this medicine for 5 days. He took it with food as directed and experienced significant pain relief within 2 days. He avoided alcohol and did not exceed the dose. He stopped the medicine after 5 days as advised.
💡 Lesson: Taking the medicine with food and adhering to the prescribed duration ensures safety and effectiveness.
👤 A 50-year-old woman with knee osteoarthritis flare
She took this medicine for 7 days for knee pain. She noticed improvement in pain and swelling. However, she developed mild stomach upset, which resolved when she took it with meals. She was advised not to use it long-term and to follow up for alternative pain management.
💡 Lesson: Short-term use with food can manage pain effectively, but long-term use should be avoided due to safety concerns.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.

Q: How long can I take this medicine?

A: It should not be taken for more than 7 to 10 days without medical advice due to the risk of liver and kidney problems.

Q: Can I take this medicine on an empty stomach?

A: It is best taken with food or milk to reduce the risk of stomach upset and bleeding.

Q: Is this medicine safe for children?

A: This medicine is not recommended for children under 12 years. Consult a pediatrician for appropriate pain relief.

Q: Can I take this medicine during pregnancy?

A: It is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safer alternatives.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe for my liver?
  • Can I take it with other painkillers?

🔄 Substitutes for Svnim P Suspension

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe for long-term use.
    Fact: This medicine is only for short-term use. Long-term use can cause serious liver, kidney, and stomach problems.
  • Myth: It is okay to take this medicine on an empty stomach.
    Fact: Taking it with food reduces the risk of stomach upset and bleeding.
  • Myth: This medicine can be taken with alcohol.
    Fact: Alcohol increases the risk of liver damage and stomach bleeding. Avoid alcohol.
  • Myth: More tablets mean faster relief.
    Fact: Taking more than the recommended dose can cause serious harm. Stick to the prescribed dose.

🔄 Alternative Options

Generic Alternatives

  • Nimesulide + Paracetamol combination tablets from other manufacturers.

Brand Alternatives

  • Nise M
  • Nimucet
  • Nimulid P
  • Nimesulide Paracetamol

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Nimesulide + Paracetamol)","composition":"Nimesulide 50 mg + Paracetamol 250 mg","uses":"Acute pain, inflammation, fever","onset":"30-60 minutes","duration":"4-6 hours","safety":"Short-term use only; liver and GI risks"},{"medicine":"Ibuprofen + Paracetamol","composition":"Ibuprofen 400 mg + Paracetamol 325 mg","uses":"Pain, inflammation, fever","onset":"30-60 minutes","duration":"4-6 hours","safety":"GI and kidney risks; available OTC in some countries"},{"medicine":"Diclofenac + Paracetamol","composition":"Diclofenac 50 mg + Paracetamol 325 mg","uses":"Pain, inflammation","onset":"30-60 minutes","duration":"4-6 hours","safety":"GI and cardiovascular risks"}]

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