Nitnib 50 Capsule (Sunitinib 50mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Chest pain, shortness of breath, or swelling of legs
- Blood in vomit, black stools, or unusual bruising
- Sudden leg pain, swelling, or difficulty breathing
- Severe headache, seizures, confusion, or vision changes
- Decreased urine output or swelling of face and hands
- Severe skin blistering or peeling
- High fever with chills
If experiencing severe symptoms, call emergency services immediately.
What is sutent 50mg capsule used for?
This medicine contains Sunitinib 50 mg, a targeted anticancer capsule used for advanced kidney cancer, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. It is taken orally once daily, usually in 4-week cycles with a 2-week break, and requires regular monitoring of liver, heart, kidney, and blood parameters.
- Generic Name: Sunitinib (50mg)
- Manufacturer: Pfizer Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sutent 50mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा सनिटिनिब 50 मिलीग्राम कैप्सूल है, जिसका उपयोग कैंसर के इलाज में किया जाता है। यह मुख्य रूप से गुर्दे के कैंसर (रेनल सेल कार्सिनोमा), पेट और आंत के कैंसर (गैस्ट्रोइंटेस्टाइनल स्ट्रोमल ट्यूमर) और अग्न्याशय के न्यूरोएंडोक्राइन ट्यूमर के लिए दी जाती है। यह दवा कैंसर कोशिकाओं की वृद्धि और रक्त वाहिकाओं के निर्माण को रोककर काम करती है। इसे मुँह से लिया जाता है, आमतौर पर दिन में एक बार, 4 सप्ताह तक लगातार और फिर 2 सप्ताह का आराम। इस दवा का सेवन केवल कैंसर विशेषज्ञ के निर्देशन में ही करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में थकान, दस्त, जी मिचलाना, उल्टी, मुँह के छाले, भूख न लगना, उच्च रक्तचाप, त्वचा का रंग बदलना, और हाथ-पैरों में लालिमा शामिल हैं। गंभीर दुष्प्रभावों में लिवर की क्षति, हृदय की समस्या, रक्तस्राव, रक्त के थक्के, गुर्दे की समस्या, और थायरॉइड की गड़बड़ी हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। कैप्सूल को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इसे हर दिन एक ही समय पर लें। ग्रेपफ्रूट और उसके जूस से बचें। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए। स्तनपान कराने वाली महिलाएं इस दवा का सेवन न करें। इलाज के दौरान और बाद में भी प्रभावी गर्भनिरोधक उपाय अपनाएं। लिवर, किडनी, हृदय और रक्त की नियमित जाँच कराते रहें। बिना डॉक्टर की सलाह के दवा बंद न करें।
💊 sutent 50mg capsule Uses & Benefits
[{"condition":"Advanced renal cell carcinoma (kidney cancer)","description":"Used as first-line or subsequent therapy in metastatic renal cell carcinoma to slow tumor growth and improve progression-free survival.","evidence":"Well-established"},{"condition":"Gastrointestinal stromal tumor (GIST)","description":"Used after failure of imatinib therapy or intolerance to imatinib in patients with unresectable or metastatic GIST.","evidence":"Well-established"},{"condition":"Pancreatic neuroendocrine tumors (pNET)","description":"Used in progressive, well-differentiated pancreatic neuroendocrine tumors to delay tumor progression.","evidence":"Well-established"},{"condition":"Adjuvant treatment of high-risk renal cell carcinoma","description":"Studied as adjuvant therapy after nephrectomy in high-risk kidney cancer; benefit remains uncertain and is not universally recommended.","evidence":"Conflicting evidence"}]
Off-label uses: [{"condition":"Thyroid cancer","description":"Sometimes used off-label in advanced medullary or differentiated thyroid cancer after other treatments fail.","evidence":"Limited"},{"condition":"Other solid tumors","description":"Occasionally used in clinical trials or selected cases of other advanced solid tumors under specialist supervision.","evidence":"Limited"}]
Primary treatment for: Advanced renal cell carcinoma
Also treats: Gastrointestinal stromal tumor, Pancreatic neuroendocrine tumor
📋 Drug Information
| Generic Name(s) | Sunitinib (50mg) |
| Brand Name | sutent 50mg capsule |
| Manufacturer | Pfizer Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep the capsule in its original container, tightly closed, away from moisture, heat, and direct light. Do not refrigerate or freeze. |
| Shelf Life | Typically 24 months from the date of manufacture, but refer to the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a small-molecule tyrosine kinase inhibitor that blocks multiple receptor tyrosine kinases, including vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3), platelet-derived growth factor receptors (PDGFR-alpha and PDGFR-beta), stem cell factor receptor (KIT), FMS-like tyrosine kinase-3 (FLT-3), colony-stimulating factor-1 receptor (CSF-1R), and rearranged during transfection (RET). By inhibiting these receptors, it reduces tumor angiogenesis, slows cancer cell proliferation, and promotes apoptosis in susceptible tumor cells.
Mechanism Steps
💡 How to Take sutent 50mg capsule
Strength: Capsule, 50 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for renal cell carcinoma and gastrointestinal stromal tumor is 50 mg taken orally once daily for 4 consecutive weeks, followed by 2 weeks off treatment, in repeated 6-week cycles. For pancreatic neuroendocrine tumors, the usual dose is 37.5 mg taken orally once daily continuously without a scheduled break. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and tolerability. Dose reductions may be needed for side effects. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more sensitive to side effects and should be monitored closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is required for mild to moderate renal impairment. In severe renal impairment or end-stage renal disease, use with caution and monitor closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No dose adjustment is required for mild to moderate hepatic impairment (Child-Pugh class A or B). In severe hepatic impairment (Child-Pugh class C), the starting dose should be reduced as advised by a specialist. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 50 mg for the 4-weeks-on/2-weeks-off schedule, and 37.5 mg for the continuous daily schedule. Doses above these are not recommended. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sutent 50mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampin | Major | |
| Warfarin | Major | |
| Clarithromycin | Major | |
| Phenytoin | Major | |
| St. John's wort | Major | |
| Ondansetron | Moderate | |
| Amlodipine | Moderate | |
| Live vaccines | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
- Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John's wort)
- Warfarin and other anticoagulants
- QT-prolonging drugs (e.g., ondansetron, haloperidol, methadone)
⚡ Moderate Interactions
- Grapefruit juice
- Antihypertensive drugs
- Live vaccines
🍷 Alcohol Interaction
Alcohol may worsen fatigue, dizziness, and liver stress. It is advisable to avoid or limit alcohol while taking this medicine, especially if liver function is impaired.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to sunitinib or any component of the capsule","Pregnancy","Breastfeeding without medical advice","Severe hepatic impairment without specialist supervision","Concurrent use with strong CYP3A4 inducers or inhibitors without dose adjustment"]
⚠️ Warnings & Precautions
["This medicine can cause serious liver injury; monitor liver function.","This medicine can cause heart failure and heart attack; monitor cardiac function.","This medicine can cause severe bleeding; monitor for signs of bleeding.","This medicine can cause blood clots; seek immediate care for symptoms.","This medicine can cause high blood pressure; monitor and treat.","This medicine can cause thyroid dysfunction; monitor thyroid function.","This medicine can cause kidney impairment; monitor kidney function.","This medicine can cause fetal harm; use effective contraception.","Avoid live vaccines during treatment.","Do not crush or open the capsule; swallow whole."]
🤱 Lactation Safety
It is not known whether sunitinib is excreted in human milk. Because of the potential for serious adverse reactions in breastfed infants, breastfeeding is not recommended during treatment and for at least 4 weeks after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, stop the medicine and seek immediate medical attention. Supportive care and monitoring of vital signs, liver function, and blood counts are recommended. Gastric lavage may be considered if ingestion is recent and the patient is stable.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than 12 hours have passed since the scheduled time. If more than 12 hours have passed, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your oncologist. Swallow the capsule whole with a glass of water; do not crush, chew, or open it. You may take it with or without food, but try to take it at the same time each day. Avoid grapefruit and grapefruit juice because they can increase the level of this medicine in your body. Do not breastfeed while taking this medicine and for at least 4 weeks after the last dose. Use effective contraception during treatment and for at least 4 weeks after stopping if you are a woman of childbearing potential, and for at least 7 weeks after stopping if you are a man. Avoid live vaccines during treatment. Tell your doctor about all other medicines, supplements, and herbal products you take, especially blood thinners, blood pressure medicines, and drugs that affect liver enzymes. Do not stop this medicine suddenly without talking to your oncologist. Keep all scheduled blood tests, including liver function, kidney function, blood counts, thyroid tests, and blood pressure checks. Store at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially fatigue, high blood pressure, and heart problems. Close monitoring is recommended. Dose adjustment based on age alone is not usually required, but individualization by a clinician is essential.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 4 weeks after the last dose. Men should use effective contraception during treatment and for at least 7 weeks after the last dose. Discuss pregnancy planning with your oncologist before starting treatment.
🏥 Post-Surgery Considerations
This medicine may affect wound healing and increase the risk of bleeding. Inform your surgeon and oncologist if you are taking this medicine before any surgery. Treatment may need to be temporarily interrupted before and after surgery as advised by your doctor.
🦷 Dental Procedures
This medicine may increase the risk of bleeding and infection during dental procedures. Inform your dentist that you are taking this medicine. Your dentist may recommend postponing elective dental work or taking precautions to prevent bleeding and infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild to moderate exercise such as walking or gentle yoga may help manage fatigue, but avoid strenuous activity if you feel weak or dizzy. Consult your doctor before starting any new exercise program, especially if you have heart or kidney problems.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or difficulty concentrating, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. Discuss work adjustments with your employer if needed. Most patients can continue light work with modifications.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your oncologist. Treatment may be stopped or interrupted if you develop serious side effects such as severe liver injury, heart failure, or severe bleeding. Your oncologist will decide whether to reduce the dose, interrupt treatment, or stop it permanently based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to persistent fatigue, thyroid dysfunction, kidney impairment, liver injury, and cardiac problems. Regular monitoring of liver, kidney, thyroid, and cardiac function is essential. Some side effects may be reversible after stopping treatment, but others may require ongoing management. Your oncologist will periodically reassess the benefits and risks of continuing treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another oral tyrosine kinase inhibitor used for renal cell carcinoma.
Evidence: Well-establishedmTOR inhibitor used for renal cell carcinoma and neuroendocrine tumors.
Evidence: Well-establishedImmune checkpoint inhibitors may be used alone or in combination for advanced kidney cancer.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because of the risk of vaccine-related infections. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your oncologist before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in the original container tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes. If traveling across time zones, maintain your dosing schedule as close to every 24 hours as possible; consult your oncologist for specific advice. Store at room temperature and avoid direct sunlight. Check customs regulations for carrying prescription medicines internationally. Carry enough supply for the entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The anticancer effect of this medicine is assessed over weeks to months. Your oncologist will monitor your response with regular scans and blood tests.
A: Yes, this medicine can be taken with or without food. However, avoid grapefruit and grapefruit juice.
A: If less than 12 hours have passed, take the missed dose. If more than 12 hours have passed, skip it and continue with your regular schedule. Do not double dose.
A: This medicine can harm the unborn baby. Use effective contraception during treatment and for at least 4 weeks after the last dose. Consult your doctor for family planning advice.
A: Breastfeeding is not recommended during treatment and for at least 4 weeks after the last dose because of the potential for serious side effects in the infant.
🤔 Common Patient Concerns
🔄 Substitutes for sutent 50mg capsule
View AllAlternative brands with exact same active ingredient:
-
sutib 50 capsuleGlenmark Pharmaceuticals Ltd ₹1,750.00 97.1% CHEAPER
-
nitnib 50 capsuleZydus Cadila ₹1,795.00 97.1% CHEAPER
-
svitinib 50 capsuleMylan Pharmaceuticals Pvt Ltd ₹2,050.00 96.6% CHEAPER
-
sunisam 50mg capsuleSamarth Life Sciences Pvt Ltd ₹3,250.00 94.7% CHEAPER
-
sunimaps 50mg tabletAMPS Biotech Pvt Ltd ₹3,565.00 94.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a traditional chemotherapy that kills all fast-growing cells.
Fact: This medicine is a targeted therapy that blocks specific tyrosine kinases involved in tumor growth and blood vessel formation. - Myth: This medicine can be stopped as soon as you feel better.
Fact: This medicine must be taken exactly as prescribed by your oncologist; stopping early can allow the cancer to progress. - Myth: This medicine does not require any blood tests.
Fact: Regular blood tests are essential to monitor liver, kidney, heart, and blood counts while on this medicine.
🔄 Alternative Options
Generic Alternatives
- Sunitinib
Brand Alternatives
- Sutent