Supime 500 mg/250 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or bloody diarrhea
- Seizures or confusion
- Decreased urine output or swelling in the legs
- Severe skin rash with blistering or peeling
- Yellowing of the eyes or skin
If experiencing severe symptoms, call emergency services immediately.
What is supime 500 mg/250 mg injection used for?
This medicine is a combination antibiotic injection containing cefepime and sulbactam. It is used to treat serious bacterial infections in hospitalized patients. It works by killing bacteria and preventing their growth.
- Generic Name: Cefepime (500mg) + Sulbactam (250mg)
- Manufacturer: Venus Remedies Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 supime 500 mg/250 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयुक्त एंटीबायोटिक इंजेक्शन है जिसमें सेफेपाइम और सल्बैक्टम शामिल हैं। इसका उपयोग अस्पताल में भर्ती मरीजों में गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है, जैसे कि मूत्र मार्ग संक्रमण, निमोनिया, त्वचा संक्रमण और पेट के संक्रमण। यह दवा बैक्टीरिया को मारती है और उनके विकास को रोकती है। यह केवल डॉक्टर की देखरेख में ही दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, उल्टी, सिरदर्द और दाने शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, दौरे और गुर्दे की समस्या हो सकती है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में डॉक्टर या नर्स द्वारा दी जानी चाहिए। अपनी सभी एलर्जी और गुर्दे या लीवर की समस्याओं के बारे में डॉक्टर को बताएं। इलाज के दौरान शराब न पिएं। दवा का पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें।
💊 supime 500 mg/250 mg injection Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used to treat serious kidney and bladder infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Hospital-acquired pneumonia","description":"Effective against many gram-negative and gram-positive bacteria causing lung infections in hospitalized patients.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe skin infections including cellulitis and abscesses caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for complicated abdominal infections.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for fever in patients with low white blood cell counts.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Meningitis","description":"Sometimes used off-label for bacterial meningitis when other options are not suitable.","evidence":"Limited"},{"condition":"Endocarditis","description":"May be used off-label for certain cases of heart valve infections.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Complicated urinary tract infections, Hospital-acquired pneumonia, Skin and soft tissue infections, Intra-abdominal infections, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Cefepime (500mg) + Sulbactam (250mg) |
| Brand Name | supime 500 mg/250 mg injection |
| Manufacturer | Venus Remedies Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular) |
| Storage | Store the unopened vial at room temperature (15-30°C). Protect from light and moisture. Once reconstituted, use immediately or store as directed by the pharmacist. |
| Shelf Life | Typically 24 months from the date of manufacture. Refer to the packaging for the exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting bacterial cell wall synthesis. Cefepime binds to penicillin-binding proteins, disrupting peptidoglycan cross-linking and causing bacterial cell death. Sulbactam irreversibly inhibits certain beta-lactamase enzymes, protecting cefepime from degradation and extending its spectrum against beta-lactamase-producing bacteria.
Mechanism Steps
💡 How to Take supime 500 mg/250 mg injection
Strength: 500 mg cefepime + 250 mg sulbactam per vial, injection
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 500 mg cefepime plus 250 mg sulbactam given intravenously every 8 to 12 hours, depending on the severity of the infection and kidney function. For severe infections, higher doses may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and require lower doses. Dose must be individualized by a qualified clinician based on renal function. |
| Renal Impairment | Dosage adjustment is required in patients with renal impairment. The dose and frequency should be reduced according to creatinine clearance. Consult a clinician for specific recommendations. |
| Hepatic Impairment | No specific dosage adjustment is established for hepatic impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 g cefepime plus 1 g sulbactam, but this may vary based on the infection and renal function. Dose must be individualized by a qualified clinician. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of supime 500 mg/250 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | |
| Warfarin | Major | |
| Loop diuretics | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Aminoglycosides
- Warfarin
⚡ Moderate Interactions
- Loop diuretics
- Probenecid
🍷 Alcohol Interaction
Alcohol may worsen side effects such as nausea, dizziness, and liver stress. It is advisable to avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to cefepime, sulbactam, or other beta-lactam antibiotics","Previous anaphylactic reaction to penicillins or cephalosporins"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment is necessary.","May cause seizures, especially in patients with renal failure.","Clostridioides difficile-associated diarrhea can occur; monitor for severe diarrhea.","Serious allergic reactions can occur; discontinue immediately if suspected.","Prolonged use may lead to superinfection with resistant organisms."]
🤱 Lactation Safety
Cefepime and sulbactam are excreted in breast milk in small amounts. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, and seizures. Treatment is supportive and symptomatic. Hemodialysis may be considered to remove cefepime from the blood in severe cases. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
Since this medicine is given by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer an extra dose.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a clinical setting. Inform your doctor about all your allergies, especially to antibiotics, and about any kidney or liver problems. Do not attempt to self-administer this injection. Complete the full course as prescribed, even if you feel better, to prevent resistance. Avoid alcohol during treatment as it may worsen side effects. Report any signs of allergic reaction, severe diarrhea, or seizures immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function and may require lower doses. They are also at higher risk of seizures and other side effects. Close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It should be used during pregnancy only if clearly needed and prescribed by a doctor.
🏥 Post-Surgery Considerations
This medicine may be used to prevent or treat surgical site infections. Follow your surgeon's instructions regarding its use and duration.
🦷 Dental Procedures
Inform your dentist if you are on this medicine. It may be used prophylactically before certain dental procedures in patients at risk of infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while recovering from a serious infection. Light activity such as walking is fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work or school while receiving this medicine, especially if you are hospitalized. Driving is not recommended if you feel dizzy or unwell. Follow your doctor's advice regarding return to normal activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and superinfections. It can also cause kidney or liver problems with prolonged use. Regular monitoring of kidney and liver function is recommended during extended therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For less severe infections, oral antibiotics may be used instead of injections.
Evidence: Well-establishedDepending on the bacteria, other antibiotics like piperacillin-tazobactam or meropenem may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, ensure you are up to date with recommended vaccines as advised by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is given in a healthcare setting, so travel is not applicable. If you are prescribed this medicine as an outpatient, carry your prescription and medical records. Store the vials at room temperature and protect them from light. Inform airport security about your medication and carry it in original packaging.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 48 to 72 hours, but it is important to complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Report any side effects to your doctor immediately. Do not try to manage them on your own.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is not effective against viruses. - Myth: You can stop the injection once you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance.
🔄 Alternative Options
Generic Alternatives
- Cefepime and sulbactam injection
Brand Alternatives
- Supime 500 mg/250 mg injection