atropin infusion - Uses, Price, Side Effects & Substitutes
Atropine (0.6mg)
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💊 What is atropin infusion used for?
Atropine Sulphate Injection (Atropine) is used to treat Preoperative medication to reduce secretions. It contains Atropine (0.6mg), which Competitive antagonist of acetylcholine at muscarinic receptors, blocking parasy. Always consult your doctor before use. Take as prescribed.
💊 Generic Name
Atropine
Atropine
🏭 Manufacturer
Venus Remedies Ltd
Venus Remedies Ltd
📦 Form
Allopathy
Allopathy
🤰 Pregnancy Category
Category A
Category A
🇮🇳 atropin infusion के बारे में संक्षिप्त जानकारी
atropin infusion का उपयोग मुख्य रूप से ophthal और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Atropine (0.6mg) मौजूद है।
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.
📋 Complete Drug Information
| Generic Name(s) | Atropine |
|---|---|
| Brand Name | Atropine Sulphate Injection |
| Manufacturer | Venus Remedies Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Anticholinergics |
| Route of Administration | Intravenous, intramuscular, subcutaneous; ophthalmic (eye drops). |
| Storage | Store at 20-25°C (68-77°F); protect from light. |
🔬 Pharmacology
Pharmacokinetics
AbsorptionRapidly absorbed after intramuscular or subcutaneous injection; well absorbed from gastrointestinal tract but not used orally for systemic effects.
DistributionWidely distributed throughout the body; crosses blood-brain barrier and placenta.
Protein BindingApproximately 50% bound to plasma proteins.
MetabolismHepatic metabolism via enzymatic hydrolysis.
Half-LifeApproximately 2-3 hours.
ExcretionRenal excretion (about 30-50% unchanged) with small amounts in feces.
BioavailabilityNot applicable for injection; 100% bioavailability via IV route.
Onset of ActionRapid (within minutes) after IV administration; 15-30 minutes after IM/SC.
Peak Plasma Time15-30 minutes after IM injection.
Duration of Action4-6 hours depending on dose and route.
Mechanism of Action
Competitive antagonist of acetylcholine at muscarinic receptors, blocking parasympathetic effects.
Step-by-Step Mechanism
1
Atropine binds to muscarinic receptors
2
Blocks acetylcholine binding
3
Prevents parasympathetic nerve transmission
4
Results in inhibition of secretions, smooth muscle relaxation, and increased heart rate
💡 How to take atropin infusion
Prescribed Dosage: Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose.
- ✅ Complete the full course of medication.
- ✅ Store at 20-25°C (68-77°F); protect from light.
⚠️ Side Effects of atropin infusion
✅ Common Side Effects
- Dry mouth
- Blurred vision
- Photophobia
- Tachycardia
- Constipation
- Urinary retention
🚨 Serious Side Effects
- Severe tachycardia
- Arrhythmias
- Acute glaucoma
- Central anticholinergic syndrome (confusion, hallucinations)
⚠️ Rare Side Effects
- Anaphylaxis
- Paralytic ileus
- Hyperthermia
Important: Consult your doctor if you experience any unusual symptoms or severe side effects.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Anticholinesterases | Major | Antagonism of effects; used in organophosphate poisoning. |
| Potassium chloride | Major | Increased risk of gastrointestinal lesions. |
| Metoclopramide | Major | Antagonism of gastrointestinal motility effects. |
| Antihistamines | Moderate | Additive anticholinergic effects. |
| Phenothiazines | Moderate | Increased anticholinergic side effects. |
| Tricyclic antidepressants | Moderate | Additive anticholinergic effects. |
| Digoxin | Minor | Increased digoxin absorption due to slowed GI motility. |
| Corticosteroids | Minor | Possible increased intraocular pressure. |
🚨 Major Interactions
- Anticholinesterases
- Potassium chloride
- Metoclopramide
⚡ Moderate Interactions
- Antihistamines
- Phenothiazines
- Tricyclic antidepressants
🍽️ Food Interactions
No significant food interactions.
🍷 Alcohol Interaction
May increase CNS depression; avoid excessive alcohol.
🛡️ Safety & Warnings
Pregnancy
Category A
Liver Risk
Low
Kidney Risk
Low
Heart Risk
Low
🚫 Contraindications
Hypersensitivity, glaucoma, tachycardia, thyrotoxicosis, obstructive GI disorders, myasthenia gravis (relative).
📊 Monitoring Parameters
Heart rate, blood pressure, intraocular pressure, urinary output, mental status.
🤱 Lactation Safety
Excreted in breast milk in small amounts; use with caution.
💊 Overdose
Supportive care; physostigmine as antidote for severe anticholinergic syndrome.
⏰ Missed Dose
Not applicable for acute use; administer as needed.