supertol-d tablet - Tolperisone (150mg) + Diclofenac (50mg) medicine

Tolperitas-D Tablet: Complete Medicine Guide

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🏭 Superlative Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Diclofenac is generally avoided in the third trimester due to risk of premature closure of ductus arteriosus. Tolperisone is not recommended during pregnancy unless clearly needed. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for the combination in acute musculoskeletal pain; individual components have well-established evidence.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is supertol-d tablet used for?

This medicine is a combination of tolperisone (a muscle relaxant) and diclofenac (an NSAID) used for short-term relief of painful muscle spasms and inflammation in conditions like back pain and sports injuries. It is taken orally with food, usually 1 tablet up to three times daily, and should not be used long-term without medical supervision.

  • Generic Name: Tolperisone (150mg) + Diclofenac (50mg)
  • Manufacturer: Superlative Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 supertol-d tablet के बारे में (Hindi Summary)

उपयोग: यह दवा टॉलपेरिसोन और डाइक्लोफेनाक का संयोजन है, जिसका उपयोग मांसपेशियों में ऐंठन और दर्द के इलाज के लिए किया जाता है। यह पीठ दर्द, गर्दन में दर्द, चोट या सर्जरी के बाद होने वाले दर्द और सूजन में राहत देती है। यह दवा मांसपेशियों को आराम देती है और सूजन कम करती है। इसे डॉक्टर की सलाह के अनुसार ही लें और लंबे समय तक न लें।

साइड इफेक्ट्स: आम दुष्प्रभावों में जी मिचलाना, पेट दर्द, सिरदर्द, चक्कर आना और मुंह सूखना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, गुर्दे की समस्या, यकृत की समस्या और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, तेज पेट दर्द, सांस लेने में कठिनाई या चेहरे पर सूजन हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। शराब न पिएं क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। यदि आपको चक्कर आते हैं तो वाहन न चलाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 supertol-d tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Relieves pain and reduces muscle spasm in conditions such as neck pain, back pain, and sports injuries.","evidence":"Well-established"},{"condition":"Low back pain","description":"Provides short-term relief of pain and improves mobility in acute low back pain associated with muscle spasm.","evidence":"Well-established"},{"condition":"Post-operative pain and spasm","description":"Used after surgery to reduce pain and muscle spasm, often as part of multimodal analgesia.","evidence":"Moderate"},{"condition":"Post-traumatic pain","description":"Helps manage pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling after injuries such as sprains and strains.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Tension-type headache","description":"Sometimes prescribed off-label for tension headaches with muscle tightness, but evidence is limited.","evidence":"Limited"},{"condition":"Fibromyalgia","description":"Occasionally used off-label for fibromyalgia pain, but not recommended as first-line therapy.","evidence":"Limited"}]

Primary treatment for: Musculoskeletal pain with muscle spasm

Also treats: Low back pain, Neck pain, Post-operative pain, Post-traumatic pain

📋 Drug Information

Generic Name(s)Tolperisone (150mg) + Diclofenac (50mg)
Brand Namesupertol-d tablet
ManufacturerSuperlative Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Do not exceed the prescribed dose or duration of treatment.
3
Avoid alcohol while taking this medicine to prevent stomach bleeding.
4
Do not drive or operate heavy machinery if you feel dizzy or drowsy.
5
Inform your doctor if you have a history of ulcers, kidney, liver, or heart disease.
6
Do not take other NSAIDs or blood thinners without consulting your doctor.
7
If you miss a dose, follow the missed dose instructions carefully.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Muscle spasm
This medicine is used for muscle spasm.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionTolperisone is rapidly absorbed after oral administration. Diclofenac is also well absorbed from the gastrointestinal tract. Food may delay the absorption of diclofenac but does not significantly reduce the extent of absorption.
DistributionTolperisone is widely distributed in the body and crosses the blood-brain barrier. Diclofenac is highly bound to plasma proteins and distributes into synovial fluid.
Protein BindingTolperisone: approximately 80% bound to plasma proteins. Diclofenac: greater than 99% bound to plasma proteins, primarily albumin.
MetabolismTolperisone is extensively metabolized in the liver, mainly by cytochrome P450 enzymes. Diclofenac is metabolized in the liver by CYP2C9 to 4'-hydroxydiclofenac and by CYP3A4 and other enzymes to other metabolites.
Half-LifeTolperisone: approximately 1.5 to 2.5 hours. Diclofenac: approximately 1 to 2 hours.
ExcretionTolperisone metabolites are excreted mainly in the urine. Diclofenac metabolites are excreted primarily in urine and bile.
BioavailabilityTolperisone: approximately 20% due to first-pass metabolism. Diclofenac: approximately 50-60% due to first-pass metabolism.
Onset of ActionPain relief from diclofenac may begin within 30 to 60 minutes. Muscle relaxant effects of tolperisone may take a few hours to become noticeable.
Peak Plasma TimeTolperisone: approximately 0.5 to 1.5 hours. Diclofenac: approximately 1 to 2 hours after oral administration.
Duration of ActionPain relief typically lasts 4 to 6 hours for diclofenac. Muscle relaxant effects may last 4 to 8 hours.

How It Works

This medicine combines two active ingredients with different mechanisms. Tolperisone is a centrally acting muscle relaxant that blocks voltage-gated sodium channels and reduces excitatory neurotransmitter release in the spinal cord and brainstem, leading to decreased muscle tone and spasm. Diclofenac is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. The combination provides both muscle relaxation and anti-inflammatory pain relief.

Mechanism Steps

1
Tolperisone blocks sodium channels: Tolperisone inhibits voltage-gated sodium channels in the central nervous system, reducing the excitability of motor neurons.
2
Reduced neurotransmitter release: This leads to decreased release of excitatory neurotransmitters, resulting in reduced muscle tone and spasm.
3
Diclofenac inhibits cyclooxygenase: Diclofenac reversibly inhibits COX-1 and COX-2 enzymes, blocking the conversion of arachidonic acid to prostaglandins.
4
Decreased prostaglandin synthesis: Lower prostaglandin levels reduce pain, inflammation, and fever.
5
Combined effect: The combination provides muscle relaxation and anti-inflammatory pain relief, addressing both components of musculoskeletal pain.

💡 How to Take supertol-d tablet

Strength: Tablet containing tolperisone 150 mg and diclofenac 50 mg.

1Take the tablet whole with a glass of water.
2Take with food or milk to reduce stomach irritation.
3Do not crush, chew, or break the tablet unless advised by your doctor.
4Follow the prescribed schedule exactly.
5Do not take more than the recommended dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally one to three times daily, depending on the severity of pain and muscle spasm. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Take with food or milk to reduce stomach upset. Use for the shortest duration necessary.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Use the lowest effective dose and monitor closely for side effects, especially gastrointestinal bleeding and kidney problems. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with kidney disease. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with liver disease. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is one tablet three times daily (tolperisone 450 mg and diclofenac 150 mg). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of stomach bleeding and liver problems.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of supertol-d tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk. If nausea persists, consult your doctor.
Stomach pain or heartburn (Common (5-10%))
Take with food. Avoid spicy foods. Consult doctor if severe.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if persistent.
Dizziness or drowsiness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Dry mouth (Common (5-10%))
Sip water or chew sugar-free gum. Consult doctor if bothersome.

🚨 Serious Side Effects

Gastrointestinal bleeding or ulcer (Rare (<0.1%))
Seek immediate medical attention if you notice black or bloody stools, vomiting blood, or severe abdominal pain.
Kidney problems (Rare (<0.1%))
Report decreased urine output, swelling, or fatigue to your doctor immediately.
Liver injury (Rare (<0.1%))
Seek medical attention if you develop yellowing of eyes or skin, dark urine, or severe fatigue.
Severe allergic reaction (Rare (<0.1%))
Call emergency services if you experience swelling of face, lips, or throat, difficulty breathing, or rash.
Cardiovascular events (Rare (<0.1%))
Seek immediate care for chest pain, shortness of breath, or sudden weakness.

⚠️ Rare Side Effects

Anaphylaxis
Emergency treatment required. Call for help immediately.
Aseptic meningitis
Seek immediate medical attention for severe headache, stiff neck, and fever.
Pancreatitis
Seek immediate care for severe upper abdominal pain radiating to back.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Corticosteroids Major
Methotrexate Major
Lithium Major
ACE inhibitors Moderate
Diuretics Moderate
SSRIs Moderate
Fluconazole Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, naproxen)
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • ACE inhibitors and ARBs
  • Diuretics
  • SSRIs
  • CYP2C9 inhibitors (e.g., fluconazole)

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding and may worsen liver toxicity. It can also increase drowsiness and dizziness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active peptic ulcer or gastrointestinal bleeding","Severe kidney disease","Severe liver disease","Heart failure (NYHA class III-IV)","History of asthma, urticaria, or allergic reaction to NSAIDs","Third trimester of pregnancy","Known allergy to tolperisone or diclofenac","Coronary artery bypass graft surgery (peri-operative period)"]

⚠️ Warnings & Precautions

["Use with caution in elderly patients due to increased risk of side effects.","Avoid in patients with dehydration or hypovolemia.","Use with caution in patients with hypertension or cardiovascular disease.","May impair ability to drive or operate machinery.","Do not use with other NSAIDs.","Monitor for signs of gastrointestinal bleeding.","Use with caution in patients with asthma.","Avoid alcohol consumption."]

🤱 Lactation Safety

Not established from the available information. Diclofenac is excreted in breast milk in small amounts. Tolperisone may also pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause nausea, vomiting, abdominal pain, dizziness, drowsiness, and in severe cases, gastrointestinal bleeding, kidney failure, or liver damage. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be considered if overdose is recent. Monitor vital signs, kidney and liver function, and manage complications.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach irritation. Avoid alcohol because it can increase the risk of stomach bleeding and liver problems. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of ulcers, kidney or liver disease, heart problems, or asthma. Do not use this medicine with other NSAIDs or blood thinners unless your doctor approves. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before taking this medicine. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy, especially in the third trimester. If you are planning pregnancy, consult your doctor to discuss alternative treatments.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain and muscle spasm. However, it should be used with caution after surgery due to the risk of bleeding and kidney problems. Follow your surgeon's instructions.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may advise you to stop it temporarily.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.
🌞
Avoid heavy lifting and sudden movements.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you feel dizzy or drowsy. Gentle stretching and low-impact activities may be beneficial. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Eat plenty of fruits and vegetables

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause stomach upset, so take it with food.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach bleeding, kidney problems, or allergic reactions. Do not stop abruptly without consulting your doctor if you have been taking it for a long time.

📅 Long-Term Use Effects

Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney problems, liver toxicity, and cardiovascular events. It is not recommended for extended use without medical supervision. Regular monitoring of kidney and liver function may be required.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Heat or cold therapy

May help relieve muscle spasm and pain.

Evidence: Moderate
Acupuncture

May provide pain relief for some patients.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Declare it at customs if required. Keep it in your carry-on luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old man with acute low back pain
Was prescribed this medicine for severe back spasm. He took it with food and avoided alcohol. Pain and spasm improved within 3 days. He was advised not to drive due to drowsiness.
💡 Lesson: Following safety advice and not driving while on this medicine prevents accidents.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Pain relief may begin within 30 to 60 minutes, while muscle relaxant effects may take a few hours.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach irritation.

Q: Is it safe to take with other painkillers?

A: No, taking with other NSAIDs can increase the risk of side effects. Consult your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for supertol-d tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken long-term for chronic pain.
    Fact: This medicine is intended for short-term use only. Long-term use increases the risk of serious side effects.
  • Myth: It is safe to take with other painkillers.
    Fact: Taking with other NSAIDs can increase the risk of bleeding and kidney problems. Always consult your doctor.
  • Myth: It can be taken on an empty stomach.
    Fact: It should be taken with food or milk to reduce stomach irritation.

🔄 Alternative Options

Generic Alternatives

  • Tolperisone + Diclofenac combination tablets from other manufacturers

Brand Alternatives

  • Tolperitas-D Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Tolperisone + Diclofenac","composition":"Tolperisone 150 mg + Diclofenac 50 mg","onset":"30-60 minutes","duration":"4-8 hours","sedation":"Less sedating"},{"medicine":"Chlorzoxazone + Diclofenac","composition":"Chlorzoxazone 500 mg + Diclofenac 50 mg","onset":"30-60 minutes","duration":"4-6 hours","sedation":"More sedating"},{"medicine":"Thiocolchicoside + Diclofenac","composition":"Thiocolchicoside 4 mg + Diclofenac 50 mg","onset":"30-60 minutes","duration":"4-6 hours","sedation":"Less sedating"}]

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