Myotop 450 SR Tablet (Tolperisone 450mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, or throat
- Difficulty breathing or wheezing
- Severe dizziness or fainting
- Irregular or fast heartbeat
- Yellowing of skin or eyes
- Severe abdominal pain or vomiting
- Unusual muscle weakness or tremors
If experiencing severe symptoms, call emergency services immediately.
What is Supertol 450 SR Tablet used for?
This medicine contains Tolperisone 450 mg, a centrally acting muscle relaxant used to treat painful muscle spasms and spasticity. It works by blocking sodium channels in the nervous system to reduce muscle tightness. It is available as a sustained-release tablet and should be taken orally as prescribed by a doctor.
- Generic Name: Tolperisone (450mg)
- Manufacturer: Superlative Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Supertol 450 SR Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टॉलपेरिसोन 450 मिलीग्राम युक्त एक मसल रिलैक्सेंट है। इसका उपयोग मांसपेशियों में ऐंठन, अकड़न और दर्द को कम करने के लिए किया जाता है। यह स्ट्रोक, मल्टीपल स्क्लेरोसिस या रीढ़ की समस्याओं के कारण होने वाली मांसपेशियों की अकड़न में भी प्रभावी है। यह दवा दिमाग और रीढ़ की हड्डी में उन संकेतों को कम करती है जो मांसपेशियों को अनियंत्रित रूप से सिकोड़ते हैं। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, जी मिचलाना, मुंह सूखना और कमजोरी शामिल हो सकते हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको सांस लेने में तकलीफ, चेहरे या गले में सूजन, धड़कन अनियमित होना या बहुत ज्यादा चक्कर आना महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को चबाएं या तोड़ें नहीं, पूरा निगल लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक गाड़ी चलाने या मशीन चलाने से बचें। शराब न पिएं क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। डॉक्टर की सलाह के बिना दवा बंद न करें।
💊 Supertol 450 SR Tablet Uses & Benefits
[{"condition":"Painful muscle spasms","description":"Relieves involuntary muscle contractions and associated pain, commonly arising from spine disorders or musculoskeletal strain.","evidence":"Well-established"},{"condition":"Spasticity due to neurological disorders","description":"Reduces muscle stiffness and spasms in conditions such as stroke, multiple sclerosis, or spinal cord injury.","evidence":"Well-established"},{"condition":"Post-operative muscle spasm","description":"May be used to ease muscle tightness and pain after certain surgical procedures.","evidence":"Limited"},{"condition":"Tension-type headache with muscle spasm","description":"Sometimes prescribed to relax neck and shoulder muscles contributing to headache.","evidence":"Limited"}]
Off-label uses: [{"condition":"Neuropathic pain","description":"Occasionally used as an add-on for nerve pain, though evidence is not strong.","evidence":"Limited"},{"condition":"Fibromyalgia","description":"May be tried for muscle pain in fibromyalgia, but not a standard treatment.","evidence":"Limited"}]
Primary treatment for: Painful muscle spasms and spasticity
Also treats: Stroke, Multiple sclerosis, Spinal cord injury, Spine disorders
📋 Drug Information
| Generic Name(s) | Tolperisone (450mg) |
| Brand Name | Supertol 450 SR Tablet |
| Manufacturer | Superlative Healthcare |
| Packaging / Form | strip of 10 tablet sr (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works centrally by blocking voltage-gated sodium channels and reducing excitatory neurotransmitter release in the spinal cord and brainstem. This dampens abnormal reflex activity that leads to excessive muscle contraction. It also has mild local anesthetic and membrane-stabilizing effects. The result is relaxation of skeletal muscle without causing significant sedation or weakness at usual doses.
Mechanism Steps
💡 How to Take Supertol 450 SR Tablet
Strength: Sustained-release tablet containing Tolperisone 450 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 450 mg once daily or as directed by your doctor. The dose may be adjusted based on your condition and response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be needed. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be needed. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 450 mg, but this may vary based on clinical judgment. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Supertol 450 SR Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Diazepam | Major | |
| Morphine | Major | |
| Amitriptyline | Moderate | |
| Amlodipine | Moderate | |
| Phenelzine | Major | |
| Fluoxetine | Moderate | |
| Ritonavir | Moderate | |
| Carbamazepine | Moderate | |
| Warfarin | Minor | |
| Paracetamol | Minor |
🚨 Major Interactions
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
- MAO inhibitors
⚡ Moderate Interactions
- Antihypertensives
- Tricyclic antidepressants
🍷 Alcohol Interaction
Alcohol can increase the sedative and dizziness effects of this medicine. It is best to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to Tolperisone or any component of the formulation","Myasthenia gravis","Pregnancy (unless clearly needed)","Breastfeeding (unless clearly needed)","Children (unless specifically prescribed)","Severe liver or kidney disease (relative)"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Do not crush, chew, or break the sustained-release tablet.","Use with caution in elderly patients due to increased risk of side effects.","Inform your doctor if you have liver or kidney disease.","Do not stop suddenly without medical advice."]
🤱 Lactation Safety
It is not known whether Tolperisone passes into breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause severe drowsiness, dizziness, nausea, and low blood pressure. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the sustained-release tablet; swallow it whole with water. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness or dizziness. Do not drink alcohol while taking this medicine because it can increase sedation and impair your alertness. Inform your doctor about all other medicines you are taking, especially those for blood pressure, pain, or mental health conditions. Do not stop this medicine suddenly without medical advice. Keep it out of reach of children and store it in a cool, dry place.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Start with a lower dose and monitor closely. Falls risk may be increased.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed and prescribed by a doctor.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to relieve muscle spasms. Follow your surgeon's instructions regarding its use and any precautions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with sedatives or anesthetics used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel drowsy or dizzy. Avoid activities that require high alertness, such as heavy lifting or high-impact sports, until you know how the medicine affects you. Gentle stretching and physical therapy are encouraged as advised by your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves operating heavy machinery.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Your doctor will advise you on whether to stop or adjust the dose.
📅 Long-Term Use Effects
Long-term use of this medicine should be monitored by a doctor. Periodic assessment of liver and kidney function may be advised. Do not use for prolonged periods without medical supervision. If you experience any unusual symptoms, report them to your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and spasticity.
Evidence: Well-establishedMay help relax muscles and reduce pain.
Evidence: LimitedSome people find relief from muscle pain, but evidence is mixed.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Keep it in your carry-on luggage to avoid loss. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Relief from muscle spasm may begin within 30-60 minutes after taking a dose, but full benefit may take a few days of regular use.
A: No, alcohol can increase the sedative effects of this medicine and should be avoided.
A: Long-term use should be under medical supervision. Your doctor may monitor liver and kidney function periodically.
A: This medicine may cause drowsiness or dizziness. Avoid driving until you know how it affects you.
A: Take it as soon as you remember, but if it's almost time for your next dose, skip it and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for Supertol 450 SR Tablet
View AllAlternative brands with exact same active ingredient:
-
toperizone 450mg tablet srEmcure Pharmaceuticals Ltd ₹143.44 45% CHEAPER
-
myo-mr od 450mg tabletStrides shasun Ltd ₹150.00 42.4% CHEAPER
-
tolflex 450 sr tabletMerck Ltd ₹154.41 40.8% CHEAPER
-
egason 450mg tablet srSnu Biocare ₹220.31 15.5% CHEAPER
-
Tolrest 450mg TabletMSN Laboratories ₹220.31 15.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller.
Fact: This medicine is a muscle relaxant, not a general painkiller. It relieves pain caused by muscle spasm. - Myth: You can stop this medicine abruptly.
Fact: You should not stop this medicine without consulting your doctor, as it may cause withdrawal effects or worsening of symptoms. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol can increase the sedative effects of this medicine and should be avoided.
🔄 Alternative Options
Generic Alternatives
- Tolperisone 450 mg sustained-release tablet
Brand Alternatives
- Myotop 450 SR Tablet