Glura 50mg Tablet (Sitagliptin): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain that may radiate to the back, with or without nausea and vomiting
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- Large fluid-filled blisters on the skin
- Severe joint pain that interferes with daily activities
- Symptoms of low blood sugar such as shakiness, sweating, confusion, or rapid heartbeat
- Yellowing of the skin or eyes
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is Staglob 50mg Tablet used for?
This medicine contains Sitagliptin 50 mg, an oral DPP-4 inhibitor used to treat type 2 diabetes. It works by increasing incretin hormones, which help the pancreas release more insulin when blood sugar is high. It is taken once daily with or without food.
- Generic Name: Sitagliptin (50mg)
- Manufacturer: Globela Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Staglob 50mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज में ब्लड शुगर को कंट्रोल करने के लिए इस्तेमाल की जाती है। इसमें सिटाग्लिप्टिन 50 मिलीग्राम होता है, जो एक ओरल एंटीडायबिटिक दवा है। यह शरीर में इंसुलिन हार्मोन को बढ़ाने में मदद करती है, जिससे खून में शुगर का स्तर कम होता है। यह दवा आमतौर पर डाइट और एक्सरसाइज के साथ ली जाती है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के आम साइड इफेक्ट्स में सिरदर्द, नाक बंद होना, गले में खराश, और पेट में हल्की तकलीफ शामिल हैं। कुछ लोगों को जी मिचलाना या दस्त भी हो सकता है। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर साइड इफेक्ट्स में अग्नाशय की सूजन (पैन्क्रियाटाइटिस), एलर्जी, और त्वचा पर छाले शामिल हैं। अगर आपको पेट में तेज दर्द, सांस लेने में तकलीफ, या चेहरे पर सूजन हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे खाने के साथ या बिना खाने के लिया जा सकता है। अगर आपको कोई डोज मिस हो जाए, तो याद आते ही ले लें, लेकिन अगर अगली डोज का समय हो गया है, तो मिस की गई डोज छोड़ दें। एक साथ दो डोज न लें। अपने डॉक्टर को अपनी सभी दवाओं और बीमारियों के बारे में बताएं। शराब का सेवन कम करें। नियमित रूप से ब्लड शुगर की जांच करें। स्वस्थ आहार और व्यायाम को अपनाएं।
💊 Staglob 50mg Tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus (monotherapy)","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes when metformin is not suitable or not tolerated.","evidence":"Well-established"},{"condition":"Type 2 diabetes mellitus (combination therapy)","description":"Used in combination with metformin, a sulfonylurea, a thiazolidinedione, or insulin when a single agent does not provide adequate glycemic control.","evidence":"Well-established"},{"condition":"Type 2 diabetes mellitus with renal impairment","description":"Used with dose adjustment in patients with mild to moderate renal impairment; not recommended in severe renal impairment or dialysis.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Non-alcoholic fatty liver disease (NAFLD)","description":"Some studies suggest sitagliptin may improve liver enzymes and insulin resistance in NAFLD, but evidence is not conclusive.","evidence":"Limited"},{"condition":"Polycystic ovary syndrome (PCOS)","description":"Occasionally used off-label to improve insulin resistance in PCOS, but not a standard treatment.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Obesity, Metabolic syndrome, Non-alcoholic fatty liver disease
📋 Drug Information
| Generic Name(s) | Sitagliptin (50mg) |
| Brand Name | Staglob 50mg Tablet |
| Manufacturer | Globela Pharma Pvt Ltd |
| Packaging / Form | strip of 10 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed. Protect from moisture and direct sunlight. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. However, sitagliptin is included in some international guidelines as an option for second-line or third-line therapy in type 2 diabetes. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for type 2 diabetes management may include DPP-4 inhibitors as an option. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4). DPP-4 is responsible for breaking down incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By inhibiting DPP-4, this medicine increases the active levels of these incretin hormones in the bloodstream. GLP-1 and GIP then act on the pancreas to stimulate insulin release when blood glucose levels are high and to reduce glucagon secretion. This leads to better blood sugar control, particularly after meals, without causing hypoglycemia when used alone.
Mechanism Steps
💡 How to Take Staglob 50mg Tablet
Strength: Sitagliptin 50 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual recommended dose of this medicine for adults with normal kidney function is 50 mg taken orally once daily, with or without food. For patients with moderate renal impairment (eGFR 30 to 45 mL/min/1.73 m2), the dose is reduced to 25 mg once daily. For severe renal impairment (eGFR <30 mL/min/1.73 m2) or dialysis, a lower dose of 25 mg once daily may be used, but it is not recommended. When used in combination with insulin or a sulfonylurea, a lower dose of the insulin or sulfonylurea may be needed to reduce the risk of hypoglycemia. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required based on age alone. However, elderly patients are more likely to have reduced renal function, so renal function should be assessed before and during treatment. Dose should be adjusted according to renal function. |
| Renal Impairment | For patients with mild renal impairment (eGFR ≥60 mL/min/1.73 m2), no dose adjustment is needed. For moderate renal impairment (eGFR 30 to 45 mL/min/1.73 m2), the dose is 25 mg once daily. For severe renal impairment (eGFR <30 mL/min/1.73 m2) or dialysis, the dose is 25 mg once daily, but it is not recommended. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No dose adjustment is necessary for patients with mild to moderate hepatic impairment. There is limited experience in patients with severe hepatic impairment; use with caution. |
| Maximum Daily Dose | 50 mg once daily for normal renal function; 25 mg once daily for moderate to severe renal impairment. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Staglob 50mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | |
| Sulfonylureas | Major | |
| Digoxin | Moderate | |
| Thiazide diuretics | Moderate | |
| Corticosteroids | Minor | |
| Sympathomimetics | Minor |
🚨 Major Interactions
- Insulin
- Sulfonylureas (e.g., glimepiride, glyburide)
⚡ Moderate Interactions
- Digoxin
- Thiazide diuretics
🍷 Alcohol Interaction
Alcohol may affect blood sugar control and can increase the risk of hypoglycemia or hyperglycemia. It is advisable to limit alcohol consumption while taking this medicine. If you choose to drink alcohol, do so in moderation and monitor your blood sugar closely.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to sitagliptin or any component of the formulation","Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Pancreatitis: Acute pancreatitis, including fatal cases, has been reported. Monitor for signs and symptoms; discontinue if suspected.","Hypoglycemia: Increased risk when used with insulin or sulfonylureas. Consider dose reduction of these agents.","Renal impairment: Dose adjustment required for moderate renal impairment; not recommended for severe impairment.","Hypersensitivity reactions: Anaphylaxis, angioedema, and exfoliative skin conditions have been reported. Discontinue if suspected.","Bullous pemphigoid: Reported with DPP-4 inhibitors. Discontinue if blisters develop.","Severe joint pain: Reported with DPP-4 inhibitors. Discontinue if severe joint pain occurs.","Not for type 1 diabetes or diabetic ketoacidosis.","Not a substitute for diet and exercise."]
🤱 Lactation Safety
Not established from the available information. It is not known whether sitagliptin is excreted in human breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
In case of overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Sitagliptin is not significantly removed by hemodialysis, but prolonged dialysis may be considered in severe cases. Monitor blood glucose and vital signs.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. This medicine is usually taken once daily with or without food. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Inform your doctor if you have a history of pancreatitis, kidney disease, or heart failure. Your doctor may need to adjust the dose if your kidney function is reduced. Tell your doctor about all other medicines you are taking, especially insulin, sulfonylureas, or diuretics, as they may interact with this medicine. Avoid excessive alcohol consumption while taking this medicine, as it can affect blood sugar control. Check your blood sugar regularly as advised by your doctor. Follow a healthy diet and exercise regularly to get the best results from this medicine. Do not share this medicine with others, even if they have similar symptoms. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function, so renal function should be assessed before and during treatment. Dose adjustment may be needed. No dose adjustment based on age alone is required.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning to become pregnant, consult your doctor to discuss alternative treatments for diabetes that are safe during pregnancy.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. Blood sugar levels may need to be monitored closely during and after surgery. Your doctor may temporarily adjust your diabetes medications.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. No specific precautions are usually needed, but maintain good oral hygiene and monitor blood sugar levels.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is beneficial for blood sugar control, but if you are taking this medicine with insulin or a sulfonylurea, be aware of the increased risk of hypoglycemia during or after exercise. Check your blood sugar before and after exercise and carry a fast-acting sugar source.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience hypoglycemia (especially when used with insulin or sulfonylureas), avoid driving until your blood sugar is stable. It does not usually interfere with daily activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as pancreatitis, severe allergic reactions, or bullous pemphigoid, stop the medicine and seek immediate medical attention. Your doctor may adjust or discontinue the medicine based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and well tolerated. It does not cause weight gain and has a low risk of hypoglycemia when used alone. Regular monitoring of blood sugar, kidney function, and HbA1c is recommended. Rarely, long-term use may be associated with pancreatitis or severe joint pain. Consult your doctor if you experience any unusual symptoms.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are essential for managing type 2 diabetes and can complement medicine.
Evidence: Well-establishedMetformin, sulfonylureas, or SGLT2 inhibitors may be alternatives based on individual needs.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, people with diabetes are advised to receive routine vaccinations such as influenza and pneumococcal vaccines. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or exposure to extreme temperatures. Store at room temperature and protect from moisture. If crossing time zones, continue taking your dose at the same local time as usual, but consult your doctor if you are unsure. Carry enough supply for your entire trip and a few extra days in case of delays. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within a few hours, but the full effect on HbA1c may take several weeks to months. Regular monitoring is important.
A: Yes, this medicine is often prescribed in combination with metformin. Your doctor will determine the appropriate doses.
A: This medicine is primarily excreted by the kidneys, so dose adjustment is needed if you have kidney problems. Your doctor will monitor your kidney function.
A: Signs include shakiness, sweating, confusion, rapid heartbeat, and hunger. If you experience these, treat with fast-acting sugar and inform your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for Staglob 50mg Tablet
View AllAlternative brands with exact same active ingredient:
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sitazee 50 tabletZeelab Pharmacy Pvt Ltd ₹30.00 82.9% CHEAPER
-
sitason 50 tabletUnison Pharmaceuticals Pvt Ltd ₹36.00 79.4% CHEAPER
-
stegsita 50 tabletMetalis Lifesciences Pvt Ltd ₹59.50 66% CHEAPER
-
xitoglip 50mg tabletExito Pharma ₹84.38 51.8% CHEAPER
-
sitafirst 50mg tabletAkned Healthcare Pvt. Ltd. ₹89.06 49.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. It must be taken along with diet and exercise. - Myth: This medicine causes weight gain.
Fact: This medicine is weight-neutral and does not typically cause weight gain. - Myth: This medicine can be taken without a prescription.
Fact: This medicine is a prescription drug and should only be taken under a doctor's supervision. - Myth: This medicine can be used for type 1 diabetes.
Fact: This medicine is not effective for type 1 diabetes and is not approved for that use.
🔄 Alternative Options
Generic Alternatives
- Sitagliptin 50 mg tablet (generic)
Brand Alternatives
- Januvia 50 mg tablet
- Istavel 50 mg tablet
- Sitagliptin 50 mg tablet (various brands)