Netocold Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or stool
- Severe abdominal pain
- Yellowing of skin or eyes
- Difficulty breathing or swelling of face, lips, or throat
- Severe drowsiness or confusion
- Unusual bleeding or bruising
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is Sitrizin Cold Syrup used for?
This medicine is a combination syrup containing chlorpheniramine maleate (an antihistamine) and paracetamol (a pain reliever and fever reducer). It is used to treat symptoms of common cold and allergies such as runny nose, sneezing, and mild fever. It should not be used for more than 7 days without medical advice.
- Generic Name: Chlorpheniramine Maleate (2.5mg/5ml) + Paracetamol (125mg/5ml)
- Manufacturer: Pranshu Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Sitrizin Cold Syrup के बारे में (Hindi Summary)
उपयोग: यह दवा आम सर्दी और एलर्जी के लक्षणों जैसे नाक बहना, छींक आना, आंखों में खुजली और हल्के बुखार से राहत दिलाने के लिए इस्तेमाल की जाती है। इसमें क्लोरफेनिरामाइन मेलिएट और पैरासिटामोल होते हैं। यह दवा केवल लक्षणों का इलाज करती है, बीमारी का नहीं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि और पेट में गड़बड़ी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, लीवर की समस्या या खून की बीमारी हो सकती है। कोई भी गंभीर लक्षण दिखने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा की अनुशंसित खुराक से अधिक न लें। पैरासिटामोल युक्त अन्य दवाओं के साथ इसका सेवन न करें। शराब का सेवन न करें। इस दवा से नींद आ सकती है, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। 7 दिनों से अधिक इसका उपयोग न करें।
💊 Sitrizin Cold Syrup Uses & Benefits
[{"condition":"Common cold","description":"Relieves runny nose, sneezing, and mild fever associated with the common cold.","evidence":"Well-established for symptomatic relief."},{"condition":"Allergic rhinitis","description":"Reduces sneezing, rhinorrhea, and itching of the nose and throat.","evidence":"Well-established for symptomatic relief."},{"condition":"Allergic conjunctivitis","description":"Helps relieve watery, itchy eyes due to allergies.","evidence":"Limited, but commonly used."},{"condition":"Mild pain and fever","description":"Paracetamol component provides relief from mild pain and reduces fever.","evidence":"Well-established."}]
Off-label uses: [{"condition":"Insomnia","description":"Sometimes used off-label for its sedative effects, but not recommended due to potential side effects.","evidence":"Limited and not recommended."},{"condition":"Motion sickness","description":"Chlorpheniramine may help prevent motion sickness, but this is not a primary indication.","evidence":"Limited."}]
Primary treatment for: Common cold and allergic rhinitis
Also treats: Allergic conjunctivitis, Sinusitis, Pharyngitis
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (2.5mg/5ml) + Paracetamol (125mg/5ml) |
| Brand Name | Sitrizin Cold Syrup |
| Manufacturer | Pranshu Healthcare |
| Packaging / Form | bottle of 60 ml Syrup (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place, away from direct sunlight. Keep the bottle tightly closed. Do not refrigerate. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors on effector cells, thereby preventing histamine-mediated allergic responses such as vasodilation, increased vascular permeability, and sensory nerve stimulation. It also possesses anticholinergic properties, which contribute to drying of secretions. Paracetamol (acetaminophen) acts primarily in the central nervous system by inhibiting prostaglandin synthesis, likely through COX-3 inhibition or modulation of the endogenous cannabinoid system, leading to analgesic and antipyretic effects. The combination provides symptomatic relief of allergic and cold symptoms.
Mechanism Steps
💡 How to Take Sitrizin Cold Syrup
Strength: Each 5 ml of syrup contains 2.5 mg chlorpheniramine maleate and 125 mg paracetamol.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 ml (2 teaspoons) every 4 to 6 hours as needed for symptoms, not to exceed 6 doses (60 ml) in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Use the measuring cup provided with the product for accurate dosing. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially drowsiness, confusion, and anticholinergic effects. Use with caution and consider lower doses. Consult a doctor for individualized dosing. |
| Renal Impairment | In patients with renal impairment, chlorpheniramine may accumulate and cause increased side effects. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, paracetamol metabolism may be reduced, increasing the risk of hepatotoxicity. Chlorpheniramine metabolism may also be affected. Use with caution and consider lower doses. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | For adults: Maximum 60 ml (containing 30 mg chlorpheniramine maleate and 1500 mg paracetamol) in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Sitrizin Cold Syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Alcohol | Major | |
| Other paracetamol products | Major | |
| CNS depressants | Moderate | |
| Anticholinergics | Moderate | |
| Warfarin | Moderate | |
| Antihypertensives | Minor | |
| Diuretics | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Alcohol
- Other paracetamol-containing products
⚡ Moderate Interactions
- CNS depressants (e.g., benzodiazepines, opioids, sedatives)
- Anticholinergic drugs (e.g., tricyclic antidepressants, atropine)
- Warfarin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol enhances the sedative effects of chlorpheniramine and increases the risk of liver damage from paracetamol. Concomitant use can lead to severe drowsiness, impaired motor skills, and potential hepatotoxicity.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpheniramine, paracetamol, or any component of the formulation","Severe liver disease or active liver disease","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","MAOI therapy within the last 14 days","Children under 2 years of age"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Do not exceed recommended dose; high doses of paracetamol can cause liver damage.","Avoid alcohol while taking this medicine.","Use with caution in patients with asthma, COPD, or sleep apnea.","Use with caution in elderly patients due to increased risk of confusion, sedation, and anticholinergic effects.","Consult a doctor before use if pregnant or breastfeeding.","Do not use for more than 7 days without medical advice."]
🤱 Lactation Safety
Chlorpheniramine and paracetamol are excreted in breast milk in small amounts. Chlorpheniramine may cause drowsiness in the infant. Consult a doctor before use during breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and severe anticholinergic effects from chlorpheniramine. Symptoms of paracetamol overdose include nausea, vomiting, abdominal pain, and liver failure. Symptoms of chlorpheniramine overdose include drowsiness, confusion, tachycardia, hallucinations, and seizures. If overdose is suspected, seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours, acetylcysteine for paracetamol toxicity, and supportive care. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Do not exceed the recommended dose of this medicine. Avoid using other products containing paracetamol while taking this medicine to prevent accidental overdose. Do not consume alcohol while taking this medicine, as it can increase the risk of liver damage and enhance drowsiness. This medicine may cause drowsiness; avoid driving or operating heavy machinery until you know how it affects you. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not use this medicine for more than 7 days without consulting a doctor. Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of chlorpheniramine, such as drowsiness, confusion, dry mouth, and urinary retention. They may also be at higher risk of paracetamol-induced liver toxicity. Use with caution and consider lower doses. Consult a doctor for individualized dosing.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Chlorpheniramine and paracetamol are generally considered safe in pregnancy when used as directed, but the lowest effective dose for the shortest duration is recommended. Avoid unnecessary use.
🏥 Post-Surgery Considerations
After surgery, consult your doctor before taking this medicine, as it may interact with anesthetics or other medications. Paracetamol can be used for pain relief, but chlorpheniramine may cause excessive drowsiness. Follow your surgeon's instructions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may cause dry mouth and drowsiness. Your dentist may recommend adjusting the dose or timing.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you exercise, do so with caution and stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid these activities until you know how the medicine affects you. If your work requires alertness, discuss with your doctor about alternative options.
🛑 When to Stop This Medicine
Stop taking this medicine when your symptoms improve or as directed by your doctor. Do not use it for more than 7 days without consulting a doctor. If you experience any serious side effects, stop immediately and seek medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of paracetamol can increase the risk of liver damage, especially at high doses. Chlorpheniramine may cause tolerance, dependence, and cognitive impairment with long-term use. If you need this medicine for more than 7 days, consult a doctor to evaluate the underlying condition.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps relieve nasal congestion without medication.
Evidence: Well-established for symptom relief.Can help loosen mucus and relieve congestion.
Evidence: Commonly used, limited evidence.For allergic conjunctivitis, targeted relief.
Evidence: Well-established.💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are sick with a fever, it is best to postpone vaccination until you recover. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription in case of customs checks. Store it in a cool, dry place, away from direct sunlight. If traveling across time zones, continue your regular dosing schedule as prescribed. Do not leave it in a hot car. Check local regulations regarding carrying medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts to relieve symptoms within 30-60 minutes after taking a dose.
A: It can be taken with or without food, but if it upsets your stomach, take it with food or milk.
A: This medicine is not recommended for children under 2 years. For older children, consult a pediatrician for appropriate dosing.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Do not take it with other medicines containing paracetamol or antihistamines without consulting a doctor, as it may lead to overdose or increased side effects.
🤔 Common Patient Concerns
🔄 Substitutes for Sitrizin Cold Syrup
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection. - Myth: It is safe to take this medicine for weeks.
Fact: Prolonged use can lead to side effects and mask serious conditions. Use for more than 7 days only under medical supervision. - Myth: More is better.
Fact: Taking more than the recommended dose can cause serious harm, including liver damage.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine maleate + Paracetamol syrup (various manufacturers)
Brand Alternatives
- Netocold syrup