Grakof Expectorant: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe rash, blistering, or peeling skin
- Unusual bruising or bleeding
- Severe drowsiness or confusion
- Inability to pass urine
- Seizures or convulsions
- Yellowing of the skin or eyes
- Persistent fever or worsening symptoms
If experiencing severe symptoms, call emergency services immediately.
What is koflatch syrup used for?
This medicine is a combination of chlorpheniramine maleate (an antihistamine) and ammonium chloride (an expectorant) used for temporary relief of cough, sneezing, runny nose, and congestion due to colds or allergies. It works by blocking histamine and thinning mucus. It can cause drowsiness, so avoid driving. Take as directed by your doctor.
- Generic Name: Chlorpheniramine Maleate (2.5mg/5ml) + Ammonium Chloride (125mg/5ml)
- Manufacturer: Liza Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 koflatch syrup के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरफेनिरामाइन मेलिएट और अमोनियम क्लोराइड का संयोजन है, जिसका उपयोग सर्दी, खांसी, छींक, नाक बहना और गले में खराश जैसे लक्षणों से राहत के लिए किया जाता है। यह एलर्जी और श्वसन संबंधी समस्याओं में भी प्रभावी है। यह दवा बलगम को पतला करके खांसी को आसान बनाती है। इसे डॉक्टर की सलाह के अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, जी मिचलाना और धुंधली दृष्टि शामिल हैं। कुछ लोगों को कब्ज या पेशाब करने में कठिनाई हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या त्वचा पर गंभीर दाने हों तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इससे नींद आ सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें। शराब का सेवन न करें। अन्य दवाओं के साथ लेने से पहले डॉक्टर से सलाह लें। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के इसका सेवन न करें। बच्चों को डॉक्टर की सलाह के बिना न दें।
💊 koflatch syrup Uses & Benefits
[{"condition":"Common cold with cough and nasal congestion","description":"Provides temporary relief of cough, sneezing, runny nose, and throat irritation associated with the common cold.","evidence":"Well-established for symptomatic relief"},{"condition":"Allergic rhinitis","description":"Helps reduce sneezing, nasal itching, runny nose, and watery eyes caused by allergies.","evidence":"Well-established for antihistamine component"},{"condition":"Productive cough","description":"Ammonium chloride helps loosen mucus, making cough more productive and easier to clear.","evidence":"Traditionally used; evidence is supportive but limited"},{"condition":"Upper respiratory tract infection with cough","description":"Used for short-term relief of cough and congestion in mild upper respiratory infections.","evidence":"Symptomatic use supported by clinical experience"}]
Off-label uses: [{"condition":"Pruritus (itching) due to mild allergic skin conditions","description":"Antihistamine component may help relieve itching, but this combination is not primarily intended for skin allergies.","evidence":"Limited"},{"condition":"Motion sickness","description":"Chlorpheniramine has some antiemetic properties, but this combination is not a standard treatment for motion sickness.","evidence":"Limited"}]
Primary treatment for: Cough and upper respiratory allergy symptoms
Also treats: Common cold, Allergic rhinitis, Productive cough, Upper respiratory tract infection
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (2.5mg/5ml) + Ammonium Chloride (125mg/5ml) |
| Brand Name | koflatch syrup |
| Manufacturer | Liza Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergy symptoms such as sneezing, runny nose, and watery eyes. It also has anticholinergic properties that contribute to dry mouth and drowsiness. Ammonium chloride is an expectorant that irritates the gastric mucosa, reflexively increasing respiratory tract fluid secretion, which helps thin bronchial mucus and makes cough more productive.
Mechanism Steps
💡 How to Take koflatch syrup
Strength: Each 5 mL of oral liquid contains chlorpheniramine maleate 2.5 mg and ammonium chloride 125 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 to 10 mL orally every 4 to 6 hours as needed for cough and congestion, not to exceed 6 doses in 24 hours. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not self-medicate beyond the recommended duration. Follow your doctor's instructions carefully. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. This medicine is contraindicated in children under 2 years of age due to risk of severe respiratory depression. |
| Elderly Dosage | Older adults are more sensitive to the anticholinergic and sedative effects of this medicine. Use with caution and at the lowest effective dose. Dose must be individualized by a qualified clinician based on renal and hepatic function and overall health status. |
| Renal Impairment | Use with caution in patients with renal impairment. Ammonium chloride may worsen metabolic acidosis and electrolyte imbalances. Dose adjustment may be necessary. Consult a clinician for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Chlorpheniramine is metabolized in the liver, and ammonium chloride is metabolized to urea. Dose adjustment may be necessary. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose for adults is 60 mL in 24 hours (equivalent to 30 mg chlorpheniramine maleate and 1500 mg ammonium chloride). Do not exceed this dose without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of koflatch syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Alcohol | Major | |
| Benzodiazepines | Major | |
| Opioids | Major | |
| Tricyclic antidepressants | Major | |
| Fluoxetine | Moderate | |
| Paroxetine | Moderate | |
| Quinidine | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Central nervous system depressants (e.g., alcohol, benzodiazepines, opioids)
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- CYP2D6 substrates (e.g., metoprolol, tamoxifen)
- Diuretics and corticosteroids
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Both chlorpheniramine and alcohol cause central nervous system depression, and their combination can lead to excessive drowsiness, dizziness, impaired coordination, and increased risk of accidents. It can also increase the risk of respiratory depression, especially in high doses.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to chlorpheniramine maleate, ammonium chloride, or any component of the formulation","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy with residual urine","Severe liver disease","Severe kidney disease","MAOI therapy within the last 14 days","Children under 2 years of age (due to risk of severe respiratory depression)","Breastfeeding without medical advice"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants while taking this medicine.","Use with caution in patients with asthma, COPD, or other respiratory conditions.","Use with caution in older adults due to increased risk of confusion, urinary retention, and falls.","Do not use for chronic cough or cough with excessive secretions without medical advice.","Do not exceed the recommended dose.","Keep out of reach of children.","Consult a doctor if symptoms persist beyond 7 days or worsen.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Use with caution in patients with cardiovascular disease, hypertension, or hyperthyroidism."]
🤱 Lactation Safety
Chlorpheniramine maleate passes into breast milk and may cause drowsiness in the nursing infant. Ammonium chloride may also pass into breast milk. This medicine should be used during breastfeeding only if prescribed by a clinician. Monitor the infant for excessive drowsiness or poor feeding.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, hallucinations, seizures, respiratory depression, and cardiac arrhythmias. Ammonium chloride overdose can cause metabolic acidosis. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic, including gastric lavage if within 1-2 hours of ingestion, activated charcoal, and monitoring of vital signs. There is no specific antidote. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your clinician. Do not exceed the recommended dose. Avoid driving or operating machinery until you know how this medicine affects you, because it can cause drowsiness. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dizziness. Tell your doctor about all other medicines you take, especially sedatives, antidepressants, opioid painkillers, and other antihistamines. Do not use this medicine for more than a few days without medical advice. Keep out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. If you have glaucoma, prostate enlargement, urinary retention, liver disease, or kidney disease, inform your doctor before taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more sensitive to the sedative and anticholinergic effects of this medicine. They may experience increased drowsiness, confusion, dry mouth, urinary retention, and risk of falls. Use with caution at the lowest effective dose. Regular monitoring for side effects is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy has not been established. Your doctor will weigh the benefits and risks and may recommend alternative treatments.
🏥 Post-Surgery Considerations
After surgery, use this medicine only if prescribed by your doctor. It may interact with anesthetics and other medications used during surgery. Inform your surgeon and anesthesiologist about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it can cause dry mouth and may interact with medications used during dental procedures. It may also increase drowsiness when combined with sedatives used in dentistry.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine, especially if you feel drowsy or dizzy. Light activities like walking may be fine, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. It is best to avoid these activities until you know how the medicine affects you. If your work requires mental alertness, discuss with your doctor about timing or alternative options.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of chlorpheniramine may lead to tolerance, dependence, and increased risk of side effects such as confusion, urinary retention, and constipation. Ammonium chloride can cause metabolic acidosis and electrolyte imbalances with prolonged use. Regular monitoring of renal function, electrolytes, and liver function may be required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and relieve nasal congestion.
Evidence: Well-established for symptomatic reliefCan help clear nasal passages and reduce congestion.
Evidence: Well-establishedSoothes the throat and may help reduce cough frequency.
Evidence: ModerateAlternative for allergic rhinitis symptoms.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are unwell with a fever or severe symptoms, it is advisable to postpone vaccination until you recover. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or doctor's note, especially for international travel. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, continue your regular dosing schedule as prescribed, but consult your doctor for specific advice. Check local customs regulations regarding carrying liquid medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The antihistamine effect usually starts within 30 to 60 minutes, and peak effects occur in 2 to 6 hours. The expectorant effect may take longer.
A: Yes, but it may cause drowsiness, which can be helpful at night. However, avoid driving or operating machinery after taking it.
A: It is not recommended for children under 2 years. For older children, consult a pediatrician for appropriate dosing.
A: No, alcohol should be avoided as it increases drowsiness and the risk of serious side effects.
A: Take it as soon as you remember if it is not almost time for your next dose. Otherwise, skip it and continue your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for koflatch syrup
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases drowsiness and the risk of serious side effects; it should be avoided. - Myth: More medicine means faster relief.
Fact: Taking more than the recommended dose can cause serious harm and does not improve relief. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with certain conditions like glaucoma, urinary retention, or severe liver/kidney disease.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine maleate + ammonium chloride oral liquid