Adtrinib 200mg Tablet (sorafenib): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit, black or tarry stools, or coughing up blood
- Chest pain, shortness of breath, or swelling of the legs
- Sudden severe headache, confusion, seizures, or vision changes
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- Decreased urine output or swelling of the face, hands, or feet
- Fever, chills, or other signs of infection
- Severe skin rash with blisters or peeling
- Unusual bruising or bleeding that does not stop
If experiencing severe symptoms, call emergency services immediately.
What is shilfenib 200mg tablet used for?
This medicine contains sorafenib 200 mg, a targeted anticancer tablet used for advanced liver cancer, kidney cancer, and certain thyroid cancers. It is taken orally, usually 400 mg twice daily, under the supervision of an oncologist.
- Generic Name: Sorafenib (200mg)
- Manufacturer: Shilpa Medicare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 shilfenib 200mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सोराफेनिब 200 मिलीग्राम की गोली है, जिसका उपयोग कैंसर के इलाज में किया जाता है। यह मुख्य रूप से लीवर कैंसर (जिगर का कैंसर), किडनी कैंसर और थायरॉइड कैंसर के कुछ प्रकारों के लिए दी जाती है, जब अन्य इलाज काम नहीं करते। यह दवा कैंसर कोशिकाओं की वृद्धि को धीमा करती है और ट्यूमर तक खून की आपूर्ति को कम करती है। इसे मुँह से लिया जाता है, आमतौर पर दिन में दो बार 400 मिलीग्राम की खुराक पर, लेकिन सही खुराक डॉक्टर तय करते हैं। यह दवा केवल कैंसर रोग विशेषज्ञ की देखरेख में ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के कई दुष्प्रभाव हो सकते हैं। सबसे आम हैं दस्त, जी मिचलाना, उल्टी, मुँह के छाले, भूख न लगना, थकान, त्वचा पर दाने, हाथ-पैर की त्वचा का लाल होना या छिलना, और रक्तचाप बढ़ना। कुछ गंभीर दुष्प्रभाव भी हो सकते हैं जैसे गंभीर रक्तस्राव, दिल की समस्या, लीवर या किडनी की क्षति, और संक्रमण। कोई भी नया या बिगड़ता लक्षण दिखे तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इसे भोजन के साथ या बिना भोजन के लिया जा सकता है। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए क्योंकि इससे बच्चे को नुकसान हो सकता है। इलाज के दौरान और आखिरी खुराक के बाद कम से कम दो सप्ताह तक गर्भनिरोधक का इस्तेमाल करें। अंगूर और अंगूर का जूस न लें। बिना डॉक्टर की सलाह के दवा बंद न करें। नियमित रूप से रक्तचाप, लीवर और किडनी की जाँच कराते रहें।
💊 shilfenib 200mg tablet Uses & Benefits
[{"condition":"Advanced hepatocellular carcinoma","description":"Used as a first-line oral targeted therapy for liver cancer that cannot be removed by surgery or has spread to other organs.","evidence":"Well-established"},{"condition":"Advanced renal cell carcinoma","description":"Used for advanced kidney cancer after other treatments such as immunotherapy or other targeted therapies have not worked.","evidence":"Well-established"},{"condition":"Radioactive iodine-refractory differentiated thyroid cancer","description":"Used for a type of thyroid cancer that no longer responds to radioactive iodine treatment.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Desmoid tumours","description":"Sometimes used off-label for aggressive desmoid tumours when other treatments are not suitable.","evidence":"Limited"},{"condition":"Advanced medullary thyroid cancer","description":"Occasionally used off-label in some patients with advanced medullary thyroid cancer.","evidence":"Limited"}]
Primary treatment for: Advanced hepatocellular carcinoma
Also treats: Advanced renal cell carcinoma, Radioactive iodine-refractory differentiated thyroid cancer
📋 Drug Information
| Generic Name(s) | Sorafenib (200mg) |
| Brand Name | shilfenib 200mg tablet |
| Manufacturer | Shilpa Medicare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep the tablets in their original container and out of reach of children. |
| Shelf Life | Not established from the available information. Refer to the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a multikinase inhibitor that blocks several enzymes involved in cancer growth and blood vessel formation. It inhibits RAF kinases, including BRAF and CRAF, which are part of the MAPK signalling pathway that drives cancer cell division. It also blocks vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3), platelet-derived growth factor receptor beta (PDGFR-beta), and other kinases such as KIT, FLT-3, and RET. By blocking these targets, it slows tumour cell proliferation and starves the tumour of its blood supply.
Mechanism Steps
💡 How to Take shilfenib 200mg tablet
Strength: Immediate-release tablet containing 200 mg of sorafenib.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 400 mg (two 200 mg tablets) taken orally twice daily, approximately 12 hours apart, with or without food. However, the exact dose and schedule must be individualized by a qualified clinician based on the type of cancer, stage, response to treatment, and the patient's liver and kidney function. Dose reductions may be needed if side effects occur. Do not change the dose without consulting your oncologist. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially heart and kidney problems. Dose selection should be cautious, and close monitoring is recommended. No specific dose adjustment is established solely based on age. |
| Renal Impairment | No dose adjustment is required for mild to moderate kidney impairment. The safety and efficacy in severe kidney impairment are not established. Use with caution and monitor closely. |
| Hepatic Impairment | No dose adjustment is required for mild to moderate liver impairment (Child-Pugh A or B). This medicine is contraindicated in severe liver impairment (Child-Pugh C). Monitor liver function regularly. |
| Maximum Daily Dose | The maximum recommended daily dose is 800 mg (400 mg twice daily). Doses above this are not recommended. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of shilfenib 200mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ketoconazole | Major | |
| Rifampicin | Major | |
| St John's wort | Major | |
| Dexamethasone | Moderate | |
| Phenytoin | Moderate | |
| Doxorubicin | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Warfarin
- Ketoconazole
- Rifampicin
- St John's wort
⚡ Moderate Interactions
- Dexamethasone
- Phenytoin
- Doxorubicin
🍷 Alcohol Interaction
Alcohol may worsen liver toxicity and increase the risk of bleeding or stomach upset. It is best to avoid alcohol while taking this medicine, especially if you have liver problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to sorafenib or any component of the tablet","Severe liver impairment","Pregnancy","Breastfeeding","Concurrent use with strong CYP3A4 inducers or inhibitors without dose adjustment","Certain severe heart conditions as determined by the treating doctor"]
⚠️ Warnings & Precautions
["This medicine can cause serious bleeding; avoid activities that increase bleeding risk and report any unusual bleeding.","High blood pressure is common; monitor blood pressure regularly and take prescribed medicines.","Hand-foot skin reaction can be painful; moisturise and protect hands and feet, and report early.","Liver and kidney function must be checked regularly.","This medicine can cause heart problems; report chest pain or shortness of breath immediately.","Avoid grapefruit and grapefruit juice.","Use effective contraception during treatment and for at least two weeks after the last dose for women and three months for men.","Do not stop treatment without consulting your doctor."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious side effects in a breastfed infant, breastfeeding should be stopped during treatment and for at least two weeks after the last dose. Consult your doctor for guidance.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. In case of suspected overdose, stop the medicine and seek immediate medical attention. Treatment should be supportive and symptomatic, with close monitoring of vital signs, blood counts, and liver and kidney function. Contact a poison control centre or emergency department for guidance.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
This medicine must only be taken exactly as prescribed by your oncologist. Swallow the tablet whole with water, with or without food, at the same times each day. Do not crush, chew, or split the tablet unless your doctor specifically tells you to. Because this medicine can cause birth defects, both men and women must use effective contraception during treatment and for at least two weeks after the last dose for women and three months for men. Avoid grapefruit and grapefruit juice, as they can increase the amount of medicine in your body. Tell your doctor about all other medicines, vitamins, and herbal products you take, especially blood thinners, blood pressure medicines, and antibiotics. Do not stop this medicine on your own; stopping suddenly can allow the cancer to grow. Keep all scheduled blood tests, blood pressure checks, and scans, and report any unusual bleeding, bruising, fever, or skin changes immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as heart problems, kidney problems, and bleeding. Close monitoring of blood pressure, liver function, kidney function, and blood counts is recommended. Dose adjustments may be needed based on tolerability.
🤰 Pregnancy Planning (TTC)
This medicine can cause birth defects. Women of childbearing potential should use effective contraception during treatment and for at least two weeks after the last dose. Men should use effective contraception for at least three months after the last dose. If you are planning pregnancy, consult your doctor before stopping contraception.
🏥 Post-Surgery Considerations
This medicine can increase the risk of bleeding and impair wound healing. It is usually stopped before surgery and restarted after the surgical wound has healed, as advised by your surgeon. Inform your surgeon that you are taking this medicine.
🦷 Dental Procedures
This medicine can increase the risk of bleeding during dental procedures. Inform your dentist that you are taking this medicine. Your dentist may recommend stopping the medicine temporarily before a procedure, in consultation with your oncologist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild to moderate exercise such as walking or yoga may be beneficial, but avoid strenuous activities that could increase the risk of bleeding or injury. Consult your doctor before starting any new exercise programme, especially if you have low blood counts or heart problems.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or high blood pressure, which can affect your ability to drive or operate machinery. Avoid driving if you feel tired or unwell. Most patients can continue their daily activities with adjustments, but discuss your work and lifestyle with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor may stop treatment if the cancer progresses, if you experience severe side effects, or if you develop certain medical conditions. Always seek medical advice before stopping.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to persistent side effects such as fatigue, skin changes, high blood pressure, and liver or kidney problems. Regular monitoring of blood pressure, liver function, kidney function, and blood counts is essential. Some patients may develop resistance to the medicine over time, requiring a change in treatment. Your doctor will assess the benefits and risks periodically.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines such as lenvatinib or regorafenib may be options for some cancers.
Evidence: Well-establishedImmunotherapy drugs may be used alone or in combination for certain cancers.
Evidence: Well-establishedParticipation in clinical trials may provide access to new treatments.
Evidence: Varies💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because of the potential risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store at room temperature and avoid direct sunlight. If crossing time zones, adjust the timing of doses gradually in consultation with your doctor. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working soon after you begin taking it, but its effects on the cancer may take several weeks to months to become apparent. Your doctor will monitor your response with regular scans and blood tests.
A: Yes, you can take this medicine with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember if less than 6 hours have passed. If more than 6 hours have passed, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly can allow the cancer to grow. Your doctor will decide when it is safe to stop.
A: No, this medicine can harm the unborn baby and is not recommended during pregnancy. Use effective contraception during treatment and for at least two weeks after the last dose.
🤔 Common Patient Concerns
🔄 Substitutes for shilfenib 200mg tablet
View AllAlternative brands with exact same active ingredient:
-
sorepto 200mg tabletLupin Ltd ₹1,985.00 73.7% CHEAPER
-
adtrinib 200mg tabletAdley Formulations ₹2,350.00 68.9% CHEAPER
-
sorafenat tabletNatco Pharma Ltd ₹2,350.00 68.9% CHEAPER
-
soranib tabletCipla Ltd ₹2,503.61 66.9% CHEAPER
-
sorafenat 200mg tabletNatco Pharma Ltd ₹8,880.00 17.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure cancer completely.
Fact: This medicine can slow cancer growth and shrink tumours in some patients, but it is not a guaranteed cure. It is used to control the disease and improve survival. - Myth: You can stop this medicine once you feel better.
Fact: Stopping this medicine without medical advice can allow the cancer to grow. Always consult your oncologist before stopping. - Myth: This medicine has no side effects because it is a targeted therapy.
Fact: Targeted therapies also have side effects. This medicine can cause diarrhoea, skin reactions, high blood pressure, and other problems that need monitoring.
🔄 Alternative Options
Generic Alternatives
- Sorafenib 200 mg tablet
Brand Alternatives
- Nexavar