seumol plus tablet - Caffeine (30mg) + Chlorpheniramine Maleate (4mg) medicine

Arexol P 30mg/4mg Tablet: Complete Medicine Guide

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🏭 Mac Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
🤰 Pregnancy Category Chlorpheniramine is classified as Pregnancy Category B by the FDA. Caffeine is classified as Category C. However, this combination should be used during pregnancy only if clearly needed and under medical supervision. Consult your doctor for personalized advice. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Seizures or convulsions
  • Irregular heartbeat or palpitations

If experiencing severe symptoms, call emergency services immediately.

What is seumol plus tablet used for?

This medicine is a combination of caffeine and chlorpheniramine maleate used to treat allergic symptoms such as sneezing, runny nose, and itchy eyes. It works by blocking histamine and reducing drowsiness.

  • Generic Name: Caffeine (30mg) + Chlorpheniramine Maleate (4mg)
  • Manufacturer: Mac Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 seumol plus tablet के बारे में (Hindi Summary)

उपयोग: यह दवा कैफीन और क्लोरफेनिरामाइन मेलिएट का संयोजन है, जिसका उपयोग एलर्जी के लक्षणों जैसे छींक आना, नाक बहना, आंखों में खुजली और पानी आना, और त्वचा पर खुजली के इलाज के लिए किया जाता है। यह एलर्जी पैदा करने वाले हिस्टामिन को रोककर काम करती है और कैफीन के कारण नींद कम आती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि, मतली और कब्ज शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, दिल की धड़कन तेज होना, दौरे पड़ना आदि हो सकते हैं। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। शराब और अन्य नींद लाने वाली दवाओं से बचें। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसे असर करती है। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या कोई अन्य बीमारी है तो डॉक्टर को बताएं।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 seumol plus tablet Uses & Benefits

[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itchy and watery eyes, and nasal congestion associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Urticaria","description":"Helps reduce itching and hives associated with allergic skin reactions.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides symptomatic relief of runny nose, sneezing, and watery eyes due to colds or other upper respiratory infections.","evidence":"Established"},{"condition":"Allergic conjunctivitis","description":"Reduces itching, redness, and tearing of the eyes caused by allergies.","evidence":"Established"}]

Off-label uses: [{"condition":"Insomnia","description":"Sometimes used off-label for its sedative effects to promote sleep, but this is not recommended due to potential side effects.","evidence":"Limited"},{"condition":"Motion sickness","description":"May be used off-label to prevent nausea and vomiting associated with motion sickness, though not a primary indication.","evidence":"Limited"}]

Primary treatment for: Allergic rhinitis

Also treats: Urticaria, Common cold, Allergic conjunctivitis

📋 Drug Information

Generic Name(s)Caffeine (30mg) + Chlorpheniramine Maleate (4mg)
Brand Nameseumol plus tablet
ManufacturerMac Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Avoid driving or operating machinery until you know how this medicine affects you.
3
Do not drink alcohol while taking this medicine.
4
Do not exceed the recommended dose of 6 tablets in 24 hours.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding, bruising, or signs of infection immediately.
7
Use with caution in elderly patients due to increased risk of confusion and falls.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Sneezing and runny nose
This medicine is commonly prescribed for allergic rhinitis.
Likely Use
Itchy, watery eyes
This medicine helps relieve allergic conjunctivitis symptoms.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary
Chronic cough
This medicine is not indicated for chronic cough unless due to allergies.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionChlorpheniramine is well absorbed from the gastrointestinal tract after oral administration. Caffeine is also rapidly and completely absorbed from the gastrointestinal tract. Food may slightly delay the absorption of both components but does not significantly affect the extent of absorption.
DistributionChlorpheniramine is widely distributed throughout the body, including the central nervous system. It crosses the blood-brain barrier and placenta, and is excreted in breast milk. Caffeine also distributes widely, crossing the blood-brain barrier and placenta, and is excreted in breast milk.
Protein BindingChlorpheniramine is approximately 70% bound to plasma proteins. Caffeine is about 10-35% bound to plasma proteins.
MetabolismChlorpheniramine is extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4 enzymes, to inactive metabolites. Caffeine is metabolized in the liver by CYP1A2 to paraxanthine, theobromine, and theophylline.
Half-LifeThe elimination half-life of chlorpheniramine is approximately 12-43 hours, with an average of 24 hours. The half-life of caffeine is about 3-7 hours, which may be prolonged in individuals with liver impairment or those taking certain medications.
ExcretionChlorpheniramine and its metabolites are excreted primarily in the urine. Caffeine and its metabolites are also excreted in the urine, with about 1-2% excreted unchanged.
BioavailabilityThe oral bioavailability of chlorpheniramine is approximately 25-50% due to first-pass metabolism. Caffeine has nearly 100% oral bioavailability.
Onset of ActionThe onset of action for chlorpheniramine is typically within 30-60 minutes after oral administration. Caffeine's effects begin within 15-45 minutes.
Peak Plasma TimePeak plasma concentrations of chlorpheniramine are reached in about 2-6 hours. Caffeine reaches peak plasma levels in about 30-60 minutes.
Duration of ActionThe duration of action of chlorpheniramine is about 4-6 hours, but its sedative effects may last longer. Caffeine's effects last for about 3-5 hours.

How It Works

This medicine combines two active ingredients with complementary actions. Chlorpheniramine Maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, thereby preventing histamine-mediated allergic responses such as vasodilation, increased vascular permeability, and sensory nerve stimulation. Caffeine is a central nervous system stimulant that antagonizes adenosine receptors, leading to increased alertness and reduced drowsiness. The combination aims to provide allergy relief while mitigating the sedative effects of the antihistamine.

Mechanism Steps

1
Histamine H1 receptor blockade: Chlorpheniramine binds to H1 receptors on target cells, preventing histamine from binding and triggering allergic symptoms.
2
Adenosine receptor antagonism: Caffeine blocks adenosine receptors in the brain, reducing drowsiness and increasing alertness.
3
Reduction of allergic response: By blocking histamine, chlorpheniramine reduces vasodilation, edema, and itching in allergic reactions.
4
Counteraction of sedation: Caffeine's stimulant effect helps offset the sedative properties of chlorpheniramine, improving daytime alertness.

💡 How to Take seumol plus tablet

Strength: Each tablet contains Caffeine 30 mg and Chlorpheniramine Maleate 4 mg.

1Take this medicine orally with a full glass of water.
2It can be taken with or without food, but taking it with food may reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take it at the same times each day if prescribed on a regular schedule.
5Do not take more than the recommended dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally every 4 to 6 hours as needed for symptoms, not to exceed 6 tablets in 24 hours. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) are more sensitive to the anticholinergic and sedative effects of chlorpheniramine and the stimulant effects of caffeine. Use with caution, and dose reduction may be necessary. Consult a doctor for personalized dosing.
Renal ImpairmentIn patients with renal impairment, the clearance of chlorpheniramine and caffeine may be reduced. Dose adjustment may be required. Consult a doctor for appropriate dosing.
Hepatic ImpairmentIn patients with hepatic impairment, the metabolism of chlorpheniramine and caffeine may be reduced, leading to increased plasma levels and risk of adverse effects. Dose reduction and close monitoring are advised. Consult a doctor.
Maximum Daily DoseThe maximum recommended daily dose is 6 tablets in 24 hours for adults. Do not exceed this dose without medical advice.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Caffeine-containing beverages
Limit
May increase stimulant effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of seumol plus tablet

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If persistent, consult your doctor.
Dry mouth (Common (5-15%))
Sip water, chew sugarless gum, or use saliva substitutes. Consult if severe.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid alcohol.
Nausea (Uncommon (1-5%))
Take with food or milk to reduce stomach upset.
Constipation (Uncommon (1-5%))
Increase fiber and fluid intake. Consult if persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of face, lips, or throat, difficulty breathing.
Seizures (Rare (<0.1%))
Call emergency services if seizures occur.
Irregular heartbeat (Rare (<0.1%))
Seek immediate medical attention if you notice palpitations, chest pain, or shortness of breath.
Hallucinations or confusion (Rare (<0.1%))
Discontinue and consult a doctor immediately.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, or signs of infection to your doctor.
Hepatotoxicity
Report yellowing of skin or eyes, dark urine, or abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAO inhibitors Major
CNS depressants Major
Anticholinergics Moderate
CYP2D6 inhibitors Moderate
CYP1A2 inhibitors Moderate
Antihypertensives Minor
Diuretics Minor

🚨 Major Interactions

  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • CNS depressants (e.g., alcohol, benzodiazepines, opioids)

⚡ Moderate Interactions

  • Anticholinergic drugs (e.g., atropine, benztropine)
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
  • CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impairment of judgment and coordination. Combining alcohol with chlorpheniramine can also enhance central nervous system depression, leading to respiratory depression and other serious effects.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to chlorpheniramine, caffeine, or any component of the formulation","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe liver disease","MAO inhibitor therapy within the last 14 days","Breastfeeding without medical advice","Children under 12 years of age"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with asthma, COPD, or sleep apnea.","May cause anticholinergic effects; use with caution in the elderly.","Do not exceed the recommended dose.","Consult a doctor if symptoms persist beyond 7 days.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep out of reach of children."]

🤱 Lactation Safety

Chlorpheniramine and caffeine are excreted in breast milk and may cause drowsiness or stimulation in the nursing infant. Breastfeeding mothers should consult their doctor before using this medicine. Alternative antihistamines with better safety profiles may be preferred.

💊 Overdose Management

Overdose of this medicine may cause severe drowsiness, confusion, hallucinations, seizures, irregular heartbeat, and respiratory depression. If overdose is suspected, seek immediate medical attention or contact a poison control center. Treatment is supportive and symptomatic, including gastric lavage if within 1-2 hours of ingestion, activated charcoal, and monitoring of vital signs. There is no specific antidote. Hemodialysis may be considered in severe cases.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid alcohol and other central nervous system depressants while taking this medicine, as they can increase drowsiness and dizziness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have glaucoma, prostate enlargement, urinary retention, asthma, or liver or kidney disease. This medicine may interact with other medications, including MAO inhibitors, sedatives, and antihistamines. Do not use this medicine for longer than directed without consulting your doctor. Keep out of reach of children. Store at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more susceptible to the anticholinergic effects of chlorpheniramine, such as confusion, dry mouth, constipation, and urinary retention. They are also more sensitive to the stimulant effects of caffeine, which can cause insomnia and palpitations. Use with caution and consider dose reduction.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Chlorpheniramine is generally considered safe in pregnancy (Category B), but caffeine should be limited. Your doctor may recommend alternative treatments.

🏥 Post-Surgery Considerations

After surgery, the use of this medicine should be discussed with your surgeon. Chlorpheniramine may interact with anesthetics and other postoperative medications, increasing sedation. Caffeine may affect heart rate and blood pressure. Do not self-administer without medical advice.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It may interact with local anesthetics or sedatives used during dental work, increasing the risk of side effects. Your dentist may adjust the treatment plan accordingly.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce allergy severity.
🥗
Regular low-impact exercise like walking or swimming.
😴
Practice good hygiene to reduce allergen exposure.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep to support immune function.

🏋️ Exercise Considerations

This medicine may cause drowsiness and dizziness, which can affect your coordination. Avoid strenuous exercise or activities requiring alertness until you know how the medicine affects you. Stay hydrated during exercise.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseed.
Reduce processed food intake.
Stay well hydrated.
Avoid known food allergens.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job requires alertness.

🛑 When to Stop This Medicine

Do not stop taking this medicine abruptly without consulting your doctor, especially if you have been on it for a long time. If you experience severe side effects, seek medical advice immediately. Your doctor will guide you on tapering or stopping the medicine safely.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to tolerance to the stimulant effects of caffeine and increased sensitivity to the anticholinergic effects of chlorpheniramine. Regular monitoring of liver and kidney function is advisable. Dependence on caffeine can occur. Consult your doctor for periodic evaluation if used for more than a few weeks.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Allergen avoidance

Identifying and avoiding allergens can reduce the need for medication.

Evidence: Well-established
Nasal saline irrigation

Helps clear allergens and relieve nasal congestion.

Evidence: Established
Immunotherapy

Allergy shots or sublingual tablets can provide long-term relief.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you are scheduled for allergy testing, antihistamines like chlorpheniramine should be stopped 3-7 days before the test as they can interfere with results. Consult your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust dosing times gradually to avoid missed doses. Check local customs regulations regarding prescription medicines before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies
She started taking this medicine as prescribed for her sneezing and runny nose. She noticed relief within an hour but felt drowsy, so she took it at bedtime. She emphasized not driving after taking it.
💡 Lesson: Taking this medicine at bedtime can help manage drowsiness while providing allergy relief.
👤 A 50-year-old man with chronic urticaria
He was prescribed this medicine for itching and hives. He found that taking it with food reduced his stomach upset. He also avoided alcohol as advised by his doctor.
💡 Lesson: Taking with food and avoiding alcohol improves tolerability and safety.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes after taking it.

Q: Can I take it with other allergy medicines?

A: You should consult your doctor before combining with other antihistamines to avoid additive side effects.

Q: Is it safe for long-term use?

A: Long-term use should be under medical supervision due to potential side effects and tolerance.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for seumol plus tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe for children under 12.
    Fact: This medicine is not recommended for children under 12 years due to lack of established safety and efficacy.
  • Myth: It is a non-drowsy allergy medicine.
    Fact: Chlorpheniramine is a first-generation antihistamine that commonly causes drowsiness, though caffeine may partially counteract it.
  • Myth: You can take it with alcohol without any issues.
    Fact: Alcohol increases the sedative effects and should be avoided.

🔄 Alternative Options

Generic Alternatives

  • Caffeine + Chlorpheniramine Maleate tablet

Brand Alternatives

  • Arexol P 30mg/4mg/500mg/5mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredients":"Caffeine 30mg + Chlorpheniramine Maleate 4mg","primary_use":"Allergic rhinitis, urticaria","sedation":"Moderate","onset":"30-60 minutes"},{"medicine":"Cetirizine 10mg","active_ingredients":"Cetirizine","primary_use":"Allergic rhinitis, urticaria","sedation":"Low","onset":"1 hour"},{"medicine":"Levocetirizine 5mg","active_ingredients":"Levocetirizine","primary_use":"Allergic rhinitis, urticaria","sedation":"Low","onset":"1 hour"}]

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