Sebri H 100mg/12.5mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or swallowing
- Severe dizziness or fainting
- Decreased urine output or swelling in legs
- Irregular heartbeat or palpitations
- Severe abdominal pain with nausea and vomiting
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is Sebri H 100mg/12.5mg Tablet used for?
This medicine is a combination of Irbesartan and Hydrochlorothiazide used to treat high blood pressure. It works by relaxing blood vessels and removing excess fluid from the body. It is taken once daily by mouth.
- Generic Name: Irbesartan (100mg) + Hydrochlorothiazide (12.5mg)
- Manufacturer: Grownbury Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Sebri H 100mg/12.5mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। यह इर्बेसार्टन और हाइड्रोक्लोरोथियाजाइड का संयोजन है। यह रक्त वाहिकाओं को आराम देकर और शरीर से अतिरिक्त तरल पदार्थ निकालकर रक्तचाप को कम करती है। यह आमतौर पर तब दी जाती है जब एक दवा से रक्तचाप नियंत्रित नहीं होता। इसे डॉक्टर की सलाह के अनुसार ही लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में चक्कर आना, सिरदर्द, थकान और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, गुर्दे की समस्या, इलेक्ट्रोलाइट असंतुलन और बहुत कम रक्तचाप शामिल हो सकते हैं। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। शराब से बचें क्योंकि इससे चक्कर आ सकते हैं। पर्याप्त पानी पिएं। गुर्दे की कार्यप्रणाली और इलेक्ट्रोलाइट्स की नियमित जांच कराएं। गर्भावस्था में यह दवा न लें। स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 Sebri H 100mg/12.5mg Tablet Uses & Benefits
[{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure in adults, reducing the risk of stroke, heart attack, and kidney problems.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Hypertension
Also treats: Heart failure, Diabetic nephropathy
📋 Drug Information
| Generic Name(s) | Irbesartan (100mg) + Hydrochlorothiazide (12.5mg) |
| Brand Name | Sebri H 100mg/12.5mg Tablet |
| Manufacturer | Grownbury Pharmaceuticals Pvt Ltd |
| Packaging / Form | strip of 10 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from causing vasoconstriction and aldosterone release, which lowers blood pressure and reduces sodium retention. Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water, thereby reducing blood volume and lowering blood pressure. The combination provides additive blood pressure reduction.
Mechanism Steps
💡 How to Take Sebri H 100mg/12.5mg Tablet
Strength: Tablet containing Irbesartan 100 mg and Hydrochlorothiazide 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (Irbesartan 100 mg + Hydrochlorothiazide 12.5 mg) taken orally once daily, with or without food. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and blood pressure response. Some patients may require a lower starting dose, especially if volume-depleted or elderly. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor closely for dizziness, falls, and electrolyte imbalances. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate renal impairment (creatinine clearance 30-60 mL/min), no dose adjustment is usually needed, but monitor renal function. In severe renal impairment (creatinine clearance <30 mL/min), this medicine is contraindicated. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no dose adjustment is usually needed. In severe hepatic impairment, this medicine is contraindicated. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | One tablet (Irbesartan 100 mg + Hydrochlorothiazide 12.5 mg) once daily. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Sebri H 100mg/12.5mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Potassium-sparing diuretics | Major | |
| Lithium | Major | |
| NSAIDs | Major | |
| ACE inhibitors | Major | |
| Corticosteroids | Moderate | |
| Diabetes medications | Moderate | |
| Cholestyramine | Moderate | |
| Antacids | Minor | |
| Digoxin | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Potassium-sparing diuretics (e.g., spironolactone, triamterene)
- Lithium
- NSAIDs (e.g., ibuprofen, naproxen)
- ACE inhibitors (e.g., lisinopril)
⚡ Moderate Interactions
- Corticosteroids
- Diabetes medications (e.g., insulin, sulfonylureas)
- Cholestyramine and colestipol
🍷 Alcohol Interaction
Alcohol may increase the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid alcohol or limit consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy","Hypersensitivity to irbesartan, hydrochlorothiazide, or sulfonamide-derived drugs","Anuria (inability to urinate)","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["This medicine can cause fetal harm; discontinue as soon as pregnancy is detected.","May cause symptomatic hypotension, especially in volume-depleted patients.","Monitor renal function and electrolytes periodically.","May exacerbate or precipitate gout.","May cause photosensitivity reactions; use sun protection.","Can cause acute angle-closure glaucoma; seek immediate care for eye pain or vision changes.","May increase blood sugar levels; monitor in diabetics.","Avoid potassium supplements without medical advice."]
🤱 Lactation Safety
Not recommended. Both irbesartan and hydrochlorothiazide are excreted in human milk. Because of the potential for adverse effects in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose may cause severe hypotension, electrolyte imbalances, and dehydration. Treatment is supportive and symptomatic. If overdose is suspected, contact a poison control center or emergency room immediately. Induce vomiting if recent ingestion and patient is conscious. Monitor vital signs and electrolytes closely.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. This medicine can cause dizziness, especially when standing up quickly; rise slowly from sitting or lying positions. Avoid alcohol as it may increase dizziness and low blood pressure. Stay well hydrated, especially in hot weather or during exercise. Inform your doctor if you have kidney disease, liver disease, diabetes, gout, or lupus. Regular monitoring of blood pressure, kidney function, and electrolytes is necessary. Do not use potassium supplements or salt substitutes containing potassium without doctor's approval. This medicine is not safe during pregnancy and should be stopped immediately if pregnancy is suspected. Breastfeeding is not recommended while on this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects and electrolyte imbalances caused by this medicine. Start with a lower dose and monitor closely for dizziness, falls, and dehydration.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative before conception. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery due to its effects on blood pressure and electrolytes. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or dizziness during dental procedures. Maintain good oral hygiene and stay hydrated.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe while taking this medicine, but it can cause dizziness or low blood pressure, especially during intense workouts. Stay hydrated and avoid sudden changes in position. If you feel dizzy or faint, stop exercising and rest. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal activities once they adjust to the medication.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects or your blood pressure is well-controlled, your doctor may adjust or discontinue the dose. Abrupt withdrawal can cause rebound hypertension.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of kidney function, electrolytes, and blood pressure. It can increase the risk of electrolyte imbalances, kidney impairment, and gout. Periodic blood tests are necessary to detect any abnormalities early. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors, calcium channel blockers, or beta-blockers may be alternatives if this medicine is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your healthcare provider about this medicine before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Carry enough supply for the entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within 1-2 hours, but the full effect may take 2-4 weeks of regular use.
A: Yes, but it may affect blood sugar levels. Monitor your blood glucose and inform your doctor.
A: No, this medicine is contraindicated during pregnancy as it can harm the fetus. Consult your doctor immediately if you become pregnant.
A: No, do not stop without consulting your doctor. High blood pressure often has no symptoms, and stopping can cause it to rise again.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken without a prescription.
Fact: This medicine is a prescription drug and should only be taken under a doctor's supervision. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: High blood pressure often has no symptoms, and stopping medication can cause it to rise again. Always consult your doctor before stopping. - Myth: This medicine causes kidney damage in everyone.
Fact: While it can affect kidney function, regular monitoring helps prevent serious problems. Most people can take it safely.
🔄 Alternative Options
Generic Alternatives
- Irbesartan + Hydrochlorothiazide (generic)