Scafer Lotion - Cetrimide (0.5% w/v) + Permethrin (5% w/v) medicine

Scafer Lotion: Complete Guide to Uses, Dosage, and Safety

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🏭 Rekin Pharma Pvt. Ltd. 📦 bottle of 60 ml Lotion 💊 Allopathy 📅 Updated: Oct 24, 2026
🤰 Pregnancy Category Permethrin is considered safe for use during pregnancy when used as directed. The FDA has not assigned a pregnancy category for the combination product. Consult your doctor before use if you are pregnant or planning to become pregnant. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for permethrin in scabies; limited for the combination with cetrimide.
Reviewed by
SaathiMed Expert Panel | Oct 24, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction (difficulty breathing, swelling of face, lips, tongue, or throat)
  • Severe skin blistering or peeling
  • Signs of secondary bacterial infection (increased redness, warmth, swelling, pus, fever)
  • Persistent itching or rash that worsens after treatment
  • No improvement after 2 weeks of treatment
  • Accidental ingestion of the lotion
  • Eye contact with the lotion causing severe irritation

If experiencing severe symptoms, call emergency services immediately.

What is Scafer Lotion used for?

This medicine is a topical lotion containing cetrimide (0.5% w/v) and permethrin (5% w/v). It is primarily used to treat scabies, a skin infestation caused by mites. Permethrin kills the mites, while cetrimide provides antiseptic action. Apply as directed by your doctor, usually leaving it on for 8-14 hours before washing off.

  • Generic Name: Cetrimide (0.5% w/v) + Permethrin (5% w/v)
  • Manufacturer: Rekin Pharma Pvt. Ltd.
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 Scafer Lotion के बारे में (Hindi Summary)

उपयोग: यह दवा मुख्य रूप से खुजली (स्केबीज़) के इलाज के लिए इस्तेमाल की जाती है। स्केबीज़ एक संक्रामक त्वचा रोग है जो सूक्ष्म कीड़ों (माइट्स) के कारण होता है। इस दवा में सेट्रीमाइड और परमेथ्रिन दो सक्रिय तत्व होते हैं। परमेथ्रिन कीड़ों को मारता है, जबकि सेट्रीमाइड त्वचा को संक्रमण से बचाता है। यह दवा लोशन के रूप में उपलब्ध है और इसे त्वचा पर लगाया जाता है। डॉक्टर के निर्देशानुसार इसे गर्दन से नीचे पूरे शरीर पर लगाएं और 8-14 घंटे बाद धो लें। यह दवा बच्चों और वयस्कों दोनों के लिए उपयुक्त है, लेकिन 2 महीने से छोटे बच्चों में डॉक्टर की सलाह के बिना न लगाएं।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में त्वचा में हल्की जलन, खुजली, लालिमा या जलन की भावना शामिल हो सकती है। ये आमतौर पर अस्थायी होते हैं और अपने आप ठीक हो जाते हैं। कभी-कभी गंभीर एलर्जी प्रतिक्रिया हो सकती है जैसे सूजन, छाले, या सांस लेने में कठिनाई। ऐसी स्थिति में तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा का उपयोग केवल बाहरी त्वचा पर करें। आंखों, मुंह और अन्य श्लेष्मा झिल्ली के संपर्क में न आने दें। यदि संपर्क हो जाए तो तुरंत पानी से धो लें। टूटी या घायल त्वचा पर न लगाएं। उपयोग के बाद हाथ धो लें। बच्चों की पहुंच से दूर रखें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा को ठंडी और सूखी जगह पर रखें, धूप से बचाएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 Scafer Lotion Uses & Benefits

  • [{"condition":"Scabies","description":"This medicine is used to treat scabies infestation by killing the mites and their eggs.
  • It helps relieve itching and prevents the spread of infestation.","evidence":"Well-established"},{"condition":"Pediculosis (lice infestation)","description":"This medicine may be used to treat lice infestations on the body, although permethrin is more commonly used for head lice.
  • The cetrimide component provides antiseptic action.","evidence":"Limited"}]

Off-label uses: [{"condition":"Bacterial skin infections","description":"The cetrimide component may provide antiseptic benefits for minor skin infections, but this is not a primary indication.","evidence":"Limited"}]

Primary treatment for: Scabies

Also treats: Pediculosis, Secondary bacterial skin infections

📋 Drug Information

Generic Name(s)Cetrimide (0.5% w/v) + Permethrin (5% w/v)
Brand NameScafer Lotion
ManufacturerRekin Pharma Pvt. Ltd.
Packaging / Formbottle of 60 ml Lotion (Allopathy)
Therapeutic Class
Action Class
Route of AdministrationTopical
StorageStore at room temperature (15-30°C). Protect from direct sunlight. Do not freeze. Keep the container tightly closed. Keep out of reach of children.
Shelf Life24 months from the date of manufacture, unless otherwise specified on the packaging.
WHO GuidelinePermethrin 5% is recommended by the World Health Organization for the treatment of scabies. The combination with cetrimide is not specifically mentioned in WHO guidelines.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply this medicine to clean, dry skin and cover the entire body from the neck down, including the soles of the feet and between the fingers.
2
Leave the lotion on for at least 8 hours, preferably overnight, for maximum effectiveness.
3
Wash all clothing, bedding, and towels in hot water and dry them on high heat to prevent re-infestation.
4
Treat all household members and close contacts at the same time, even if they do not have symptoms.
5
Avoid using this medicine on children under 2 months of age without medical advice.
6
If itching persists for more than 2 weeks after treatment, consult your doctor to rule out re-infestation or other causes.
7
Do not use this medicine for any other skin condition without consulting a doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Intense itching, especially at night
This medicine is commonly prescribed for scabies, which causes nocturnal itching.
Likely Use
✅
Rash with small bumps or blisters
Scabies rash often appears as small bumps or blisters, and this medicine treats the underlying infestation.
Likely Use
✅
Lice on the body or pubic area
This medicine may be used for lice infestations, although permethrin is more commonly used for head lice.
Likely Use
❌
Fever
This medicine is not a fever reducer. Fever may indicate a secondary infection and requires medical evaluation.
Not Primary
❌
Skin infection with pus
This medicine has antiseptic properties but is not a primary treatment for bacterial skin infections. Consult a doctor.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionPermethrin is minimally absorbed through intact skin. Systemic absorption is low when applied topically as directed. Cetrimide is also poorly absorbed through intact skin. Not established from the available information for specific absorption rates.
DistributionDue to minimal systemic absorption, distribution of permethrin and cetrimide to body tissues is limited. Both act locally at the site of application.
Protein BindingNot established from the available information.
MetabolismPermethrin is metabolized in the liver by esterases and cytochrome P450 enzymes when absorbed systemically. Cetrimide is not significantly metabolized. However, because systemic absorption is minimal after topical application, metabolism is not a major factor.
Half-LifeNot established from the available information for topical use. For systemically absorbed permethrin, the half-life is approximately 12-24 hours, but this is not clinically relevant for topical application.
ExcretionAny absorbed permethrin is excreted primarily in the urine as metabolites. Cetrimide is excreted unchanged in urine and feces. Due to minimal absorption, excretion is not a significant concern.
BioavailabilityNot established from the available information. Topical bioavailability is low due to minimal percutaneous absorption.
Onset of ActionThe scabicidal effect of permethrin begins within minutes of application, but relief from itching may take several days to weeks as the dead mites and their debris are cleared from the skin.
Peak Plasma TimeNot established from the available information. Systemic levels are negligible after topical application.
Duration of ActionThe antiparasitic effect of permethrin persists on the skin for several days after application. A single application is often sufficient for scabies treatment, but a second application may be needed after 7 days in some cases.

How It Works

This medicine works through the combined actions of its two active ingredients. Permethrin, a synthetic pyrethroid, acts on the nerve cell membranes of parasites such as scabies mites and lice. It binds to sodium channels and prolongs their opening, leading to repetitive nerve firing, paralysis, and death of the parasite. Cetrimide is a quaternary ammonium antiseptic that disrupts bacterial cell membranes, leading to leakage of cellular contents and bacterial death. Together, they provide antiparasitic and antiseptic effects.

Mechanism Steps

1
Permethrin binding to sodium channels: Permethrin binds to voltage-gated sodium channels in the nerve cells of scabies mites and lice, causing them to remain open for prolonged periods.
2
Prolonged depolarization: The prolonged opening of sodium channels leads to continuous depolarization of the nerve membrane, resulting in repetitive firing and eventually paralysis of the parasite.
3
Parasite death: The paralysis and subsequent inability to feed or reproduce leads to the death of the scabies mite or louse.
4
Cetrimide antiseptic action: Cetrimide disrupts bacterial cell membranes, causing leakage of intracellular components and bacterial cell death, which helps prevent secondary bacterial infections.

💡 How to Take Scafer Lotion

Strength: Lotion containing cetrimide 0.5% w/v and permethrin 5% w/v.

1Read the patient information leaflet or follow your doctor's instructions carefully.
2Shake the bottle well before use.
3Wash and dry the affected area gently.
4Apply a thin layer of the lotion to the skin, covering the entire area from the neck down to the soles of the feet, including skin folds and creases.
5Avoid contact with eyes, mouth, and other mucous membranes.
6Leave the lotion on for the recommended time (usually 8-14 hours) before washing it off with soap and water.
7Wash your hands thoroughly after application, unless your hands are being treated.
8Do not cover the treated area with tight bandages or clothing that does not allow air circulation.
9Clean clothing, bedding, and towels in hot water to prevent re-infestation.
10If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageFor scabies: Apply a thin layer of this medicine to the entire body from the neck down to the toes, ensuring coverage of all skin surfaces including the webs of fingers, under nails, wrists, armpits, buttocks, and genital area. Leave on for 8-14 hours, then wash off thoroughly with soap and water. A single application is usually sufficient, but a second application after 7 days may be recommended by your doctor. For lice: Apply to affected areas and surrounding skin, leave on for 8-12 hours, then wash off. Dose must be individualized by a qualified clinician based on indication, age, weight, and response to treatment.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. For children over 2 months, the same application instructions as adults may be followed, but a doctor's guidance is essential.
Elderly DosageNo specific dosage adjustments are required for elderly patients. However, elderly individuals may have more sensitive skin and should use with caution. Consult a doctor for personalized advice.
Renal ImpairmentNo dosage adjustment is required for patients with renal impairment due to minimal systemic absorption.
Hepatic ImpairmentNo dosage adjustment is required for patients with hepatic impairment due to minimal systemic absorption.
Maximum Daily DoseNot applicable for topical use. Apply as directed by your doctor. Do not exceed the recommended application frequency.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

No specific food interactions
Not applicable
This medicine is for topical use and does not interact with food.

⏰ What to Do If You Miss a Dose

📌 If you miss a scheduled application
→ Apply the missed dose as soon as you remember.
💡 If it is almost time for the next dose, skip the missed dose and continue with your regular schedule.
📌 If you miss the second application (if prescribed)
→ Apply it as soon as you remember, but do not exceed the recommended frequency.
💡 Consult your doctor if you are unsure.

⚠️ Side Effects of Scafer Lotion

✅ Common Side Effects

Mild skin irritation (Common (1-10%))
Usually resolves without treatment. If irritation persists or worsens, consult your doctor.
Itching (Common (1-10%))
Itching may be due to the scabies infestation itself and can persist for up to 2 weeks after treatment. Consult your doctor if it is severe or prolonged.
Redness or rash (Common (1-10%))
Usually temporary. Avoid scratching. If it spreads or becomes severe, seek medical advice.
Burning or stinging sensation (Common (1-10%))
May occur immediately after application. If it persists, consult your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience difficulty breathing, swelling of the face, lips, tongue, or throat, or a severe rash.
Severe skin reactions (e.g., blistering, peeling) (Rare (<0.1%))
Stop using this medicine and consult a doctor immediately if you notice severe skin blistering or peeling.

⚠️ Rare Side Effects

Contact dermatitis
Discontinue use and consult a doctor if you develop a persistent rash or skin inflammation.
Headache or dizziness
These effects are unlikely with topical use. If they occur, consult your doctor.

Consult your doctor if you experience any unusual symptoms.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to cetrimide, permethrin, or any component of the formulation","Use on broken or inflamed skin","Use in the eyes or on mucous membranes","Infants under 2 months of age (unless directed by a doctor)"]

⚠️ Warnings & Precautions

["For external use only. Do not ingest.","Avoid contact with eyes, mouth, and other mucous membranes. If contact occurs, rinse thoroughly with water.","Do not apply to large areas of the body or for prolonged periods without medical advice.","Do not use on children under 2 months of age unless prescribed by a doctor.","Consult a doctor if you are pregnant, breastfeeding, or have a history of skin allergies.","If symptoms persist after treatment, consult a doctor as re-infestation or treatment failure may occur.","Discontinue use if severe irritation or allergic reaction develops."]

🤱 Lactation Safety

Permethrin is considered safe for use during breastfeeding when applied to the skin. However, avoid applying to the breast area to prevent infant exposure. Consult your doctor for guidance.

💊 Overdose Management

Overdose with this medicine is unlikely due to its topical route. If accidental ingestion occurs, seek immediate medical attention. Symptoms of permethrin overdose may include dizziness, headache, nausea, vomiting, and in severe cases, seizures. Treatment is supportive and symptomatic. Contact a poison control center or emergency department if ingestion is suspected.

⏰ Missed Dose

This medicine is usually applied as a single application or as directed by your doctor. If you miss a dose, apply it as soon as you remember, unless it is almost time for the next dose. Do not apply a double dose to make up for a missed one. Follow your doctor's instructions carefully.

Additional Safety Advice

General Safety

For external use only. Avoid contact with eyes, mouth, and other mucous membranes. If accidental contact occurs, rinse thoroughly with water. Do not apply to broken or inflamed skin. Do not cover the treated area with tight bandages or dressings unless instructed by a doctor. Wash hands thoroughly after applying this medicine. Avoid inhaling the lotion. Keep out of reach of children. Do not use this medicine for any condition other than that prescribed by your doctor. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Do not use this medicine if you are allergic to any of its ingredients. If symptoms persist or worsen after treatment, consult your doctor. Do not use this medicine after the expiry date. Store in a cool, dry place away from direct sunlight. Do not freeze. This medicine is for individual use only; do not share it with others.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may have more sensitive skin and should use this medicine with caution. Monitor for signs of irritation. No dosage adjustment is required, but consult a doctor for personalized advice.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. Permethrin is considered safe during pregnancy, but the combination with cetrimide should be used under medical supervision.

🏥 Post-Surgery Considerations

If you have recently undergone surgery, consult your doctor before applying this medicine to surgical wounds or nearby areas. Avoid applying to broken or healing skin unless directed.

🦷 Dental Procedures

This medicine is for topical use and does not affect dental procedures. However, inform your dentist about all medications you are using.

💚 Lifestyle Tips for Better Results

🏃
Maintain good personal hygiene and wash your hands frequently.
🥗
Avoid sharing clothing, towels, or bedding with others until treatment is complete.
😴
Wash all personal items in hot water and dry on high heat.
💧
Keep your fingernails short to prevent scratching and secondary infection.
🧘
Apply a soothing moisturizer after washing off the medicine to reduce dryness.
🌞
Avoid close physical contact with others until you have completed treatment.
🚭
Vacuum carpets and furniture to remove any mites.

🏋️ Exercise Considerations

There are no specific exercise restrictions while using this medicine. However, avoid excessive sweating or activities that may cause the lotion to be washed off prematurely. If you exercise, ensure the medicine has been on for the recommended duration before washing it off.

🥗 Diet Recommendations

Stay well hydrated to maintain healthy skin.
Include foods rich in vitamin C and zinc to support skin healing.
Avoid excessive alcohol consumption as it may worsen skin irritation.
Eat a balanced diet to support overall immune function.

💼 Impact on Daily Work & Life

This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or drowsiness (rare), avoid these activities until you feel normal. You can continue your daily activities, but avoid close contact with others until treatment is complete to prevent spread.

🛑 When to Stop This Medicine

Stop using this medicine and consult your doctor if you experience severe skin irritation, allergic reactions, or if your symptoms do not improve after the recommended treatment period. Do not stop treatment prematurely unless advised by your doctor, as this may lead to treatment failure.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended unless directed by a doctor. Prolonged use may increase the risk of skin irritation or allergic reactions. If you require repeated treatments, consult your doctor to confirm the diagnosis and rule out other conditions. There is no evidence of systemic toxicity with proper topical use.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Benzyl benzoate lotion

An alternative scabicide that can be used if permethrin is not effective or not tolerated.

Evidence: Well-established
Crotamiton cream

Used for scabies and to relieve itching, but less effective than permethrin.

Evidence: Moderate
Sulfur ointment

An older treatment for scabies, often used in infants and pregnant women.

Evidence: Limited
Ivermectin (oral)

An oral medication for scabies, used in cases resistant to topical treatments.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. You can receive vaccinations while using this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate or freeze

✅ DO

Keep in the original container with the cap tightly closed

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight and heat

❌ DON'T

Do not store in the bathroom or near a sink

✅ DO

Keep out of reach of children and pets

❌ DON'T

Do not use after the expiry date

✈️ Traveling with This Medicine

When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If you are traveling across time zones, continue with your regular application schedule as prescribed. For international travel, check the customs regulations of your destination regarding prescription medications. Always keep the medicine in your carry-on luggage to avoid loss or temperature extremes.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with scabies infestation
She noticed intense itching at night and a rash on her hands and wrists. Her doctor diagnosed scabies and prescribed this medicine. She applied it from neck to toe, left it on overnight, and washed it off in the morning. She also washed all her bedding and clothes in hot water. Within a week, the itching reduced significantly, and the rash cleared up after two weeks.
💡 Lesson: Proper application and simultaneous cleaning of personal items are crucial to prevent re-infestation.
👤 A 6-year-old child with scabies
The child had itchy bumps on the fingers and abdomen. The pediatrician prescribed this medicine, instructing the parents to apply it to the child's entire body and leave it on for 8 hours. The parents also treated themselves and washed all toys and bedding. The child's symptoms improved within a few days, and a follow-up application after a week ensured complete cure.
💡 Lesson: Treating the whole family and following the application instructions carefully leads to successful scabies treatment.

💬 Questions Patients Often Ask

Q: How long does it take for this medicine to work?

A: The medicine starts killing mites soon after application, but itching may persist for up to 2-4 weeks as your skin reacts to the dead mites. If symptoms do not improve after 2 weeks, consult your doctor.

Q: Can I use this medicine on my face?

A: This medicine is generally not recommended for the face unless specifically directed by a doctor. Avoid contact with eyes, mouth, and mucous membranes.

Q: Is this medicine safe for children?

A: This medicine can be used in children over 2 months of age under medical supervision. For infants under 2 months, consult a pediatrician.

Q: Can I use this medicine during pregnancy?

A: Permethrin is considered safe during pregnancy when used as directed. However, consult your doctor before use.

Q: What should I do if I miss a dose?

A: If you miss a dose, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Do I need to wash my clothes and bedding?

A: Yes, wash all clothing, bedding, and towels in hot water and dry on high heat to kill any mites and prevent re-infestation.

Q: Can I use this medicine for lice?

A: This medicine may be used for lice infestations, but permethrin 5% is more commonly used for scabies. Consult your doctor for appropriate treatment.

Q: What are the side effects of this medicine?

A: Common side effects include mild skin irritation, itching, redness, or burning. Serious allergic reactions are rare but require immediate medical attention.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine on my face?
  • How long should I leave the lotion on?
  • Do I need to treat my whole family?
  • Can I use this medicine if I am pregnant?
  • What should I do if I accidentally swallow the lotion?
  • Will this medicine cure my itching immediately?
  • Can I use this medicine for head lice?
  • How should I clean my house to prevent re-infestation?

🛑 Myths vs. Facts

  • Myth: Scabies is caused by poor hygiene.
    Fact: Scabies is caused by a mite infestation and can affect anyone, regardless of hygiene.
  • Myth: You only need to treat the itchy areas.
    Fact: For scabies, the entire body from the neck down must be treated to kill all mites.
  • Myth: Scabies will go away on its own.
    Fact: Scabies requires treatment with scabicidal medication to eradicate the mites.
  • Myth: You can stop treatment once itching stops.
    Fact: Itching may persist for weeks after successful treatment; complete the full course as prescribed.

🔄 Alternative Options

Generic Alternatives

  • Permethrin 5% lotion
  • Cetrimide 0.5% solution

Brand Alternatives

  • Permethrin 5% w/v lotion (various brands)
  • Cetrimide 0.5% w/v lotion (various brands)

📊 Comparison with Similar Medicines

[{"medicine":"Permethrin 5% alone","composition":"Permethrin 5% w/v","uses":"Scabies, lice","notes":"First-line treatment for scabies."},{"medicine":"Benzyl benzoate 25%","composition":"Benzyl benzoate 25%","uses":"Scabies","notes":"Alternative for permethrin allergy; may cause irritation."},{"medicine":"Crotamiton 10%","composition":"Crotamiton 10%","uses":"Scabies, itching","notes":"Less effective than permethrin; used for itching relief."}]

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