Sayana Press 104mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction with swelling of face, lips, tongue, or throat
- Difficulty breathing or chest pain
- Sudden severe headache or vision changes
- Leg swelling, pain, or redness suggesting a blood clot
- Heavy or prolonged vaginal bleeding
- Yellowing of the skin or eyes
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is sayana press 104mg injection used for?
This medicine is a long-acting progestin-only contraceptive injection given under the skin once every 12 to 14 weeks. It prevents pregnancy mainly by stopping ovulation, thickening cervical mucus, and thinning the uterine lining. It does not protect against sexually transmitted infections.
- Generic Name: Medroxyprogesterone acetate (104mg)
- Manufacturer: Pfizer Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sayana press 104mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक दीर्घकालिक प्रोजेस्टिन-ओनली गर्भनिरोधक इंजेक्शन है जिसे त्वचा के नीचे हर 12 से 14 सप्ताह में एक बार दिया जाता है। यह मुख्य रूप से ओव्यूलेशन को रोककर, गर्भाशय ग्रीवा के बलगम को गाढ़ा करके और गर्भाशय की परत को पतला करके गर्भधारण को रोकती है। यह दवा एचआईवी या अन्य यौन संचारित संक्रमणों से सुरक्षा नहीं देती, इसलिए कंडोम का उपयोग करना चाहिए। यह उन महिलाओं के लिए उपयुक्त है जो रोजाना गोली नहीं लेना चाहतीं और लंबे समय तक चलने वाला, प्रतिवर्ती गर्भनिरोधक विकल्प चाहती हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में अनियमित मासिक धर्म, स्पॉटिंग, मासिक धर्म का बंद हो जाना, वजन बढ़ना, स्तनों में कोमलता, सिरदर्द, मूड में बदलाव और इंजेक्शन लगाने की जगह पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन गंभीर एलर्जी, रक्त के थक्के और लंबे समय तक उपयोग से हड्डियों के घनत्व में कमी हो सकती है। यदि आपको बहुत अधिक रक्तस्राव, तेज दर्द, सांस लेने में कठिनाई या पैर में सूजन हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्यकर्मी द्वारा त्वचा के नीचे इंजेक्शन के रूप में दी जानी चाहिए। अपने इंजेक्शन का समय न चूकें क्योंकि यह हर 12 से 14 सप्ताह में दोबारा लगाना आवश्यक है। इंजेक्शन लगाने के बाद जगह को जोर से न रगड़ें। अपने डॉक्टर को अपनी सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में बताएं। यौन संचारित संक्रमणों से बचाव के लिए कंडोम का उपयोग करें। यदि आपको गर्भधारण का संदेह है तो अगले इंजेक्शन से पहले डॉक्टर से संपर्क करें।
💊 sayana press 104mg injection Uses & Benefits
[{"condition":"Contraception","description":"This medicine is used as a long-acting reversible contraceptive to prevent pregnancy in adult women.","evidence":"Well-established"},{"condition":"Endometriosis-associated pain","description":"Medroxyprogesterone acetate is sometimes used to reduce pain related to endometriosis by suppressing the growth of endometrial tissue.","evidence":"Moderate"},{"condition":"Abnormal uterine bleeding","description":"It may be used to control certain types of abnormal uterine bleeding by thinning the uterine lining.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Menstrual suppression","description":"Sometimes used off-label to reduce or stop menstrual bleeding for medical or personal reasons.","evidence":"Limited"},{"condition":"Hormone-related headache","description":"Occasionally prescribed off-label for menstrual migraine or hormone-related headache, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Contraception
Also treats: Endometriosis, Abnormal uterine bleeding
📋 Drug Information
| Generic Name(s) | Medroxyprogesterone acetate (104mg) |
| Brand Name | sayana press 104mg injection |
| Manufacturer | Pfizer Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Progestins (First generation) |
| Route of Administration | Parenteral |
| Storage | Store this medicine in its original packaging at room temperature between 20°C and 25°C (68°F to 77°F). Do not freeze. Protect from light and moisture. |
| Shelf Life | The shelf life is typically 24 to 36 months from the date of manufacture. Check the expiry date on the packaging before use. |
| WHO Guideline | The World Health Organization recognizes progestin-only injectables, including medroxyprogesterone acetate, as effective contraceptive methods. Specific recommendations should be checked in the latest WHO medical eligibility criteria. |
| ICMR Guideline | The Indian Council of Medical Research has supported the use of injectable contraceptives in India as part of the national family planning program. Follow national guidance and your clinician's advice. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works primarily by suppressing ovulation through negative feedback on the hypothalamic-pituitary-ovarian axis. Medroxyprogesterone acetate reduces the mid-cycle surge of luteinizing hormone, which prevents the release of a mature egg. It also thickens cervical mucus, making it difficult for sperm to travel through the cervix, and it thins the endometrium, which reduces the likelihood of implantation if fertilization occurs. These combined actions provide contraceptive protection when the injection is given on schedule.
Mechanism Steps
💡 How to Take sayana press 104mg injection
Strength: Subcutaneous injection, 104 mg per 0.65 mL prefilled device.
Dosage Information
| Adult Dosage | The standard adult dose of this medicine is 104 mg given as a subcutaneous injection once every 12 to 14 weeks. The first injection is usually given during the first 5 days of the menstrual cycle. If given at another time, use backup contraception for 7 days. Dose must be individualized by a qualified clinician based on your medical history, medicines, and reproductive goals. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or adolescent health specialist. |
| Elderly Dosage | This medicine is not intended for use in women who have reached menopause. Elderly women should not use it for contraception. |
| Renal Impairment | No specific dose adjustment is established for kidney disease. Discuss with your clinician if you have kidney problems. |
| Hepatic Impairment | This medicine should not be used in women with active liver disease or liver tumors. For mild liver impairment, your clinician will decide whether it is safe based on your condition. |
| Maximum Daily Dose | This medicine is not taken daily. The maximum recommended dose is 104 mg per injection, given every 12 to 14 weeks. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sayana press 104mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampin | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| St. John's wort | Major | |
| Warfarin | Moderate | |
| Aminoglutethimide | Moderate | |
| Bosentan | Moderate | |
| Broad-spectrum antibiotics | Minor |
🚨 Major Interactions
- Strong CYP3A4 inducers such as rifampin, carbamazepine, phenytoin, and St. John's wort
- Warfarin and other anticoagulants
⚡ Moderate Interactions
- Aminoglutethimide
- Bosentan
🍷 Alcohol Interaction
There is no direct interaction between this medicine and alcohol, but alcohol can worsen dizziness, mood changes, and liver stress. It is best to limit alcohol while using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known or suspected pregnancy","Known or suspected breast cancer","Active liver disease or liver tumors","Unexplained vaginal bleeding","Severe allergic reaction to medroxyprogesterone acetate or any ingredient in the injection","Current or past blood clot disorder unless cleared by a specialist"]
⚠️ Warnings & Precautions
["This medicine does not protect against HIV or other sexually transmitted infections.","Use backup contraception for the first 7 days if the injection is not given during the first 5 days of your cycle.","Long-term use may reduce bone mineral density; discuss risk factors with your clinician.","Tell your clinician if you have a history of depression, migraine, or blood clots.","Do not self-administer unless you have been trained and cleared by your clinician.","Keep all follow-up appointments for repeat injections."]
🤱 Lactation Safety
Medroxyprogesterone acetate passes into breast milk in small amounts. It is generally considered compatible with breastfeeding, but discuss timing and any concerns with your clinician, especially in the first 6 weeks after delivery.
💊 Overdose Management
Overdose with this medicine is unlikely because it is given as a single injection by a healthcare professional. If an accidental overdose occurs, seek medical attention. Treatment is supportive and based on symptoms.
⏰ Missed Dose
If you miss your scheduled injection, contact your clinician as soon as possible. You may need a repeat injection and backup contraception for 7 days. Do not try to catch up by taking extra doses on your own.
Additional Safety Advice
This medicine must be given by a healthcare professional as a subcutaneous injection, usually in the front of the thigh or abdomen. Keep your appointment schedule because the injection needs to be repeated every 12 to 14 weeks to remain effective. Do not massage or rub the injection site vigorously after the dose. Tell your clinician about all medicines, supplements, and herbal products you take, especially those that affect liver enzymes or blood clotting. Use condoms to protect against sexually transmitted infections because this medicine does not prevent them. If you suspect you are pregnant, contact your clinician before the next injection. Do not stop or restart this medicine on your own; your clinician will help you plan the next step if you want to switch methods or become pregnant.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not intended for use in women who have reached menopause. It should not be used for contraception in elderly women.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, stop this medicine and consult your clinician. Fertility usually returns after stopping, but it may take several months for your menstrual cycles to become regular.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are using this medicine. There are no specific restrictions, but they should be aware of all medicines you take.
🦷 Dental Procedures
Tell your dentist that you are using this medicine. There are no specific dental precautions, but it is important for your dental team to know your full medicine list.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is encouraged, especially weight-bearing activities that help maintain bone strength. If you experience dizziness or fatigue after the injection, avoid strenuous activity until you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine usually does not affect your ability to work or drive. Some women may experience dizziness or mood changes; if affected, avoid driving or operating heavy machinery until you feel normal.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your clinician. If you wish to become pregnant or switch methods, your clinician will guide you on the best timing and transition plan.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to a decrease in bone mineral density, especially in adolescents and women with additional risk factors. This effect is generally reversible after stopping the injection, but recovery may take time. Regular follow-up with your clinician is important to monitor bone health and discuss whether continued use is appropriate.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Daily pills that contain estrogen and progestin or progestin only.
Evidence: Well-establishedA small rod placed under the skin that releases progestin for up to 3 years.
Evidence: Well-establishedA device placed in the uterus that provides long-acting contraception.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive routine vaccinations while using this medicine.
📦 Storage Guide
✅ DO
Store at room temperature between 20°C and 25°C
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it at room temperature and protect it from extreme heat or cold. If you are traveling across time zones, plan your injection schedule with your clinician so you do not miss a dose. Check customs rules for carrying prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: If given during the first 5 days of your menstrual cycle, it works within 7 days. Otherwise, use backup contraception for 7 days.
A: You need a repeat injection every 12 to 14 weeks to stay protected.
A: Some women may gain weight, but it varies. A healthy diet and regular exercise can help.
A: Yes, fertility usually returns after stopping, but it may take several months for your cycles to become regular.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine causes permanent infertility.
Fact: Fertility usually returns after stopping the injection, but it may take several months for cycles to become regular. - Myth: This medicine protects against sexually transmitted infections.
Fact: It does not protect against HIV or other sexually transmitted infections. Use condoms for protection. - Myth: You need to take a pill every day with this method.
Fact: This is an injection given every 12 to 14 weeks, not a daily pill.
🔄 Alternative Options
Generic Alternatives
- Medroxyprogesterone acetate 104 mg subcutaneous injection
Brand Alternatives
- Sayana Press 104mg injection