Ederoz 400mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, muscle twitching, or diarrhea (signs of serotonin syndrome).
- Unusually elevated mood, decreased need for sleep, racing thoughts, or impulsive behavior (signs of mania).
- Rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing (signs of allergic reaction).
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain (signs of liver problems).
- Severe or persistent nausea, vomiting, or diarrhea leading to dehydration.
- Chest pain, palpitations, or shortness of breath.
- Any new or worsening symptoms that concern you.
If experiencing severe symptoms, call emergency services immediately.
What is samorac 400 tablet used for?
This medicine contains S-Adenosyl L-Methionine 400mg, used for liver health and mood support. It works by donating methyl groups and is taken orally with food. Common side effects include nausea and headache. It should be avoided in bipolar disorder and with MAO inhibitors.
- Generic Name: S-Adenosyl L-Methoinine Disulfate Tosylate (400mg)
- Manufacturer: Vitalae Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 samorac 400 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से लिवर की समस्याओं जैसे इंट्राहेपेटिक कोलेस्टेसिस और गर्भावस्था के दौरान होने वाले कोलेस्टेसिस के इलाज में उपयोग की जाती है। यह लिवर में पित्त के प्रवाह को सुधारने और लिवर की सूजन को कम करने में मदद करती है। इसके अलावा, यह दवा अवसाद (डिप्रेशन) के इलाज में सहायक के रूप में भी इस्तेमाल की जाती है, खासकर जब अन्य दवाएं पूरी तरह से काम नहीं कर रही हों। यह मूड को बेहतर बनाने में मदद कर सकती है। कुछ लोग इसे जोड़ों के दर्द और फाइब्रोमायल्जिया में भी आजमाते हैं, लेकिन इसके लिए मजबूत सबूत नहीं हैं। यह दवा डॉक्टर की सलाह के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में मतली, पेट में असहजता, दस्त और सिरदर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कुछ लोगों को बेचैनी, घबराहट, नींद न आना या चक्कर आना भी महसूस हो सकता है। दुर्लभ मामलों में एलर्जी, मूड में अचानक बदलाव या सेरोटोनिन सिंड्रोम जैसी गंभीर समस्या हो सकती है। अगर आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब का सेवन बिल्कुल न करें क्योंकि इससे लिवर पर दबाव बढ़ सकता है। अगर आप डिप्रेशन, बाइपोलर डिसऑर्डर या पार्किंसन की दवाएं ले रहे हैं तो डॉक्टर को जरूर बताएं। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग डॉक्टर की सलाह के बिना न करें। दवा को बच्चों से दूर रखें और सूखी ठंडी जगह पर संभालें।
💊 samorac 400 tablet Uses & Benefits
[{"condition":"Intrahepatic cholestasis","description":"This medicine is used to improve bile flow and reduce liver enzyme elevation in people with intrahepatic cholestasis, including cholestasis of pregnancy.","evidence":"Well-established"},{"condition":"Major depressive disorder (adjunct)","description":"This medicine is sometimes used as an add-on treatment to standard antidepressants to improve mood symptoms, especially when response is incomplete.","evidence":"Moderate"},{"condition":"Osteoarthritis","description":"This medicine may help reduce joint pain and improve function in some people with osteoarthritis, although results vary.","evidence":"Limited"},{"condition":"Fibromyalgia","description":"This medicine has been studied for reducing pain and fatigue in fibromyalgia, but evidence is not consistent.","evidence":"Limited"},{"condition":"Liver support in chronic liver disease","description":"This medicine is sometimes used to support liver function in chronic liver conditions, but it is not a cure for any liver disease.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"This medicine is occasionally prescribed off-label to reduce the frequency of migraines, but evidence is not strong.","evidence":"Limited"},{"condition":"Attention deficit hyperactivity disorder (ADHD)","description":"This medicine has been explored as an off-label adjunct in ADHD, but it is not a standard treatment.","evidence":"Limited"},{"condition":"Bipolar depression","description":"This medicine may be used off-label in bipolar depression, but it carries a risk of triggering mania and must be monitored closely.","evidence":"Limited"}]
Primary treatment for: Intrahepatic cholestasis
Also treats: Major depressive disorder, Osteoarthritis, Fibromyalgia, Chronic liver disease
📋 Drug Information
| Generic Name(s) | S-Adenosyl L-Methoinine Disulfate Tosylate (400mg) |
| Brand Name | samorac 400 tablet |
| Manufacturer | Vitalae Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F). Keep it in its original container, tightly closed, away from direct sunlight, heat, and moisture. Do not store it in the bathroom. Keep out of the reach of children and pets. |
| Shelf Life | Not established from the available information. Refer to the expiry date printed on the packaging. Do not use this medicine after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by donating methyl groups in a process called transmethylation. The active ingredient, S-Adenosyl L-Methionine, is a natural molecule that participates in three key pathways: it acts as a methyl donor for the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine; it contributes to the production of glutathione, a major antioxidant that protects liver cells; and it supports the conversion of phosphatidylethanolamine to phosphatidylcholine, which is important for bile flow and liver cell membrane health. By supporting these pathways, this medicine can help improve mood, reduce liver inflammation, and promote better bile drainage in conditions such as intrahepatic cholestasis.
Mechanism Steps
💡 How to Take samorac 400 tablet
Strength: This medicine is available as an immediate-release tablet containing 400mg of S-Adenosyl L-Methionine Disulfate Tosylate.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 400mg taken by mouth once or twice daily, but the exact dose and frequency depend on the condition being treated, your age, kidney and liver function, and other medicines you take. For liver conditions, the dose may be 400mg twice daily. For mood support, the dose may be 400mg once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and monitor for side effects such as dizziness, confusion, or mood changes. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Dose adjustment may be needed in patients with kidney disease. Consult your doctor for personalized dosing. |
| Hepatic Impairment | Dose adjustment may be needed in patients with severe liver disease. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of samorac 400 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| SSRIs | Major | |
| SNRIs | Major | |
| Triptans | Major | |
| Tramadol | Major | |
| Levodopa | Moderate | |
| Antipsychotics | Moderate | |
| Anticonvulsants | Moderate | |
| Warfarin | Moderate | |
| Alcohol | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- SSRIs (e.g., fluoxetine, sertraline)
- SNRIs (e.g., venlafaxine, duloxetine)
- Triptans (e.g., sumatriptan)
- Tramadol
⚡ Moderate Interactions
- Levodopa
- Antipsychotics (e.g., haloperidol, risperidone)
- Anticonvulsants (e.g., carbamazepine, phenytoin)
- Anticoagulants (e.g., warfarin)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of liver damage and may worsen side effects such as nausea, headache, and mood changes. If you drink alcohol regularly, discuss this with your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to S-Adenosyl L-Methionine or any component of this medicine.","Bipolar disorder, unless under close psychiatric supervision, because of the risk of triggering mania.","Use with MAO inhibitors or within 14 days of stopping an MAO inhibitor.","Pregnancy and breastfeeding, unless specifically advised by a doctor.","Children, unless prescribed by a pediatrician."]
⚠️ Warnings & Precautions
["This medicine may trigger mania or hypomania in people with bipolar disorder. Use with caution and monitor mood closely.","This medicine may interact with serotonergic drugs and increase the risk of serotonin syndrome. Inform your doctor about all medicines you take.","This medicine may reduce the effectiveness of levodopa in Parkinson's disease. Monitor symptoms.","Avoid alcohol while taking this medicine to reduce liver stress and side effects.","Do not drive or operate heavy machinery until you know how this medicine affects you, as it may cause dizziness or drowsiness.","Use with caution in people with kidney or liver disease. Dose adjustment may be needed.","Do not use this medicine for self-treatment of depression without professional supervision.","Keep this medicine out of the reach of children."]
🤱 Lactation Safety
Not established from the available information. It is not known whether this medicine passes into breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
If you suspect an overdose of this medicine, seek immediate medical attention or contact a poison control center. Symptoms of overdose may include severe nausea, vomiting, diarrhea, agitation, confusion, rapid heartbeat, and mood changes. Treatment is supportive and symptomatic. There is no specific antidote. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than half the dosing interval has passed. If more than half the dosing interval has passed, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, and do not change the dose on your own. Swallow the tablet whole with a glass of water, preferably with food to reduce stomach upset. Avoid alcohol while taking this medicine because it can worsen liver stress and increase the risk of side effects. Do not take this medicine with other supplements or medicines that increase serotonin without first checking with your doctor, as this can lead to a serious condition called serotonin syndrome. If you have bipolar disorder, a history of mania, or are taking medicines for Parkinson's disease, tell your doctor before starting this medicine. Do not use this medicine during pregnancy or breastfeeding unless your doctor specifically advises it. Keep this medicine out of the reach of children and store it in its original container away from heat and moisture. If you miss a dose, follow the missed dose guidance provided in this profile, and never double the dose to catch up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially dizziness, confusion, and mood changes. Start with a lower dose and monitor closely. Regular follow-up with your doctor is recommended to adjust the dose as needed based on kidney and liver function.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss this medicine with your doctor before conception. The safety of this medicine during pregnancy is not fully established. Your doctor will weigh the benefits and risks and may recommend alternative treatments or close monitoring.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with other medicines used during surgery. Your doctor may advise you to stop this medicine temporarily before surgery. Do not stop it without medical advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There are no known direct interactions with dental anesthetics, but it is important for your dentist to know your complete medication list. Continue taking this medicine as prescribed unless your doctor advises otherwise.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or drowsiness in some people. Avoid strenuous exercise or activities requiring alertness until you know how this medicine affects you. If you experience dizziness, rest and hydrate. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or mood changes in some people. If you experience these effects, avoid driving or operating heavy machinery until you feel alert. Most people can continue their normal work and daily activities, but it is important to monitor how you feel and report any concerns to your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as serotonin syndrome, mania, or allergic reactions, seek immediate medical attention. Your doctor will decide if and when to stop this medicine based on your condition and response to treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally considered safe when taken under medical supervision. However, regular monitoring of liver function and mood may be advised, especially if you have liver disease or bipolar disorder. Some people may experience persistent gastrointestinal side effects. The benefits and risks of long-term use should be discussed with your doctor, who will determine the appropriate duration of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another medicine used for cholestasis that works by improving bile flow.
Evidence: Well-establishedAn antioxidant that may support liver health.
Evidence: LimitedA herbal supplement sometimes used for liver support.
Evidence: LimitedA non-drug approach for depression that can complement medicine.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking. Continue taking this medicine as prescribed unless your doctor advises otherwise.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store the medicine in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your doses at the same intervals as prescribed, but consult your doctor for specific advice. Do not pack this medicine in checked luggage; keep it in your carry-on bag. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Some people may notice improvements in mood or liver symptoms within 1 to 2 weeks, but full effects may take 4 to 6 weeks. Continue taking it as prescribed.
A: Yes, taking this medicine with food is recommended to reduce stomach upset and nausea.
A: If you miss a dose, take it as soon as you remember if less than half the dosing interval has passed. If more than half has passed, skip the missed dose and continue with your regular schedule. Do not double dose.
A: The safety of this medicine during pregnancy is not fully established. It may be used for cholestasis of pregnancy under medical supervision. Consult your doctor before use.
A: Do not stop this medicine without consulting your doctor, as sudden discontinuation may lead to return of symptoms.
🤔 Common Patient Concerns
🔄 Substitutes for samorac 400 tablet
View AllAlternative brands with exact same active ingredient:
-
livsam 400mg tabletSkyglow Pharmaceuticals Private Limited ₹459.38 45.5% CHEAPER
-
adesure 400mg tabletSolarium Pharmaceuticals ₹525.00 37.7% CHEAPER
-
adniva 400 tabletPalvin Pharmaceuticals ₹550.00 34.7% CHEAPER
-
lesamy 400mg tabletLeeford Healthcare Ltd ₹620.00 26.4% CHEAPER
-
ederoz 400mg tabletHauz Pharma Pvt Ltd ₹655.31 22.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a natural supplement, so it is completely safe.
Fact: Even natural substances can cause side effects and interact with other medicines. This medicine should be used under medical supervision. - Myth: This medicine can cure depression on its own.
Fact: This medicine may help as an add-on treatment, but it is not a standalone cure for depression. It should be part of a comprehensive treatment plan. - Myth: You can stop this medicine suddenly without any problems.
Fact: You should consult your doctor before stopping this medicine, as sudden discontinuation may lead to return of symptoms.
🔄 Alternative Options
Generic Alternatives
- S-Adenosyl L-Methionine 400mg tablet
Brand Alternatives
- Ederoz 400mg tablet